Journal of epilepsy最新文献

Journal of epilepsy Pub Date : 2016-11-12 DOI: 10.4172/2472-0895.1000E114

K. Hung

引用次数: 1

High Frequency Neuromagnetic Signals: A New Biomarker for Localizing Epileptic Areas Running Title: High-Frequency Neuromagnetic Signals in Epilepsy 高频神经磁信号:一种定位癫痫区域的新生物标志物

Journal of epilepsy Pub Date : 2016-10-26 DOI: 10.4172/2472-0895.1000E113

J. Xiang, K. Leiken, C. Wu, X. Wang, Y. Fan, L. Qi, H. Qiao

引用次数: 0

Neuromodulation of Bilateral Hippocampal Foci, an Alternative for Mesial Temporal Lobe Seizures in Patients with Non-Lesional MRI: Long-Term Follow-up 双侧海马病灶的神经调节，非病变MRI患者中颞叶癫痫的一种选择:长期随访

Journal of epilepsy Pub Date : 2016-10-16 DOI: 10.4172/2472-0895.1000116

F. Velasco, D. PÃ©rez-PÃ©rez, M. CuÃ©llar-Herrera, D. Trejo, M. Montesdeoca, A. Velasco

{"title":"Neuromodulation of Bilateral Hippocampal Foci, an Alternative for Mesial Temporal Lobe Seizures in Patients with Non-Lesional MRI: Long-Term Follow-up","authors":"F. Velasco, D. PÃ©rez-PÃ©rez, M. CuÃ©llar-Herrera, D. Trejo, M. Montesdeoca, A. Velasco","doi":"10.4172/2472-0895.1000116","DOIUrl":"https://doi.org/10.4172/2472-0895.1000116","url":null,"abstract":"Background: Patients with bilateral independent hippocampal refractory seizures, who show no evidence of lesion in the MRI, constitute a challenge for their treatment. The risk of severe retrograde amnesia and/or residual seizures is high when bilateral temporal lobectomy is performed. Several groups have reported electrical neuromodulation of the hippocampus as a reversible surgical alternative for mesial temporal lobe epilepsy seizures that are refractory to medical treatment. Methods: In the Epilepsy Clinic of the General Hospital we have had three patients with bilateral independent foci and non-lesional MRI. The present publication shows their long-term seizure status and their neuropsychological outcome. Stimulation parameters were 3.0 V amplitude, high frequency (130 Hz), 450 μs pulse width, one minute ON and 4 min OFF cyclic stimulation. Follow-up extended over 9 years. Results: Patients showed dramatic seizure reduction. In two patients in whom stimulation was stopped (due to battery depletion or skin erosion), seizure reduction persisted for months after stimulation stopped, but eventually seizures reappeared slowly. One patient has had uninterrupted stimulation and has been seizure free for nine years. The neuropsychological tests showed no functional decrease at the selected modulation parameters. Conclusion: Bilateral hippocampal stimulation is effective in seizure control in patients in whom ablative surgery is not recommended.","PeriodicalId":81656,"journal":{"name":"Journal of epilepsy","volume":"2016 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2472-0895.1000116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70316824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dysplasia Type Ia, Ib and Hippocampal Sclerosis: Is Reelin the Missing Link? Ia型、Ib型发育不良与海马硬化:Reelin是缺失的环节吗?

Journal of epilepsy Pub Date : 2016-09-30 DOI: 10.4172/2472-0895.1000115

R. Andrade-Machado, P. Aguledo-Flórez, L. Salazar-Peláez

引用次数: 1

Neonatal Seizures Characteristics and Prognosis 新生儿癫痫发作的特点和预后

Journal of epilepsy Pub Date : 2016-09-29 DOI: 10.4172/2472-0895.1000114

M. Knežević-Pogančev

引用次数: 2

Conflict Processing and Response Inhibition in Patients with Temporal Lobe Epilepsy: fMRI Study 颞叶癫痫患者的冲突加工和反应抑制:fMRI研究

Journal of epilepsy Pub Date : 2016-09-02 DOI: 10.4172/2472-0895.1000113

J. Alvarez-Alamilla, Velasco Al, Río-Portilla Yd

引用次数: 5

Early Atherosclerotic Changes in the Patients with Idiopathic Epilepsy: Egyptian Preliminary Study 特发性癫痫患者的早期动脉粥样硬化改变:埃及的初步研究

Journal of epilepsy Pub Date : 2016-08-20 DOI: 10.4172/2472-0895.1000112

Hala A. Shaheen, Sayed S. Sayed, L. Daker, Mostafa Magdy

{"title":"Early Atherosclerotic Changes in the Patients with Idiopathic Epilepsy: Egyptian Preliminary Study","authors":"Hala A. Shaheen, Sayed S. Sayed, L. Daker, Mostafa Magdy","doi":"10.4172/2472-0895.1000112","DOIUrl":"https://doi.org/10.4172/2472-0895.1000112","url":null,"abstract":"Background: Patients with epilepsy are at higher risk for atherosclerosis which may be due to epilepsy or antiepileptic drugs. The frequency of atherosclerosis in patients with epilepsy was not previously studied in Egypt. Objective of this study: This study aimed to detect the frequency of subclinical atherosclerosis and some vascular risk factors in patients with idiopathic epilepsy and to correlate it to clinical and laboratory data. Patients and methods: Ninety patients with idiopathic epilepsy and 30 ages, sex matched healthy controls subjected to neurological examination, extra cranial carotid duplex, lipid profile, uric acid and CRP levels. Results: The level of high density lipoprotein cholesterol was significantly lower in all patients with epilepsy and those treated with enzyme inducer antiepileptic drugs than the control subjects. Level of serum uric acid was statistically significantly higher in all patients with epilepsy including the untreated patients and those treated with non-enzyme inducer and poly antiepileptic drugs than control subjects. The Common Carotid Artery Intima Media Thickness (CCA IMT) was significantly higher in all patients with epilepsy including untreated and treated patients with enzyme inducer or non-inducer than control. There was a significant positive correlation between the CCA IMT and duration of illness as well as duration of the antiepileptic drugs. Conclusion: Frequency of subclinical atherosclerosis in the patients with idiopathic epilepsy was 63.33%. The epilepsy itself could result in subclinical atherosclerotic changes in the patients with epilepsy, which could be exacerbated by the antiepileptic drugs, particularly the enzyme inducer drugs.","PeriodicalId":81656,"journal":{"name":"Journal of epilepsy","volume":"2 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2472-0895.1000112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70316665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Which are the Molecular Basis of Dysplasia Type IIIa, What Should We Know and Why? IIIa型发育不良的分子基础是什么?我们应该知道什么?为什么?

