APCBEE Procedia最新文献_第6页

Pharmacokinetics Study of Metformin – Mathematical Modelling and Simulation 二甲双胍的药代动力学研究——数学建模与模拟

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.01.027

Sukankana Chakraborty , Kriti Arora , Prakash Kumar Sharma , Arijit Nath , Chiranjib Bhattacharjee

{"title":"Pharmacokinetics Study of Metformin – Mathematical Modelling and Simulation","authors":"Sukankana Chakraborty , Kriti Arora , Prakash Kumar Sharma , Arijit Nath , Chiranjib Bhattacharjee","doi":"10.1016/j.apcbee.2014.01.027","DOIUrl":"10.1016/j.apcbee.2014.01.027","url":null,"abstract":"<div><p>In the present investigation, a deterministic mathematical model of the pharmacokinetics of Metformin was developed using the first principle of chemical engineering (mass balance). The mathematical model developed with precision, can predict the concentration time history of the drug interest in stomach, liver, intestine, and the peripheral areas. According to this model, after administration, the drug is dissolved in the stomach following first order kinetics. The intestinal absorption of Metformin is majorly mediated by plasma membrane monoamine transporter. In liver Metformin takes part in various metabolic pathways which subsequently aid the adsorption of the drug in different cellular systems. No intermediate metabolites of Metformin have been identified till now. The major route for elimination of Metformin is through tubular secretion, in an unchanged form in the urine. The outcome of the predicted data closely matches the experimental finding, extracted after a meticulous scrutiny of the accessible literature, and results of clinical trials. The model is highly realistic and pragmatic in its practice.</p></div>","PeriodicalId":8107,"journal":{"name":"APCBEE Procedia","volume":"9 ","pages":"Pages 151-158"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.apcbee.2014.01.027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83535024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Vermicompost as an Important Component in Substrate: Effects on Seedling Quality and Growth of Muskmelon (Cucumis Melo L.) 蚯蚓堆肥作为基质重要成分对甜瓜幼苗品质和生长的影响

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.01.076

Vo H. Manh , C. Ho Wang

引用次数: 45

Temporal Variation of BTEX at the Area of Petrol Station in Bangkok, Thailand 泰国曼谷加油站区域BTEX的时间变化

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.10.011

Pattamaporn Rattanajongjitrakorn , Tassanee Prueksasit

引用次数: 22

Uncertainty Quantification of Hydrologic Model 水文模型的不确定性量化

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.10.042

P. Vallam, X.S. Qin, J.J. Yu

引用次数: 8

Immunogenicity of Malaria Vaccine Candidate - Plasmodium Falciparum Merozoite Surface Protein 5 (PfMSP5) Expressed in Bacillus subtilis 恶性疟原虫Merozoite表面蛋白5 (PfMSP5)在枯草芽孢杆菌中表达的免疫原性

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.01.021

Chittibabu Gottimukkala , Charles Ma , Hans J. Netter , Santosh B. Noronha , Ross L. Coppel

{"title":"Immunogenicity of Malaria Vaccine Candidate - Plasmodium Falciparum Merozoite Surface Protein 5 (PfMSP5) Expressed in Bacillus subtilis","authors":"Chittibabu Gottimukkala , Charles Ma , Hans J. Netter , Santosh B. Noronha , Ross L. Coppel","doi":"10.1016/j.apcbee.2014.01.021","DOIUrl":"10.1016/j.apcbee.2014.01.021","url":null,"abstract":"<div><p>Malaria is one of the major health problems of the world. A number of vaccine candidates have been identified and are at different stages of the clinical trials. Wide spread deployment of malaria vaccines requires a cost effective and scalable production platform. We have chosen a non-pathogenic bacterial host, <em>Bacillus subtilis</em>, to produce a malaria vaccine candidate PfMSP5. Merozoite surface protein 5 (MSP5) is present during the asexual stage of <em>Plasmodium falciparum</em>, and is a recognized target that can be used as a subunit vaccine against blood stages of malaria. PfMSP5 was successfully expressed in <em>B. subtilis</em> and recovered from the culture supernatant in single step (nickel-affinity chromatography) purification. <em>B. subtilis</em> derived PfMSP5 induced very strong immune responses in mouse immunization experiments. The antibodies raised against PfMSP5 were reactive with proteins expressed by the parasite as shown by immunofluorescence. Our results conclude that the <em>B. subtilis</em> is an efficient expression host for the production of the malaria vaccine candidate PfMSP5.</p></div>","PeriodicalId":8107,"journal":{"name":"APCBEE Procedia","volume":"9 ","pages":"Pages 113-119"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.apcbee.2014.01.021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91415274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambient Vibration Tests and Finite Element Analysis for Dynamic Properties of Brick Masonry Inverted Bell-shaped Chedi 砖砌体倒钟形车体动力特性环境振动试验及有限元分析

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.01.038

Chayanon Hansapinyo , Nakhorn Poovarodom

引用次数: 3

Evaluation of Different Commercial Feeds for Culture of Juvenile Sobaity (Sparidentex Hasta Valenciennes) in Kuwait 科威特不同商业饲料对幼鱼社会性培养的评价

