Annals of Dermatology最新文献

{"title":"Anti-melanogenesis Effect of a Dual-delivery Long-pulsed 1,064-nm Neodymium-doped Yttrium Aluminum Garnet and 755-nm Alexandrite Laser on Human Skin Explants.","authors":"Young Jae Kim, Hee Joo Yang, Woo Jin Lee, Seung Hyun Bang, Sung Eun Chang","doi":"10.5021/ad.20.261","DOIUrl":"https://doi.org/10.5021/ad.20.261","url":null,"abstract":"Dear Editor: Long-pulsed (LP) lasers can be applied for pigmentary disorders, with high efficacy and a low risk of side effects, along with a short procedure time. Recently, a dual-wavelength LP laser system was introduced. This system seems to be theoretically more effective because it allows targeting of chromophores elaborately. However, there are still no clinical results for human skin. Actual human research on laser application Brief Report Annals of Dermatology 2023;35(3) • https://doi.org/10.5021/ad.20.261","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"236-239"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/7e/ad-35-236.PMC10258549.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9617552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural History of Nevus Depigmentosus: A Long-term Follow-up Study of 102 Cases.","authors":"Jae Min Sung, Jin Cheol Kim, Jung Min Bae, Ji Young Yang, Hee Young Kang, Eun-So Lee, You Chan Kim","doi":"10.5021/ad.20.209","DOIUrl":"https://doi.org/10.5021/ad.20.209","url":null,"abstract":"Dear Editor: Nevus depigmentosus (ND) is a common depigmented nevus which manifests as well-circumscribed hypopigmented patch. Though the pathogenesis of ND is not fully understood, the number of melanocytes and amount of melanin are decreased in ND lesion compared to uninvolved normal skin. It is generally known to be stable in its relative size and distribution, though there is no long-term follow-up study yet. In the present study, therefore, we sought to reveal the natural history of ND with long-term follow-up.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"233-235"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/8b/ad-35-233.PMC10258554.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-myc Downstream Regulated Gene 1 Promotes Adipocyte Differentiation in Endothelial Cells of Infantile Hemangioma.","authors":"Seon Bok Lee, Hye Young An, Ho Yun Chung, Seok Jong Lee, Ji Won Byun","doi":"10.5021/ad.20.262","DOIUrl":"https://doi.org/10.5021/ad.20.262","url":null,"abstract":"IH","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"229-232"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/5e/ad-35-229.PMC10258551.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9617551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topographical Difference in the Prognosis of Alopecia Areata.","authors":"Young Bin Lee, Won-Soo Lee","doi":"10.5021/ad.20.329","DOIUrl":"https://doi.org/10.5021/ad.20.329","url":null,"abstract":"Dear Editor: Although macroscopic clinical parameters such as disease duration, extra-scalp hair loss, and extent of hair loss can be used as prognostic markers for alopecia areata (AA), these factors have limitations in directly explaining the localized shortterm course of individual alopecia patches. The inf luence of regional factors on the course of AA is unclear due to the randomness of occurrence and chronic relapsing course. This study aimed to evaluate the clinical characteristics and prognosis of AA according to the area affected. This retrospective analysis included patients with AA who visited Wonju Severance Christian Hospital from March 2013 to February 2020. Among patients, individuals with alopecia patches were analyzed using Olsen/Canfield SALT (Severity of Alopecia Tool) score. Olsen/Canfield SALT was divided into top, posterior, and lateral areas, so we arbitrarily divided it into four areas (frontal, temporoparietal, vertex, and occipital) to determine the correlation with the anatomical location region in more detail. Involving only one of the four areas within the scalp were included in the analysis. The patients were divided into four groups according to the affected area. Demographic data including age, sex, disease duration, initial extent of hair loss, and presence of extra-scalp hair loss were compared between groups. The prognosis and recurrence between groups were analyzed using the Kaplan-Meier method. This study was approved by the institutional review board of Wonju Severance Christian Hospital (CR317095). A waiver of informed consent was granted owing to the deidentified data used. No clinical variables, except age and sex, were significantly different between groups (Table 1). On cumulative incidence analysis, there was significant difference between groups with regard to complete hair regrowth (>90% hair regrowth compared to initial extent) unlike major hair regrowth (>60% hair regrowth compared to initial extent) (Fig. 1). In