Archives of pathology最新文献

{"title":"Histological clonal change - A feature for dysplasia diagnosis","authors":"Lewei Zhang, Tarinee Lubpairee, D. Laronde, M. Guillaud, C. MacAulay, M. Rosin","doi":"10.29328/JOURNAL.APCR.1001008","DOIUrl":"https://doi.org/10.29328/JOURNAL.APCR.1001008","url":null,"abstract":"Aims: Histological diagnostic criteria are used for the assessment of the degree of dysplasia and hence the risk of cancer progression for premalignant lesions. Clonal changes in the form of hyperorthokeratosis and hyperchromasia that are sharply demarcated from adjacent areas are not currently part of the criterion for dysplasia diagnosis. The objective of this study was to determine whether such clonal change should be regarded as a diagnostic feature for dysplasia. The following histological conditions were used to defi ne such change: (1) hyperorthokeratosis; (2) hyperchromatism but no other features of dysplasia; (3) sharp margin demarcation from adjacent area by both the hyperorthokeratosis and hyperchromasia (clonal change), and (4) no prominent rete ridges, marked acanthosis or heavy infl ammation. Lesions fi tting these criteria were termed orthokeratotic lesions with no dysplasia. Methods: Patients from a population-based longitudinal study with more than 10 years of follow up were analyzed. Of the 214 patients with primary oral premalignant lesions, 194 had mild or moderate dysplasia (dysplasia group) and 20 fi t the criteria for orthokeratotic lesions without dysplasia (orthokeratotic with no dysplasia group). The two groups were compared for their cancer risks using clinical (site and toluidine blue), histological (nuclear phenotype score), and molecular criteria (loss of heterozygosity) and by outcome (progression). Results and conclusions: The lesions from orthokeratotic with no dysplasia group showed a similar cancer risk (clinical, histological and molecular risk) and time to progression as the dysplastic lesions. We recommend that the clonal change should be included as a criterion for dysplasia diagnosis. Research Article Histological clonal change A feature for dysplasia diagnosis Lewei Zhang1-3*, Tarinee Lubpairee1,3, Denise M Laronde1,3,4, Martial Guillaud3,4, Calum E MacAulay3,4 and Miriam P Rosin3-5 1Department of Oral Biological and Medical Sciences, Faculty of Dentistry, the University of British Columbia (BC), Vancouver, Canada 2BC Oral Biopsy Service, Vancouver General Hospital, Vancouver, Canada 3BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, Canada 4BC Cancer Research Centre, Vancouver, Canada 5School of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada *Address for Correspondence: Lewei Zhang, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, BC Oral Biopsy Service, Vancouver General Hospital, BC Oral Cancer Prevention Program, BC Cancer Agency, 2199 Wesbrook Mall, Vancouver BC, Canada, V6T 1Z3, Tel: +1-604-875-4318 / 778-387-3885; Email: leweizhang888@gmail.com Submitted: 23 September 2017 Approved: 27 August 2018 Published: 28 August 2018 Copyright: © 2018 Zhang L, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and re","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"2 1","pages":"020-028"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49039408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A great mimicker of Bone Secondaries: Brown Tumors, presenting with a Degenerative Lumber Disc like pain","authors":"Z. Bayramoğlu, R. Yılmaz, A. Bayram","doi":"10.29328/JOURNAL.HJPCR.1001004","DOIUrl":"https://doi.org/10.29328/JOURNAL.HJPCR.1001004","url":null,"abstract":"This report presents an adult patient suffering from sacroiliitis like low back pain, lumbosacral radiculopathy and elbow swelling. Multimodality imaging revealed multiple lytic bone lesions located in supra acetabular iliac bone, sacrum, and distal end of radius. Painful numerous lesions due to the extension to the articular surfaces are not expected for Brown tumors. Less than ten cases with multiple Brown tumor due to primary hyperparathyroidism has been reported. Although Brown tumors are mostly diagnosed incidentally, this case would awake the physicians about rheumatological symptoms in the presentation of Brown tumors. Since Brown tumors are non-touch bone lesions that are expected to regress after parathyroid adenoma removal, it is important to distinguish Brown tumors from the giant cell tumors. Case Report A great mimicker of Bone Secondaries: Brown Tumors, presenting with a Degenerative Lumber Disc like pain Zuhal Bayramoglu1*, Ravza Yılmaz1 and Aysel Bayram2 1Department of Radiology, Istanbul Medical Faculty, Istanbul University, Capa, Fatih, 34093, Istanbul, Turkey 2Department of Pathology, Istanbul Medical Faculty, Istanbul University, Capa, Fatih, 34093, Istanbul, Turkey *Address for Correspondence: Dr. Zuhal Bayramoglu, Department of Radiology, Istanbul Medical Faculty, Istanbul University, Capa, Fatih, 34093, Istanbul, Turkey, Tel: +90-212414-20-00, Fax: +90-212-631-07-28; Email: incezuhal@yahoo.com Submitted: 06 June 2017 Approved: 14 July 2017 Published: 17 July 2017 Copyright: 2017 Bayramoglu Z. