Archives of Pharmaceutical Sciences Ain Shams University最新文献_第2页

The Association between ATP-Binding Cassette C2 (ABCC2) Transporter Genetic Polymorphism and Peripheral Neuropathy in Gastrointestinal Cancer Patients Receiving Oxaliplatin. 接受奥沙利铂治疗的胃肠道癌症患者的 ATP 结合盒 C2 (ABCC2) 转运体基因多态性与周围神经病变之间的关系

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2024-02-18 DOI: 10.21608/aps.2023.254995.1153

Sara Abdel Aziz, Diaa Eldin Sherif, Nagwa Sabri, May Shawki

{"title":"The Association between ATP-Binding Cassette C2 (ABCC2) Transporter Genetic Polymorphism and Peripheral Neuropathy in Gastrointestinal Cancer Patients Receiving Oxaliplatin.","authors":"Sara Abdel Aziz, Diaa Eldin Sherif, Nagwa Sabri, May Shawki","doi":"10.21608/aps.2023.254995.1153","DOIUrl":"https://doi.org/10.21608/aps.2023.254995.1153","url":null,"abstract":"Single nucleotide polymorphisms (SNPs) in the ATP-binding cassette C2 (ABCC2) gene increased intracellular oxaliplatin accumulation in the dorsal root ganglia may result in an increased risk of oxaliplatin-induced peripheral neuropathy (OXAIPN). The present study aims to study the association between the SNPs rs1885301 G>A, rs4148396 C>T, and rs3740066 C>T in the ABCC2 gene and the incidence of OXAIPN in gastrointestinal cancer patients. The study was a prospective cohort study carried out at the Clinical Oncology Department, Ain Shams University Hospitals. Eligible patients received FOLFOX6 and FOLFIRINOX for 8-12 cycles. The SNPs assessment was performed using Real-time PCR using the Rotor gene Q (QIAGEN ® ) system. The patients were followed up with each cycle to assess the incidence and severity of OXAIPN and other common toxicities including diarrhea, vomiting, and neutropenia. One hundred and twenty patients were included in the study. The minor allele frequency for the SNPs rs1885301 G>A, rs4148396 C>T, and rs3740066 C>T were 0.4-0.2, and 0.3 respectively. The current study showed no association between the three SNPs and the incidence and grade of OXAIPN with less than 50% of the participants reporting grade III and IV peripheral neuropathy. A significant association was found between rs4148396 C>T and the occurrence of neutropenia where TT haplotype showed a significantly higher incidence of neutropenia compared to CC + CT. In conclusion, no association was found between the SNPs and the occurrence of PN, diarrhea, and vomiting. There was only a significant difference in the incidence grades of neutropenia among haplotypes of rs4148396 C>T.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology of depression: inflammation and its relation with oxidative stress and the hypothalamic-pituitary-adrenal axis 抑郁症的病理生理学：炎症及其与氧化应激和下丘脑-垂体-肾上腺轴的关系

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2024-02-18 DOI: 10.21608/aps.2024.249632.1143

Engy Nady, M. El-Derany, Haidy Michel, E. El-demerdash

{"title":"Pathophysiology of depression: inflammation and its relation with oxidative stress and the hypothalamic-pituitary-adrenal axis","authors":"Engy Nady, M. El-Derany, Haidy Michel, E. El-demerdash","doi":"10.21608/aps.2024.249632.1143","DOIUrl":"https://doi.org/10.21608/aps.2024.249632.1143","url":null,"abstract":"Depression is well-known to be a widespread, disabling mental disorder. Despite the many theories that have been put forth to explain the underlying pathophysiology of depression, the exact pathophysiology remains uncertain. In this review, we aim to summarize pathophysiological pathways and experimental animal models for depression, focusing mainly on inflammatory pathways. Stress is a well-known predisposing factor for depression. So, we aim to demonstrate the link between stress and inflammation in depression pathophysiology, highlighting the role of microglia activation, the release of proinflammatory cytokines, and the production of neurotoxic metabolites. We also aim to show the link between inflammation and the disturbance of serotonin, which is also known as 5-hydroxytryptamine (5-HT), and norepinephrine (NE) levels in the brain. Activated microglia produce reactive oxygen species (ROS), which further enhances the inflammatory response. Additionally, we aim to illustrate the hypothalamic-pituitary-adrenal (HPA) axis hyperactivity that occurs as a result of stressful conditions and the consequent resistance of glucocorticoid receptors (GRs), leading to the failure of glucocorticoids to suppress inflammation. We also aim to demonstrate experimental animal models of depression that are based on psychological stress, such as the maternal separation model and the social defeat stress (SDS) model, as well as reviewing the lipopolysaccharide (LPS) inflammation-based model. We also aim to briefly review the widely used chronic unpredictable mild stress (CUMS) model.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemotherapy and cognitive function: comprehensive review on methotrexate‐induced chemobrain 化疗与认知功能：甲氨蝶呤诱导的化疗脑综合评述

