Archives of Biological Sciences最新文献_第7页

Overexpression of BNIP3 in rat intervertebral disk cells triggers autophagy and apoptosis BNIP3在大鼠椎间盘细胞中过表达可引发自噬和凋亡

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220310013w

Wu Tingsheng, Shaoyong Fan, Bin Zhang, Zhiqiang Tao, H. Hua, Min Dai

{"title":"Overexpression of BNIP3 in rat intervertebral disk cells triggers autophagy and apoptosis","authors":"Wu Tingsheng, Shaoyong Fan, Bin Zhang, Zhiqiang Tao, H. Hua, Min Dai","doi":"10.2298/abs220310013w","DOIUrl":"https://doi.org/10.2298/abs220310013w","url":null,"abstract":"Excessive apoptosis of intervertebral disk cells and intervertebral disk degeneration (IDD) is the prime cause of low back pain. B-cell lymphoma 2 (Bcl-2) and adenovirus E1B 19 kDa interacting protein 3 (BNIP3), a member of the Bcl-2 family, are involved in cell autophagy and apoptosis. The roles and mechanisms of BNIP3 in intervertebral disk cell autophagy and apoptosis are unclear. In this study, primary rat intervertebral disk cells were prepared to study the effect of BNIP3 overexpression on their autophagy and apoptosis. The cell counting kit (CCK)-8 assay showed that BNIP3 overexpression decreased cell viability. Real-time PCR and Western blotting showed that BNIP3 overexpression significantly upregulated the expression of autophagy-related proteins and pro-apoptotic proteins, including hypoxia-inducible factor-1?, apoptotic protease activating factor 1, caspase 3 and cleaved caspase 3, microtubule-associated proteins 1A/1B light chain 3 (LC3) and Beclin-1 while downregulating the expression of anti-apoptotic protein Bcl-2. Cell staining detection of autophagy and apoptosis showed that BNIP3 overexpression significantly increased the autophagy and apoptosis of rat intervertebral disk cells. BNIP3 RNA interference revealed that the effects of BNIP3 overexpression can be reversed. These findings suggested that BNIP3 enhanced the autophagy and apoptosis in the rat intervertebral disk cells in vitro, which might promote IDD development.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68389771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-1β, interleukin-6 and interleukin-10 polymorphisms in Tnisian patients with colorectal cancer and liver metastasis 白介素-1β、白介素-6和白介素-10在大肠癌及肝转移患者中的多态性

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220607032h

Meriam Hazgui, M. Weslati, Donia Ounissi, Rahma Boughriba, D. Bacha, Basma Loueslati

{"title":"Interleukin-1β, interleukin-6 and interleukin-10 polymorphisms in Tnisian patients with colorectal cancer and liver metastasis","authors":"Meriam Hazgui, M. Weslati, Donia Ounissi, Rahma Boughriba, D. Bacha, Basma Loueslati","doi":"10.2298/abs220607032h","DOIUrl":"https://doi.org/10.2298/abs220607032h","url":null,"abstract":"The balance between pro- and anti-inflammatory cytokine expression is essential for an efficient immune response and for the regulation of cancer development and progression. This study analyzed the expression and genetic variation in IL-1?, IL-6 and IL-10 genes and the possible associations with colorectal cancer (CRC) and colorectal liver metastases (CRLM).We examined IL-1?, IL-6 and IL-10 mRNA expression and three gene variants: IL-1? (rs1143627), IL-10 (rs1800872) and IL-6 (rs1800795), in 198 CRC, 65 CRLM patients and 230 controls. Carriers of the C/T genotype of IL-1? (rs1143627) have an increased risk of developing CRC and CRLM. T/T genotype carriers have a higher risk of CRLM incidence. For IL-10 (rs1800872), patients harboring the C/A genotype have a lower risk of CRC and CRLM occurrence. For IL-6 (rs1800795), the C/C genotype heightens the risk of CRLM development. Overall survival analysis showed that carriers of the C/T genotype of IL-1? (rs1143627) have a worse overall survival in CRC patients. It can be concluded that interleukin genetic variants can be used as biomarkers to detect and predict clinical outcomes and prognostic factors for CRC and CRLM.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anticancer and apoptotic effects of a polysaccharide extract isolated from Lactarius chrysorrheus Fr. in HepG2 and PANC-1 cell lines 乳酸菌多糖提取物对HepG2和PANC-1细胞株的抗癌和凋亡作用

