Archivum Immunologiae et Therapiae Experimentalis最新文献_第7页

Elevated Levels of Soluble CD147 are Associated with Hyperinflammation and Disease Severity in COVID-19: A Proof-of-Concept Clinical Study 可溶性CD147水平升高与COVID-19的高炎症和疾病严重程度相关:一项概念验证临床研究

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-08-03 DOI: 10.1007/s00005-022-00657-6

Rashidi Springall, Julieta González-Flores, Carlos García-Ávila, Yaneli Juárez-Vicuña, Adrián Hernández-Diazcouder, Ricardo Márquez-Velasco, Sergio Cásares-Alvarado, Fausto Sánchez-Muñoz, Edna Basilio-Gálvez, Mauricio Castillo-Salazar, Martha A. Ballinas-Verdugo, Malinalli Brianza-Padilla, José L. Sánchez-Gloria, Claudia Tavera-Alonso, Julio Sandoval, Héctor González-Pacheco, Luis M. Amezcua-Guerra

{"title":"Elevated Levels of Soluble CD147 are Associated with Hyperinflammation and Disease Severity in COVID-19: A Proof-of-Concept Clinical Study","authors":"Rashidi Springall, Julieta González-Flores, Carlos García-Ávila, Yaneli Juárez-Vicuña, Adrián Hernández-Diazcouder, Ricardo Márquez-Velasco, Sergio Cásares-Alvarado, Fausto Sánchez-Muñoz, Edna Basilio-Gálvez, Mauricio Castillo-Salazar, Martha A. Ballinas-Verdugo, Malinalli Brianza-Padilla, José L. Sánchez-Gloria, Claudia Tavera-Alonso, Julio Sandoval, Héctor González-Pacheco, Luis M. Amezcua-Guerra","doi":"10.1007/s00005-022-00657-6","DOIUrl":"10.1007/s00005-022-00657-6","url":null,"abstract":"<div><p>To evaluate soluble CD147 levels in COVID-19 and identify whether these are associated with hyperinflammation and disease severity. One-hundred and nine COVID-19 patients and 72 healthy blood donors were studied. Levels of CD147, matrix metalloproteases (MMP) and inflammatory markers were measured on hospital arrival, while the need for mechanical ventilation and the occurrence of death during hospitalization were recorded. CD147 levels were higher in COVID-19 (1.6, 1.0–2.3 vs 1.3, 1.0–1.6 ng/ml; <i>P</i> = 0.003) than controls. MMP-2 (9.2, 4.5–12.9 vs 4.2, 3.7–4.6 ng/ml; <i>P</i> < 0.001), MMP-3 (1.1, 0.9–1.3 vs 0.9, 0.7–1.0 ng/ml; <i>P</i> < 0.001) and MMP-9 (0.9, 0.5–1.2 vs 0.4, 0.2–0.6 ng/ml; <i>P</i> < 0.001) were also higher in COVID-19, while MMP-1 (0.6, 0–1.4 vs 0.6, 0.3–0.7 ng/ml; <i>P</i> = 0.711) was not different. Significant correlations were found between CD147 and MMP-2 (<i>ρ</i> = 0.34), MMP-3 (<i>ρ</i> = 0.21), interleukin 6 (<i>ρ</i> = 0.21), and the neutrophil/lymphocyte ratio (<i>ρ</i> = 0.26). Furthermore, CD147 levels were higher in patients who required mechanical ventilation (1.8, 1.4–2.4 <i>vs</i> 1.2, 0.8–1.9 ng/ml; <i>P</i> < 0.001) and in those who ultimately died (1.9, 1.4–2.7 vs 1.4, 0.9–1.9 ng/ml; <i>P</i> = 0.009). CD147 is elevated in COVID-19 and appears to contribute to hyperinflammation and disease severity.</p></div>","PeriodicalId":8389,"journal":{"name":"Archivum Immunologiae et Therapiae Experimentalis","volume":"70 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00005-022-00657-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40579968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Effect of Inhaled Air Particulate Matter SRM 1648a on the Development of Mild Collagen-Induced Arthritis in DBA/J Mice 吸入空气颗粒物SRM 1648a对DBA/J小鼠轻度胶原性关节炎发展的影响

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-07-28 DOI: 10.1007/s00005-022-00654-9

Bernadeta Nowak, Grzegorz Majka, Małgorzata Śróttek, Anna Skałkowska, Janusz Marcinkiewicz

