Shaaban Sherif G, Khan Mohammed K, Savage Natasha, Yan Weisi, Pishgou Mahboubeh, Davis Loretta, Mourad Waleed F
{"title":"Total Skin Electron Irradiation (TSEI) May Induce Systemic Progression of Mycosis Fungoides (MF) - Cutaneous T-Cell Lymphoma (CTCL)","authors":"Shaaban Sherif G, Khan Mohammed K, Savage Natasha, Yan Weisi, Pishgou Mahboubeh, Davis Loretta, Mourad Waleed F","doi":"10.36959/661/301","DOIUrl":"https://doi.org/10.36959/661/301","url":null,"abstract":"The management of MF-CTCL is based on a 'stage-based' approach and an evaluation by a multidisciplinary team is preferred. Initial treatment in patients with local (patch/plaque) disease includes skin-directed therapies (localized or generalized), with the addition of systemic biologic therapy for refractory, or progressive disease. In patients with unfavorable prognostic features (e.g., folliculotropic or large-cell transformed MF, or B1 involvement) systemic biologic therapies may be introduced earlier in the treatment algorithm.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76304311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Menon, R. Bernert, K. Jared, Burrell Wolk, Neil F. Fernandes
{"title":"Cutaneous Metastatic Renal Cell Carcinoma to the Skin Presenting as a Zosteriform Eruption","authors":"H. Menon, R. Bernert, K. Jared, Burrell Wolk, Neil F. Fernandes","doi":"10.36959/661/300","DOIUrl":"https://doi.org/10.36959/661/300","url":null,"abstract":"Cutaneous metastasis of internal malignancy is an uncommon but not rare phenomenon. Renal cell carcinoma is a visceral malignancy that rarely metastasizes to the skin and typically presents as a solitary red, purple nodule when it does. We describe a case of metastatic renal cell carcinoma to the skin presenting as a zosteriform eruption.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74311229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parigini Aníbal María, Diego María Clara de, Beguerie Julieta Ruiz, Paredes Victoria Duran, A. Javier
{"title":"Excellent Response to Hydroxychloroquine in a Young Man with Lupus Erythematosus Panniculitis","authors":"Parigini Aníbal María, Diego María Clara de, Beguerie Julieta Ruiz, Paredes Victoria Duran, A. Javier","doi":"10.36959/661/298","DOIUrl":"https://doi.org/10.36959/661/298","url":null,"abstract":"Lupus erythematosus panniculitis is a rare variant of lupus erythematosus. We present the case of a young man with ulcerative colitis treated with mesalazine and a history of recurrent painful and indurated lesions on his face. A diagnosis of lupus profundus was made taking in account the clinical manifestations and the histological and immunofluorescence findings.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74831077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quality of Life in Women with Alopecia","authors":"Dawes Danyelle","doi":"10.36959/661/299","DOIUrl":"https://doi.org/10.36959/661/299","url":null,"abstract":"Hair loss is a psychologically devastating disorder, causing grave distress to patients of all ages, genders, and nationalities. Due to the visible nature of hair loss, individuals become increasingly self-conscious, and over time may develop anxiety or depression [1]. Furthermore, the psychological stress related to alopecia can impair functioning in social and professional arenas, affecting relationships and creating work related problems [1]. Despite the available treatments for alopecia, their efficacy is not well established and following disease course and treatment success relies on patient perception [2]. Quality of life (QoL) studies are a valuable tool in assessing patient well-being, coping mechanisms, and disease burden on patients’ activities of daily living, as well as effects of therapy [2,3].","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77199951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Long-term Use of Oral Isotretinoin for the Management of Morbihan Disease: A Case Series Report and Review of the Literature.","authors":"Lauren A Smith, David E Cohen","doi":"10.1001/archdermatol.2012.3109","DOIUrl":"https://doi.org/10.1001/archdermatol.2012.3109","url":null,"abstract":"<p><p>BACKGROUND Morbihan disease (MD) is characterized by persistent erythema and solid edema of the upper two-thirds of the face. It is generally regarded as a late-stage complication of rosacea, although its etiology is poorly understood. The standard therapeutic management includes systemic anti-inflammatory medications; however, the clinical response, if any, is often unsatisfactory. We review the current challenges and a promising new option