Archives of Industrial Hygiene and Toxicology最新文献_第3页

Vitamin C pretreatment protects from nickel-induced acute nephrotoxicity in mice 维生素C预处理对小鼠镍致急性肾毒性有保护作用

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-22 DOI: 10.1515/aiht-2016-67-2753

Imededdine Kadi, F. Dahdouh

{"title":"Vitamin C pretreatment protects from nickel-induced acute nephrotoxicity in mice","authors":"Imededdine Kadi, F. Dahdouh","doi":"10.1515/aiht-2016-67-2753","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2753","url":null,"abstract":"Abstract Nickel is an abundant carcinogenic and nephrotoxic metal whose activity leads to renal impairment. Previous studies have shown a protective effect of simultaneous vitamin C administration on acute and chronic nickel toxicity. However, very little research relating to the effect of vitamin C pretreatment in preventing nickel-induced acute nephrotoxicity is available. Therefore, the present study aimed to determine the efficiency of vitamin C (VC) pretreatment in preventing acute renal toxicity of nickel. Mice were pretreated orally with vitamin C (16.6 mg kg-1 body weight, b.w.) for seven consecutive days, prior to intraperitoneal (i.p.) administration of nickel chloride at different doses (3, 5, and 10 mg Ni kg-1 b.w.) for an exposure period of 24 hours. Thereafter, animals were killed and kidney tissue and blood samples were taken for histological examination and biochemical marker analyses. Vitamin C pretreatment alone did not alter the levels of serum kidney markers (creatinine, urea, and uric acid). However, treatment with Ni alone showed a significant increase in the levels of serum creatinine, urea, and uric acid with marked necrotic epithelial cells and infiltration by inflammatory cells in kidney sections as compared to the control group. Pretreatment with vitamin C and treatment with Ni at all doses tested for 24 hours showed a significant decrease in the levels of serum creatinine, urea, and uric acid, as well as an improvement in histological changes compared to those previously seen in the group treated with Ni alone. It is concluded that vitamin C pretreatment effectively improved renal function and tissue damage caused by nickel.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"6 1","pages":"210 - 215"},"PeriodicalIF":0.0,"publicationDate":"2016-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90207773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Occurrence of intersex in wild freshwater fish in Slovenian rivers: a histological evaluation 斯洛文尼亚河流中野生淡水鱼中双性人的发生:组织学评价

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-22 DOI: 10.1515/aiht-2016-67-2730

M. Vrecl, V. Jenčič

{"title":"Occurrence of intersex in wild freshwater fish in Slovenian rivers: a histological evaluation","authors":"M. Vrecl, V. Jenčič","doi":"10.1515/aiht-2016-67-2730","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2730","url":null,"abstract":"Abstract The aim of this preliminary research was to establish if there are intersex occurrences in wild freshwater fish in Slovenian rivers and streams. In the first study we evaluated all fish species of both sexes obtained from the river Ljubljanica from its source to mouth. In the second study we focused on the rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta m. fario) males from 30 rivers and streams in different parts of Slovenia. The male gonads were histologically assessed for the presence of oocytes to determine the frequency and degree of intersex. Oocytes were found in the testicular tissue of a single grayling (Thymallus thymallus) and in the adipose tissue adjacent to the testis of a single common barbel (Barbus barbus), both from the Ljubljanica. Several cyst-like structures that resemble degenerated presumptive oocytes were also present in several trout testes. This preliminary report is the first of its kind in Slovenia. To gain a better insight into the intersex issue in Slovenia, we plan to regularly biomonitor freshwater pollution by histologically examining fish gonads and, if possible, by determining vitellogenin plasma levels in fish.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"40 1","pages":"216 - 222"},"PeriodicalIF":0.0,"publicationDate":"2016-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73846690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variations in lead, cadmium, arsenic, and mercury concentrations during honeybee wax processing using casting technology 在使用铸造技术处理蜂蜡过程中铅、镉、砷和汞浓度的变化

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-22 DOI: 10.1515/aiht-2016-67-2780