particular, the difference in prognosis between groups was found to be more noticeable with long-term treatment. Although the recurrence rate was the highest in the temporoparietal group, there was no difference between groups in the survival analysis of hair loss after achieving hair regrowth (Supplementary Fig. 1). Differences in the anatomical structure, vascularity, and innervation are involved in topographical differences of AA. Recently, based on the relationship between mechanical stress and autoimmunity in the skin or other organs, it has been speculated that site-specific activation of mechanical stress may induce regional differences in autoimmunity. Differences in mechanical properties according to the scalp regions have been experimentally proven, extending beyond numerical differences in terminal hair or hair follicle units. These differences would provide another clue in explaining topographic differences in AA. However, it is unclear whether these stresses or differences in i","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"240-242"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/26/ad-35-240.PMC10258555.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Sleep Disturbance in Alopecia Areata through Questionnaire: Pittsburgh Sleep Quality Index as a Reasonable Tool.","authors":"So Hee Park,&nbsp;Ki Hwan Ji,&nbsp;Jong Uk Kim,&nbsp;Seung Hee Jang,&nbsp;Sang Woo Ahn,&nbsp;Seong Min Hong,&nbsp;Woo Jung Jin,&nbsp;Jung Eun Seol,&nbsp;Hyojin Kim","doi":"10.5021/ad.22.136","DOIUrl":"https://doi.org/10.5021/ad.22.136","url":null,"abstract":"<p><strong>Background: </strong>Alopecia areata (AA) is common non-scarring hair loss disease. Sleep distrubance has been regarded as a triggering or aggravating factor for AA. However, objective evaluation of sleep disturbance and its clinical effect on AA has not been clearly demonstrated.</p><p><strong>Objective: </strong>This study investigated objective sleep evaluation tool for AA patients and their clinical correlation.</p><p><strong>Methods: </strong>Patients presenting with new-onset AA or recurrences of pre-existing AA were included, and those who reported sleep disturbance in the preliminary survey were designated as the sleep disturbance group (SD group). Sleep quality was investigated for them using three self-administered questionnaires: Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Epworth Sleep Scale (ESS). Demographic information and clinical features of AA were analyzed according to sleep quality.</p><p><strong>Results: </strong>A total of 400 participants were enrolled, and 53 were categorized into the SD group. The incidence of stressful events was significantly higher in the SD group (54.7%) than in the non-SD group (25.1%) (<i>p</i><0.001). Based on the PSQI, 77.3% of participants were objective poor sleepers (score of 5 or more), and they showed a significantly higher incidence of stressful events compared to good sleepers (<i>p</i>=0.019). The proportion of poor sleepers was significantly lower in patients with mild AA (S1) than in those with moderate to severe AA (S2~S5) (<i>p</i>=0.045).</p><p><strong>Conclusion: </strong>This study demonstrated a positive correlation among stress, SD, and AA. The degree of SD was objectively represented by the PSQI score, showing different scores according to AA severity.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"183-189"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/74/ad-35-183.PMC10258550.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basic Therapeutic Approach for Patients with Plaque Psoriasis: Korean Expert Consensus Using the Modified Delphi Method.","authors":"Seong Jin Jo,&nbsp;Yoo Sang Baek,&nbsp;Tae-Gyun Kim,&nbsp;Ki-Heon Jeong,&nbsp;Jeong Eun Kim,&nbsp;Yu Sung Choi,&nbsp;Byungsoo Kim,&nbsp;Eun-So Lee,&nbsp;Yong Beom Choe","doi":"10.5021/ad.22.216","DOIUrl":"https://doi.org/10.5021/ad.22.216","url":null,"abstract":"<p><strong>Background: </strong>Currently, there is no consensus on the treatment of psoriasis in Korean patients.</p><p><strong>Objective: </strong>This study aimed to establish a consensus on the basic therapeutic principles for Korean patients with plaque psoriasis.</p><p><strong>Methods: </strong>Using the modified Delphi method, a steering committee proposed 53 statements for the first Delphi round, which covered five subjects: (1) the goal of treatment and evaluation of disease severity, (2) topical therapy, (3) phototherapy, (4) conventional systemic therapy, and (5) biologic therapy. The panel of dermatologists scored the level of agreement for each statement on a ten-point scale with scores ranging from 1 (strongly disagree) to 10 (strongly agree). After discussing the results of the first round, the committee reformulated 41 statements. Finally, consensus was defined as more than 70% of the second round scores being ≥7.