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220803030m

Dogukan Mutlu, C. Cakir, M. Ozturk, Ş. Arslan

{"title":"Anticancer and apoptotic effects of a polysaccharide extract isolated from Lactarius chrysorrheus Fr. in HepG2 and PANC-1 cell lines","authors":"Dogukan Mutlu, C. Cakir, M. Ozturk, Ş. Arslan","doi":"10.2298/abs220803030m","DOIUrl":"https://doi.org/10.2298/abs220803030m","url":null,"abstract":"Mushrooms are widely used in many cultures for nutritional and health benefits. The Lactarius species is found in the Aegean region of Turkey. Lactarius chrysorrheus Fr. is a wild mushroom that contains a milky juice. In this study, we investigated the in vitro cytotoxic potential and apoptotic effect of the polysaccharide extract prepared from L. chrysorrheus by water extraction and alcohol precipitation using the tetrazolium MTT dye assay, annexin V staining, wound healing and colony formation, and qRT-PCR. The molecular weights of three peaks observed in HPLC chromatograms were calculated as 1869.9, 3043.92 and 16821.47 Da. The extract exhibited cytotoxic activity at 72 h, with an IC50 value of 296.42 ?g/mL in HepG2 and 444.43 ?g/mL in PANC-1 cells; the extract that was tested on the normal HEK293 cell line exhibited no cytotoxicity. Further, L. chrysorrheus upregulated the expression of CASPASE 3 and CASPASE 9 while downregulating B-cell lymphoma 2 (BCL-2) and B-cell lymphoma-extra large (Bcl-xL) genes, and inhibited cell migration and colony formation in HepG2 and PANC-1 cells. This study provides new insight into the use of the polysaccharide from L. chrysorrheus in the development of novel anticancer agents.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Patterns of leaf morphological variation in Quercus frainetto Ten. growing on different soil types in Serbia 栎叶形态变异模式的研究。在塞尔维亚不同的土壤类型上生长

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220405018j

M. Jovanovic, Filip Grbovic, J. Milovanović, M. Nonić, M. Šijačić‐Nikolić, S. Branković

引用次数: 1

Erianin, a promising agent in the treatment of glioblastoma multiforme triggers apoptosis in U373 and A172 glioblastoma cells Erianin是一种治疗多形性胶质母细胞瘤的有前景的药物，可触发U373和A172胶质母细胞瘤细胞的凋亡

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220219021s

Kocoglu Serter, Mücahit Seçme, L. Elmas

{"title":"Erianin, a promising agent in the treatment of glioblastoma multiforme triggers apoptosis in U373 and A172 glioblastoma cells","authors":"Kocoglu Serter, Mücahit Seçme, L. Elmas","doi":"10.2298/abs220219021s","DOIUrl":"https://doi.org/10.2298/abs220219021s","url":null,"abstract":"Glioblastoma is an aggressive, common and deadly primary intracranial brain tumor in adults. The antitumor activity of erianin, a dibenzyl compound found in Dendrobium chrysotoxum Lindl. extract, has not been previously demonstrated in glioblastoma. We investigated the anticancer activity and underlying mechanisms of erianin in human U373 and A172 glioma cells. The effects of erianin on cell viability, apoptosis, migration and invasion were estimated by the XTT test, the reverse transcription-polymerase chain reaction (RT-PCR)/annexin V wound healing assay, and Matrigel? invasion chamber, respectively. The effective amounts of erianin in U373 and A172 cells were 16 and 64 ?M at 48 h, respectively. Erianin also significantly induced apoptosis by inhibiting B-cell lymphoma 2 (Bcl-2), caspase-8, caspase-9 and tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD), and activation of caspase-3 and BH3 interacting domain death agonist (BID) gene expression. In addition, erianin significantly increased the number of apoptotic cells in U373 and A172 cells and significantly decreased invasion and migration in U373 and A172 cells. Taken together, our results suggest that erianin may be a new therapeutic anticancer drug component with a potent apoptotic effect and a potential for treating glioblastoma.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68389640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

SET and MYND domain-containing protein 2 (SMYD2): A prognostic biomarker associated with immune infiltrates in cervical squamous cell carcinoma and endocervical adenocarcinoma SET和MYND结构域蛋白2 (SMYD2):与宫颈鳞状细胞癌和宫颈腺癌免疫浸润相关的预后生物标志物

