Annals of clinical and laboratory science最新文献

In Memoriam: Clive R. Hamlin, PhD, FACSc (1941 - 2026). 纪念：克莱夫·r·哈姆林，博士，FACSc（1941 - 2026）。

IF 1 4区医学

Annals of clinical and laboratory science Pub Date : 2026-04-02

Charles D Hawker

引用次数: 0

Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Variation Among Normoglycemia, Prediabetes, and Diabetes. 血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分在正常血糖、糖尿病前期和糖尿病患者中的差异。

IF 1 4区医学

Annals of clinical and laboratory science Pub Date : 2026-04-02

Ayed A Dera, Gaffar Sarwar Zaman

{"title":"Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Variation Among Normoglycemia, Prediabetes, and Diabetes.","authors":"Ayed A Dera, Gaffar Sarwar Zaman","doi":"","DOIUrl":"","url":null,"abstract":"Objective: The association between the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and mortality among individuals with diabetes or prediabetes has not been clearly established. The aim of the present study was to compare the HALP score of individuals with disglycemic status in a tertiary care hospital.Methods: A retrospective analysis was conducted on 3,545 participants (2022-2024) from the Future Lab Pioneer database. Participants were classified as type 2 diabetes mellitus (T2DM), impaired fasting glucose (IFG), or normoglycemic. HALP was calculated and compared by Mann-Whitney U or Kruskal-Wallis tests. Linear regression assessed group differences and correlations with glycemic and metabolic indicators, while principal component analysis (PCA) explored key laboratory contributors to glycemic variation.Results: HALP scores varied by age and sex, with males showing higher values (p<0.0001). Higher HALP correlated inversely with HbA1c (p<0.0001) but not fasting blood glucose. Participants in the highest HALP quartile had higher hemoglobin, albumin, and lymphocyte counts and lower platelet and WBC counts. PCA highlighted inflammation-related markers, particularly WBC and neutrophils, as major contributors to glycemic variability, emphasizing systemic inflammation's role in dysglycemia.Conclusion: HALP reflects immunonutritional status and systemic inflammatory burden and shows associations with long-term glycemic status. Owing to its simplicity, low cost, and derivation from routine laboratory parameters, HALP may serve as a complementary index for characterizing metabolic and inflammatory profiles across glycemic categories, particularly in younger males. However, prospective longitudinal studies are required to determine whether HALP has independent predictive value for dysglycemia in clinical practice.","PeriodicalId":8228,"journal":{"name":"Annals of clinical and laboratory science","volume":"56 1","pages":"10-22"},"PeriodicalIF":1.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review: Differentiating Various Renal Cell Tumors with Clear Cytoplasmic Features, Old and New, Based on Their Different Renal Tubular Origins. 综述：基于不同肾小管起源鉴别具有明确细胞质特征的各种肾细胞瘤的新旧。

IF 1 4区医学

Annals of clinical and laboratory science Pub Date : 2026-02-03

Kevin J Zhang, Jason M Hafron, Catherine Xie, Shivam M Patel, Brandon M Metcalf, Ping L Zhang

{"title":"Review: Differentiating Various Renal Cell Tumors with Clear Cytoplasmic Features, Old and New, Based on Their Different Renal Tubular Origins.","authors":"Kevin J Zhang, Jason M Hafron, Catherine Xie, Shivam M Patel, Brandon M Metcalf, Ping L Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Clear cell renal cell carcinoma (ccRCC) is the prototypical renal tumor with clear cell features in which the clear cell cytoplasm results from the melted lipid of the cytoplasm after fixation. ccRCC can be associated with a high risk of tumor metastasis.Methods: In recent years, several new renal mass entities such as RCC with fibromyomatous stroma (FMS), clear cell papillary renal cell tumor (CCP-RCT), multilocular cystic renal cell neoplasm of low malignancy potential (MCRCNLMP), and eosinophilic vacuolated tumor (EVT) have been recognized with some clear-appearing cytoplasm.Results: Previously identified renal tumor entities like chromophobe renal cell carcinoma (Ch-RCC) and translocation renal cell carcinoma (tRCC) often have clear cytoplasmic features as well. While often challenging due to their morphologic similarities, differentiating these renal tumor entities from ccRCC is important given their varying biological behaviors.Conclusion: This review will provide a comprehensive roadmap to pathologically differentiate the variants of renal masses with clear cytoplasmic features. In addition, their clinical outcomes and management will be briefly discussed.","PeriodicalId":8228,"journal":{"name":"Annals of clinical and laboratory science","volume":"55 6","pages":"845-858"},"PeriodicalIF":1.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Monoclonal Antibody against hIL18 Receptor Accessory Protein Chain Promotes Anti-Tumor Activity in Triple-Negative Breast Cancer. 人抗hIL18受体辅助蛋白链单克隆抗体促进三阴性乳腺癌的抗肿瘤活性

IF 1 4区医学

Annals of clinical and laboratory science Pub Date : 2026-02-03

Fang Hu, Yonggang Wang, Guowei Qian, Wenxi Yu, Lina Tang, Feng Lin

{"title":"Human Monoclonal Antibody against hIL18 Receptor Accessory Protein Chain Promotes Anti-Tumor Activity in Triple-Negative Breast Cancer.","authors":"Fang Hu, Yonggang Wang, Guowei Qian, Wenxi Yu, Lina Tang, Feng Lin","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks effective targeted therapies. The interleukin-18 (IL-18) signaling pathway contributes to cancer progression and poor survival outcomes in several tumor types, including TNBC. IL-18 receptor accessory protein chain (IL-18RAcP), binding to the IL18/IL18Rα complex, plays a critical role in initiating and transducing IL-18 signaling. Targeting IL-18RAcP with human antibodies may offer a promising therapeutic strategy for TNBC.Methods: Human single-chain variable fragment (scFv) antibodies targeting IL-18RAcP were screened via phage display and characterized using ELISA, SPR, and crystallography. The functional assays that were used included qRT-PCR, MTT, Western blotting, flow cytometry, and xenograft models. Binding interactions were further validated through yeast two-hybrid assays and structural analysis.Results: We found that elevated IL-18RAcP expression in TNBC is associated with poor recurrence-free survival (RFS), suggesting its potential as both a clinical marker and a therapeutic target. Using combinatorial scFv antibody phage display libraries, we identified a human monoclonal antibody, scFvAPC10, which binds IL-18RAcP with high affinity. scFvAPC10 significantly inhibits TNBC cell proliferation in vitro and reduces tumor growth in vivo by inducing apoptosis. Mechanistic studies reveal that scFvAPC10 impairs both NF-κB and MAPK signaling pathways. Structural analysis shows that scFvAPC10 interacts with the D1-D2 domains of IL-18RAcP through three hydrogen bonds, confirming the specificity of the interaction.Conclusions: Our findings highlight the therapeutic potential of targeting IL-18RAcP in TNBC through modulation of IL-18/IL-18R-mediated signaling pathways. The development of scFvAPC10 offers a promising approach for novel antibody-based therapies in the treatment of TNBC.","PeriodicalId":8228,"journal":{"name":"Annals of clinical and laboratory science","volume":"55 6","pages":"906-919"},"PeriodicalIF":1.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coinfection of Human Cytomegalovirus and Pneumocystis jirovecii Caused Severe Pneumonia in a Non-HIV Elderly Patient: A Case Report. 非hiv老年人巨细胞病毒与肺囊虫合并感染致重症肺炎1例。

IF 1 4区医学