Technology (Elmsford, N.Y.)最新文献_第6页

On the Design of Sparse But Efficient Structures in Operations 操作中稀疏而高效的结构设计

Technology (Elmsford, N.Y.) Pub Date : 2016-11-08 DOI: 10.2139/ssrn.2899008

Zhenzhen Yan, S. Y. Gao, C. Teo

引用次数: 36

Designing Multi-Period Supply Contracts in a Two-Echelon Supply Chain Asymmetric Information 信息不对称下两梯队供应链的多期供给契约设计

Technology (Elmsford, N.Y.) Pub Date : 2016-11-01 DOI: 10.2139/ssrn.2862652

Z. Mobini, Wilco van den Heuvel, A. Wagelmans

{"title":"Designing Multi-Period Supply Contracts in a Two-Echelon Supply Chain Asymmetric Information","authors":"Z. Mobini, Wilco van den Heuvel, A. Wagelmans","doi":"10.2139/ssrn.2862652","DOIUrl":"https://doi.org/10.2139/ssrn.2862652","url":null,"abstract":"We study a two-echelon supply chain consisting of a supplier and a retailer, where the supplier uses a simple and easily implementable incentive scheme - making a side payment - to influence the retailer’s ordering plan. The supplier makes a take-it-or-leave-it offer to the retailer in the form of a menu of contracts, each consisting of a procurement plan plus a side payment. The retailer, who possesses private information about customer demand and his cost parameters, either accepts one of the contracts or imposes his own optimal plan. We formulate the supplier’s problem of designing optimal contracts with the realistic assumption that the retailer’s outside option depends on his private information. Taking into account the retailer’s reaction to the proposed offer, the supplier faces a nested (bi-level) optimization problem, which we transform into a single-level mixed integer programming formulation. In our analysis, we use a network interpretation for the set of incentive constraints and show some properties of optimal contracts. This enables us to considerably reduce the number of incentive constraints and to find optimal values of the side payment quantities. Our findings regarding the possible behavior of the opportunistic retailer deviate from those of previous studies as a result of considering more realistic assumptions.","PeriodicalId":82888,"journal":{"name":"Technology (Elmsford, N.Y.)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72658302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical Validity and Derivation of Balance Equations for the Two-Level Model of a Production Line 生产线两层模型平衡方程的统计有效性及推导

Technology (Elmsford, N.Y.) Pub Date : 2016-10-30 DOI: 10.15587/1729-4061.2016.81308

O. Pihnastyi

{"title":"Statistical Validity and Derivation of Balance Equations for the Two-Level Model of a Production Line","authors":"O. Pihnastyi","doi":"10.15587/1729-4061.2016.81308","DOIUrl":"https://doi.org/10.15587/1729-4061.2016.81308","url":null,"abstract":"A method of constructing a system of multi-moment balance equations, based on the statistical description of a production system is proposed. The need for research is determined by current trends in the development of production systems. The system of equations, which simulates the behavior of the production line for the transient conditions is obtained. It is shown that the resulting balance equations are not closed. The methods of closure of the self-linking chain of balance equations: the small-parameter method and the method of setting the equations of states for higher-order moments are considered. The known models using various methods of closure of the system of equations are analyzed. The model of the production line for the assembly-line production method is considered. The limitations and constraint equations, which enable the transition to single-moment PDE model of description of the assembly line and two-moment PDE model of the production line using the Burgers' equation are shown. The model of the production line for the company with the flow production method is considered. One-, two- and three-moment systems of equations for the two-level model of the production line are obtained. A general system of balance equations for the flow parameters of the production line is constructed.","PeriodicalId":82888,"journal":{"name":"Technology (Elmsford, N.Y.)","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84849579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

When Prospect Theory Meets Consumer Choice Models: Assortment and Pricing Management with Reference Prices 当前景理论遇到消费者选择模型:参考价格下的分类与定价管理

Technology (Elmsford, N.Y.) Pub Date : 2016-08-06 DOI: 10.2139/ssrn.2819600

Ruxian Wang

引用次数: 56

Contract Manufacturing and Quality Risk: Theory and Empirical Evidence 合同制造与质量风险:理论与实证

