Thiago Costa de Oliveira, Ivo Alves de Campos Neto, Manuel Hermínio de Aguiar-Oliveira, Francisco de Assis Pereira
{"title":"锂盐对精神病患者甲状旁腺功能和矿物质代谢的影响。","authors":"Thiago Costa de Oliveira, Ivo Alves de Campos Neto, Manuel Hermínio de Aguiar-Oliveira, Francisco de Assis Pereira","doi":"10.1590/0004-2730000002983","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts.</p><p><strong>Materials and methods: </strong>We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).</p><p><strong>Results: </strong>The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.</p><p><strong>Conclusion: </strong>Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.</p>","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":"58 6","pages":"619-24"},"PeriodicalIF":0.0000,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000002983","citationCount":"5","resultStr":"{\"title\":\"Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts.\",\"authors\":\"Thiago Costa de Oliveira, Ivo Alves de Campos Neto, Manuel Hermínio de Aguiar-Oliveira, Francisco de Assis Pereira\",\"doi\":\"10.1590/0004-2730000002983\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts.</p><p><strong>Materials and methods: </strong>We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).</p><p><strong>Results: </strong>The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.</p><p><strong>Conclusion: </strong>Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.</p>\",\"PeriodicalId\":8395,\"journal\":{\"name\":\"Arquivos brasileiros de endocrinologia e metabologia\",\"volume\":\"58 6\",\"pages\":\"619-24\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1590/0004-2730000002983\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arquivos brasileiros de endocrinologia e metabologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1590/0004-2730000002983\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arquivos brasileiros de endocrinologia e metabologia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/0004-2730000002983","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
摘要
目的:评价使用锂盐的精神病患者甲状旁腺功能和矿物质代谢。材料与方法:测定35例经诊断为双相情感障碍且使用碳酸锂(LC)至少一年的患者(锂组- LG)和35例健康受试者(对照组- CG)血清钙、离子钙、无机磷、碱性磷酸酶、白蛋白、甲状旁腺激素(PTH)、尿素、肌酐、25-羟基维生素D和锂的水平。结果:LG、CG在性别、年龄上基本一致。PTH、离子钙水平差异有统计学意义，p < 0.004, p < 0.03。在8例(22.8%)LG患者中发现继发性甲状旁腺功能亢进(HPT)，而在CG中没有发现。血氧浓度与使用时间、剂量无相关性。结论:我们的数据表明，锂可能会造成甲状旁腺轴失衡，其特征是甲状旁腺激素水平升高。
Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts.
Objective: To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts.
Materials and methods: We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).
Results: The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.
Conclusion: Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