for the treatment of MD. OBSERVATIONS Five cases of MD were treated with long-term (>6 months; mean, 16 months) oral isotretinoin, with documented nonrecurrence. The mean sustained daily dose was 60 mg/d (range, 40-80 mg/d), and the mean cumulative dose was approximately 285 mg/kg (range, 170-491 mg/kg). The total treatment period ranged from 10 to 24 months, with a mean disease-free follow-up period of 9 months (range, 1-24 months). A substantial clinical improvement was not noted until 6 months of treatment in all 5 cases. CONCLUSIONS We report 5 cases of MD that were successfully treated with long-term oral isotretinoin, with lasting results. Further research is required to better understand the pathogenesis of MD and isotretinoin's mechanism of action in this condition.</p>","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"148 12","pages":"1395-8"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archdermatol.2012.3109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31233714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Top-Accessed Article: Successful Treatment of Vitiligo With 0.1% Tacrolimus Ointment","authors":"R. Halder, Ife J. Rodney","doi":"10.1001/ARCHDERMATOL.2012.2385","DOIUrl":"https://doi.org/10.1001/ARCHDERMATOL.2012.2385","url":null,"abstract":"1. Lipsker D, Rondeau M, Massard G, Grosshans E. The AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) syndrome: report of 4 cases of a new syndrome revealing POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) syndrome at a curable stage. Medicine (Baltimore). 2003;82(1):51-59. 2. Gupta RM, Roy DC, Gupta IM, Khanna S. Extramedullary plasmacytoma IgG type I presenting as mediastinal syndrome. Br J Dis Chest. 1974;68(1):65-70. 3. Read D, Warlow C. Peripheral neuropathy and solitary plasmacytoma. J Neurol Neurosurg Psychiatry. 1978;41(2):177-184. 4. Feddersen RM, Burgdorf W, Foucar K, Elias L, Smith SM. Plasma cell dyscrasia: a case of POEMS syndrome with a unique dermatologic presentation. J Am Acad Dermatol. 1989;21(5, pt 2):1061-1068. 5. Weichenthal M, Stemm AV, Ramsauer J, Mensing H, Feller AC, Meigel W. POEMS syndrome: cicatricial alopecia as an unusual cutaneous manifestation associated with an underlying plasmacytoma. J Am Acad Dermatol. 1999; 40(5, pt 2):808-812.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"33 5","pages":"1432-1432"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/ARCHDERMATOL.2012.2385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50616935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maya Barsky, H William Higgins, Kachiu C Lee, Leslie Robinson-Bostom, Jennie J Muglia
{"title":"Acrally distributed purpuric and necrotic lesions with pustular features.","authors":"Maya Barsky, H William Higgins, Kachiu C Lee, Leslie Robinson-Bostom, Jennie J Muglia","doi":"10.1001/archderm.148.12.1411-b","DOIUrl":"https://doi.org/10.1001/archderm.148.12.1411-b","url":null,"abstract":"A 27-year-old woman with a painful, reddish-blue (livedoid) skin area showing small ulcerations on the lower abdomen (Figure 1) was examined. The lesion appeared a few centimeters above the inconspicuous, vertically oriented scar 4 weeks after a cesarean section. A regimen of systemic antibiotics had not been successful. Her medical records revealed a problem with excess weight (body mass index 40 [calculated as weight in kilograms divided by height in meters squared]) and a smoking habit. Laboratory test findings were unrevealing, except for increased antinuclear antibody level (1:160) and a slightly elevated parathyroid hormone level (calcium, phosphate, and vitamin D were within normal levels), which both returned to normal within 6 months. Prothrombotic factors (cryoglobulins and anticardiolipin antibodies) were negative. A biopsy was obtained from a central, nonulcerated region and analyzed with hematoxylin-eosin and CD31 staining (Figure 2 and Figure 3). What is your diagnosis?","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"148 12","pages":"1411-6"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archderm.148.12.1411-b","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31129434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Grouped erythematous papules and nodules on the thigh.","authors":"Julia M Kwan, Elizabeth K Satter","doi":"10.1001/archderm.148.12.1411-c","DOIUrl":"https://doi.org/10.1001/archderm.148.12.1411-c","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"148 12","pages":"1411-6"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archderm.148.12.1411-c","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31129435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cliff Rosendahl, Alan Cameron, Giuseppe Argenziano, Iris Zalaudek, Philipp Tschandl, Harald Kittler
