Annals of Dermatology最新文献

{"title":"Impact of Hand Hygiene and Mask-Wearing Practices on Hand Eczema and Facial Acne Incidence in Healthcare Workers during COVID-19 Outbreak.","authors":"Adinia Santosa,&nbsp;Ellie Choi,&nbsp;Nisha Suyien Chandran","doi":"10.5021/ad.20.189","DOIUrl":"https://doi.org/10.5021/ad.20.189","url":null,"abstract":"Dear Editor: In response to the COVID-19 outbreak, Singapore raised the Disease Outbreak Response System Condition (DORSCON) from Yellow to Orange on 7th February 2020. All healthcare professionals (HCP) in Singapore were mandated to wear masks and strict hand hygiene was reinforced. Frequent mask-wearing may contribute to an occlusive form of acne, while frequent handwashing contributes to occupational hand dermatitis. In this cross-sectional study, we distributed electronic surveys to HCP with direct patient contact in the National University Hospital, Singapore between 14 April 2020 and 21 May 2020. Univariable and multivariable logistic regression were performed to identify factors associated with worsening hand eczema or new hand eczema-related symptoms, and worsening acne or new acne-related symptoms. Statistical analysis was performed using SPSS version 21.0 (IBM Corp.). A p-value <0.05 was considered to be statistically significant. Approval from the National Health Group Domain Specific Review Board Singapore (Reference number 2020/00267) was obtained before commencement of study. Waiver of consent was obtained as data collected was anonymized and participation in the study was voluntary. No identifying information is included in this manuscript. A total of 515 HCP took part in the survey. Results reflected changing hand hygiene practices after DORSCON Orange. The number of participants washing hands less than 15 times a day at work decreased from 177 (34.4%) to 80 (15.5%), while the number washing hands more than 40 times at work increased from 106 (20.6%) to 191 (37.1%). Hand hygiene frequency outside work similarly increased, with 472 (91.7%) participants washing hands more than 6 times a day from just 314 (61.0%) previously. Wilcoxon signed-rank test showed a statistically significant increase in frequency of handwashing at work (Z=-15.1, p<0.001) and outside work (Z=-15.6, p<0.001). Of 88 participants with existing hand eczema, 49 (55.7%) reported worsening symptoms. New hand eczemarelated symptoms (dryness, itching, redness, scaling, vesicles, or skin cracks) were observed in 242 (46.9%) participants without previous eczema. Of 165 participants with existing acne, 111 (67.3%) expressed worsening, of whom 102 (91.9%) reported worsening in mask covered areas, while 212 participants without prior acne reported new acne-related symptoms (oiliness, comedones or pimples). Results for the univariable and multivariable logistic regression for factors associated with worsening hand eczema or new hand eczema-related symptoms and worsening acne or new acne-related symptoms are shown in Table 1, 2 respectively. Being female and more frequent handwashing at work were associated with worsening hand eczema or new hand eczema-related symptoms (multivariable analysis, female: odds-ratio [OR], 1.71, 95% confidence interval [CI], 1.02~2.88,","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 4","pages":"313-317"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/12/ad-35-313.PMC10407335.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infections and Exposure to Antibiotics May Affect the Development of Late-onset Rather than Early-onset Atopic Dermatitis.","authors":"Chong Won Choi,&nbsp;Bo Ram Yang,&nbsp;Dong In Suh,&nbsp;Mi-Sook Kim,&nbsp;Jungyoon Ohn,&nbsp;Jong Soo Hong,&nbsp;Joongyub Lee,&nbsp;Kyu Han Kim","doi":"10.5021/ad.21.240","DOIUrl":"https://doi.org/10.5021/ad.21.240","url":null,"abstract":"Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea; College of Pharmacy, Chungnam National University, Daejeon, Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea; Division of Clinical Epidemiology, Medical Research Collaborating Center, Biomedical Research Institution, Seoul National University Hospital, Seoul, Korea; Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea; Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 4","pages":"325-328"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/e9/ad-35-325.PMC10407339.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Positive Patch Test Allergens in Allergic Contact Dermatitis Patients with Atopic Dermatitis.","authors":"Yoon Jin Choi,&nbsp;Ji Yeon Byun,&nbsp;You Won Choi,&nbsp;Joo Young Roh,&nbsp;Hae Young Choi","doi":"10.5021/ad.23.001","DOIUrl":"https://doi.org/10.5021/ad.23.001","url":null,"abstract":"<p><strong>Background: </strong>There has been debate regarding whether patients with atopic dermatitis (AD) have an altered frequency of contact allergen sensitization. Increased exposure to topical medications and moisturizers as well as impaired skin barrier function increase the risk of contact sensitization, whereas the Th2-skewed inflammatory pathway of AD is associated with a reduced risk.