Technology (Elmsford, N.Y.) Pub Date : 2016-07-28 DOI: 10.2139/ssrn.2815520

John V. Gray, A. Roth, Brian Tomlin

{"title":"Contract Manufacturing and Quality Risk: Theory and Empirical Evidence","authors":"John V. Gray, A. Roth, Brian Tomlin","doi":"10.2139/ssrn.2815520","DOIUrl":"https://doi.org/10.2139/ssrn.2815520","url":null,"abstract":"This paper investigates the relationship between contract manufacturing and quality risk — a term defined as the propensity of a manufacturing plant to operate out of compliance with required procedures. Contract manufacturing plants (hereafter, CM) are increasingly being used in many industrial sectors. While CMs have been anecdotally blamed for many recalls and other outgoing product quality failures, there is a neither a strong coherent theory in operations and supply chain management nor empirical evidence that considers whether and when CMs pose a differential quality risk in contrast to internal plants (IPs). By definition, CMs produce products to another firm’s specifications, whereas IPs make products to their own firm’s specifications. This basic difference between CMs and IPs potentially leads to systemic dissimilarities in their operational contexts. Drawing upon these contextual dissimilarities, we posit that, on average, CMs will operate with higher quality risk than IPs. Subsequently, we develop contingencies related to key factors that moderate the relationship between plant type (CM vs. IP) and quality risk. We test our hypotheses using a plant-level measure of process compliance based on Food and Drug Administration (FDA) inspection data on a sample of 152 plants classified as drug manufacturers by the FDA. In addition to finding moderate evidence of a first-order difference, we do find evidence that production experience and the intensity of external regulation serve as important contingencies regarding quality risk. We find strong evidence that among plants with low production experience, CMs operate with higher quality risk than IPs, but this difference is mitigated as CMs gain production experience. We also find that increased regulatory intensity seems to influence CMs to reduce quality risk more than it does IPs.","PeriodicalId":82888,"journal":{"name":"Technology (Elmsford, N.Y.)","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85327879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Two-stage nanoparticle delivery of piperlongumine and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) anti-cancer therapy. 两阶段纳米递送胡椒曲明与肿瘤坏死因子相关凋亡诱导配体(TRAIL)抗癌治疗。

Technology (Elmsford, N.Y.) Pub Date : 2016-05-18 DOI: 10.1142/S2339547816500011

Charles C. Sharkey, Jiahe Li, S. Roy, Qianhui Wu, M. King

引用次数: 16

Signal transduction of the physical environment in the neural differentiation of stem cells. 物理环境在干细胞神经分化中的信号转导。

Technology (Elmsford, N.Y.) Pub Date : 2016-05-18 DOI: 10.1142/S2339547816400070

Ryan Thompson, C. Chan

引用次数: 14

Dextran functionalization enhances nanoparticle-mediated siRNA delivery and silencing. 右旋糖酐功能化增强纳米颗粒介导的siRNA传递和沉默。

Technology (Elmsford, N.Y.) Pub Date : 2016-05-18 DOI: 10.1142/S2339547816400100

D. Vocelle, Olivia M Chesniak, A. Malefyt, Georgina Comiskey, Kwasi Adu-Berchie, Milton R. Smith, C. Chan, S. Walton

引用次数: 9

Quantitative assessments of glycolysis from single cells. 单细胞糖酵解的定量评估。

Technology (Elmsford, N.Y.) Pub Date : 2015-12-23 DOI: 10.1142/S2339547815200058

Y. Shin, Jungwoo Kim, Dazy Johnson, A. Dooraghi, Wilson X. Mai, Lisa Ta, A. Chatziioannou, M. Phelps, D. Nathanson, J. Heath

引用次数: 2

A microfluidic biochip for complete blood cell counts at the point-of-care. 一种微流控生物芯片，用于在护理点进行全血细胞计数。

Technology (Elmsford, N.Y.) Pub Date : 2015-12-23 DOI: 10.1142/S2339547815500090

U. Hassan, B. Reddy, G. Damhorst, O. Sonoiki, T. Ghonge, C. Yang, R. Bashir

{"title":"A microfluidic biochip for complete blood cell counts at the point-of-care.","authors":"U. Hassan, B. Reddy, G. Damhorst, O. Sonoiki, T. Ghonge, C. Yang, R. Bashir","doi":"10.1142/S2339547815500090","DOIUrl":"https://doi.org/10.1142/S2339547815500090","url":null,"abstract":"Complete blood cell counts (CBCs) are one of the most commonly ordered and informative blood tests in hospitals. The results from a CBC, which typically include white blood cell (WBC) counts with differentials, red blood cell (RBC) counts, platelet counts and hemoglobin measurements, can have implications for the diagnosis and screening of hundreds of diseases and treatments. Bulky and expensive hematology analyzers are currently used as a gold standard for acquiring CBCs. For nearly all CBCs performed today, the patient must travel to either a hospital with a large laboratory or to a centralized lab testing facility. There is a tremendous need for an automated, portable point-of-care blood cell counter that could yield results in a matter of minutes from a drop of blood without any trained professionals to operate the instrument. We have developed microfluidic biochips capable of a partial CBC using only a drop of whole blood. Total leukocyte and their 3-part differential count are obtained from 10 μL of blood after on-chip lysing of the RBCs and counting of the leukocytes electrically using microfabricated platinum electrodes. For RBCs and platelets, 1 μL of whole blood is diluted with PBS on-chip and the cells are counted electrically. The total time for measurement is under 20 minutes. We demonstrate a high correlation of blood cell counts compared to results acquired with a commercial hematology analyzer. This technology could potentially have tremendous applications in hospitals at the bedside, private clinics, retail clinics and the developing world.","PeriodicalId":82888,"journal":{"name":"Technology (Elmsford, N.Y.)","volume":"71 1","pages":"201-213"},"PeriodicalIF":0.0,"publicationDate":"2015-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73472405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36