{"title":"Dermoscopy of squamous cell carcinoma and keratoacanthoma.","authors":"Cliff Rosendahl, Alan Cameron, Giuseppe Argenziano, Iris Zalaudek, Philipp Tschandl, Harald Kittler","doi":"10.1001/archdermatol.2012.2974","DOIUrl":"https://doi.org/10.1001/archdermatol.2012.2974","url":null,"abstract":"<p><p>OBJECTIVES To characterize dermoscopic criteria of squamous cell carcinoma (SCC) and keratoacanthoma and to compare them with other lesions. DESIGN Observer-masked study of consecutive lesions performed from March 1 through December 31, 2011. SETTING Primary care skin cancer practice in Brisbane, Australia. PARTICIPANTS A total of 186 patients with 206 lesions. MAIN OUTCOME MEASURES Sensitivity, specificity, predictive values, and odds ratios. RESULTS In a retrospective analysis of 60 invasive SCC and 43 keratoacanthoma cases, keratin, surface scale, blood spots, white structureless zones, white circles, and coiled vessels were commonly found in both types of lesions. We reevaluated the significance of these criteria in 206 raised, nonpigmented lesions (32 SCCs, 29 keratoacanthomas, and 145 other lesions). Central keratin was more common in keratoacanthoma than in SCC (51.2% vs 30.0%, P = .03). Keratin had the highest sensitivity for keratoacanthoma and SCC (79%), and white circles had the highest specificity (87%). When keratoacanthoma and SCC were contrasted with basal cell carcinoma, the positive predictive values of keratin and white circles were 92% and 89%, respectively. When SCC and keratoacanthoma were contrasted with actinic keratosis and Bowen disease, the positive predictive value of keratin was 50% and that of white circles was 92%. In a multivariate model, white circles, keratin, and blood spots were independent predictors of SCC and keratoacanthoma. White circles had the highest odds ratio in favor of SCC and keratoacanthoma. The interobserver agreement for white circles was good (0.55; 95% CI, 0.44-0.65). CONCLUSIONS White circles, keratin, and blood spots are useful clues to differentiate SCC and keratoacanthoma from other raised nonpigmented skin lesions by dermoscopy. The significance of these criteria depends on the clinical context.</p>","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"148 12","pages":"1386-92"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archdermatol.2012.2974","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30912473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lara K Butler, Elizabeth A Kiracofe, Victor J Marks
{"title":"Circumscribed acral hypokeratosis: successful treatment of a potentially premalignant condition.","authors":"Lara K Butler, Elizabeth A Kiracofe, Victor J Marks","doi":"10.1001/archdermatol.2012.2919","DOIUrl":"https://doi.org/10.1001/archdermatol.2012.2919","url":null,"abstract":"C ircumscribed acral hypokeratosis (CAH) is a rare benign dermatosis of unknown origin first described in 2002. This uncommon dermatosis is seen predominantly on the palms of adult women with a mean age of 65 years. Lesions have a predilection for the thenar or hypothenar eminence of the predominant palm and less frequently on the soles. Typically, the lesions are solitary, but multiple lesions have been reported. Circumscribed acral hypokeratosis has characteristic clinicopathologic features and runs a chronic course. Histologically, the lesions show a classic abrupt decrease in the thickness of the stratum corneum, forming a sharp stair between normal and involved acral skin. The lack of epidermal atypia or cornoid lamellae clearly differentiates CAH from its clinical mimics, Bowen disease and porokeratosis. Circumscribed acral hypokeratosis is generally considered a benign condition, but Kanitakis et al recently reported a case of CAH that underwent premalignant transformation and hypothesized that the absence of the horny layer rendered the underlying keratinocytes susceptible to photocarcinogenesis. This report emphasized the need for close follow-up and suggested that treatment of CAH lesions may be useful to prevent malignant transformation. We describe herein a patient who experienced a sustained complete clinical response after treatment with liquid nitrogen cryotherapy.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"148 12","pages":"1427-8"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archdermatol.2012.2919","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31128826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}