Archives of Industrial Hygiene and Toxicology最新文献

Radiological Impact of An Active Quarry in The Papuk Nature Park, Croatia 克罗地亚帕普克自然公园一个活跃采石场的辐射影响

Archives of Industrial Hygiene and Toxicology Pub Date : 2022-03-01 DOI: 10.2478/aiht-2022-73-3616

B. Petrinec, Davor Rašeta, D. Babić

{"title":"Radiological Impact of An Active Quarry in The Papuk Nature Park, Croatia","authors":"B. Petrinec, Davor Rašeta, D. Babić","doi":"10.2478/aiht-2022-73-3616","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3616","url":null,"abstract":"Abstract Papuk Nature Park, unlike most similar parks and preserves in the world, contains active quarries. Quarries dig stone from the ground, creating dust and exposing deeper, potentially more radioactive layers. Since the forest trails in the Park lead right up to the quarries, we believed it was important to determine the radiological impact of the quarries on the Park environment. We measured ambient dose rate equivalent H*(10) and sampled moss at 26 Park locations along two of four quarries, along the road between them, and near Lake Orahovac, a very popular tourist destination close to the quarries. Moss is a standard bioindicator of exposure to heavy metals, including radionuclides. Using-gamma ray spectrometry we determined the activity concentration of 137Cs and of representative naturally occurring radionuclides – 238U, 226Ra, 210Pb, 232Th, and 40K – in sampled moss. H*(10) at selected locations was similar to the background H*(10) measured continuously all over Croatia. The ranges of measured activity concentrations of 137Cs and naturally occurring radionuclides in moss did not differ significantly from other parts of Croatia and nearby countries.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"24 1","pages":"15 - 22"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87436757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicopathological Changes Induced By Combined Exposure To Noise and Toluene in New Zealand White Rabbits 噪声和甲苯联合暴露对新西兰大白兔的毒性病理改变

Archives of Industrial Hygiene and Toxicology Pub Date : 2022-03-01 DOI: 10.2478/aiht-2022-73-3602

Amirreza Abouee-Mehrizi, Y. Rasoulzadeh, Tohid Kazemi, Ahmad Mehdipour, M. Mesgari-Abbasi

{"title":"Toxicopathological Changes Induced By Combined Exposure To Noise and Toluene in New Zealand White Rabbits","authors":"Amirreza Abouee-Mehrizi, Y. Rasoulzadeh, Tohid Kazemi, Ahmad Mehdipour, M. Mesgari-Abbasi","doi":"10.2478/aiht-2022-73-3602","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3602","url":null,"abstract":"Abstract Noise and toluene can have significant adverse effects on different systems in the human body, but little is known about their combination. The aim of this study was to see how their combined action reflects on serum levels of inflammatory cytokines tumour necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), body weight, and pathological changes in the heart, lung, stomach, and spleen tissues. To do that we exposed New Zealand rabbits to 1000 mg/L toluene and 100 dB of white noise in a chamber specifically designed for the purpose over two consecutive weeks. Serum levels of TNF-α and IL-1β were measured with the enzyme-linked immunosorbent assay (ELISA), whereas Bax and Bcl-2 expressions in tissues were determined with real-time polymerase chain reaction (PCR). Noise and toluene changed TNF-α and IL-1β serum levels on different days following the end of exposure and significantly increased the Bax/Bcl-2 ratio in the lung and spleen. In addition, they induced different pathological changes in the heart, lung, spleen, and stomach tissues. This study has confirmed that exposure to noise and toluene can induce a range of toxicopathological changes, probably by inducing inflammatory pathways and apoptosis, but their combined effects look weaker than those of its components, although histopathological findings suggest the opposite.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"29 21 1","pages":"31 - 42"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72776173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ochratoxin a Potentiates Citrinin Accumulation in Kidney and Liver of Rats 赭曲霉毒素a可增强大鼠肾脏和肝脏中橙黄霉素的积累

