Preventive cardiology最新文献_第2页

Quantification of the clinical modifiers impacting high-density lipoprotein cholesterol in the community: Personalized Medicine Research Project. 量化影响社区高密度脂蛋白胆固醇的临床调节剂:个体化医学研究项目。

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2009.00055.x

Russell A Wilke, Richard L Berg, James G Linneman, Peggy Peissig, Justin Starren, Marilyn D Ritchie, Catherine A McCarty

{"title":"Quantification of the clinical modifiers impacting high-density lipoprotein cholesterol in the community: Personalized Medicine Research Project.","authors":"Russell A Wilke, Richard L Berg, James G Linneman, Peggy Peissig, Justin Starren, Marilyn D Ritchie, Catherine A McCarty","doi":"10.1111/j.1751-7141.2009.00055.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2009.00055.x","url":null,"abstract":"<p><p>High-density lipoprotein (HDL) cholesterol levels are inversely correlated with the development of cardiovascular disease. To date, genetic association studies have explained only a small proportion of the overall variance in HDL cholesterol. Further studies are needed, within practice-based cohorts, to place genetic findings into context alongside important clinical variables (eg, age, sex, body mass index, medication use, and clinical comorbidity). The Marshfield Clinic Personalized Medicine Research Project database was designed for large-scale studies of genetic epidemiology in a clinical practice-based setting. Because of its size and its unique practice-based design, this resource will provide adequate statistical power for the assessment of genetic findings related to HDL cholesterol level within the context of covariates known to modify lipid homeostasis. The authors report construction and validation of novel electronic phenotyping algorithms that can be used to model individual baseline HDL cholesterol levels within this practice-based resource. Because these algorithms were developed in a setting that reflects routine clinical care, future genetic studies using these algorithms within practice-based DNA biobanks should facilitate the identification of markers with optimal effect size after adjustment for known clinical factors contributing to the overall variance in HDL cholesterol level within the community.</p>","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"13 2","pages":"63-8"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2009.00055.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28910472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

A soccer scholarship. 足球奖学金。

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2009.00056.x

Zachary R Paterick, Gerald Fletcher, Timothy E Paterick

引用次数: 0

Should we focus on novel risk markers and screening tests to better predict and prevent cardiovascular disease? Or are we putting the cart before the horse? 我们是否应该关注新的风险标记和筛选测试来更好地预测和预防心血管疾病?还是本末倒置?

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2010.00083.x

Nathan D Wong

{"title":"Should we focus on novel risk markers and screening tests to better predict and prevent cardiovascular disease? Or are we putting the cart before the horse?","authors":"Nathan D Wong","doi":"10.1111/j.1751-7141.2010.00083.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2010.00083.x","url":null,"abstract":"ur American Society for Preventive Cardio-logy–sponsored debate at the recent March2010 meeting of the American Heart Associa-tion Council on Epidemiology and Preventionand Council on Nutrition, Physical Activity andMetabolism was titled ‘‘Should We Focus onNovel Risk Markers and Screening Tests to BetterPredict and Prevent Cardiovascular Disease?’’ DrJames DeLemos took the pro side, titled ‘‘NovelRisk Markers and Screening Tests Will Improvethe Prediction and Prevention of CardiovascularDisease,’’ and Dr. Donald Lloyd-Jones took thecon side, titled ‘‘Better Implementation of Exist-ing Knowledge Will Save More Lives Than All ofthe Novel Biomarkers in the World.’’Since the development of the original Framing-ham Risk Scores approximately 20 years ago, therehas been increasing interest in the concept of assess-ing total coronary heart disease (CHD) risk on thebasis of simple-to-use and inexpensive ofﬁce-basedmeasures including total and high-density lipopro-tein cholesterol, systolic blood pressure, and knowl-edge of the patient’s smoking and diabetes status,age, and sex.","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"13 4","pages":"149-51"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2010.00083.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29298171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Improving the landscape for prevention. 改善预防环境。

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2010.00066.x

Peter W F Wilson

引用次数: 1

Subclinical atherosclerosis: evolving role of carotid intima-media thickness. 亚临床动脉粥样硬化:颈动脉内膜-中膜厚度的演变作用。

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2010.00072.x

Farouk Mookadam, Sherif E Moustafa, Steven J Lester, Tahlil Warsame

引用次数: 43

ARBITER-6 HALTS and lipid concentrations and heart failure incidence: Framingham Heart Study. 停药、脂质浓度和心力衰竭发生率:Framingham心脏研究。

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2010.00069.x

Philip R Liebson

引用次数: 2

Should we focus on novel risk markers and screening tests to better predict and prevent cardiovascular disease? Point. 我们是否应该关注新的风险标记和筛选测试来更好地预测和预防心血管疾病?点。

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2010.00080.x

Jonathan R Enriquez, James A de Lemos

引用次数: 7

Cognitive impairment: a new predictor of exercise trainability and outcomes in cardiac rehabilitation? 认知障碍:运动可训练性和心脏康复预后的新预测指标?