I. Tlak Gajger, M. Kosanović, N. Bilandžić, M. Sedak, Bruno Čalopek

{"title":"Variations in lead, cadmium, arsenic, and mercury concentrations during honeybee wax processing using casting technology","authors":"I. Tlak Gajger, M. Kosanović, N. Bilandžić, M. Sedak, Bruno Čalopek","doi":"10.1515/aiht-2016-67-2780","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2780","url":null,"abstract":"Abstract Beeswax foundations are a necessary material in intensive modern beekeeping. Heavy metals can accumulate in these foundations for decades, as it is a common beekeeping practice to recycle wax. Beeswax samples were analysed using GFAAS for As, Cd, Pb, and Hg concentrations during the production of beeswax foundations using casting technology with a prolonged cooling and sedimentation phase. Significant differences were determined in the concentrations of As, Cd, Pb (p<0.01, all), and Hg (p<0.05) between the three levels of wax in a double-walled steel casting container and comb foundations (CF) during the processing stage. Concentrations (mg kg-1) of the examined metals in comb foundations as the final product ranged as follows: As 0.01-0.88; Cd 1.26-3.55; Pb 82.5-171, and Hg 0.29-1.46. All examined element concentrations demonstrated similar distribution and ratio in different layers, ranging from the lowest concentrations in layers from which wax material is used for comb foundations as the final product, to the highest concentrations in sedimented layer, which represents waste. The obtained results suggest that the described method could effectively eliminate a significant amount of heavy metals from the initial material used for the production of new beeswax foundations.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"39 1","pages":"223 - 228"},"PeriodicalIF":0.0,"publicationDate":"2016-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78366949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Phytoremediation potential of wild plants growing on soil contaminated with heavy metals 重金属污染土壤中野生植物的修复潜力

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-01 DOI: 10.1515/aiht-2016-67-2829

Vladica Čudić, D. Stojiljković, A. Jovović

{"title":"Phytoremediation potential of wild plants growing on soil contaminated with heavy metals","authors":"Vladica Čudić, D. Stojiljković, A. Jovović","doi":"10.1515/aiht-2016-67-2829","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2829","url":null,"abstract":"Abstract Phytoremediation is an emerging technology that employs higher plants to cleanup contaminated environments, including metal-polluted soils. Because it produces a biomass rich in extracted toxic metals, further treatment of this biomass is necessary. The aim of our study was to assess the five-year potential of the following native wild plants to produce biomass and remove heavy metals from a polluted site: poplar (Populus ssp.), ailanthus (Ailanthus glandulosa L.), false acacia (Robinia pseudoacacia L.), ragweed (Artemisia artemisiifolia L.), and mullein (Verbascum thapsus L). Average soil contamination with Pb, Cd, Zn, Cu, Ni, Cr, and As in the root zone was 22,948.6 mg kg-1, 865.4 mg kg-1, 85,301.7 mg kg-1, 3,193.3 mg kg-1, 50.7 mg kg-1, 41.7 mg kg-1,and 617.9 mg kg-1, respectively. We measured moisture and ash content, concentrations of Pb, Cd, Zn, Cu, Ni, Cr, and As in the above-ground parts of the plants and in ash produced by combustion of the plants, plus gross calorific values. The plants’ phytoextraction and phytostabilisation potential was evaluated based on their bioconcentration factor (BCF) and translocation factor (TF). Mullein was identified as a hyperaccumulator for Cd. It also showed a higher gross calorific value (19,735 kJ kg-1) than ragweed (16,469 kJ kg-1).The results of this study suggest that mullein has a great potential for phytoextraction and for biomass generation, and that ragweed could be an effective tool of phytostabilisation.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"466 1","pages":"229 - 239"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76829571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Impact of meteorological parameters and air pollution on emergency department visits for cardiovascular diseases in the city of Zagreb, Croatia 气象参数和空气污染对克罗地亚萨格勒布市心血管疾病急诊就诊的影响

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-01 DOI: 10.1515/aiht-2016-67-2770