Archives of Industrial Hygiene and Toxicology Pub Date : 2022-03-01 DOI: 10.2478/aiht-2022-73-3605

D. Rašić, S. Stefanović, D. Milićević, M. Mladinić, D. Želježić, A. Pizent, P. Konjevoda, M. Peraica

引用次数: 1

Effects of Naringin and Valproate Interaction on Liver Steatosis and Dyslipidaemia Parameters in Male C57BL6 Mice 柚皮苷和丙戊酸相互作用对雄性C57BL6小鼠肝脏脂肪变性和血脂异常参数的影响

Archives of Industrial Hygiene and Toxicology Pub Date : 2022-03-01 DOI: 10.2478/aiht-2022-73-3608

David Jutrić, D. Đikić, Almoš Boroš, Dyna Odeh, Sandra Domjanić Drozdek, Romana Gračan, P. Dragičević, Irena Crnić, I. L. Jurčević

{"title":"Effects of Naringin and Valproate Interaction on Liver Steatosis and Dyslipidaemia Parameters in Male C57BL6 Mice","authors":"David Jutrić, D. Đikić, Almoš Boroš, Dyna Odeh, Sandra Domjanić Drozdek, Romana Gračan, P. Dragičević, Irena Crnić, I. L. Jurčević","doi":"10.2478/aiht-2022-73-3608","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3608","url":null,"abstract":"Abstract Valproate is a common antiepileptic drug whose adverse effects include liver steatosis and dyslipidaemia. The aim of our study was to see how natural flavonoid antioxidant naringin would interact with valproate and attenuate these adverse effects. For this reason we treated male C57BL6 mice with a combination of 150 mg/kg of valproate and 25 mg/kg naringin every day for 10 days and compared their serum triglycerides, cholesterol, LDL, HDL, VLDL, and liver PPAR-alpha, PGC-1 alpha, ACOX1, Nrf2, SOD, CAT, GSH, and histological signs of steatosis. Valproate increased lipid peroxidation parameters and caused pronounced microvesicular steatosis throughout the hepatic lobule in all acinar zones, but naringin co-administration limited steatosis to the lobule periphery. In addition, it nearly restored total serum cholesterol, LDL, and triglycerides and liver ACOX1 and MDA to control levels. and upregulated PPAR-alpha and PGC-1 alpha, otherwise severely downregulated by valproate. It also increased SOD activity. All these findings suggest that naringin modulates key lipid metabolism regulators and should further be investigated in this model, either alone or combined with other lipid regulating drugs or molecules.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"35 1","pages":"71 - 82"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90543945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Light and Heavy Ferritin Chain Expression in The Liver and Kidneys of Wistar Rats: Aging, Sex Differences, and Impact of Gonadectomy Wistar大鼠肝脏和肾脏轻、重铁蛋白链表达:衰老、性别差异和性腺切除术的影响

Archives of Industrial Hygiene and Toxicology Pub Date : 2022-03-01 DOI: 10.2478/aiht-2022-73-3621

Mirela Pavić Vulinović, P. Turčić, V. Micek, Marija Ljubojević

引用次数: 3

In Vitro Antifungal Effect of Phenylboronic and Boric Acid on Alternaria Alternata 苯硼酸和硼酸对交替孢菌的体外抑菌作用

Archives of Industrial Hygiene and Toxicology Pub Date : 2022-03-01 DOI: 10.2478/aiht-2022-73-3620