Journal of epilepsy Pub Date : 2016-08-02 DOI: 10.4172/2472-0895.1000E112

R. Andrade-Machado

引用次数: 1

Implementation of Ketogenic Diet Therapy in Refractory Epilepsies 生酮饮食治疗难治性癫痫的实施

Journal of epilepsy Pub Date : 2016-08-02 DOI: 10.4172/2472-0895.1000111

J. Liao, L. Xiong

{"title":"Implementation of Ketogenic Diet Therapy in Refractory Epilepsies","authors":"J. Liao, L. Xiong","doi":"10.4172/2472-0895.1000111","DOIUrl":"https://doi.org/10.4172/2472-0895.1000111","url":null,"abstract":"The Ketogenic Diet (KD) has been used in treatment of epilepsy in mainland China since 2004. Clinical indications of KD include: Glucose Transporter Type 1 (GLUT-1) deficiency, Pyruvate Dehydrogenase Deficiency (PDHD, myoclonus-astatic epilepsy (Doose syndrome), tuberous sclerosis complicated with or without epilepsy, Rett syndrome, Dravet syndrome, infantile spasms, and Landau-Kleffner syndrome, Lafora disease, and super-refractory status epilepticus. The contraindications of KD include: Inborn error of lipid metabolism, porphyria, and patients who are unable to cooperate with the KD. There should be standardized clinical consultation and evaluation before starting KD treatment; and special attention should be paid to selection and preparation of food, and to indication of age and geographic area etc. During the KD treatment, the transition time from ordinary diet to KD often takes 1-2 weeks; and a final 2: 1-4: 1 ketogenic diet ratio will normally produce ketosis of clinical therapeutic effect. The KD could be combined with anticonvulsant treatment. A qualified ketogenic diet therapy means: (1) Proper nutrition and growth with normal nutrition biomarkers; (2) Tasty foods: patients are willing to accept the therapeutic diet; (3) Ideal state of ketosis: urine ketone remains above (+++), blood ketone at about 4.0 mmol/L, blood sugar is controlled at 4.0 mmol/L, ratio of blood sugar/blood ketone is about 1: 1-2: 1; (4) Reasonable balanced food composition, defecate daily and naturally without constipation; (5) No remarkable complication(s). It is recommended that KD could be tried at least for three months continuously. Good responders should maintain the KD therapy for 2 yrs. or so. It often needs to take 3-6 months to return back to a regular diet. KD therapy should be monitored with close follow-ups and assessments. Our extensive experience has confirmed that it is safe in clinical practice.","PeriodicalId":81656,"journal":{"name":"Journal of epilepsy","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2472-0895.1000111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70316625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A New de novo Mutation Associated with Neurofibromatosis (NF-1) 与神经纤维瘤病(NF-1)相关的一个新的新生突变

Journal of epilepsy Pub Date : 2016-08-02 DOI: 10.4172/2472-0895.1000110

Jose g. Gonzalez, Isabella Rendon, Marisol Vilamizar, J. Campos, L. González

{"title":"A New de novo Mutation Associated with Neurofibromatosis (NF-1)","authors":"Jose g. Gonzalez, Isabella Rendon, Marisol Vilamizar, J. Campos, L. González","doi":"10.4172/2472-0895.1000110","DOIUrl":"https://doi.org/10.4172/2472-0895.1000110","url":null,"abstract":"Neurofibromatrosis type 1 (NF-1) in the most common neurocutaneous disease with a autosomal dominant inheritance pattern and a frequency of 1:3.500 lives births in the general population, regardless of race and sex. NF-1 is a progressive disorder characterized by multiples cafe-au-lait macules, neurofibromas, Lish nodules and others manifestations such as bone abnormalities, short stature, epilepsy, learning disabilities, hyperactivity, with a highly variable and unpredictable expression. Half of its cause comes from different mutations in a gene on chromosome 17, resulting in less or performance neurofibromin having the regulatory domain of tumor activity. The other 50% of the case are caused by de novo mutation. It is an infant 13 months old, no family history of neurofibromatosis, which features six cafe-au lait spots 1 cm of diameter in the legs, chest, auxiliary region a and short stature. The clinical diagnostic criteria of NF-1 were established by The National Institutes Heath Consensus Development Conference in 1987. It has been suggested that pathogenic mutation in the NF-1 gene be added to the list of diagnostic criteria, but not yet accepted. A molecular genetics study showed an alteration in exon 16 c.2540T>G (p.Leu847 Arg). No genetic alterations found in phenotypic parents. After six year of follow-up she was not observed clinical or radiographic abnormalities. The genetic study is mandatory for confirmation of the suspected diagnosis and to monitor de novo mutations that knowledge and phenotypic expression thereof.","PeriodicalId":81656,"journal":{"name":"Journal of epilepsy","volume":"9 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2472-0895.1000110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70316612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1