Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons最新文献_第3页

Effects of Alverine on electrical properties of vagal afferent neurons in isolated rabbit nodose ganglion Alverine对兔离体结节神经节迷走神经传入神经元电特性的影响

Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons Pub Date : 1997-01-01 DOI: 10.1163/092996397750131937

N. Clerc, J. Puizillout, C. Ducreux

{"title":"Effects of Alverine on electrical properties of vagal afferent neurons in isolated rabbit nodose ganglion","authors":"N. Clerc, J. Puizillout, C. Ducreux","doi":"10.1163/092996397750131937","DOIUrl":"https://doi.org/10.1163/092996397750131937","url":null,"abstract":"The possibility for Alverine to change the activity of primary afferent neurons was investigated in rabbit nodose ganglion in vitro. Alverine, applied by pressure ejection or by superfusion, depolarized 92% of the C-type neurons and had no effect on the membrane potential A-type neurons. These results were not correlated with the values of input resistances which could be unchanged, increased or decreased. Alverine induces a strong increase (up to 100%) in the duration of the action potentials, due to a decrease of the voltage-dependent outward K + current. Using a higher dose, this effect is followed by an important decrease in the amplitude of the action potentials, resulting in a change of the full somatic spike into a smaller axonic one, called an 'A spike'. The application of tetrodotoxin (TTX 10 -6 M) revealed the presence of a TTX-resistant component. Alverine decreased the amplitude and increased the duration of this component, which depends on Ca 2+ channels as it persists in Na + reduced Krebs solution. Some C-neurons in the nodose ganglion have a slow after-hyperpolarization following the fast one; Alverine completely suppresses the slow after-hyperpolarization. Voltage-clamp experiments showed that Alverine has no immediate effect on the inward currents but progressively decreased the late potassium outward currents, which were maximal at positive membrane potentials. It is concluded that Alverine has powerful effects on different g Na , g K and g Ca conductances of the vagal afferent neurons. Depending on the doses injected, Alverine has excitatory or inhibitory influences on these visceral afferents. If the same channel equipment is present at the terminal level, Alverine can positively or negatively affect the synaptic transmission of vagal afferents in the nucleus of the solitary tract.","PeriodicalId":82360,"journal":{"name":"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons","volume":"2 1","pages":"143-157"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/092996397750131937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64533174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Electrophysiological study of the effect of transcranial electrical stimulation on the functional recovery of the damaged sciatic nerve in the rat 经颅电刺激对大鼠坐骨神经损伤功能恢复影响的电生理研究

Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons Pub Date : 1997-01-01 DOI: 10.1163/092996397750131964

V. Lebedev, A. Moisseeva, G. Akoev, L. Kolosova, O. V. Riabchikova

引用次数: 1

Properties of an A-current in slowly and rapidly adapting stretch receptor neurones of lobster 龙虾慢速和快速适应拉伸受体神经元中a电流的特性

Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons Pub Date : 1997-01-01 DOI: 10.1163/092996397750132008

W. Grampp, S. Theander

{"title":"Properties of an A-current in slowly and rapidly adapting stretch receptor neurones of lobster","authors":"W. Grampp, S. Theander","doi":"10.1163/092996397750132008","DOIUrl":"https://doi.org/10.1163/092996397750132008","url":null,"abstract":"A previously unnoticed outward membrane current has been identified, characterized and specified as a so-called A-current in the slowly and rapidly adapting lobster stretch receptor neurone. In both cells the current was, after blockage of a tetrodotoxin-sensitive Na + current and a tetraethylammonium- and 4-aminopyridine-sensitive delayed rectifier current, seen to activate fully within about 25 ms of square-shaped depolarizations beyond voltage levels of -40 to -30 mV and, then, to inactivate completely with a (voltage independent, within the voltage span under observation) time constant of 110 ms. The A-currents of rapidly and slowly adapting receptors were noticed to differ significantly from each other in that the A-current of the rapidly adapting cell is activated, and inactivated, at 10-15 mV more negative voltage levels than the A-current of the slowly adapting cell. Also, the maximum permeability of the A-channel system appeared to be distinctly larger in the rapidly than in the slowly adapting cell. Both of these circumstances were able to explain why, at a given level of membrane depolarization, a markedly stronger A-current is activated in the rapidly than in the slowly adapting cell. On the basis of experimental data it was possible to formulate a mathematical A-current description which was incorporated into a previously published model of the lobster stretch receptor neurone. Using this model, evidence was obtained that the A-current may play a functionally significant role (in the rapidly adapting cell) by increasing the speed of action potential repolarization and thereby enhancing the cell's dynamic stimulus sensitivity.","PeriodicalId":82360,"journal":{"name":"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons","volume":"2 1","pages":"211-227"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/092996397750132008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64533367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Acetylsalicylic acid reduces pH-induced excitation of rat cutaneous nociceptors in vitro 乙酰水杨酸降低ph诱导的大鼠皮肤伤害感受器的体外兴奋

Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons Pub Date : 1997-01-01 DOI: 10.1163/092996397750131892