</p><p><strong>Results: </strong>The panel participants strongly agreed that the ideal treatment goals for Korean patients with plaque psoriasis should include complete skin clearance and high dermatological quality of life. A strong consensus was also reached on the use of topical agents for psoriasis of any severity, the consideration of phototherapy before biologics therapy, the conventional systemic agents for moderate-to-severe psoriasis, and the recommendation of biologic for retractable psoriasis to conventional systemic therapy and phototherapy.</p><p><strong>Conclusion: </strong>This modified Delphi panel established an expert consensus on the therapeutic approach for Korean patients with plaque psoriasis. This consensus may improve the treatment outcomes for psoriasis in Korea.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 3","pages":"173-182"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/19/ad-35-173.PMC10258552.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greetings from the New Editor-in-Chief.","authors":"Soyun Cho","doi":"10.5021/ad.35e.201","DOIUrl":"https://doi.org/10.5021/ad.35e.201","url":null,"abstract":"","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 2","pages":"89-90"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/3e/ad-35-89.PMC10112375.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Areolar Polythelia: A Case Report of a Rare Anomaly.","authors":"Eun Ji Chun,&nbsp;Joon Ki Kim,&nbsp;Si Young Yang,&nbsp;Kang Su Kim,&nbsp;Sang Seok Kim,&nbsp;Chul Woo Kim","doi":"10.5021/ad.20.251","DOIUrl":"https://doi.org/10.5021/ad.20.251","url":null,"abstract":"","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 2","pages":"160-161"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/af/ad-35-160.PMC10112365.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9330462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Concurrent Pyostomatitis Vegetans-Like/Intercellular Immunoglobulin A Dermatosis and Uveitic Macular Edema Reacting Exclusively with Desmocollins: A Possible Common Pathogenesis.","authors":"Xavier Bosch-Amate,&nbsp;Pilar Iranzo-Fernández,&nbsp;José Manuel Mascaró,&nbsp;Norito Ishii,&nbsp;Takashi Hashimoto","doi":"10.5021/ad.20.299","DOIUrl":"https://doi.org/10.5021/ad.20.299","url":null,"abstract":"","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 2","pages":"155-157"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/15/ad-35-155.PMC10112367.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9330465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Vancomycin-Induced Drug Reaction with Eosinophilia, Systemic Symptoms and Multiorgan Involvement Proven Using Lymphocyte Transformation Test.","authors":"Kyung Bae Chung,&nbsp;Ji-Hye Hwang,&nbsp;Doyoung Kim","doi":"10.5021/ad.20.341","DOIUrl":"https://doi.org/10.5021/ad.20.341","url":null,"abstract":"<p><p>Drug-induced hypersensitivity syndrome (DiHS), also referred to as drug reaction with eosinophilia and systemic symptoms (DRESS), is a rare but potentially life-threatening condition induced by drug hypersensitivity that leads to significant morbidity and mortality and often occurs in patients undergoing combination antibiotic therapy. Due to a recent increase in the incidence of methicillin-resistant <i>Staphylococcus aureus</i> infections, the occurrence of vancomycin-induced DiHS/DRESS has increased rapidly. However, because of insufficient pharmacogenetic data on vancomycin-induced drug eruptions in Asians coupled with the risk of re-eliciting the symptoms by provocation tests, confirmation of the culprit drug in vancomycin-induced DiHS/DRESS is often challenging. Here, we report a case of vancomycin-induced DiHS/DRESS, where the causal relationship was confirmed using a lymphocyte transformation test (LTT). A 51-year-old woman was treated with combination antibiotics, including vancomycin, for infective pericarditis. The patient subsequently developed fever, facial edema, generalized rash followed by multiple internal organ involvement, including the kidney, lung, liver, and heart. Thus, based on the International Registry of Severe Cutaneous Adverse Reaction (RegiSCAR) criteria, the case was diagnosed as 'definite' DiHS/DRESS, although the culprit drug was obscured by combination antibiotic therapy. The LTT confirmed that vancomycin, but not other glycopeptide antibiotics, specifically induced T-cell proliferation in this case. Collectively, our case suggests that clinicians can utilize LTT to identify the causative medication of DiHS/DRESS when the clinical information is limited to defining the culprit drug.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"35 2","pages":"140-145"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/2a/ad-35-140.PMC10112376.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9330459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}