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-12-10 DOI: 10.21608/aps.2023.243591.1140

Nadine Sabry, Haidy Michel, Esther Menze

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Penetration enhancer containing vesicles for dermal and transdermal drug delivery. A review. 用于皮肤和透皮给药的含渗透增强剂的囊泡。综述。

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-12-10 DOI: 10.21608/aps.2023.246357.1141

Fatma Sarhan, Riham Elgogary, Manal Yassin, Mahmoud Soliman

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Serum NLRP3 and S1P as Potential Diagnostic and Prognostic Biomarkers in Female Metastatic and Non-Metastatic Breast Cancer Patients 血清 NLRP3 和 S1P 作为女性转移性和非转移性乳腺癌患者的潜在诊断和预后生物标记物

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-12-10 DOI: 10.21608/aps.2023.226758.1130

Amany Kamal, Anas Soltan, Reham A. El-Shemy, Hala El-Mesallamy

引用次数: 0

Advancements in Skin Aging Treatment: Exploring Antioxidants and Nanoparticles for Enhanced Skin Permeation 皮肤老化治疗的进展：探索抗氧化剂和纳米粒子以增强皮肤渗透性

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-12-10 DOI: 10.21608/aps.2023.250333.1146

Raghda Elsisi, Dina Helal, George Mekhail, Dalia Abou Hussein, Amany Osama

引用次数: 0

Lignin from a disposable by-product to a repository of value-added compounds 木质素从一次性副产品转化为增值化合物储存库

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-10-09 DOI: 10.21608/aps.2023.229635.1132

Sarah Milad, Sarra Saleh, Mohammad Aboulwafa, Nadia Hassouna

{"title":"Lignin from a disposable by-product to a repository of value-added compounds","authors":"Sarah Milad, Sarra Saleh, Mohammad Aboulwafa, Nadia Hassouna","doi":"10.21608/aps.2023.229635.1132","DOIUrl":"https://doi.org/10.21608/aps.2023.229635.1132","url":null,"abstract":"Across the planet, lignin is widely distributed as one of the most pervasive polymers in existence. It naturally exists as an inherent component of the plant’s structure. In the paper industry, kraft lignin (KL) disposal in large amounts as a waste by-product may potentially result in toxicity to aquatic ecosystems. We can get more value from this plentiful polymer and convert it to value-added products instead of its disposal. Several methods have been described to degrade lignin. These procedures are frequently severe and harmful to the environment. Out of them, biological methods are eco-friendly, ensure consistent production, and cause lower toxicity to the environment. Due to their extensive environmental adaptability and easy genetic engineering, numerous ligninolytic bacteria have been found and studied for lignin use. This includes biodegradation and valorization of lignin into commercial compounds such as fuels, phenolic compounds, ferulic acid, polyhydroxyalkanoates (PHAs), and vanillin. Besides, ligninolytic enzymes produced from several microorganisms have tremendous applications in other industrial fields including textile dye effluent decolorization and bioremediation. This review elucidates the current approaches to lignin degradation. We give an overview of the recent research on the discovery and application of bacterial ligninolytic enzymes and their various optimization strategies. This article also includes the new applications for the utilization of lignin as an economical and alternative-resource material either in the medical field or through biological conversion to value-added products and highlights future perspectives for the improvement of the lignin biodegradation process.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights on the role of TLR-4 in neuroinflammation: a hint on COVID-19 relationship TLR-4在神经炎症中的作用:对COVID-19关系的提示