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.03.046

M.A. Hossain, K. Al-Abdul-Elah, S. El-Dakour

{"title":"Evaluation of Different Commercial Feeds for Culture of Juvenile Sobaity (Sparidentex Hasta Valenciennes) in Kuwait","authors":"M.A. Hossain, K. Al-Abdul-Elah, S. El-Dakour","doi":"10.1016/j.apcbee.2014.03.046","DOIUrl":"10.1016/j.apcbee.2014.03.046","url":null,"abstract":"<div><p>A 6-month long growth trial was conducted to evaluate three commercial feeds: Skretting (Turkey), Biomar (Greece), and Arasco (Saudi Arabia) in juvenile sobaity, <em>Sparidentex hasta.</em> For confidentiality, these feeds were randomly given code names diets 1, 2 and 3 and trash fish was used as diet 4 (control). Protein in commercial diets ranged between 47.17 and 48.80% while trash fish had 57.40% protein (% dry basis). Sobaity juveniles (51.39±0.63g) were stocked at the rate of 50fish/tank, each treatment with three replicates. Fish were fed twice daily at satiation level. The results showed that diet 2 (48.80% protein) resulted in significantly (P<0.05) better weight gain, specific growth rate (SGR), feed conversion ratio, protein efficiency ratio, apparent net protein utilization and energy retention compared to other diets. There were no significant (P>0.05) differences between the weight gain and SGR values of fish fed diet 1 (48.50% protein) and trash fish (57.40% protein) while diet 3 resulted in the lowest weight gain and SGR. The muscle fatty acid composition reflected the dietary fatty acids particularly eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) and n-3/n-6 ratios which were significantly higher in fish fed diet 2. The results showed that diet 2 (48.80% protein) may be recommended for culture of sobaity in Kuwait.</p></div>","PeriodicalId":8107,"journal":{"name":"APCBEE Procedia","volume":"8 ","pages":"Pages 310-316"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.apcbee.2014.03.046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91323401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Variation of Flux in Membrane Distillation 膜蒸馏中通量的变化

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.01.018

S.R. Selvi , R. Baskaran

引用次数: 8

The Impact of Landscape Design on House Prices and Values in Residential Development in Urban Areas 景观设计对城市住宅开发中房价和价值的影响

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.10.059

Mohd Ramzi Mohd Hussain, Izawati Tukiman, Ismawi Hj. Zen, Fitrynadia Mohd Shahli

{"title":"The Impact of Landscape Design on House Prices and Values in Residential Development in Urban Areas","authors":"Mohd Ramzi Mohd Hussain, Izawati Tukiman, Ismawi Hj. Zen, Fitrynadia Mohd Shahli","doi":"10.1016/j.apcbee.2014.10.059","DOIUrl":"10.1016/j.apcbee.2014.10.059","url":null,"abstract":"<div><p>Focusing on a world class living environment, a good quality residential area can be highlighted as an important issue in creating a sustainable living environment. However, limited green spaces within the proximity of residential properties are not supporting the landscape space and are not conducive to living space. The aim of the paper is to investigate the impact of landscape design on house prices and values in residential development particularly in urban areas. The paper employed quantitative approaches which include i) a questionnaire survey; and ii) an observation. This empirical study is based on the findings of case studies conducted in several residential areas in Klang Valley. The findings show that the residents have very clear ideas on how much green space is really important in residential areas in order to create a sustainable residential environment. Despite the absence of public actions in terms of providing information, encouraging participations in the survey and promoting awareness of those interviewed have shown considerable interest in promoting landscape design to be applied in residential development. The perceptions of the quality and quantity of landscape designs in residential areas especially in Klang Valley can be further researched for future study.</p></div>","PeriodicalId":8107,"journal":{"name":"APCBEE Procedia","volume":"10 ","pages":"Pages 316-320"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.apcbee.2014.10.059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83526175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Developing a Five-year Maintenance and Rehabilitation (M&R) Plan for HMA and Concrete Pavement Networks 制定HMA和混凝土路面网络的五年维护和修复计划

APCBEE Procedia Pub Date : 2014-01-01 DOI: 10.1016/j.apcbee.2014.01.041

Hakan Sahin, Paul Narciso, Narain Hariharan

{"title":"Developing a Five-year Maintenance and Rehabilitation (M&R) Plan for HMA and Concrete Pavement Networks","authors":"Hakan Sahin, Paul Narciso, Narain Hariharan","doi":"10.1016/j.apcbee.2014.01.041","DOIUrl":"10.1016/j.apcbee.2014.01.041","url":null,"abstract":"<div><p>In the face of increased demand and exposure to environmental effects, the condition of road pavements continues to decline while resources for their preservation remain limited. Thus, the task of managing pavements has to be done systematically and objectively. This paper outlines the steps involved in developing a multi-year pavement Maintenance and Rehabilitation (M&R) plan. These include: (1) condition assessment; (2) network inventory and database development; (3) identification of pavement sections requiring M&R; (3) needs analysis; and (4) impact analysis. As a case study, the project was performed on the road network inside the Texas A&M University campus that consists of 13.95 miles of roadway, 80% and 20% of which are concrete and HMA pavements respectively. Condition assessment was done according to ASTM D 6433-07 and using the Pavement Condition Index (PCI) as indicator of pavement performance. Data collected were then entered into a database which also contains information on traffic and roadway characteristics. PCI threshold values were established to identify sections that are in need of M&R and the most cost- effective treatment based on long-term performance benefit and life-cycle cost was proposed for each project. Candidate projects were then prioritized by ranking based on benefit-cost analysis. The needs estimate provides meaningful information on the total amount of budget required to correct all deficiencies in the network. Finally, the impact analysis is used to determine the impact of a reduced budget on network condition as well as the amount of backlog that needs to be addressed.</p></div>","PeriodicalId":8107,"journal":{"name":"APCBEE Procedia","volume":"9 ","pages":"Pages 230-234"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.apcbee.2014.01.041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88102033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9