Applied Materials Today最新文献

{"title":"Impedimetric identification of heteroMOFs modified porous nickel foam self-supports as robust electrodes for CA 19-9 pancreatic tumor marker in human serum","authors":"Sathyadevi Palanisamy, Priya Vijayaraghavan, Tsu-Yin Cheng, Sarin Kumar Kappithottam, Duraisamy Senthil Raja, Xiao-Qi Chen, Tsai-Te Lu, Chiao-Yun Chen, Yun-Ming Wang","doi":"10.1016/j.apmt.2024.102375","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102375","url":null,"abstract":"An impedance-based electrochemical immunosensor for direct and binder-free target recognition of carbohydrate antigen (CA 19-9) tumor biomarker for the early diagnosis of pancreatic cancer was reported. This study uses an in situ solvothermal process to develop a simple method for the one-pot construction of Ni-Fe heteroMOFs (HFNMOFs,) self-supported on conductive nickel foam (NicFm). Utilizing HFNMOFs@NicFm developed in this study, the electrochemical performance of the biosensor was studied for the first time. The as-prepared mixed MOFs decorated NicFm electrodes displayed potential electrochemical outputs. They demonstrated the potential for developing binder-free non-enzymatic immunosensors with wide linear limits, high selectivity, stability, and excellent sensitivity. The bifunctional MOFs exhibit improved electrochemical conductivity owing to the highly exposed metal sites and hierarchical porosity. The changes in the charge transfer resistance present a linear response against increasing target concentrations. The immunosensor developed in this study exhibited its detection limit of 2.56 U/mL. Further, the bioelectrodes produced were validated against real human spiked serum with good results of percentage recovery, indicating the immunosensor is well-suitable to be tested in real-time analysis.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"84 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric review on application of machine learning in additive manufacturing and practical justification","authors":"Quoc-Phu Ma, Hoang-Sy Nguyen, Jiri Hajnys, Jakub Mesicek, Marek Pagac, Jana Petru","doi":"10.1016/j.apmt.2024.102371","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102371","url":null,"abstract":"This paper delves into the cutting-edge applications of Machine Learning (ML) within modern Additive Manufacturing (AM), employing bibliometric analysis as its methodology. Formulated around three pivotal research questions, the study navigates through the current landscape of the research field. Utilizing data sourced from Web of Science, the paper conducts a comprehensive statistical and visual analysis to unveil underlying patterns within the existing literature. Each category of ML techniques is elucidated alongside its specific applications, providing researchers with a holistic overview of the research terrain and serving as a practical checklist for those seeking to address particular challenges. Culminating in a vision for the Smart Additive Manufacturing Factory (SAMF), the paper envisions seamless integration of reviewed ML techniques. Furthermore, it offers critical insights from a practical standpoint, thereby facilitating shaping future research directions in the field.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"76 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural engineering of metal-organic framework catalysts for efficient conversion of glucose into 5-HydroxyMethylFurfural","authors":"Mohammad Hammoud, Mohamad Hmadeh, Mohammad Ahmad","doi":"10.1016/j.apmt.2024.102359","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102359","url":null,"abstract":"The research on sustainable and efficient routes to produce valuable chemicals from renewable biomass has garnered considerable attention in recent years. Among these chemicals, 5-hydroxymethylfurfural (5-HMF) holds significant promise as a versatile platform molecule for various applications in the chemical industry. This study investigates the production of 5-HMF from glucose using zirconium-based metal-organic frameworks (Zr-MOFs) as environmentally friendly catalysts, an alternative to the traditional homogeneous catalysts. UiO-66 and its functionalized derivatives (e.g. UiO-66UiO-66, and UiO-66) were synthesized to study the effect of the functional groups on the dehydration reaction. The synthesized MOFs were fully characterized using powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), N adsorption-desorption, Infrared spectroscopy (IR), Pyridine-Fourier Transform Infrared spectroscopy (Py-FTIR), and scanning electron microscopy (SEM). The catalytic performance of the synthesized MOFswas evaluated for the dehydration of glucose to 5-HMF in DMSO and further optimized in other monophasic and biphasic systems. Results indicated that UiO-66 exhibited exceptional catalytic activity for the conversion of glucose to HMF, with a significantly higher HMF yield of 44 % compared