Archives of oto-rhino-laryngology最新文献_第3页

Kinetic experiments with radionuclides concerning the perilymph-blood barrier in a guinea pig model. 放射性核素对豚鼠淋巴周围-血液屏障的动力学实验。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00454128

W K Jung, G Gattaz, F J Schön

{"title":"Kinetic experiments with radionuclides concerning the perilymph-blood barrier in a guinea pig model.","authors":"W K Jung, G Gattaz, F J Schön","doi":"10.1007/BF00454128","DOIUrl":"https://doi.org/10.1007/BF00454128","url":null,"abstract":"Since 1950 many animal radiotracer experiments have been performed to study inner ear kinetics. For the most part in these studies, radionuclides were applied systemically, following which a discontinuous probing of inner ear fluids or of inner ear tissues was done. Two techniques have been developed in the Section for Experimental Otorhinolaryngology of the University of Würzburg. These have been adapted to the direct and continuous measurements of inner ear efflux kinetics for several hour periods. For this purpose, only a tiny amount of radiotracer need be applied directly to the inner ear. Experiments were done on the anesthetized guinea pig as an animal model. In the first technique, a collimator-detector system is focused precisely on the cochlea, which had been quickly resealed after application of the radionuclide bolus via two small holes in the basal turn of the cochlea. The second technique makes use of a perilymph cycling system, whereby a small outer volume includes a microcuvette with a so-called artificial round window. By this latter cycling technique, perilymph clearance kinetics of all kinds of radiotracers--with the exception of tritium labelled ones--can be measured. Calculations from clearance kinetics show that quite small particles with particle weights up to 100, such as the chlorine anion and the potassium cation, as well as urea, glycerol, pyruvate, and lactate, exhibit perilymphatic half-lives varying from 45 to 60 min. These half-live data are plausible in regard to cochlear blood flow measured previously via an independent technique developed by Angelborg et al.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 1","pages":"11-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00454128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13875369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx. 喉疣状癌诊断和治疗的临床和组织病理学考虑。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00456652

B Sllamniku, W Bauer, C Painter, D Sessions

{"title":"Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx.","authors":"B Sllamniku, W Bauer, C Painter, D Sessions","doi":"10.1007/BF00456652","DOIUrl":"https://doi.org/10.1007/BF00456652","url":null,"abstract":"Verrucous carcinoma of the larynx is quite distinct from well-differentiated squamous cell carcinoma has a characteristic morphology and specific clinical behavior. It accounts for approximately 1%-2% of all laryngeal carcinomas. However, difficulties are encountered clinically in separating verrucous carcinomas from keratoses, verruca vulgaris and squamous cell carcinomas with a verrucous appearance. Between 1962 and 1982, 1504 patients with squamous cell carcinomas of the larynx were diagnosed and treated by staff physicians in the Department of Otolaryngology--Head and Neck Surgery, Washington University in St. Louis. Fifteen of these patients (1%) had verrucous carcinomas. These cases were studied in order to clarify any diagnostic problems, trace the biologic behavior of the tumors and report the results of the treatment used. Of these 15 patients, we were able to follow up 8. The latter had been treated only with surgery and none of them had received radiotherapy. One death occurred, but the patient died of other causes and remained free of cancer. Reports in the literature describe a high rate of recurrence of verrucous carcinomas following radiotherapy with occasional anaplastic transformation of tumors. No patients in our series developed a metastasis in the neck, indicating that neck dissection is not justified for patients with these neoplasms even though clinically enlarged neck nodes may be present.","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 3","pages":"126-32"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00456652","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13897280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Observations of cochlear blood flow dynamics using the laser Doppler flowmeter. 激光多普勒血流仪对耳蜗血流动力学的观察。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00456656

M Kawakami, K Makimoto, T Nakajima, H Takahashi

引用次数: 3

Magnetic resonance investigations of non-acoustic petrous lesions. 非声学性岩性病变的磁共振检查。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00463570

D Doyon, K Y Chan, M Attia, P Halimi, R Sigal, P Corlieu, S Bobin

引用次数: 2

Rhabdomyoma of the larynx recurring after 12 years: immunocytochemistry and differential diagnosis. 喉横纹瘤复发12年:免疫细胞化学和鉴别诊断。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00453667

K Hamper, J Renninghoff, H Schäfer

引用次数: 14

Determination of lipid A in human middle ear effusions with the competitive ELISA technique. 竞争ELISA法测定人中耳积液中脂质A。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00457458

F Tanimura

引用次数: 1

Proceedings of the First European Congress of Oto-Rhino-Laryngology and Cervico-Facial Surgery. Paris, 26-29 September 1988. Selected papers. 第一届欧洲耳-鼻-喉及颈-面外科会议论文集。1988年9月26日至29日，巴黎。选定的文件。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01

引用次数: 0

The relationship between nuclear DNA content in salivary gland tumors and prognosis. Comparison of mucoepidermoid tumors and acinic cell tumors. 唾液腺肿瘤核DNA含量与预后的关系。粘液表皮样瘤与腺泡细胞瘤的比较。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00463587

K Hamper, J Caselitz, H Arps, U Askensten, G Auer, G Seifert

引用次数: 3

Aesthetic surgery for microtia. 小脑畸形的美容手术。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00463592

P Boudard, C Benassayag, R S Dhillon, J P Bebear, M Portmann

引用次数: 4

The use of microfluorometry to study DNA in nasopharyngeal carcinomas: a possible prognostic tool? 使用微荧光法研究鼻咽癌DNA:一种可能的预后工具?

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00463596

U Caliceti, A Rinaldi Ceroni, G Lisignoli, P Chieco, O Cavicchi

{"title":"The use of microfluorometry to study DNA in nasopharyngeal carcinomas: a possible prognostic tool?","authors":"U Caliceti, A Rinaldi Ceroni, G Lisignoli, P Chieco, O Cavicchi","doi":"10.1007/BF00463596","DOIUrl":"https://doi.org/10.1007/BF00463596","url":null,"abstract":"A microfluorometric method was used to determine the nuclear DNA content in the nasopharyngeal carcinomas (NPC) of 25 patients treated before 1983. Eleven patients are still alive with no evidence of disease (NED), while the rest died of their disease (DOD). All of the patients received a cycle of radiotherapy, while some also received chemotherapy or neck dissections. The neoplastic cells studied were taken from the original biopsy blocks, deparaffinized, isolated by enzymatic treatment and mechanical fragmentation, and then Feulgen-stained. The cytofluorometric measurement was carried out by a microphotometer equipped for fluorescence excitation and connected to a computer. This method allowed us to construct a histogram of the DNA content in the neoplastic cells. Different neoplastic classes were identified and represent the heteroclonality of the tumor, which can be expressed by the heteroclonality index (HCT). From the collected data it appears that the NED patients all had a low HTC (less than 1) and only 7 of the DOD patients had low HTCs (less than 1). Six of the DOD patients with a low HTC were in advanced stages of their tumor at the time of diagnosis, while the remaining patient did not complete his treatment. Our results show that the DNA analysis of the NPC cell population may offer a useful tool in predicting the biological behavior of this tumor and also improving its treatment.","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"365-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463596","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13733491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0