Journal of the Institute of Actuaries最新文献

Comparative Effectiveness of Second Generation Long-acting Injectable Antipsychotics Based on Nationwide Database Research in Hungary: An Update. 基于匈牙利全国性数据库研究的第二代长效注射用抗精神病药物的疗效比较：更新。

Journal of the Institute of Actuaries Pub Date : 2022-01-31 eCollection Date: 2022-01-01 DOI: 10.1093/schizbullopen/sgac013

Péter Takács, Péter Kunovszki, Valeria Timtschenko, László Fehér, Tamás Balázs, Ramóna Hegyi, Pál Czobor, István Bitter

{"title":"Comparative Effectiveness of Second Generation Long-acting Injectable Antipsychotics Based on Nationwide Database Research in Hungary: An Update.","authors":"Péter Takács, Péter Kunovszki, Valeria Timtschenko, László Fehér, Tamás Balázs, Ramóna Hegyi, Pál Czobor, István Bitter","doi":"10.1093/schizbullopen/sgac013","DOIUrl":"10.1093/schizbullopen/sgac013","url":null,"abstract":"Greater 1-year and 2-year treatment continuation rates and longer median time to discontinuation for second-generation antipsychotic (SGA) long-acting injectables (LAIs) vs oral antipsychotics (OAPs) in Hungary were previously reported. This study reports an updated comparison between new LAIs vs OAPs in Hungary. De-identified claims data from Hungarian National Health Insurance Fund database of schizophrenia patients who were newly initiated on SGAs (November 01, 2016 to June 30, 2017) were retrospectively analyzed. Primary outcomes were likelihood of all-cause 1-year and 1.5-year discontinuation of newly initiated SGA and median time till discontinuation. Among 5400 patients, 3977 (73.6%) were OAP users and 1423 (26.4%) were LAI users. The 1-year continuation rate were 12.7% (risperidone)-34.1% (olanzapine) for OAPs and 26.4% (risperidone LAI)-78.6% (paliperidone 3-monthly [PP3M]) for LAIs. The 1.5-year continuation rates were 9.3%-29.5% for OAPs and 24.9%-76.4% for LAIs. Median (95% CI) time to discontinuation was 52 (33-67) days (clozapine)-152 (134-168) days (aripiprazole) for OAPs and 125 (64-196) days (risperidone LAI)-491 (250-not reached) days (aripiprazole LAI) for LAIs. All-cause discontinuation risk was significantly higher in all OAPs vs PP3M and aripiprazole LAI (P < .01) as well as in each LAI vs PP3M (P < .05). Patients switching on new LAIs from another LAI remained longer than those who switched from OAPs/no previous treatment. Results showed the advantage of LAIs over OAPs in terms of time to treatment discontinuation. Moreover, new SGA LAIs (PP3M) seem to be better than previous LAIs in terms of time to treatment discontinuation.","PeriodicalId":81715,"journal":{"name":"Journal of the Institute of Actuaries","volume":"97 1","pages":"sgac013"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11205877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78632841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular domestication of transposable elements: from detrimental parasites to useful host genes. 转座元件的分子驯化：从有害的寄生虫到有用的宿主基因。

IF 8

Journal of the Institute of Actuaries Pub Date : 2009-03-01 DOI: 10.1007/s00018-009-8376-3

L Sinzelle, Z Izsvák, Z Ivics

引用次数: 0

Better Pensions for All . By Bryn Davies (Institute for Public Policy Research, 1993) £7.50 为所有人提供更好的养老金。布林·戴维斯著(英国公共政策研究所，1993年)，售价7.50英镑

Journal of the Institute of Actuaries Pub Date : 1994-01-01 DOI: 10.1017/S0020268100020382

A. Lowe

引用次数: 4

Reserving for catastrophe reinsurance 预留巨灾再保险

Journal of the Institute of Actuaries Pub Date : 1994-01-01 DOI: 10.1017/S0020268100020114

D. Craighead

引用次数: 2

Investment — assessing a manager's skill and monitoring the risks 投资-评估经理的技能和监控风险

Journal of the Institute of Actuaries Pub Date : 1994-01-01 DOI: 10.1017/S0020268100020096

N. Day, S. Green, J. Plymen

引用次数: 3

Life insurance company takeovers. A Report by a Working Party of the Life Assurance Joint Committee of the Institute of Actuaries and the Faculty of Actuaries, 15 October 1993 人寿保险公司收购。精算师协会和精算师学院人寿保险联合委员会工作组的报告，1993年10月15日

Journal of the Institute of Actuaries Pub Date : 1994-01-01 DOI: 10.1017/S002026810002014X

E. Sherlock, H. Froggatt, N. Gillott, R. M. Harvey, J. Jenkins, D. Keeler, M. Pickford, N. H. Taylor

引用次数: 2

Realistic reporting of life insurance company policy liabilities and profits: developments in Anglo-American countries 寿险公司保单责任与利润的现实报告:英美国家的发展

Journal of the Institute of Actuaries Pub Date : 1994-01-01 DOI: 10.1017/S0020268100020229

M. Adams, C. Scott

{"title":"Realistic reporting of life insurance company policy liabilities and profits: developments in Anglo-American countries","authors":"M. Adams, C. Scott","doi":"10.1017/S0020268100020229","DOIUrl":"https://doi.org/10.1017/S0020268100020229","url":null,"abstract":"This paper examines international developments in life insurance generally accepted accounting practice (GAAP) for policy valuation and profit recognition in four major Anglo-American markets—the U.K., Australia, the U.S.A. and Canada. Each valuation method examined has its advantages and disadvantages with respect to the needs of preparers and users of the annual corporate reports of life insurance companies. The paper documents that the statutory basis and U.S. GAAP are considered to have substantive deficiencies. In contrast, the U.K. accruals method, the Australian margin on services method and Canadian GAAP have much to commend them, particularly with regard to their flexibility to accommodate valuation adjustments for unexpected events. Nevertheless, from the preparers' point of view, the systems which would have to be developed to facilitate the U.K. accruals and Australian margin on services methods would be difficult and costly to implement. Profit reporting under Canadian GAAP is also sensitive to changes in actuarial reserving assumptions. The authors conclude that, since national preferences in actuarial and accounting practices are inevitable and because the product-market structures of life insurance markets are so distinctive, international harmonisation of life office GAAP is unlikely to occur for a very long time.","PeriodicalId":81715,"journal":{"name":"Journal of the Institute of Actuaries","volume":"121 1","pages":"441-458"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0020268100020229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56679526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

On the choice of bandwidth for kernel graduation 关于内核毕业的带宽选择

Journal of the Institute of Actuaries Pub Date : 1994-01-01 DOI: 10.1017/S0020268100020102

J. Gavin, S. Haberman, R. Verrall

引用次数: 29

Financing long-term care in Great Britain 资助英国的长期护理

Journal of the Institute of Actuaries Pub Date : 1994-01-01 DOI: 10.1017/S0020268100020084

S. Nuttall, R. Blackwood, B. Bussell, J. Cliff, M. J. Cornall, A. Cowley, P. Gatenby, J. Webber

引用次数: 75

General Insurance Study Group, Convention, 27–29 October 1993 一般保险研究小组，公约，1993年10月27日至29日

Journal of the Institute of Actuaries Pub Date : 1994-01-01 DOI: 10.1017/S0020268100020242

C. Czapiewski

引用次数: 0