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Herpes : the journal of the IHMF最新文献

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Case report: symptomatic oral herpes simplex virus type 2 and asymptomatic genital shedding. 病例报告:有症状的口腔单纯疱疹病毒2型和无症状的生殖器脱落。
Herpes : the journal of the IHMF Pub Date : 2006-05-01
Laura Olin, Anna Wald
{"title":"Case report: symptomatic oral herpes simplex virus type 2 and asymptomatic genital shedding.","authors":"Laura Olin,&nbsp;Anna Wald","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 42-year-old bisexual man with a history of recurrent oral herpes and no history of genital herpes was noted to have antibody to herpes simplex virus type 2 (HSV-2) only. During a symptomatic oral recurrence, HSV-2 was found in a perioral lesion as well as in the genital area.</p>","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"13 1","pages":"25-6"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26052856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring transplant patients for human cytomegalovirus: Diagnostic update. 移植患者巨细胞病毒监测:最新诊断。
Herpes : the journal of the IHMF Pub Date : 2006-05-01
Giuseppe Gerna, Daniele Lilleri
{"title":"Monitoring transplant patients for human cytomegalovirus: Diagnostic update.","authors":"Giuseppe Gerna,&nbsp;Daniele Lilleri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human cytomegalovirus (HCMV) infections are the major viral complications associated with the post-transplant period in haematopoietic stem cell and solid organ transplant recipients. HCMV infection may be systemic (high viral load in blood associated with fever, leucopenia and thrombocytopenia) or local (clinical symptoms of viral infection within a single organ [e.g. lungs] or apparatus [gastrointestinal tract]). Both infection types can be associated with each other. Systemic HCMV infections are diagnosed by performing antigenaemia or DNAemia assay (polymerase chain reaction [PCR]) on blood samples: both assays are quantitative. Local infections are diagnosed by virus isolation from tissue biopsies or secretions, or by PCR. To prevent HCMV disease, a prophylactic approach is usual in the USA, while a pre-emptive (presymptomatic) approach, which is more common in Europe, involves administering antivirals when a predetermined viral load is reached in blood. Simultaneous virological and immunological follow-up is the best approach to efficient monitoring of HCMV infections in transplant recipients. Lack of immune reconstitution entails repeated episodes of recurrent infection with multiple courses of antiviral treatment, whereas reconstitution of both arms of the HCMV-specific T-cell mediated immune response controls HCMV infection. The exception is for cases of graft rejection or graft versus host disease treated with steroids or antilymphocyte globulin, which require virological monitoring and (in some cases) antiviral treatment until resolution of the adverse event.</p>","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"13 1","pages":"4-11"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26052951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human herpesvirus 6: a clinical update. 人类疱疹病毒6:临床最新进展
Herpes : the journal of the IHMF Pub Date : 2006-05-01
Danielle M Zerr
{"title":"Human herpesvirus 6: a clinical update.","authors":"Danielle M Zerr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human herpesvirus 6 (HHV-6) is a member of the Roseolovirus genus of the b-herpesvirus subfamily of human herpesviruses. HHV-6 infects virtually all children during the early years of life and, like other herpesviruses, establishes latency after primary infection. In immunocompromised hosts, especially transplant recipients, HHV-6 is able to reactivate and cause disease. There are two subtypes of HHV-6: type A and type B. The two subtypes share certain biological properties and a high level of sequence homology, but differ dramatically in their epidemiology. We have learned much about the epidemiology and clinical impact of HHV-6 in the decades since it was first identified, but many questions still remain. This update focuses on new findings regarding the epidemiology and clinical syndromes of HHV-6, especially as they pertain to primary infection, neurological disease, and the transplant setting. In addition, diagnostics and antiviral treatment are reviewed.</p>","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"13 1","pages":"20-4"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26052855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein-Barr virus and Hodgkin's lymphoma. eb病毒和霍奇金淋巴瘤
Herpes : the journal of the IHMF Pub Date : 2006-05-01
Jan Andersson
{"title":"Epstein-Barr virus and Hodgkin's lymphoma.","authors":"Jan Andersson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hodgkin's lymphoma (HL) is a lymphoproliferative disorder of B-lymphocytes. Epstein-Barr virus (EBV) antigens can be detected in tumours in up to 40% of all HL cases. Patients with EBV-associated HL also show increased levels of EBV-infected B-lymphocytes in blood compared with normal individuals and non-EBV-associated HL cases. A peculiar pattern of restricted EBV-antigen expression, dominated by latent membrane protein-1 (LMP-1), LMP-2 and EBV nuclear antigen-1, is the characteristic feature of tumour-specific Hodgkin/Reed-Sternberg cells. This knowledge has generated studies examining adoptive immunotherapy of autologous or allogeneic cytotoxic T-cells for the treatment of refractory EBV-positive HL cases. Whether aborted EBV or another infectious aetiology is involved in non-EBV-associated HL cases remains an open question.</p>","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"13 1","pages":"12-6"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26052952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in herpesvirus diagnosis. 疱疹病毒诊断的进展。
Herpes : the journal of the IHMF Pub Date : 2006-05-01
Loredana Sarmati