{"title":"The Effect of Inhaled Air Particulate Matter SRM 1648a on the Development of Mild Collagen-Induced Arthritis in DBA/J Mice","authors":"Bernadeta Nowak, Grzegorz Majka, Małgorzata Śróttek, Anna Skałkowska, Janusz Marcinkiewicz","doi":"10.1007/s00005-022-00654-9","DOIUrl":"10.1007/s00005-022-00654-9","url":null,"abstract":"<div><p>Air pollution is considered to be one of a risk factor for rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is commonly used as a mouse model of human RA. However, the impact of specific particulate matter (PM) components on the incidence and severity of RA has still not been established. The aim of this study was to develop an experimental model of CIA suitable to test arthritogenicity of inhaled PM. A mild form of CIA was induced in DBA1/J mice inhaled with various components of SRM 1648a PM. The incidence and severity of arthritis was assessed, and the selected serum markers of autoimmunity and inflammation were determined. Clinical arthritis was observed from the booster CII immunisation onward. Anti-cyclic citrullinated peptide antibodies, a diagnostic marker of RA, were detected in serum of these mice. All inhaled pollutants, crude PM, PM with reduced organic content, ferric, and silica nanoparticles markedly increased CIA incidence and severity. The fastest progression of CIA development was caused by crude PM and was linked to enhanced serum levels of anti-CII IgG, the prominent arthritogenic autoantibodies. On the other hand, inhaled nanoparticles enhanced serum levels of TNFα, a major proinflammatory arthritogenic cytokine. We recommend this experimental model of mild CIA to test the mechanisms of arthritis exacerbation by inhaled air pollutants. Further studies are necessary to determine whether PM-aggravated arthritis is caused by inflammatory mediators translocated from inflamed lung into systemic circulation or whether PM translocated into the bloodstream directly exacerbate joint inflammation.</p></div>","PeriodicalId":8389,"journal":{"name":"Archivum Immunologiae et Therapiae Experimentalis","volume":"70 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00005-022-00654-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40639040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Sex Differences in Innate Immune Response of Peripheral Blood Leukocytes of Alzheimer’s Disease Patients 阿尔茨海默病患者外周血白细胞先天免疫反应的性别差异

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-06-16 DOI: 10.1007/s00005-022-00653-w

Marta Sochocka, Michał Ochnik, Maciej Sobczyński, Beata Orzechowska, Jerzy Leszek

{"title":"Sex Differences in Innate Immune Response of Peripheral Blood Leukocytes of Alzheimer’s Disease Patients","authors":"Marta Sochocka, Michał Ochnik, Maciej Sobczyński, Beata Orzechowska, Jerzy Leszek","doi":"10.1007/s00005-022-00653-w","DOIUrl":"10.1007/s00005-022-00653-w","url":null,"abstract":"<div><p>Neurodegenerative disorders, including Alzheimer’s disease (AD), are associated with a disruption of normal immune function that could potentially impact the brain. In AD sex and gender have been noted as relevant to disease prevalence or clinical manifestation. It is suggested that disease progression could vary as a result of the different inflammation state among males and females. The objective was to investigate sex-dependent difference in innate immunity of AD patients and healthy, age-matched controls. The level of innate immunity was measured with test based on peripheral blood leukocytes (PBLs) resistance to viral infection (vesicular stomatitis virus, VSV) ex vivo. Cytokine: TNF-α, IFN-γ, IL-1β, IL-10 production by uninfected and VSV-infected PBLs ex vivo with enzyme-linked immunosorbent assay were examined. In contrast to controls, women with AD exhibit lower average level of innate immunity than AD men. The mean level of TNF-α, IL-10 and IL-1β was higher in AD men than in AD women whereas such changes were not observed among controls. The level of IFN-γ was higher in AD than in controls. PBLs from AD did not increase IFN-γ production after viral infection in contrast to controls. Leukocytes from women with AD exhibited a weaker response to viral infection and much less cytokine production compared to men with AD. It is important to consider sex as a biological variable in AD as it shows promises to advance our understanding of mechanisms of AD pathology and may be the basis for future treatment of AD.</p></div>","PeriodicalId":8389,"journal":{"name":"Archivum Immunologiae et Therapiae Experimentalis","volume":"70 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50032794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Transcriptome Studies in Lupus Nephritis 狼疮性肾炎的转录组研究

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-04-25 DOI: 10.1007/s00005-022-00651-y