to other reported MOF catalysts and to that of HSO, which yielded 35 % at a temperature of 140 °C and a 6 h reaction time. This is mainly attributed to the effect of the bifunctional active acid sites of the metal nodes and the functional group of the organic linker (free carboxylic groups), which acted as the main source of Lewis and Brønsted acid sites respectively, compared to UiO-66. Additionally, the results suggested that the catalyst with higher acid density, higher relative mesopority, and a moderate B/L ratio could enhance glucose dehydration regardless of the surface area. Furthermore, the catalyst demonstrated excellent reusability and stability, with a decrease of only 10 % after four reaction cycles. The recycled catalyst revealed no structural alterations in its framework. This study contributes to the growing body of research on Zr-based MOF as a stable and efficient catalyst for glucose valorization to produce 5-HMF under mild reaction conditions.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"51 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of cantharidin/baicalin co-delivery system based on mitochondrial targeting strategy for enhanced hepatocellular carcinoma therapy","authors":"Li Huang, Zhonglan Yang, Yuan He, Lei Yang, Wangzhong Xiao, Jialuo Cai, Hongqiao Fan, Yilin Xu, Xinhua Xia","doi":"10.1016/j.apmt.2024.102374","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102374","url":null,"abstract":"Cantharidin (CTD) as a treatment for primary liver cancer are well known, and although structural alteration and nano-delivery are efficient in diminishing toxicity, its urinary and digestive toxicity has hindered its clinical application. Based on the synergistic effect of CTD and baicalin (BA) on proliferation inhibition of liver tumor cells, the highly expressed folic acid (FA) receptor of liver cancer cell membrane and the high negative membrane potential of tumor cell mitochondria, we synthesized CHEMS-FRFK and prepared a dual-ligand modified co-delivery liposomes (FA/FRFK-CTD/BA-Lips). Liposomes were spherical particles with uniform particle size, high encapsulation rate, good stability and no hemolysis. The results confirmed that FA/FRFK-CTD/BA-Lips had good targeting to mitochondria of tumor cells, and its target effect on mitochondria of HepG2 was better than that of Huh-7 cells. Compared with CTD, the cytotoxicity of liposomes on HepG2 is 7.0 times higher, while the cytotoxic effect on normal liver cells Thle-2 is 2.1 times lower. It may be related to increasing clathrin-mediated endocytosis, inhibiting tumor cell migration, arresting cell cycle in G1/G0 phase, and promoting mitochondria-mediated endogenous Bcl-2/Caspase 3 apoptosis pathway. Meanwhile, FA/FRFK-CTD/BA-Lips could alter the pharmacokinetic behavior of CTD and BA by increasing concentrations , slowing release and excretion, good anti-tumor with no obvious toxicity, and successfully delivered CTD/BA to liver tissue, tumor cells and mitochondria. Therefore, FA/FRFK-CTD/BA-Lips, as a delivery system targeting the mitochondria of liver cancer cells, has promising development potential, and could provide a new strategy for solving the problem of CTD toxicity and the treatment of hepatocellular carcinoma.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"302 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wastewater treatment using Metal-Organic Frameworks (MOFs)","authors":"Muhammad Husnain Manzoor, Namisa Naz, Syyeda Maimoona Ghayyoor Naqvi, Shumaila Ashraf, Muhammad Zain Ashiq, Francis Verpoort","doi":"10.1016/j.apmt.2024.102358","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102358","url":null,"abstract":"Water is an indispensable element for all forms of life, constituting a defining characteristic of our planet and the human body. The presence of hazardous contaminants, including emerging contaminants, heavy metal ions, and organic dyes, poses a significant threat to water supplies due to their acute toxicity and carcinogenic properties. Presently, researchers are channeling considerable efforts toward developing novel techniques, improving existing methods, and providing enduring ecologically friendly solutions to address water pollution challenges. Consequently, there is a pressing need to transform wastewater into a valuable water resource, emphasizing the imperative of optimal reuse. Metal-organic frameworks (MOFs) represent intricate structures comprising metal ions or clusters intricately linked by organic connectors, forming one or more dimensions. Numerous MOFs have demonstrated efficacy in wastewater treatment due to their expansive surface area, crystalline structure, substantial pore size, and tunability. This comprehensive review aims to delve into the synthesis, structure, classification, and properties of MOFs. Furthermore, it explores diverse applications and meticulously examines factors influencing adsorption. Finally, a thorough discussion is provided regarding the current challenges and future prospects associated with utilizing MOFs in water treatment processes.