Archives of pathology最新文献

A novel case of an infantile fibrosarcoma-like tumor with KIAA1549 - BRAF translocation and an oncogenic NF2 p.Q459* SNV with potential clinical significance 一例具有KIAA1549-BRAF易位和致癌NF2 p.Q459*SNV的婴儿纤维肉瘤样肿瘤的新病例，具有潜在的临床意义

Archives of pathology Pub Date : 2021-08-27 DOI: 10.29328/JOURNAL.APCR.1001023

A. Nagy, C. Sergi, J. D. Nanassy, Lesleigh S Abbot, A. Arnoldo, C. Hawkins, B. Ngan

{"title":"A novel case of an infantile fibrosarcoma-like tumor with KIAA1549 - BRAF translocation and an oncogenic NF2 p.Q459* SNV with potential clinical significance","authors":"A. Nagy, C. Sergi, J. D. Nanassy, Lesleigh S Abbot, A. Arnoldo, C. Hawkins, B. Ngan","doi":"10.29328/JOURNAL.APCR.1001023","DOIUrl":"https://doi.org/10.29328/JOURNAL.APCR.1001023","url":null,"abstract":"We report a case of a right gluteal mass from the sacroiliac joint to the knee of an infant girl. Biopsy showed histopathological features similar to infantile ﬁ brosarcoma (IFS). However, unlike most IFS, no ETV6-NTRK3 fusion gene abnormality was detected. Molecular analysis with TruSight RNA Pan-Cancer Panel detected the presence of KIAA1549-BRAF translocation and an oncogenic NF2p.Q459* SNV with potential clinical signiﬁ cance. A review revealed that the combination of this patient’s tumor site with the presence of a KIAA1549-BRAF translocation abnormality and an accompanying single nucleotide variant has not been previously described. The detection of this translocation abnormality raises the possibility that the spindle cell tumors in infants with an absence of the ETV6-NTRK3 fusion gene abnormality might have a distinct pathogenetic mechanism diﬀ erent from the previously known IFS and congenital mesoblastic nephroma. Furthermore, the discovery of BRAF translocation and its aberrant signaling of the mitogen-activated protein kinase (MAPK) pathway in this tumor contributes to the promise of clinical beneﬁ t of using the MEKi trametinib for the treatment of progressive disease that is refractory to conventional chemotherapy.","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"365 1","pages":"016-019"},"PeriodicalIF":0.0,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41284032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status, complications and prospects of fecal microbiota transplantation therapy 粪便微生物群移植治疗的现状、并发症及前景

Archives of pathology Pub Date : 2021-04-15 DOI: 10.29328/JOURNAL.APCR.1001021

Ohara Tadashi

引用次数: 0

Emergency care sick palliative and problems oncology in emergency department during the COVID-19 pandemic COVID-19大流行期间急诊科的急诊护理、姑息治疗和肿瘤问题

Archives of pathology Pub Date : 2020-09-30 DOI: 10.29328/JOURNAL.APCR.1001019

B. Lenjani, N. Baftiu, P. Rashiti, Gani Shabani, B. Krasniqi, Arber Demiri, Besarta Pelaj, Fllanza Spahiu, A. Demi, Dardan Lenjani

{"title":"Emergency care sick palliative and problems oncology in emergency department during the COVID-19 pandemic","authors":"B. Lenjani, N. Baftiu, P. Rashiti, Gani Shabani, B. Krasniqi, Arber Demiri, Besarta Pelaj, Fllanza Spahiu, A. Demi, Dardan Lenjani","doi":"10.29328/JOURNAL.APCR.1001019","DOIUrl":"https://doi.org/10.29328/JOURNAL.APCR.1001019","url":null,"abstract":"Emergency medical care in palliative patients during the COVID-19 pandemic, it is important to provide a consistent treatment for stable patients that should be consistent with the goals and benefi ts, the perspective of these patients, but avoiding palliative patients with a poor prognosis that is unlikely to survive. Cancer is the second leading cause of death in the world around 8.8 million deaths a year. Worldwide, about 7-10 million patients are diagnosed with cancer each year, recently there has been a signifi cant increase in the number of cases diagnosed with cancer. About 70% of cancer deaths are in lowand middle-income countries. The goals of emergency medical care based on the criteria of BLS and ACLS, that is should be done “Do not do resuscitation, do not intubate but continue medical treatment excluding endotracheal intubation without prospects for the patient, but off ering BLS only treatment concentrated symptomatic. ED is often the only place that can provide the necessary medical interventions (e.g., intravenous fl uids or pain management medications. Medications as well as immediate access to advanced diagnostic tests when needed such as CT, RM and other diagnostic and treatment procedures. Research Article","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"4 1","pages":"024-027"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46044650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular analysis of immunoglobulins related to salmonella typhi in pediatric patients 儿童伤寒沙门菌相关免疫球蛋白的分子分析

