Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts.

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI:10.1590/0004-2730000002983

Thiago Costa de Oliveira, Ivo Alves de Campos Neto, Manuel Hermínio de Aguiar-Oliveira, Francisco de Assis Pereira

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引用次数: 5

Abstract

Objective: To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts.

Materials and methods: We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group - LG) and 35 healthy subjects (Control Group - CG).

Results: The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC.

Conclusion: Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH.

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锂盐对精神病患者甲状旁腺功能和矿物质代谢的影响。

目的:评价使用锂盐的精神病患者甲状旁腺功能和矿物质代谢。材料与方法:测定35例经诊断为双相情感障碍且使用碳酸锂(LC)至少一年的患者(锂组- LG)和35例健康受试者(对照组- CG)血清钙、离子钙、无机磷、碱性磷酸酶、白蛋白、甲状旁腺激素(PTH)、尿素、肌酐、25-羟基维生素D和锂的水平。结果:LG、CG在性别、年龄上基本一致。PTH、离子钙水平差异有统计学意义，p < 0.004, p < 0.03。在8例(22.8%)LG患者中发现继发性甲状旁腺功能亢进(HPT)，而在CG中没有发现。血氧浓度与使用时间、剂量无相关性。结论:我们的数据表明，锂可能会造成甲状旁腺轴失衡，其特征是甲状旁腺激素水平升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos brasileiros de endocrinologia e metabologia 医学-内分泌学与代谢

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4-8 weeks