S. Pintarić, I. Zeljković, G. Pehnec, V. Nesek, Mislav Vrsalović, H. Pintarić

{"title":"Impact of meteorological parameters and air pollution on emergency department visits for cardiovascular diseases in the city of Zagreb, Croatia","authors":"S. Pintarić, I. Zeljković, G. Pehnec, V. Nesek, Mislav Vrsalović, H. Pintarić","doi":"10.1515/aiht-2016-67-2770","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2770","url":null,"abstract":"Abstract The aim of this study was to investigate whether nitrogen dioxide (NO2), ozone (O3), and certain meteorological conditions had an impact on cardiovascular disease (CVD)-related emergency department (ED) visits in the metropolitan area of Zagreb. This retrospective, ecological study included 20,228 patients with a cardiovascular disease as their primary diagnosis who were examined in the EDs of two Croatian University Hospitals, Sisters of Charity and Holy Spirit, in the study period July 2008-June 2010. The median of daily CVD-related ED visits during the study period was 28 and was the highest during winter. A significant negative correlation was found between CVD-related emergency visits and air temperature measured no more than three days prior to the visit, and the highest negative correlation coefficient was measured two days earlier (R=0.266, p≤0.001). The number of CVD-related emergency visits significantly correlated with the average NO2 concentration on the same day (R=0.191, p<0.001). The results of multiple stepwise regression analysis showed that the number of CVD-related emergency visits depended on air temperature, and NO2 and O3 concentrations. The higher the air temperatures, the lower the number of daily CVD-related emergency visits (p<0.001). An increase in NO2 concentrations (p=0.005) and a decrease in O3 concentrations of two days earlier (p=0.006) led to an increase in CVD-related ED visits. In conclusion, the decrease in O3 concentrations and the increase in NO2, even if below the legally binding thresholds, could be associated with an increase in CVD-related emergency visits and a similar effect was observed with lower temperature measured no more than three days prior to the visit.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"1638 1","pages":"240 - 246"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77724596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Mutagenic and carcinogenic structural alerts and their mechanisms of action 致突变和致癌结构警报及其作用机制

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-01 DOI: 10.1515/aiht-2016-67-2801

Alja Plošnik, M. Vračko, M. Dolenc

引用次数: 36

Workplace noise exposure and serum testosterone in men enrolled in the 1999-2004 National Health and Nutrition Examination Survey 1999-2004年全国健康和营养检查调查中男性的工作场所噪音暴露和血清睾酮

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-01 DOI: 10.1515/aiht-2016-67-2774

A. Dzhambov

{"title":"Workplace noise exposure and serum testosterone in men enrolled in the 1999-2004 National Health and Nutrition Examination Survey","authors":"A. Dzhambov","doi":"10.1515/aiht-2016-67-2774","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2774","url":null,"abstract":"Abstract There is compelling evidence from animal experiments that noise exposure suppresses testosterone in males by affecting the hypothalamic-pituitary-testicular axis. Virtually nothing is known about its effect in humans. Therefore, the aim of this study was to explore the association between occupational noise exposure and serum testosterone in a representative sample of the general population. The sample has been taken from the National Health and Nutrition Examination Survey (NHANES) data for the period between 1999 and 2004 and is limited to employed men aged 16-85+ years at the time. The associations between noise exposure (either established according to the Occupational Information Network - O*NET categories or self-reported) and total and free testosterone (TT and FT, respectively) were analysed using linear regression models with increasing adjustments. In the fully adjusted model (n=414), the third quartile of the O*NET noise exposure was associated with lower TT and FT, which reached statistically significant decrease of -58.32 ng dL-1 (95 % CI: -111.22, -5.42) and -1.58 ng dL-1 (95 % CI: -2.98, -0.18), respectively. In stratified analyses, younger, lower income, normal weight, better hearing, and workers not using hearing protection at work experienced significantly more severe adverse effects than the rest. The odds for hypogonadism (TT<300 ng dL-1) did not significantly rise with one interquartile range increment in O*NET noise exposure (OR=1.24, 95 % CI: 0.64, 2.39). Self-reported loud noise exposure did not significantly decrease TT when all men were considered (n=214) and only in the men ≥37 years did it decrease TT significantly by -87.55 ng dL-1 (95 % CI: -158.35, -16.74). In conclusion, noise exposure was associated with lower TT and FT only in some population subgroups and these associations were non-linear.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"70 1","pages":"247 - 258"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80941636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene 呋喃诱导的糖尿病大鼠肝毒性和血液学改变:番茄红素的保护作用