Archives of pathology Pub Date : 2020-04-24 DOI: 10.29328/journal.apcr.1001017

Farah Qudsia, Muhammad Rehan, S. Riaz

{"title":"Molecular analysis of immunoglobulins related to salmonella typhi in pediatric patients","authors":"Farah Qudsia, Muhammad Rehan, S. Riaz","doi":"10.29328/journal.apcr.1001017","DOIUrl":"https://doi.org/10.29328/journal.apcr.1001017","url":null,"abstract":"Typhoid fever is a systemic infection caused by Salmonella enterica serotype typhi. It is of major concern in tropical regions of the world. Highest episodes of typhoid fever occur in Asia i.e.93%. Early diagnosis of the disease is mandatory to lower the mortality rate associated with it as well as to prevent the emergence of antimicrobial drug resistance by Salmonella typhi. Research work was conducted in Immunology Department of the Children’s Hospital, Lahore for the period of one year including a total of 60 patients suspected of having typhoid fever. Serum samples of these patients were tested for Typhidot IgG and IgM antibodies as well as for the antibodies against TO and TH antigens using Widal test. Of the total 60 patients, 10 (16.7%) were positive for both Typhidot IgG and IgM, 16 (26.7%) were positive for Typhidot IgM, 3 (5%) were Positive for Typhidot IgG and 31 (51.66%) were negative for both Typhidot IgG and IgM. Reading the results of Widal test, 8 (13.33%) were positive for Widal TO and TH antigens, 3 (5%) were positive for Widal TO antigen, 19 (31.7%) were positive for Widal TH antigen and 30 (50%) were negative for Widal TO and TH antigens. IgM is positive at the early stage of acute typhoid fever, IgM along with IgG positive means the middle stage of acute illness. The detection of only IgG cannot discriminate between acute and convalescent phases as it can stay in the serum for at least 2 years or more. The Typhidot test is much helpful for the rapid diagnosis of typhoid fever as compared to Widal test which is still being used in some set ups in poor countries, although has become mostly obsolete. By testing the rise of IgM and IgG antibodies against Salmonella typhi, we can detect the infection at early and late stages, respectively. Research Article","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"4 1","pages":"005-010"},"PeriodicalIF":0.0,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49199887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparative carcinogenesis. 比较致癌作用。

Archives of pathology Pub Date : 2020-02-02 DOI: 10.32388/55irnb

S. Rogers

引用次数: 1

Uterine precursor lesions in patients with incidental nodal lymphangioleiomyomatosis: A report of 4 cases 偶发淋巴结性淋巴管平滑肌瘤病并发子宫前体病变4例报告

Archives of pathology Pub Date : 2020-01-14 DOI: 10.29328/journal.apcr.1001016

C. Lombard

引用次数: 1

Pregnancy and childbirth in women aged 40 and over at befelatanana maternity, Madagascar 马达加斯加befelatanana产妇中心40岁及以上妇女的怀孕和分娩

Archives of pathology Pub Date : 2019-12-24 DOI: 10.29328/journal.apcr.1001015

Rakotomalala Nivoarimelina Zoly, Rakotozanany Besaina, Razafindraibe Andriatompoina Felanarivo, Ramarokoto Malalafinaritra Patrick Marco, Rafamatanantsoa Jean Florent, Kapche Wato Edith, Randriambololona Domoina Malala Aurelia

引用次数: 0

Effect evaluation of vitamin D level amongst patients with chronic hepatitis B 慢性乙型肝炎患者维生素D水平的疗效评价

Archives of pathology Pub Date : 2019-12-03 DOI: 10.29328/journal.apcr.1001014

Osmani* Freshteh

引用次数: 2

Receptor Pharmacology and Other Relevant Factors in Lower Urinary Tract Pathology under a Functional and Toxicological Approach: Instrument to Better Manage Antimicrobials Therapy 功能和毒理学方法下尿路病理学中的受体药理学和其他相关因素：更好地管理抗菌药物治疗的工具

Archives of pathology Pub Date : 2018-12-14 DOI: 10.29328/JOURNAL.APCR.1001010

M. Luisetto

引用次数: 1

Amyotropyc Lateral Sclerosis and Endogenous -Esogenous Toxicological Movens: New model to verify other Pharmacological Strategies 肌萎缩性侧索硬化和内源性-内源性毒理学运动:验证其他药理策略的新模型

Archives of pathology Pub Date : 2018-10-05 DOI: 10.29328/journal.apcr.1001009

L. Mauro

引用次数: 1