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"1 1","pages":"018-023"},"PeriodicalIF":0.0,"publicationDate":"2017-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45200745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA Therapeutics in Triple Negative Breast Cancer","authors":"Sarmistha Mitra","doi":"10.29328/JOURNAL.HJPCR.1001003","DOIUrl":"https://doi.org/10.29328/JOURNAL.HJPCR.1001003","url":null,"abstract":"Breast cancer is a complex disease and one of the main causes of cancer-related mortality in women worldwide. In case of approximately 15% of all breast cancers, three markers i.e. estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptors-2 (HER2) are not expressed, and is commonly termed as triple-negative breast cancer (TNBC). Particularly, TNBC is associated with a higher percentage of breast cancer related mortality, which is often aggressive and most frequently found with a BRCA1 mutation or increased basal marker expression. However, due to the limitations of chemotherapy and radiation based treatment; the current challenge is to establish a new strategy of diagnosis and treatment of TNBC. The deregulation of a number of microRNAs (miRNAs) in breast cancer has been widely reported. Therefore, this review is directed towards enhancing our understanding of the involvement of various miRNAs in the pathology of TNBC, their upregulations and downregulations and the effects on various factors. From recent studies a number of miRNAs are found to be related with TNBC, which have great potential to be used as a biomarker to determine the disease prognosis and predict the fate of disease. Again miRNA can be targeted to be applied as a therapeutic to provide a great benefi t to the patients of TNBC by fi nding a new, safe, and effective treatment strategy. Review Article MicroRNA Therapeutics in Triple Negative Breast Cancer Sarmistha Mitra* Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh *Address for Correspondence: Sarmistha Mitra, Department of Pharmacy, Faculty of Biological Science, University of Chittagong, Chittagong-4331, Bangladesh, Tel: +8801521484840; Email: sarmisthacu@gmail.com Submitted: 31 May 2017 Approved: 23 June 2017 Published: 27 June 2017 Copyright: 2017 Mitra S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"1 1","pages":"009-017"},"PeriodicalIF":0.0,"publicationDate":"2017-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69930878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypernatremia and central Diabetes Insipidus following Neurosurgical procedure of Trauma","authors":"A. Magbri, Eussera El-Magbri, Seth Hershit","doi":"10.29328/journal.hjpcr.1001002","DOIUrl":"https://doi.org/10.29328/journal.hjpcr.1001002","url":null,"abstract":"The greater risk of hypernatremia in patients over 65 years old are associated with impaired mental status and physical disability which may result in impaired sensation to thirst, impaired ability to express thirst, and/or decrease access to water [1,2]. Normally, anti-diuretic hormone (ADH, also known as arginine-vasopressin, AVP) is secreted in response to 1-2% increase in osmolality which stimulate thirst, as do hypovolemia and hypotension. Broadly, speaking hypernatremia is due to hypotonic luid loss or hypertonic sodium gain. Hypotonic luid loss is mainly caused by diabetes insipidus. There are many causes of central diabetes incipidus (CDI). Pituitary and hypothalamus injuries caused by trauma, neurosurgical procedures, hemorrhage, ischemia, autoimmune diseases e.g. hypophysitis, IgG4 related disease or tumors involving hypothalamic-pituitary axis (HPA) are but few causes of CDI. Central diabetes incipidus is also reported with traumatic brain injuries causing ischemia to the HPA [3] and presented with exertion of large volumes of diluted urine (polyuria). Polyuria is de ined by a urine volume in excess of 2 L/m2/24 h or approximately 40-50 ml/kg/24 h in older children or adult.","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"1 1","pages":"005-008"},"PeriodicalIF":0.0,"publicationDate":"2017-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42856437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Carcinoma Associated Fibroblasts in Anoikis Resistance in Oral Squamous Cell Carcinoma –need of the hour","authors":"Anjali P Ganjre","doi":"10.29328/journal.hjpcr.1001001","DOIUrl":"https://doi.org/10.29328/journal.hjpcr.1001001","url":null,"abstract":"Anoikis resistance (AR) is a favorable attribute exhibited by cancer cells for metastasis. Carcinoma associated Fibroblasts (CAFs) plays a crucial role in AR in various cancers. It was proved in array of studies in different cancers that there was defi nite interrelationship between CAFs and AR. But its role in OSCC is ambiguous. It is the need of the time to reveal the correlation of CAF and oral squamous cell carcinoma (OSCC) in relation with anoikis. Molecular pathways which affects the AR via CAFs in various cancers has been highlighted in this communication. Divulging the importance of CAF in cancer will aid in designing customized novel chemoprevention