</p><p><strong>Objective: </strong>This retrospective study was performed to determine the characteristics of contact sensitization in allergic contact dermatitis (ACD) patients with a current or past history of AD.</p><p><strong>Methods: </strong>A clinical record review was conducted for patients referred to Ewha Womans University Medical Center, for patch tests between March 2017 and March 2021. We compared the rates of contact sensitization between ACD patients with and without AD.</p><p><strong>Results: </strong>In total, 515 patch test results were reviewed and divided into the AD group (n=53) and non-AD group (n=462). The AD group showed decreased any-allergen positivity (1+, 2+, or 3+) (56.6%) compared to the non-AD group (72.9%) (<i>p</i>=0.013). The positivity rate for budesonide was significantly higher in the AD group (<i>p</i>=0.011), while the prevalence of a positive result for balsam of Peru was higher in the non-AD group (<i>p</i>=0.036). Nickel sulfate, cobalt chloride, and potassium dichromate were the most common sensitized allergens in both groups.</p><p><strong>Conclusion: </strong>Our study shows a decreased prevalence of contact sensitization in AD patients compared to non-AD patients. Clinicians should be aware of the risk of corticosteroid allergies in ACD patients with history of AD.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 4","pages":"303-312"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/ba/ad-35-303.PMC10407336.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Systemic Psoriasis Treatment: Is Psoriasis Still Being Undertreated?","authors":"Sungjun Choi,&nbsp;Sohee Oh,&nbsp;Hyun-Sun Yoon","doi":"10.5021/ad.21.151","DOIUrl":"https://doi.org/10.5021/ad.21.151","url":null,"abstract":"","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 4","pages":"321-324"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/ff/ad-35-321.PMC10407342.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Involvement of Coiled-coil α-helical Rod Protein 1 (CCHCR1) in Imiquimod-induced Psoriasis Models.","authors":"Yuri Ikeda,&nbsp;Hitoshi Tsutihashi,&nbsp;Akino Wada,&nbsp;Satoshi Koyama,&nbsp;Nagisa Yoshihara,&nbsp;Shigaku Ikeda","doi":"10.5021/ad.21.279","DOIUrl":"https://doi.org/10.5021/ad.21.279","url":null,"abstract":"dermatitis in early life: evidence for at least three phenotypes? Results from the GUSTO study. Int Arch Allerg y Immunol 2015;166:273-279. 2. Wan J, Mitra N, Hoffstad OJ, Margolis DJ. Influence of FLG mutations and TSLP polymorphisms on atopic dermatitis onset age. Ann Allergy Asthma Immunol 2017;118:737-738.e1. 3. Roduit C, Frei R, Depner M, Karvonen AM, Renz H, BraunFahrländer C, et al. Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood. JAMA Pediatr 2017;171:655-662. 4. Choi CW, Yang BR, Suh DI, Kim MS, Ohn J, Hong JS, et al. Infection, antibiotic exposure and development of atopic dermatitis: a nationwide case-control study. J Dermatol 2020;47:707-713. 5. Kim JA, Yoon S, Kim LY, Kim DS. Towards actualizing the value potential of Korea Health Insurance Review and Assessment (HIRA) data as a resource for health research: strengths, limitations, applications, and strategies for optimal use of HIRA data. J Korean Med Sci 2017;32:718-728. 6. Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab 2015;66 Suppl 1:8-16. 7. Cheung DS, Grayson MH. Role of viruses in the development of atopic disease in pediatric patients. Curr Allergy Asthma Rep 2012;12:613-620. 8. Singh AM, Evans MD, Gangnon R, Roberg KA, Tisler C, DaSilva D, et al. Expression patterns of atopic eczema and respiratory illnesses in a high-risk birth cohort. J Allergy Clin Immunol 2010;125:491493.e4.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 4","pages":"328-331"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/df/ad-35-328.PMC10407331.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of CPEB1 and CPEB4 Inhibits Scar Formation via Modulation of TAK1 and SMAD Signaling.","authors":"Hui Song Cui,&nbsp;You Ra Lee,&nbsp;Yu Mi Ro,&nbsp;So Young Joo,&nbsp;Yoon Soo Cho,&nbsp;June-Bum Kim,&nbsp;Dong Hyun Kim,&nbsp;Cheong Hoon Seo","doi":"10.5021/ad.22.210","DOIUrl":"https://doi.org/10.5021/ad.22.210","url":null,"abstract":"<p><strong>Background: </strong>Cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific RNA-binding proteins that control translation via cytoplasmic polyadenylation. We previously reported that CPEB1 or CPEB4 knockdown suppresses TAK1 and SMAD signaling in an in vitro study.</p><p><strong>Objective: </strong>This study aimed to investigate whether suppression of CPEB1 or CPEB4 expression inhibits scar formation in a mice model of acute dermal wound healing.</p><p><strong>Methods: </strong>CPEB1 and CPEB4 expression levels were suppressed by siRNA treatment. Skin wounds were created by pressure-induced ulcers in mice. Images of the wound healing were obtained using a digital camera and contraction was measured by ImageJ. mRNA and protein expression was analyzed using quantitative real time polymerase chain reaction and western blotting, respectively.