Katarina Martinko, S. Ivanković, E. Đermić, Damir Đermić

{"title":"In Vitro Antifungal Effect of Phenylboronic and Boric Acid on Alternaria Alternata","authors":"Katarina Martinko, S. Ivanković, E. Đermić, Damir Đermić","doi":"10.2478/aiht-2022-73-3620","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3620","url":null,"abstract":"Abstract The ascomycete fungus Alternaria alternata causes early blight, one of economically the most important tomato diseases. Due to frequent use of fungicides, A. alternata has developed resistance with negative economic and environmental consequences. Research of new ways to control fungal pathogens has turned its eye to environmentally friendly chemicals with low toxicity such as boronic acids. The aim of our study was therefore to test the antifungal effects of phenylboronic and boric acid in vitro on A. alternata. We isolated the pathogen from a symptomatic tomato plant and determined the minimum inhibitory concentration of phenylboronic and boric acid on A. alternata mycelial growth using the poisoned food technique. The antifungal effect was tested on a wide range of phenylboronic and boric acid concentrations (from 0.04 % to 0.3 %) applied separately to agar with mycelial disc of the pathogen. After five days of incubation, phenylboronic acid at low concentration (0.05 %) completely inhibited mycelial growth. Boric acid, in turn, did not significantly slow down mycelial growth but did reduce sporulation and confirmed its fungistatic effect. Our findings point to the potential use of phenylboronic acid to control phytopathogenic fungi. This is, to our knowledge, the first report on its antifungal effect on an agriculturally important pathogen in vitro. Moreover, since A. alternata is also a human pathogen, these results may have clinical ramifications.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"271 1","pages":"83 - 87"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75978822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Kidney Cell DNA Damage Caused By Combined Exposure To Volatile Anaesthetics and 1 Gy Or 2 Gy Radiotherapy Dose in Vivo 挥发性麻醉剂和1gy或2gy放射治疗对体内肾细胞DNA损伤的影响

Archives of Industrial Hygiene and Toxicology Pub Date : 2022-03-01 DOI: 10.2478/aiht-2022-73-3600

V. Benković, N. Oršolić, A. Knežević, N. Borojević, G. Brozović, M. Milić

{"title":"Kidney Cell DNA Damage Caused By Combined Exposure To Volatile Anaesthetics and 1 Gy Or 2 Gy Radiotherapy Dose in Vivo","authors":"V. Benković, N. Oršolić, A. Knežević, N. Borojević, G. Brozović, M. Milić","doi":"10.2478/aiht-2022-73-3600","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3600","url":null,"abstract":"Abstract Patient immobilisation with volatile anaesthetics (VA) during radiotherapy is sometimes unavoidable. Although it is known that both VAs and ionising radiation can have nephrotoxic effects, there are no studies of their combined effects on DNA damage. The aim of this in vivo study was to address this gap by investigating whether 48 groups of healthy Swiss albino mice (totalling 240) would differ in kidney cell DNA damage response (alkaline comet assay) to isoflurane, sevoflurane, or halothane anaesthesia and exposure to 1 Gy or 2 Gy of ionising radiation. We took kidney cortex samples after 0, 2, 6, and 24 h of exposure and measured comet parameters: tail length and tail intensity. To quantify the efficiency of the cells to repair and re-join DNA strand breaks, we also calculated cellular DNA repair index. Exposure to either VA alone increased DNA damage, which was similar between sevoflurane and isoflurane, and the highest with halothane. In combined exposure (VA and irradiation with 1 Gy) DNA damage remained at similar levels for all time points or was even lower than damage caused by radiation alone. Halothane again demonstrated the highest damage. In combined exposure with irradiation of 2 Gy sevoflurane significantly elevated tail intensity over the first three time points, which decreased and was even lower on hour 24 than in samples exposed to the corresponding radiation dose alone. This study confirmed that volatile anaesthetics are capable of damaging DNA, while combined VA and 1 Gy or 2 Gy treatment did not have a synergistic damaging effect on DNA. Further studies on the mechanisms of action are needed to determine the extent of damage in kidney cells after longer periods of observation and how efficiently the cells can recover from exposure to single and multiple doses of volatile anaesthetics and radiotherapy.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"36 1","pages":"62 - 70"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72956701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Micronuclei and other nuclear anomalies in buccal epithelial cells of children with chronic kidney disease 慢性肾病患儿颊上皮细胞微核及其他核异常

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-12-01 DOI: 10.1515/aiht-2016-67-2851