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220413014a

Zhanglu An, Danyang Cai, Xiongzhi Lin, Shuaijun Xu, Jin Bin, Xiaojun Jin

{"title":"SET and MYND domain-containing protein 2 (SMYD2): A prognostic biomarker associated with immune infiltrates in cervical squamous cell carcinoma and endocervical adenocarcinoma","authors":"Zhanglu An, Danyang Cai, Xiongzhi Lin, Shuaijun Xu, Jin Bin, Xiaojun Jin","doi":"10.2298/abs220413014a","DOIUrl":"https://doi.org/10.2298/abs220413014a","url":null,"abstract":"The histone lysine methyltransferase SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-DEAF1) domaincontaining protein (SMYD2) plays a role in the tumorigenesis of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). However, the prognostic significance of SMYD2 in CESC and the link between SMYD2 and tumor-infiltrating immune cells are unknown. The prognostic value of SMYD2 in CESC was obtained from The Cancer Genome Atlas (TCGA). SMYD2 mRNA and protein were both highly expressed in CESC compared with normal tissues. The high expression of SMYD2 was associated with advanced tumor status and poor prognosis in CESC patients. SMYD2 was an independent prognostic factor for overall survival. In vitro experiments with knockdown of SMYD2 suppressed CESC cell migration and invasion. The online tumor immune estimation resource (TIMER) and Kaplan-Meier analysis results revealed that the infiltration of CD4+ T and CD8+ T cells was related to poor prognosis. In TIMER-based multivariate Cox regression analysis, CD8+ T cells and SMYD2 were demonstrated as independent prognostic factors of CESC. In conclusion, our data suggest that high SMYD2 expression is a predictor of poor prognosis in CESC patients; SMYD2 could serve as a prognostic biomarker and molecular therapeutic target for CESC.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68389883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bacteriome composition analysis of selected mineral water occurrences in Serbia 塞尔维亚选定矿泉水产地的细菌组成分析

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs211223005s

Vladimir Sarab, V. Dragišić, Tamara Janakiev, V. Obradović, Milica Ćopić, B. Knežević, I. Dimkić

{"title":"Bacteriome composition analysis of selected mineral water occurrences in Serbia","authors":"Vladimir Sarab, V. Dragišić, Tamara Janakiev, V. Obradović, Milica Ćopić, B. Knežević, I. Dimkić","doi":"10.2298/abs211223005s","DOIUrl":"https://doi.org/10.2298/abs211223005s","url":null,"abstract":"Bacterial metabarcoding analysis by 16S rDNA of five occurrences of mineral waters in Serbia (Torda, Slankamen Banja, Lomnicki Kiseljak, Velika Vrbnica and Obrenovacka Banja) indicated the presence of a high percentage of the Proteobacteria phylum, followed by the Bacteroidetes phylum. The families Rhodobacteraceae, Burkholderiaceae, Pseudomonadaceae, Methylophilaceae and Moraxellaceae were the most dominant in the bacterial flora of the selected occurrences, whereas the most represented genera were Acinetobacter, Pseudorhodobacter, Pseudomonas, Limnohabitans, Massilia, Limnobacter and Methylotenera. The presence of coliform bacteria was not detected. Alpha diversity analysis revealed that Slankamen Banja and Lomnicki Kiseljak were the richest of the selected occurrences, while the mineral waters of Torda, Velika Vrbnica and Obrenovacka Banja were characterized by similar diversity of bacterial communities determined by beta diversity analysis. Physical-chemical analysis revealed the value of total dissolved solids above 1 g/L, as well as elevated concentrations of some metals and non-metals. The research concluded that specific bacteria contribute to the development of biocorrosion and biofouling processes of water intake facilities. In addition, some of these bacteria might be potential indicators of the organic sources of pollution and/or biotechnological natural remediators in the treatment of contaminated waters.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68389962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of the genetic diversity of a critically endangered species Centaurea amaena (Asteraceae) 极危物种半毛茛(半毛茛科)遗传多样性评价

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220826031a

B. Atasagun

{"title":"Assessment of the genetic diversity of a critically endangered species Centaurea amaena (Asteraceae)","authors":"B. Atasagun","doi":"10.2298/abs220826031a","DOIUrl":"https://doi.org/10.2298/abs220826031a","url":null,"abstract":"Centaurea amaena is an endemic and endangered species listed as CR (critically endangered) in Turkey. ISSR markers were used to detect the level of genetic diversity in two natural populations of C. amaena. A total of 50 ISSR primers were used and 13 primers producing polymorphic and reproducible products were selected. These primers yielded 102 amplified discernible loci, of which 80 (78%) were polymorphic. A high level of genetic diversity was detected both at population and species levels; the effective number of alleles (Ne) was 1.544, the observed number of alleles (Na) was 1.784, the Nei?s genetic diversity (H) was 0.306, and Shannon's information index was 0.447. The established gene flow (Nm) was 2.329, indicating a high migration rate between the populations. A moderate level of genetic differentiation (GST: 0.176) was also observed. Analysis of molecular variance (AMOVA) revealed that 24.89% of the total genetic diversity resided among populations, while 75.10% was within the populations. Cluster analysis showed that samples from the same locality clustered together and there was no cross-clustering between the samples. The patterns of genetic variation indicate that existing C. amaena populations should be conserved.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphometric analysis of the human endoneurial extracellular matrix components during aging 衰老过程中人神经内膜细胞外基质成分的形态计量学分析