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-01 DOI: 10.1515/aiht-2016-67-2762

Hatice Baş, D. Pandır, S. Kalender

{"title":"Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene","authors":"Hatice Baş, D. Pandır, S. Kalender","doi":"10.1515/aiht-2016-67-2762","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2762","url":null,"abstract":"Abstract Furan forms as a result of thermal treatment of food and induces harmful effects on organisms. In our work, lycopene, furan, and a combination of the two were given to diabetic male rats for 28 days. Hematological changes, total protein and cholesterol, triglyceride, and albumin levels, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities of the serum, malondialdehyde levels, glutathione peroxidase, catalase, glutathione-S-transferase, superoxide dismutase activities, DNA damage in liver tissues and hepatic histopathological alterations were compared to a control group. There were significant changes in the liver function tests, DNA damage, activities of antioxidant enzymes, and malondialdehyde levels between diabetic control and non-diabetic control groups, between diabetic control and diabetic lycopene groups, and also between diabetic furan and diabetic control groups. In diabetic lycopene and diabetic furan + lycopene treated groups we designated the preventive effects of lycopene against diabetes and furan, however, on the analysed parameters only. In spite of some pathological alterations designated in diabetic furan treated group’s liver, fewer pathological alterations were observed in furan+lycopene treated groups at the end of week 4. Consequently, lycopene significantly reduced furan- and diabetes-induced toxicity in rat liver.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"73 1","pages":"194 - 203"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85936031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

A review of aluminium phosphide poisoning and a flowchart to treat it 磷化铝中毒综述及处理流程

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-01 DOI: 10.1515/aiht-2016-67-2784

Behrooz Hashemi-Domeneh, N. Zamani, H. Hassanian‐Moghaddam, Mitra Rahimi, S. Shadnia, Peyman Erfantalab, A. Ostadi

引用次数: 66

Comparison of the effects of difenacoum and brodifacoum on the ultrastructure of rat liver cells 异芬康和布罗迪法康对大鼠肝细胞超微结构影响的比较

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-09-01 DOI: 10.1515/aiht-2016-67-2783

N. Gül, N. Yigit, Fulya Saygılı, E. Demirel, Ceren Geniş

{"title":"Comparison of the effects of difenacoum and brodifacoum on the ultrastructure of rat liver cells","authors":"N. Gül, N. Yigit, Fulya Saygılı, E. Demirel, Ceren Geniş","doi":"10.1515/aiht-2016-67-2783","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2783","url":null,"abstract":"Abstract We used transmission electron microscopy to examine the cytotoxic effects of the second-generation anticoagulant rodenticides difenacoum and brodifacoum on rat liver. A single dose of difenacoum or brodifacoum was administered to rats by gastric gavage and liver samples were taken after 24 h, four days or seven days. In the livers of rats treated with difenacoum for 24 h, hepatocytes typically showed increased numbers of lysosomes, as well as enlargement of both the perinuclear space and the cisternae of the rough endoplasmic reticulum (RER), while sinusoids were irregularly shaped and contained Kupffer cells. Similar irregularities occurred in brodifacoum-treated rats at the same time point, but additionally increased numbers of vacuoles, damaged mitochondrial cristae, and clumping of chromatin were observed in hepatocytes, and hemolysed erythrocytes were noted in the sinusoids. Comparable findings were made in each group of rats after four days. After seven days of difenacoum treatment, hepatocytes suffered loss of cytoplasmic material and mitochondrial shrinkage, while RER cisternae became discontinuous. In contrast, exposure to brodifacoum for seven days caused the formation of numerous vacuoles and lipid droplets, disordered mitochondrial morphology, chromatin clumping and invagination of the nuclear envelope in hepatocytes. Sinusoids in the livers of rodenticide-treated rats contained an accumulation of dense material, lipid droplets, cells with pycnotic nuclei and hemolysed erythrocytes. Overall, our results show that brodifacoum causes more severe effects in liver cells than difenacoum. Thus our microscopic data along with additional biochemical assays point to a severe effect of rodenticide on vertebrates.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"8 1","pages":"204 - 209"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86997152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4