Marta E. Alarcón-Riquelme

引用次数: 0

Hydroxychloroquine Therapy and Serum Immunoglobulin Levels in Women with IgG Subclass Deficiency and Systemic Lupus Erythematosus, Sjögren Syndrome, and Rheumatoid Arthritis: A Retrospective Study 羟氯喹治疗和血清免疫球蛋白水平在妇女IgG亚类缺乏和系统性红斑狼疮，Sjögren综合征，类风湿关节炎:回顾性研究

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-04-11 DOI: 10.1007/s00005-022-00652-x

James C. Barton, J. Clayborn Barton, Luigi F. Bertoli

{"title":"Hydroxychloroquine Therapy and Serum Immunoglobulin Levels in Women with IgG Subclass Deficiency and Systemic Lupus Erythematosus, Sjögren Syndrome, and Rheumatoid Arthritis: A Retrospective Study","authors":"James C. Barton, J. Clayborn Barton, Luigi F. Bertoli","doi":"10.1007/s00005-022-00652-x","DOIUrl":"10.1007/s00005-022-00652-x","url":null,"abstract":"<div><p>Hydroxychloroquine (HCQ) therapy decreased immunoglobulin (Ig) levels in patients with Sjögren syndrome (SS) and rheumatoid arthritis (RA) in previous studies. We found no report of Ig levels of women with IgG subclass deficiency (IgGSD) and systemic lupus erythematosus (SLE), SS, or RA treated with HCQ. We retrospectively evaluated IgG, IgG subclass, IgA, and IgM levels and other characteristics of women at IgGSD diagnosis who did and did not take HCQ for SLE, SS, or RA. There were 132 women (48 subnormal IgG1 only, 49 combined subnormal IgG1/IgG3, and 35 subnormal IgG3 only). Mean age was 49 ± 13 years. Twenty-two women with SLE, SS, RA, or combination thereof reported HCQ ≥ 200 mg/day ≥ 6 months. In each IgGSD subtype, median Ig levels of women who took HCQ were not significantly lower than those of women who did not take HCQ. Women with combined subnormal IgG1/IgG3 who took HCQ had greater median IgG2 than women who did not take HCQ (4.89 g/L (range 4.43, 4.94) vs. 2.57 g/L (1.21, 6.44), respectively; <i>p</i> = 0.0123). Regressions on IgG1, IgG2, and IgG3 revealed positive associations with HCQ therapy (<i>p</i> = 0.0043, 0.0037, and 0.0139, respectively). There were no significant Ig associations with age, SLE, SS, or RA as independent variables. HCQ therapy of SLE, SS, or RA in women with IgGSD was not associated with significantly lower IgG, IgG subclass, IgA, or IgM levels. IgG1, IgG2, and IgG3 were positively associated with HCQ therapy, after adjustment for other variables.</p></div>","PeriodicalId":8389,"journal":{"name":"Archivum Immunologiae et Therapiae Experimentalis","volume":"70 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50018565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxychloroquine Therapy and Serum Immunoglobulin Levels in Women with IgG Subclass Deficiency and Systemic Lupus Erythematosus, Sjögren Syndrome, and Rheumatoid Arthritis: A Retrospective Study 羟氯喹治疗和血清免疫球蛋白水平在妇女IgG亚类缺乏和系统性红斑狼疮，Sjögren综合征，类风湿关节炎:回顾性研究

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-04-11 DOI: 10.1007/s00005-022-00652-x

J. Barton, J. Barton, L. Bertoli

引用次数: 0

Preliminary Results for Personalized Therapy in Pregnant Women with Polycystic Ovary Syndrome During the COVID-19 Pandemic COVID-19大流行期间孕妇多囊卵巢综合征个体化治疗的初步结果

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-03-24 DOI: 10.1007/s00005-022-00650-z