</p><p><strong>Results: </strong>Wound contraction was significantly decreased by pre-treatment with CPEB1 or CPEB4 siRNA compared to the control. Suppression of CPEB1 or CPEB4 expression decreased TAK1 signaling by reducing the levels of TLR4 and TNF-α, phosphorylated TAK1, p38, ERK, JNK, and NF-κB-p65. Decreased levels of phosphorylated SMAD2 and SMAD3 indicated a reduction in SMAD signaling as well. Consequently, the expression of α-SMA, fibronectin, and type I collagen decreased.</p><p><strong>Conclusion: </strong>CPEB1 siRNA or CPEB4 siRNA inhibit scar formation by modulating the TAK1 and SMAD signaling pathways. Our study highlights CPEB1 and CPEB4 as potential therapeutic targets for the treatment of scar formation.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 4","pages":"293-302"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/2b/ad-35-293.PMC10407338.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evaluation of Conditioned Media of Human Umbilical Cord Blood Mesenchymal Stem Cells for Improvement of Symptoms of Sensitive Skin: Prospective, Single Blinded, Split-face Study.","authors":"Hee-Jin Ahn,&nbsp;Yoon-Jin Kim,&nbsp;Sujin Myeong,&nbsp;Gyoo Huh,&nbsp;Won-Serk Kim","doi":"10.5021/ad.21.287","DOIUrl":"https://doi.org/10.5021/ad.21.287","url":null,"abstract":"<p><strong>Background: </strong>The exact definition of sensitive skin is not established yet. Since its high prevalence and significant influence on quality of life, it has become an important topic of research. Among various ingredients, conditioned media from umbilical cord blood-derived mesenchymal stem cells (UCB-MSC-CM) can be a promising source for the treatment of sensitive skin.</p><p><strong>Objective: </strong>We evaluated the efficacy and safety of UCB-MSC-CM on patients with sensitive skin.</p><p><strong>Methods: </strong>We designed a randomized, single blinded, prospective, split-face comparison study and enrolled thirty patients. All patients underwent nonablative fractional laser over the entire face before UCB-MSC-CM or normal saline was applied. Each facial area was randomly assigned to undergo treatment with either UCB-MSC-CM or normal saline. We performed three sessions at two-week intervals, and final results were assessed on six weeks after the last session. As an outcome measure, we evaluated a five-point global assessment scale, transepidermal water loss (TEWL), erythema index (EI) and Sensitive Scale-10. Twenty seven subjects were included in final analysis.</p><p><strong>Results: </strong>The treated side exhibited greater improvement compared to the untreated side based on a five-point global assessment scale. TEWL, EI of the treated side were significantly lower than those of the untreated side throughout study period. Sensitive Scale-10 was significantly improved after treatment.</p><p><strong>Conclusion: </strong>The application of UCB-MSC-CM resulted in improved skin barrier function and reduced inflammatory responsiveness, which could provide beneficial effect on sensitive skin.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"165-172"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/83/ad-35-165.PMC10258546.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin Enhances the Anticancer Effects of Binimetinib on Melanoma Cells by Inducing Mitochondrial Dysfunction and Cell Apoptosis with Necroptosis.","authors":"Yoon Jin Lee,&nbsp;Jae Young Heo,&nbsp;Dong Sung Kim,&nbsp;Yu Sung Choi,&nbsp;Sooyoung Kim,&nbsp;Hae Seon Nam,&nbsp;Sang Han Lee,&nbsp;Moon Kyun Cho","doi":"10.5021/ad.22.200","DOIUrl":"https://doi.org/10.5021/ad.22.200","url":null,"abstract":"<p><strong>Background: </strong>Recent studies suggest that MEK1/2 inhibitors, including binimetinib, significantly improve malignant melanoma (MM) patient survival. Growing evidence suggests that phytochemicals, especially curcumin, can overcome drug resistance in cancer cells through a variety of mechanisms.</p><p><strong>Objective: </strong>This study aims to examine curcumin's efficacy <i>in vitro</i> combined with binimetinib in human MM cells.</p><p><strong>Methods: </strong>We used 2D monolayer and 3D spheroid human epidermal melanocyte culture models, HEMn-MP (human epidermal melanocytes, neonatal, moderately pigmented), and two human MM cell lines, G361 and SK-MEL-2, to evaluate cell viability, proliferation, migration, death, and reactive oxygen species (ROS) production following single therapy treatment, with either curcumin or binimetinib, or a combination of both.</p><p><strong>Results: </strong>Compared to MM cells treated with single therapy, those with combination therapy showed significantly decreased cell viability and increased ROS production. We observed apoptosis following both single and combination therapies. However only those who had had combination therapy had necroptosis.