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2021-01-01 DOI: 10.2298/ABS201214006K

B. Kundalic, Sladjana Z. Ugrenović, I. Jovanovic, V. Petrovic, A. Petrović, Vesna Stojanovic, A. Antovic, Jasen Kundalić, I. Graovac

{"title":"Morphometric analysis of the human endoneurial extracellular matrix components during aging","authors":"B. Kundalic, Sladjana Z. Ugrenović, I. Jovanovic, V. Petrovic, A. Petrović, Vesna Stojanovic, A. Antovic, Jasen Kundalić, I. Graovac","doi":"10.2298/ABS201214006K","DOIUrl":"https://doi.org/10.2298/ABS201214006K","url":null,"abstract":"The aim of this study was to analyze the expression of extracellular matrix (ECM) proteins in human endoneurium during aging. We harvested 15 cadaveric sural nerves, distributed in 3 age groups (I: 25-44, II: 45-64, III: 65-86 years old). Histological sections were stained immunohistochemically for the presence of collagen type I, type IV and laminin, and the ImageJ processing program was used in morphometrical analysis to determine the percentages of these endoneurial proteins. In two younger groups, the endoneurial matrix of the sural nerve was composed from about equal proportions of these proteins, which may be considered a favorable microenvironment for the regeneration of nerve fibers. Linear regression analysis showed a significant increase in endoneurial collagen type IV with age, while collagen type I and laminin significantly decreased during the aging process. In cases older than 65 years, remodeling of the endoneurial matrix was observed to be significantly higher for the presence of collagen type IV, and lower for the expression of collagen type I and laminin. This age-related imbalance of ECM proteins could represent a disadvantageous microenvironment for nerve fiber regeneration in older adults. Our findings contribute to the development of therapeutic approaches for peripheral nerve regeneration.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68388941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of astragaloside IV against hypertension-induced vascular remodeling involves the DNMT1 and TET2 signaling pathway 黄芪甲苷对高血压血管重构的保护作用涉及DNMT1和TET2信号通路

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2021-01-01 DOI: 10.2298/ABS210426024Q

Yingchun Qin, Yilin Xie, Aihua Li, Xiao-qin Zhang, Zhiqiang Yan

{"title":"Protective effects of astragaloside IV against hypertension-induced vascular remodeling involves the DNMT1 and TET2 signaling pathway","authors":"Yingchun Qin, Yilin Xie, Aihua Li, Xiao-qin Zhang, Zhiqiang Yan","doi":"10.2298/ABS210426024Q","DOIUrl":"https://doi.org/10.2298/ABS210426024Q","url":null,"abstract":"Proliferation, migration, and the phenotypic switch of vascular smooth muscle cells (VSMCs) play an important role in vascular remodeling induced by hypertension. Astragaloside IV (AS-IV), the active ingredient of Astragalus membranaceus, has been shown to exert a beneficial role in cardiovascular disease. The present study aimed to investigate the mechanism responsible for the protective effects of AS-IV on hypertension-induced vascular remodeling. AS-IV significantly reduced blood pressure and aortic media thickness in two-kidney, one-clip (2K1C) hypertensive rats. AS-IV administration downregulated the expression levels of DNA methyltransferase1 (DNMT1), matrix metalloproteinase (MMP2) and proliferating cell nuclear antigen (PCNA) and upregulated the expression of smooth muscle 22? protein (SM22?), ?-smooth muscle actin (ACTA2) and ten-eleven translocation 2 (TET2) in the aorta of hypertensive rats. AS-IV inhibited the proliferation and migration in VSMCs treated with angiotensin II (Ang II). AS-IV increased the expression of SM22?, ACTA2 and TET2, and decreased the expression of collagen Ia (COL-1a), collagen IIIa (COL-3a), DNMT1, MMP2 and PCNA in vitro. Reduction in 5-methylcytosine (5-mC) was observed in VSMCs treated with AS-IV. Knockdown of DNMT1 induced the expression of TET2, while the level of DNMT1 did not change after knockdown of TET2. These results suggest that AS-IV reversed hypertension-induced vascular remodeling by inhibiting DNMT1 and upregulating TET2.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68388967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1