B. Aykanat, G. C. Demircigil, N. Buyan, E. Baskın, K. Gulleroglu, K. Fidan, U. Bayrakçı, A. Dalgıç, H. Karakayalı, M. Haberal, S. Burgaz

{"title":"Micronuclei and other nuclear anomalies in buccal epithelial cells of children with chronic kidney disease","authors":"B. Aykanat, G. C. Demircigil, N. Buyan, E. Baskın, K. Gulleroglu, K. Fidan, U. Bayrakçı, A. Dalgıç, H. Karakayalı, M. Haberal, S. Burgaz","doi":"10.1515/aiht-2016-67-2851","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2851","url":null,"abstract":"Abstract The objective of this study was to reveal the likely genomic instability in children with chronic kidney disease (CKD) using micronucleus (MN) assay on buccal epithelial cells (BEC). We investigated the frequencies of micronuclei and other nuclear anomalies, such as nuclear buds, binucleated cells, condensed chromatin, and karyorrhectic and pyknotic cells in BEC. Children with CKD were grouped as follows: children in the pre-dialysis (PreD) stage (N=17), children on regular haemodialysis (HD) (N=14), and children who have undergone transplantation (Tx) (N=17). As a control group, twenty age- and gender-matched healthy children were selected. The MN frequency in BEC of all groups of children with CKD was significantly elevated (5- to 7-fold) as compared to the control group (p<0.001). In contrast, the frequencies of nuclear buds were not significantly higher in the study groups compared to the control group. The frequencies of binucleated cells and condensed chromatin cells were significantly higher in all subgroups of children with CKD relative to the control group (p<0.001). Our results show that the BEC of pediatric PreD, HD, and Tx patients with CKD display increased cytogenetic, cytokinetic, and cytotoxic effects. They also point to the sensitivity and usefulness of the BEC MN assay in the assessment of genetic susceptibility of patients with CKD.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"23 1","pages":"317 - 325"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91127668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Ectoine as a promising protective agent in humans and animals 作为一种很有前途的人类和动物保护剂

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-12-01 DOI: 10.1515/aiht-2016-67-2837

A. Bownik, Z. Stępniewska

引用次数: 63

Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation 暴露于电离辐射后青春期前和成年小鼠基因组损伤的年龄和性别差异

Archives of Industrial Hygiene and Toxicology Pub Date : 2016-12-01 DOI: 10.1515/aiht-2016-67-2882

R. Stojković, A. Fucic, D. Ivanković, Z. Jukić, P. Radulović, J. Grah, N. Kovačević, Lovro Barišić, B. Krušlin

{"title":"Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation","authors":"R. Stojković, A. Fucic, D. Ivanković, Z. Jukić, P. Radulović, J. Grah, N. Kovačević, Lovro Barišić, B. Krušlin","doi":"10.1515/aiht-2016-67-2882","DOIUrl":"https://doi.org/10.1515/aiht-2016-67-2882","url":null,"abstract":"Abstract The mechanisms that lead to sex and age differences in biological responses to exposure to ionising radiation and related health risks have still not been investigated to a satisfactory extent. The significance of sex hormones in the aetiology of radiogenic cancer types requires a better understanding of the mechanisms involved, especially during organism development. The aim of this study was to show age and sex differences in genome damage between prepubertal and adult mice after single exposure to gamma radiation. Genome damage was measured 24 h, 48 h, and 72 h after exposure of 3-week and 12-week old BALB/CJ mice to 8 Gy of gamma radiation using an in vivo micronucleus assay. There was a significantly higher genome damage in prepubertal than in adult animals of both sexes for all sampling times. Irradiation caused a higher frequency of micronuclei in males of both age groups. Our study confirms sex differences in the susceptibility to effects of ionising radiation in mice and is the first to show that such a difference occurs already at prepubertal age.","PeriodicalId":8292,"journal":{"name":"Archives of Industrial Hygiene and Toxicology","volume":"22 1","pages":"297 - 303"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89090309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13