therapy and thus will help in enhancing the prognosis of patient in OSCC. Short Communication","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"41 17","pages":"001-004"},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41263476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicament of classification: Multisystem small vessel vasculitis with cresentic Glomerulonephritis","authors":"A. Magbri","doi":"10.29328/JOURNAL.APCR.1001005","DOIUrl":"https://doi.org/10.29328/JOURNAL.APCR.1001005","url":null,"abstract":"","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"2 1","pages":"001-005"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69930799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In at the deep end: Psychosocial aspects of developing autonomy in histopathology training","authors":"Finall Ai","doi":"10.29328/JOURNAL.APCR.1001007","DOIUrl":"https://doi.org/10.29328/JOURNAL.APCR.1001007","url":null,"abstract":"Medical postgraduate trainees are given increasing levels of responsibility during training in the apprenticeship-model of training [1-3]. Responsibility is said to be a key driver of deep learning and understanding [4-7]. Trainees with greater levels of responsibility for decision making have higher levels of motivation to learn compared with trainees who self-assess as having less autonomy [5]. The Royal College of Pathologists (RCPath) indicate that ‘graded responsibility’ is part of training histopathologists and provided a framework for implementation with increasingly complex specimens suitable for reporting by more senior trainees [8,9].","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"2 1","pages":"013-019"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69930859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams","authors":"U. Simon, O. David, R. Peter, Rwuaan Joseph, Chibuogwu Ijeoma, N. Celestine","doi":"10.29328/journal.apcr.1001006","DOIUrl":"https://doi.org/10.29328/journal.apcr.1001006","url":null,"abstract":"An investigation into the pathological lesions of Cypermethrin on the testes, accessory sexual and pituitary glands of Yankasa rams was carried out. Sixteen Yankasa rams aged 18 30 months and weighing between 21.5 46.5kg were used. The 16 rams were divided equally into two groups (A and B) A served as the treatment group while B served as the control. Group (A) were given Cypermethrin (3%) at the dose rate of 3mg/kg (0.1ml/kg) body weight, topically. Group (B) rams were given distilled water at the same dose rate and route. These treatments were repeated every two weeks for a period of 12 weeks. The rams were sacrifi ced at the end of 12 weeks and the following organs (testes, pituitary, vesicular and prostate glands), were collected and weighed, gross pathological lesions were observed and photographs were taken. The samples were kept for histopathology. Results showed that there were no gross pathological lesions found on the testes, pituitary, prostate glands and the seminal vesicles of both groups. The mean weight of the pituitary gland, the prostate glands and the seminal vesicles of the treated and control groups were statistically not signifi cant (P>0.05). No histologic lesions were found on them. The mean testicular weights of the treated (143.81±7.71g) and the control (130.43±0.63g) were signifi cantly different (P<0.05). There was a reduced number of spermatozoa in the lumen of the seminiferous tubules of the treated group. It was concluded that Cypermethrin reduced spermatozoa in the lumen of the seminiferous tubules. Research Article Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams Ubah Simon1*, Ogwu David1, Rekwot Peter1, Rwuaan Joseph1, Chibuogwu Ijeoma2 and Njoku Celestine3 1Department of Theriogenology and Production, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria 2Animal Science Department, Faculty of Agriculture, University of Abuja, Abuja, Nigeria 3Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria *Address for Correspondence: Ubah Simon, Department of Theriogenology and Production, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria, Tel: +2348036097428; Email: drubah2000@yahoo.com Submitted: 06 June 2018 Approved: 19 June 2018 Published: 20 June 2018 Copyright: 2018 Simon U, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"2 1","pages":"006-012"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69930805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon Causes of Stroke: Systemic lupus erythematosus","authors":"N. Futrell","doi":"10.1017/CBO9780511544897.046","DOIUrl":"https://doi.org/10.1017/CBO9780511544897.046","url":null,"abstract":"","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57060780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sickle cell anemia","authors":"L. Moreland","doi":"10.1007/3-540-29662-X_2435","DOIUrl":"https://doi.org/10.1007/3-540-29662-X_2435","url":null,"abstract":"","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"1 1","pages":"800-800"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51529646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}