Małgorzata Jerzak, Monika Szafarowska

{"title":"Preliminary Results for Personalized Therapy in Pregnant Women with Polycystic Ovary Syndrome During the COVID-19 Pandemic","authors":"Małgorzata Jerzak, Monika Szafarowska","doi":"10.1007/s00005-022-00650-z","DOIUrl":"10.1007/s00005-022-00650-z","url":null,"abstract":"<div><p>Increased androgen level, hyperinsulinemia, diabetes, impaired fibrinolysis, obesity, hypertension, chronic inflammation, abnormal immune response to infections and hyperhomocysteinemia are the most common abnormalities related to polycystic ovary syndrome (PCOS) women and are the factors predisposing to the severe course of COVID-19. The SARS-Cov-2 infection during pregnancy is associated with an increased risk of complications (spontaneous abortion), similar to those in PCOS. The treatment of PCOS pregnant women with a history of fertility failures raises many doubts, especially during the COVID pandemic. However, due to the increasing incidence of infections among reproductive people and the potentially more serious course in pregnant women, numerous questions about the safety and effectiveness of the treatment are still very current. In our study we presented a series of cases of recurrent miscarriages or recurrent implantation failure PCOS pregnant women with confirmed COVID-19. The diagnosis of infertility confirmed the presence of plasminogen activator inhibitor type 1 and/or 5,10-methylenetetrahydrofolate reductase polymorphisms in each of them. Moreover, some of the women presented immune dysfunction associated with infertility. We have described the personalized treatments of each pregnant patient included: metformin, enoxaparin and tacrolimus. The treatment applied had the expected effect, supporting the implantation processes. Furthermore, despite the ambiguous data according to immunological therapy of infertile women during the COVID pandemic, we observed a mild or asymptomatic COVID-19 course and we noticed no pregnancy complications.</p></div>","PeriodicalId":8389,"journal":{"name":"Archivum Immunologiae et Therapiae Experimentalis","volume":"70 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00005-022-00650-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40320942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Plasma Anti-CD26 Autoantibody Levels in a Cohort of Treatment-Naïve Early Arthritis Patients 早期关节炎患者血浆抗CD26自身抗体水平的研究

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-03-18 DOI: 10.1007/s00005-022-00649-6

Oscar J. Cordero, Irene Viéitez, Irene Altabás, Laura Nuño-Nuño, Alejandro Villalba, Marta Novella-Navarro, Diana Peiteado, María-Eugenia Miranda-Carús, Alejandro Balsa, Rubén Varela-Calviño, Iria Gomez-Tourino, José M. Pego-Reigosa

{"title":"Study of Plasma Anti-CD26 Autoantibody Levels in a Cohort of Treatment-Naïve Early Arthritis Patients","authors":"Oscar J. Cordero, Irene Viéitez, Irene Altabás, Laura Nuño-Nuño, Alejandro Villalba, Marta Novella-Navarro, Diana Peiteado, María-Eugenia Miranda-Carús, Alejandro Balsa, Rubén Varela-Calviño, Iria Gomez-Tourino, José M. Pego-Reigosa","doi":"10.1007/s00005-022-00649-6","DOIUrl":"10.1007/s00005-022-00649-6","url":null,"abstract":"<div><p>In rheumatoid arthritis (RA), the identification of biomarkers to adjust treatment intensity and to correctly diagnose the disease in early stages still constitutes a challenge and, as such, novel biomarkers are needed. We proposed that autoantibodies (aAbs) against CD26 (DPP4) might have both etiological importance and clinical value. Here, we perform a prospective study of the potential diagnostic power of Anti-CD26 aAbs through their quantification in plasmas from 106 treatment-naïve early and undifferentiated AR. Clinical antibodies, Anti-CD26 aAbs, and other disease-related biomarkers were measured in plasmas obtained in the first visit from patients, which were later classified as RA and non-RA according to the American College of Rheumatology criteria. Two different isotype signatures were found among ten groups of patients, one for Anti-CD26 IgA and other for Anti-CD26 IgG and IgM isotypes, both converging in patients with arthritis (RA and Unresolved Undifferentiated Arthritis: UUA), who present elevated levels of all three isotypes. The four UUA patients, unresolved after two years, were ACPA and rheumatic factor (RF) negatives. In the whole cohort, 51.3% of ACPA/RF seronegatives were Anti-CD26 positives, and a similar frequency was observed in the seropositive RA patients. Only weak associations of the three isotypes with ESR, CRP and disease activity parameters were observed. Anti-CD26 aAbs are present in treatment-naïve early arthritis patients, including ACPA and RF seronegative individuals, suggestive of a potential pathogenic and/or biomarker role of Anti-CD26 aAbs in the development of rheumatic diseases.</p></div>","PeriodicalId":8389,"journal":{"name":"Archivum Immunologiae et Therapiae Experimentalis","volume":"70 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00005-022-00649-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49006730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

New Treatment Options in Lupus Nephritis 狼疮性肾炎的新治疗选择

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-03-17 DOI: 10.1007/s00005-022-00647-8

Pauline M. Montigny, Frédéric A. Houssiau

引用次数: 2

New Treatment Options in Lupus Nephritis 狼疮性肾炎的新治疗选择

IF 3.2 4区医学

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-03-17 DOI: 10.1007/s00005-022-00647-8

P. Montigny, F. Houssiau

引用次数: 1