Total Skin Electron Irradiation (TSEI) May Induce Systemic Progression of Mycosis Fungoides (MF) - Cutaneous T-Cell Lymphoma (CTCL)

Abstract

The management of MF-CTCL is based on a 'stage-based' approach and an evaluation by a multidisciplinary team is preferred. Initial treatment in patients with local (patch/plaque) disease includes skin-directed therapies (localized or generalized), with the addition of systemic biologic therapy for refractory, or progressive disease. In patients with unfavorable prognostic features (e.g., folliculotropic or large-cell transformed MF, or B1 involvement) systemic biologic therapies may be introduced earlier in the treatment algorithm.