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2010.00077.x

Barry A Franklin

引用次数: 8

Preventive cardiology Pub Date : 2010-01-01 Epub Date: 2010-08-16 DOI: 10.1111/j.1751-7141.2010.00079.x

Michael Howe, Adam Leidel, Sangeetha M Krishnan, Alissa Weber, Melvyn Rubenfire, Elizabeth A Jackson

{"title":"Patient-related diet and exercise counseling: do providers' own lifestyle habits matter?","authors":"Michael Howe, Adam Leidel, Sangeetha M Krishnan, Alissa Weber, Melvyn Rubenfire, Elizabeth A Jackson","doi":"10.1111/j.1751-7141.2010.00079.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2010.00079.x","url":null,"abstract":"The goal of this research was to evaluate the personal health behaviors of physicians in training and attending physicians in association with patient-related lifestyle counseling. Physicians at a major teaching hospital were surveyed regarding their personal lifestyle behavior, perceived confidence, and frequency of counseling patients regarding lifestyle behaviors. One hundred eighty-three total responses were received. Trainees were more likely to consume fast food and less likely to consume fruits and vegetables than attendings. Attending physicians were more likely to exercise 4 or more days per week and more than 150 minutes per week. Attending physicians were more likely to counsel their patients regarding a healthy diet (70.7% vs 36.3%, P<.0001) and regular exercise (69.1% vs 38.2%, P<.0001) compared with trainees. Few trainees or attendings were confident in their ability to change patients' behaviors. Predictors of confidence in counseling for exercise included the provider's own exercise time of > 150 minutes per week, being overweight, and reported adequate training in counseling. Only adequate training in counseling was a predictor of strong self-efficacy for counseling in diet. Many physicians lack confidence in their ability to counsel patients regarding lifestyle. Personal behaviors including regular exercise and better training in counseling techniques may improve patient counseling.","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"13 4","pages":"180-5"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2010.00079.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29295812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 114

Cardiovascular risk in special populations IV: Congenital heart defects. 特殊人群的心血管风险IV:先天性心脏缺陷。

Preventive cardiology Pub Date : 2010-01-01 DOI: 10.1111/j.1751-7141.2009.00040.x

Philip R Liebson

{"title":"Cardiovascular risk in special populations IV: Congenital heart defects.","authors":"Philip R Liebson","doi":"10.1111/j.1751-7141.2009.00040.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2009.00040.x","url":null,"abstract":"Congenital heart defects are found in approximately 1 in 100 to 150 newborns and are associated with racial disparities in types, interventions, and mortality. Although mortality from heart defects between 1979 and 1997 in the United States for all ages declined 39% (from 2.5 to 1.5 per 100,000 population) and in a similar percentage for infants, mortality was 19% higher in blacks than whites, 68.4 vs 55.5 per 100,000, respectively. In regard to infants, mortality has decreased considerably in this 18-year period for such major congenital heart disease as transposition of the great arteries, ventricular septal defect (VSD), atrioventricular septal defect, and aortic coarctation. Moreover, although mortality decreased in blacks as well as white infants, black infant mortality rates were consistently higher during this period (Figure 1). Overall, the average age of death increased for the common congenital heart defects during this 18-year period but was higher in blacks. The changes for some common congenital heart conditions can be see in Table I. For all common congenital heart defects, between 1979–1983 and 1994–1997, the 50th percentile in mortality for whites increased from 7 months to 12 months, and for blacks only from 3 months to 5 months. For most anomalies, although the median and especially 75th percentile ages increased considerably, black mortality persisted at a younger age than whites for virtually all categories (Table II). Categories in which deaths in blacks occurred at least at one half the age as whites or lower included VSD, aortic and pulmonic valve anomalies, and single ventricle. Access to medical care, nutrition, and maternal lifestyles and education may be responsible for neural tube defects. Higher rates of neural tube defects were found in Hispanic women in Brooklyn than black or non-Hispanic whites. Racial variations in congenital defects appear to vary widely among blacks and whites in a study from Atlanta, Georgia. Congenital heart defects were found to be more common in American Indians in British Columbia than in the general population. Fetal alcohol syndrome may be associated with congenital heart anomalies and the syndrome is particularly common in Native Americans, occurring in up to 103 of 100,000 live births. On the basis of a populationbased case control study of congenital cardiovascular malformations in the Washington, DC and widespread surrounding area between 1981–1987, birth weight deficits were found for infants with tetralogy of Fallot, endocardial cushion defect, hypoplastic left heart syndrome, pulmonic stenosis, coarctation of the aorta, and atrial and VSDs. A retrospective study of racial frequencies in 3 congenital heart malformations of children born in Baltimore hospitals in the 1960’s demonstrated no significant differences between black and white infants in the presence of transposition of the great vessels, coarctation of the aorta, and aortic atresia with left heart hypoplasia. An evaluation","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"13 2","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2009.00040.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28910470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2