M Hashemi, M Yavari, N Amiri, H Taheri, I Shaigannia, L Moghadas, E Shirzadi, Z Talaee, H Shams, O L Ketabi, B Soleimani
{"title":"Uric acid: a risk factor for coronary atherosclerosis?","authors":"M Hashemi, M Yavari, N Amiri, H Taheri, I Shaigannia, L Moghadas, E Shirzadi, Z Talaee, H Shams, O L Ketabi, B Soleimani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>It is uncertain whether high serum uric acid levels are a true independent risk factor for coronary atherosclerosis or whether the association is due to other confounding variables. We therefore studied the relationship between elevated serum uric acid levels and coronary atherosclerosis after adjustment was made for confounding factors such as age, gender, body mass index, smoking, lipid profile, blood pressure and blood glucose levels.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 240 patients referred for coronary angiography to heart centres in the Shahid-Chamran and Sina hospitals, Isfahan, Iran. Blood chemistry data as well as traditional risk factors and uric acid levels were measured at enrollment. We used vessel, stenosis and extent scores to indicate the degree of coronary artery involvement.</p><p><strong>Results: </strong>This study was conducted on 240 patients with a mean age of 56 +/- 10.9 years (66% male; 37% female) who underwent coronary angiography. Student's t-test analyses revealed that there were significant differences in the mean uric acid levels between male and female patients (p = 0.001). We found no statistically significant correlation between serum uric acid levels and coronary atherosclerosis (p > 0.05). In addition, multivariate logistic regression analyses, using coronary atherosclerosis as dependent variable and traditional risk factors and uric acid levels as independent variables, did not show any significant difference.</p><p><strong>Conclusion: </strong>These findings indicated that uric acid is not associated with coronary atherosclerosis. Any correlation reported in other studies was probably due to the relationship between high serum uric acid levels and other cardiovascular risk factors.</p>","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"18 1","pages":"16-9"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26630725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frequency of the metabolic syndrome in screened South African corporate executives.","authors":"J Ker, P Rheeder, R Van Tonder","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the study was to determine the frequency of the metabolic syndrome in a specific group of people.</p><p><strong>Patients and methods: </strong>The ATP III criteria were used to identify the metabolic syndrome in a group of 1,410 corporate executives belonging to a specialist health and fitness company in South Africa.</p><p><strong>Results: </strong>Using three criteria as specified by the ATP III panel, 31% of this group of corporate executives fulfilled the criteria for the diagnosis of the metabolic syndrome. In a small subset of black executives, a similar finding was obtained. Another one-third of the executives had two criteria of the metabolic syndrome.</p><p><strong>Conclusion: </strong>The metabolic syndrome was common in a group of corporate executives.</p>","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"18 1","pages":"30-3"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26630728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inadvertent retrieval of a broken PTCA catheter from the aorta during off-pump coronary bypass.","authors":"F Nurözler, S T Kutlu, G Küçük","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To cut costs, many centres around the world utilise previously used, re-sterilized balloon catheters to perform coronary angioplasty. The fracture and lodging of an angioplasty device within the coronary arteries is a rare but increasingly noted complication. In this article, we report on the inadvertent retrieval of a coronary angioplasty catheter during off-pump coronary bypass. The accidental removal of the catheter, which extended to the descending aorta, has obviously been life saving. This experience has shown that a high degree of caution is required when planning an operation for the retrieval of PTCA hardware.</p>","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"18 1","pages":"34-5"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26630729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intensive Lipitor therapy reduced heart attack and stroke by one-third in patients with chronic kidney disease.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"18 1","pages":"62"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26631187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atorvastatin and amlodipine co-treatment in ASCOT--LLA shows benefit.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"18 1","pages":"43-4"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26631184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Off-pump coronary bypass for advanced left ventricular dysfunction.","authors":"F Nurözler, S T Kutlu, G Küçük","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In this study the results of off-pump bypass in patients with advanced left ventricular dysfunction (LVD) and without bypassable circumflex disease were analysed retrospectively.</p><p><strong>Methods: </strong>Fifty-five patients with advanced LVD underwent off-pump coronary bypass. Their ages ranged from 39 to 82 years (mean 62.3 +/- 8.4). Forty-two of the patients (76.3%) were in NYHA class III or IV. Mean left ventricular ejection fraction (LVEF) was 23.8 +/- 5.1%. Pre- and intra-operative variables, and postoperative complications and mortality of the patients were analysed. Mid-term follow-up was done by telephone either with the referring cardiologist or the patients.</p><p><strong>Results: </strong>The mean number of coronary artery bypass grafts (CABG) per patient was 2.22 +/- 0.63. Eight coronary endarterectomies were achieved; early mortality was 3.6%. Pre-operative myocardial infarction (MI) occurred in one patient (1.8%). Two patients (3.6%) were supported with an intra-aortic balloon pump (IABP) and 10 (18.1%) needed inotropic support. Mean postoperative blood loss was 425 +/- 50 cm3. A significant improvement in ejection fraction was observed in the postoperative course. Mean intensive care unit stay was 2.1 +/- 1.1 days and mean hospital stay was 7.2 +/- 1.3 days. The mean follow-up period was 21.8 +/- 6.2 months and mid-term survival was 2.4%. Freedom from cardiac events requiring hospital admission was 89.7%. Most of the patients enjoyed symptomatic relief, however 16 patients (32.6% of survivors) remained in NYHA class III.</p><p><strong>Conclusion: </strong>These results support the effectiveness of off-pump coronary bypass with good early and mid-term results in patients with ischaemic cardiomyopathy and without bypassable circumflex lesion.</p>","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"18 1","pages":"26-9"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26630727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low awareness of impact of cardiovascular disease in low- and middle-income countries.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"17 5","pages":"273"},"PeriodicalIF":0.0,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26374716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From the World Congress of Cardiology, Barcelona, 2006--Support for wider metformin usage in type 2 diabetes.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"17 5","pages":"267"},"PeriodicalIF":0.0,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26374713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effective disease management: Today's clinical interventions to control hypercholesterolemic patients.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"17 5","pages":"268"},"PeriodicalIF":0.0,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26374714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New clinical data shows enoxaparin reduces risk of repeat heart attacks and stroke in patients undergoing PCI.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80889,"journal":{"name":"Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners","volume":"17 5","pages":"264"},"PeriodicalIF":0.0,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26374719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}