</p><p><strong>Conclusion: </strong>Collectively, our data demonstrates that curcumin exerts significant synergistic anticancer effects on MM cells by inducing ROS and necroptosis when combined with binimetinib. Therefore, a strategy of adding curcumin to conventional anticancer agents holds promise for treating MM.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"217-228"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/3c/ad-35-217.PMC10258547.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9617553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the Management of Patients with Alopecia Areata in Korea: Part II Systemic Treatment.","authors":"Hyunsun Park, Jung Eun Kim, Jee Woong Choi, Do Young Kim, Yong Hyun Jang, Young Lee, Jiehyun Jeon, Hyun-Tae Shin, Min Sung Kim, Jung Won Shin, Sung Bin Cho, Bark-Lynn Lew, Gwang Seong Choi","doi":"10.5021/ad.22.167","DOIUrl":"10.5021/ad.22.167","url":null,"abstract":"<p><strong>Background: </strong>Alopecia areata (AA) is a chronic disease with an unpredictable course and can have a severe psychological impact on an individual.</p><p><strong>Objective: </strong>To provide evidence and consensus-based statements regarding the treatment of patients with AA in Korea.</p><p><strong>Methods: </strong>We searched for relevant studies from inception to May 2021 regarding the systemic treatment of AA. Evidence-based recommendations were also prepared. The evidence for each statement was graded and classified according to the strength of the recommendations. Hair experts from the Korean Hair Research Society (KHRS) voted on the statement, and an agreement of 75% or greater was considered as having reached consensus.</p><p><strong>Results: </strong>Current evidence supports the efficacy of systemic corticosteroids, oral cyclosporine monotherapy or combination with systemic corticosteroids, and oral Janus kinase inhibitors in severe AA patients. Systemic steroids may be considered for pediatric patients with severe AA. A consensus was achieved in three out of nine (33.3%), and one out of three (33.3%) statements pertaining to systemic treatment in adult and pediatric AA, respectively.</p><p><strong>Conclusion: </strong>The present study produced up-to-date, evidence-based treatment guidelines for AA associated with the consensus obtained by experts based on the Korean healthcare system.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"205-216"},"PeriodicalIF":1.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/b7/ad-35-205.PMC10258553.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the Management of Patients with Alopecia Areata in Korea: Part I Topical and Device-based Treatment.","authors":"Hyunsun Park,&nbsp;Jung Eun Kim,&nbsp;Jee Woong Choi,&nbsp;Do Young Kim,&nbsp;Yong Hyun Jang,&nbsp;Young Lee,&nbsp;Jiehyun Jeon,&nbsp;Hyun-Tae Shin,&nbsp;Min Sung Kim,&nbsp;Jung Won Shin,&nbsp;Sung Bin Cho,&nbsp;Bark-Lynn Lew,&nbsp;Gwang Seong Choi","doi":"10.5021/ad.22.168","DOIUrl":"https://doi.org/10.5021/ad.22.168","url":null,"abstract":"<p><strong>Background: </strong>Alopecia areata (AA) is a chronic disease with an unpredictable disease course and severe psychological impact.</p><p><strong>Objective: </strong>To provide evidence- and consensus-based insights regarding the treatment of patients with AA in Korea.</p><p><strong>Methods: </strong>We searched for relevant studies on the topical and device-based treatment of AA in the literature from inception until May 2021. Evidence-based recommendations were also prepared. The evidence for each statement was graded and classified according to the strength of the recommendations. Hair experts from the Korean Hair Research Society (KHRS) voted on the statements, and an agreement of 75% or greater was considered as consensus.</p><p><strong>Results: </strong>Currently, there remains a scarcity of topical treatments, which is supported by robust evidence from a number of high-quality randomized controlled trials. Current evidence supports the efficacy of topical corticosteroids, corticosteroid intralesional injection, and contact immunotherapy in AA patients. Topical corticosteroids and contact immunotherapy are recommended for pediatric AA. A consensus was achieved in 6 out of 14 (42.8%), and 1 out of 5 (20.0%) statements pertaining to topical and device-based treatments in AA, respectively. The expert consensus was from a single country, and the study may not cover all the treatments used.</p><p><strong>Conclusion: </strong>The present study provides up-to-date, evidence-based treatment guidelines for AA based on the consensus reached among experts after considering regional healthcare circumstances, adding diversity to the previous guidelines.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"190-204"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/23/ad-35-190.PMC10258548.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9617550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}