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-10-09 DOI: 10.21608/aps.2023.231700.1133

Salma Elshafey, Dalia El-Khouly, Esther Menze, Mariane Tadros

{"title":"Insights on the role of TLR-4 in neuroinflammation: a hint on COVID-19 relationship","authors":"Salma Elshafey, Dalia El-Khouly, Esther Menze, Mariane Tadros","doi":"10.21608/aps.2023.231700.1133","DOIUrl":"https://doi.org/10.21608/aps.2023.231700.1133","url":null,"abstract":"Neuroinflammation plays a crucial role in cognitive decline and neurodegenerative diseases, such as Alzheimer's. Within the central nervous system, microglia express Toll-like receptor 4 (TLR-4) abundantly, which prompts the secretion of proinflammatory cytokines like TNF-α, PGE2, IL-1β, and NO that are considered essential components of neuroinflammation. The emergence of neurological complications in patients with COVID-19 has spurred investigations into the potential involvement of TLR-4. Particularly intriguing is its contribution to the cytokine storms triggered by SARS-CoV-2 and SARS-CoV-1 infections. This comprehensive review investigates TLR-4-induced neuroinflammation, focusing on its potential connection to cognitive decline and neurological symptoms triggered by COVID-19. By unraveling the intricate mechanisms by which TLR-4 mediates neuroinflammation, this review aims to shed light on its possible role in the context of COVID-19. Understanding the implications of TLR-4 activation could pave the way for targeted interventions to alleviate the cognitive and neurological impacts of COVID-19. As the world seeks to comprehend the far-reaching effects of the pandemic, grasping the nuances of TLR-4-associated neuroinflammation stands as a crucial step in addressing the challenges posed by cognitive decline and neurological manifestations in patients with COVID-19.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyridazine Based Compounds with PARP-1 Inhibitory Activity 具有PARP-1抑制活性的吡嗪类化合物

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-10-09 DOI: 10.21608/aps.2023.224318.1127

maiy Jaballah, Norhan Abdelrahman, Ahmed Al-Karmalawy, Khaled Abouzid

引用次数: 0

Identification of Novel 4-Oxo-4H-chromen-Hydroxamic Acid Derivative Targeting Selected HDAC Isoforms 靶向HDAC亚型的新型4-氧- 4h -铬-羟肟酸衍生物的鉴定

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-10-09 DOI: 10.21608/aps.2023.226661.1128

Rosaline Ashraf, Mai Adel, Rabah Serya, Khaled Abouzid

{"title":"Identification of Novel 4-Oxo-4H-chromen-Hydroxamic Acid Derivative Targeting Selected HDAC Isoforms","authors":"Rosaline Ashraf, Mai Adel, Rabah Serya, Khaled Abouzid","doi":"10.21608/aps.2023.226661.1128","DOIUrl":"https://doi.org/10.21608/aps.2023.226661.1128","url":null,"abstract":"Histone deacetylase inhibitors (HDACIs) represent a well-known class of compounds that exhibit potential therapeutic efficacy in a variety of diseases, particularly cancer and neurodegenerative disorders. This article discusses the development of compound 6 as a new HDAC inhibitor. It was designed based on the structure-activity relationship (SAR) of the previously reported HDAC inhibitors and the molecular modeling studies. Compound 6 was synthesized, and its structure was verified using different spectroscopic methods. It was biologically evaluated to assess its inhibitory activity against different HDAC isoforms, including HDAC1, 6, and 8. The results showed moderate inhibition against HDAC 1 and HDAC 8 over HDAC 6. It was also evaluated for its antineoplastic activity against the NCI 60 cancer cell line panel. The results revealed inhibitory activity against both the UO-31 renal cancer cell line and the BT-549 breast cancer cell line. Moreover, the Molecular modeling studies revealed a favorable binding affinity for the HDAC8 active site. These results suggest that compound 6 can be considered a promising candidate for the development of new selective class I HDACIs in the future.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0