K. Steen, P. Reeh, D. Stefanidis

{"title":"Acetylsalicylic acid reduces pH-induced excitation of rat cutaneous nociceptors in vitro","authors":"K. Steen, P. Reeh, D. Stefanidis","doi":"10.1163/092996397750131892","DOIUrl":"https://doi.org/10.1163/092996397750131892","url":null,"abstract":"The effects of acetylsalicylic acid (ASA) and of salicylic acid (SA) on pH-induced nociceptor excitation were investigated in a rat skin-saphenous nerve preparation in vitro, where isolated receptive fields of identified single nerve fibers were superfused at the corium side with controlled solutions to test their chemosensitivity. A total of 133 unmyelinated mechano-heat-sensitive ('polymodal') C-fibers were superfused with an acidic solution (CO2-saturated synthetic interstitial fluid; pH 6.1) for at least 10 min. If fibers responded to the acid pH (n=89; 67%), ASA or SA was added after 10 min for a 10 min period in various concentrations (ASA: 10-5 up to 10-3 M; SA: 10-7 up to 10-3 M), and the pH stimulation was continued for at least another 15 min. In most cases, only one substance was applied at one concentration per fiber. A bell-shaped dose-response curve of reversible, weak effects on pH-induced discharge resulted from SA, with a maximum effect at 10-5 M (14% suppression, n=16, P<0.01); at 10-3 M an excitatory action of SA in acidic solution became apparent (17% increase in discharge, n=9, P= NS). The application of freshly dissolved ASA led to a linear dose-response curve, with a significant reduction in discharge rate (10-4 M: 12.4%, n=11, P<0.02; 10-3 M: 42%, n=10, P<0.03). The major reduction was irreversible within at least 26 min of wash-out. Before and after each experiment, the threshold to punctuate mechanical stimulation (von Frey) was determined and found not to be significantly altered with both ASA and SA. Plasma concentrations in the 10-4 M range are normally reached with therapeutic ASA doses and much higher concentrations have to be expected in acidic tissues. Our results may, thus, help to explain aspirin's antinociceptive action. The role of prostaglandin synthesis inhibition is discussed.","PeriodicalId":82360,"journal":{"name":"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons","volume":"2 1","pages":"77-94"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/092996397750131892","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64533556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The characteristics of slowly adapting mechanical sensory neurons in the trigeminal ganglia of crotaline snakes crotaline蛇三叉神经节缓慢适应机械感觉神经元的特征

Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons Pub Date : 1997-01-01 DOI: 10.1163/092996397750131928

Ai-Qing Zhu, S. Terashima

{"title":"The characteristics of slowly adapting mechanical sensory neurons in the trigeminal ganglia of crotaline snakes","authors":"Ai-Qing Zhu, S. Terashima","doi":"10.1163/092996397750131928","DOIUrl":"https://doi.org/10.1163/092996397750131928","url":null,"abstract":"Mechanical pressure (P) and touch (M) neurons, two types of slowly adapting neurons, can be distinguished in the trigeminal ganglion of crotaline snakes, Trimeresurus flavoviridis, by their electrophysiological membrane properties. Intracellular stimulation and the recording of the responses from P and M neurons in vivo was performed with microelectrodes. The characteristics of the receptive field (RF) of both types of neurons were examined. P neurons had a much larger RF size and a higher mechanical threshold than those of M neurons. Both of them responded with discharges to mechanical stimulation. The active and passive electrophysiological membrane properties were measured from nine P and 18 M neurons. The active membrane properties of P neurons showed a larger amplitude and longer duration of action potential, a larger after-hyperpolarization with a longer duration to half-decay, and a higher electric threshold in response to intracellularly injected depolarizing current than M neurons. The passive membrane properties of P neurons showed a higher input resistance, much longer time constant, and larger capacitance than M neurons. The rebound spike which responded to injecting sufficient hyperpolarizing current was sometimes observed, and had a longer latency in P neurons than M neurons. These results indicated that some electrophysiological membrane properties of primary sensory neurons are dependent on their sensory modalities.","PeriodicalId":82360,"journal":{"name":"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons","volume":"2 1","pages":"129-141"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/092996397750131928","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64533621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On extension of the structure of the temperature transduction model in peripheral thermoreceptors 外周热感受器温度转导模型结构的扩展

Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons Pub Date : 1997-01-01 DOI: 10.1163/092996397750131865

O. Dick, Y. A. Bedrov, G. Akoev

引用次数: 1

The resistance of cutaneous feline C-fiber mechano-heat-sensitive unit termination to tetrodotoxin and its possible relation to tetrodotoxin-resistant sodium channels 猫皮c -纤维机械热敏单元末端对河豚毒素的抗性及其与抗河豚毒素钠通道的可能关系

Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons Pub Date : 1900-01-01 DOI: 10.1163/092996397750131883

D. Borovikov, L. V. Borovikova, V. Ermishkin, S. Revenko

{"title":"The resistance of cutaneous feline C-fiber mechano-heat-sensitive unit termination to tetrodotoxin and its possible relation to tetrodotoxin-resistant sodium channels","authors":"D. Borovikov, L. V. Borovikova, V. Ermishkin, S. Revenko","doi":"10.1163/092996397750131883","DOIUrl":"https://doi.org/10.1163/092996397750131883","url":null,"abstract":"To study the features of ionic conductance system in termination of sensory units the responses of feline cutaneous A-β mechano-sensitive and C-fiber mechano-heat-sensitive (CMH) units to mechanical and heat stimuli were recorded in intact skin and under the action of subcutaneously applied tetrodotoxin (TTX). Both mechanical and thermal sensitivity of CMH units were not inhibited by 30 μM and in some units by 300 μM TTX, while the responses of A-β units to mechanical stimulation was eliminated by 3 μM TTX. Taking into account the data on low-frequency use-dependent inhibition of CMH unit termination by amine local anesthetics, the availability of TTX-resistant sodium channels in the somatic membrane of C-neurons liable to low-frequency use-dependent inhibition and the slow inactivation of these channels which corresponds to the requirements of mathematical simulation of spike initiation in C-fibers, our results are thought to indicate the presence of TTX-resistant sodium channels in the regenerative region of cutaneous afferent C-fibers.","PeriodicalId":82360,"journal":{"name":"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons","volume":"61 1","pages":"65-75"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/092996397750131883","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64533118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15