{"title":"Advances in herpesvirus diagnosis.","authors":"Loredana Sarmati","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"13 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26052950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Varicella immunization and herpes zoster. 水痘免疫和带状疱疹。
Herpes : the journal of the IHMF Pub Date : 2005-12-01
Antonio Volpi
{"title":"Varicella immunization and herpes zoster.","authors":"Antonio Volpi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"12 3","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25784110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient and partner perceptions about preventing genital herpes transmission. 患者和性伴对预防生殖器疱疹传播的认知。
Herpes : the journal of the IHMF Pub Date : 2005-12-01
Lisa Gilbert, Kelli Scanlon, Rachele Peterson, Charles Ebel
{"title":"Patient and partner perceptions about preventing genital herpes transmission.","authors":"Lisa Gilbert,&nbsp;Kelli Scanlon,&nbsp;Rachele Peterson,&nbsp;Charles Ebel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Research over the past decade has provided a new understanding of genital herpes transmission and measures that can reduce transmission risk. It is unclear, however, how those affected by genital herpes access and interpret this information to make decisions about risk behaviours. This study measured how people with genital herpes and their partners perceived prevention methods, barriers and facilitating factors, and information sources. Formative evaluation was conducted, and survey data were collected from visitors to four websites (n=1849). Results suggest that the prevention messages of refraining from sex during disease outbreaks and condom use have had the greatest reach. Misconceptions about the potential role of suppressive antiviral therapy for genital herpes prevention persist among a substantial percentage of respondents. Accurate information concerning transmission between outbreaks, the effectiveness of condoms and the role of antiviral medication is critical in preventing the spread of genital herpes.</p>","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"12 3","pages":"60-5"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25783543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in cytomegalovirus vaccine development. 巨细胞病毒疫苗的研究进展。
Herpes : the journal of the IHMF Pub Date : 2005-12-01
Mark Schleiss
{"title":"Progress in cytomegalovirus vaccine development.","authors":"Mark Schleiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) causes considerable morbidity and disability in infants who acquire the infection in utero. Despite potent antiviral therapies, CMV also continues to be a major cause of disease in immunocompromised patients. Vaccines for CMV, therefore, could provide protection against CMV disease in an array of high-risk patient populations. Although the correlates of vaccine-engendered immunity that limit CMV disease are not fully understood, there has been significant progress in elucidating some of the key immunological correlates of protection. The optimal CMV vaccine strategy may depend on the patient population being targeted for protection. This review provides an update on CMV vaccines that are currently in preclinical and clinical development, and outlines important, as yet unanswered, questions about the nature of protective immune responses that will be required of potential CMV immunization strategies. Such questions must be answered before an optimal vaccine, and vaccine use strategy, can be implemented in clinical practice.</p>","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"12 3","pages":"66-75"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25783544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human cytomegalovirus, endothelial function and atherosclerosis. 人巨细胞病毒，内皮功能和动脉粥样硬化。
Herpes : the journal of the IHMF Pub Date : 2005-10-01
Cairistine Grahame-Clarke
{"title":"Human cytomegalovirus, endothelial function and atherosclerosis.","authors":"Cairistine Grahame-Clarke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human cytomegalovirus (HCMV) serology is linked to several measures of endothelial dysfunction. There is substantial evidence for HCMV having an aetiological role in transplant arterial disease and accumulating evidence for HCMV in the origins of preeclampsia. However, whether HCMV is a clinically significant cause of atherosclerosis in the general, immunocompetent population remains to be seen.</p>","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"12 2","pages":"42-5"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25624386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HHV-6 and seizures. HHV-6和癫痫。
Herpes : the journal of the IHMF Pub Date : 2005-10-01
Nobuko Yamashita, Tsuneo Morishima
{"title":"HHV-6 and seizures.","authors":"Nobuko Yamashita,&nbsp;Tsuneo Morishima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human herpes virus-6 (HHV-6) is a ubiquitous virus, but one that can induce various neurological diseases. Recently, several seizures have been reported as new HHV-6-associated diseases based on virological analysis. Neonates who are perinatally infected with HHV-6 can develop afebrile seizures, which are considered to be exanthem subitum (ES) in the neonatal period. Infants with ES also tend to develop atypical febrile seizures. After primary infection, HHV-6 commonly establishes latency in the central nervous system (CNS) and sometimes reactivates in the hippocampus, causing limbic encephalitis and temporal lobe epilepsy. These HHV-6-associated CNS diseases due to virus reactivation can occur in both immunocompromised and immunocompetent hosts. This article summarizes HHV-6-associated seizures during childhood.</p>","PeriodicalId":83725,"journal":{"name":"Herpes : the journal of the IHMF","volume":"12 2","pages":"46-9"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25624387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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