Y. Shin, Jungwoo Kim, Dazy Johnson, A. Dooraghi, Wilson X. Mai, Lisa Ta, A. Chatziioannou, M. Phelps, D. Nathanson, J. Heath
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Quantitative assessments of glycolysis from single cells.
The most common positron emission tomography (PET) radio-labeled probe for molecular diagnostics in patient care and research is the glucose analog, 2-deoxy-2-[F-18]fluoro-D-glucose (18F-FDG). We report on an integrated microfluidics-chip/beta particle imaging system for in vitro18F-FDG radioassays of glycolysis with single cell resolution. We investigated the kinetic responses of single glioblastoma cancer cells to targeted inhibitors of receptor tyrosine kinase signaling. Further, we find a weak positive correlation between cell size and rate of glycolysis.
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