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"27 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4D printing thermo-magneto-responsive PETG-Fe3O4 nanocomposites with enhanced shape memory effects","authors":"Davood Rahmatabadi, Kiandokht Mirasadi, Abbas Bayati, Mahdi Khajepour, Ismaeil Ghasemi, Majid Baniassadi, Karen Abrinia, Mahdi Bodaghi, Mostafa Baghani","doi":"10.1016/j.apmt.2024.102361","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102361","url":null,"abstract":"In this groundbreaking study, Polyethylene Terephthalate Glycol (PETG)-FeO nanocomposites were developed for 4D printing, incorporating iron oxide (FeO) nanoparticles into PETG matrix. The research contribution lies in its innovative approach to enhancing the shape memory effect (SME) through thermo-magnetic responsiveness, positioning PETG-FeO as a revolutionary material in smart additive manufacturing. The composites were synthesized using a melt mixing method, followed by 3D printing into specimens for comprehensive evaluation through dynamic mechanical thermal analysis (DMTA), scanning electron microscopy (SEM), and uniaxial tensile tests. The findings revealed that the incorporation of FeO nanoparticles significantly boosts the composites’ storage modulus and glass transition temperature, indicative of improved stiffness and thermal properties. Notably, the 15 % FeO composite emerged as the optimal blend, exhibiting the highest tensile strength and a favourable balance between mechanical integrity and flexibility. A key result was the enhanced SME under both thermal and magnetic stimuli, with recovery efficiency and speed escalating with nanoparticle concentration. This advancement underscores the potential of PETG-FeO nanocomposites in fabricating smart structures capable of environmental adaptability, paving the way for impacts in biomedical, aerospace, and robotic devices. Through this work, a new paradigm in material functionality for 4D printing has been established, demonstrating the viability of magnetic nanoparticle integration for added smart capabilities.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"17 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vat photopolymerization of silica reinforced styrene-butadiene rubber elastomeric nanocomposites","authors":"Yiqun Fu, Zhen Shi, Keyton D. Feller, Michael D. Schulz, Timothy E. Long, Christopher B. Williams","doi":"10.1016/j.apmt.2024.102370","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102370","url":null,"abstract":"Compared to their unfilled counterparts, elastomeric nanocomposites offer tailorable combinations of properties, including improved mechanical properties, increased durability, and enhanced thermal and electrical conductivity. However, the high viscosity caused by the presence of both the high molecular weight elastomer and the inclusion of fillers complicates additive manufacturing (AM) of elastomeric nanocomposites. This is especially challenging in vat photopolymerization (VP) AM, which requires resins that possess low viscosity (< 10 Pa·s) and exhibit sufficient storage modulus (∼ 10 Pa) when photocured. To address this process limitation, the authors have previously demonstrated decoupling the relationship between viscosity and molecular weight via VP of a photocurable composite latex resin. In this approach, a photocurable matrix is photocured as a scaffold around the latex particles, which provides sufficient modulus for the printed \"green\" part. Following a dehydration post-processing step, the latex particles coalesce to provide the final elastomeric mechanical properties without compromising feature resolution.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"15 Suppl 1 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disulfide bond-based oxidation-responsive triptolide-loaded nanodrug for inflammation-targeted treatment of collagen-induced arthritis","authors":"Huahui Zeng, Man Li, Zhirong Wang, Tianqi Wang, Zhenqiang Zhang, Xiangxiang Wu","doi":"10.1016/j.apmt.2024.102350","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102350","url":null,"abstract":"M1 macrophages play a crucial role in the development of rheumatoid arthritis (RA), which can produce various inflammation cytokines, and reactive oxygen species (ROS). Disulfide bonds as reduction-responsive linkages have been extensively employed in the drug delivery systems. However, disulfide bonds are rarely reported in the development of the oxidation-responsive drug carriers. Herein, we designed and synthetized novel oxidation-responsive drug carriers based on disulfide bonds, and further developed nanoparticles (FA-TP@NPs) by self-assembly for the RA treatment. FA-TP@NPs was decorated with folic acid and loaded with triptolide (TP), a potent anti-inflammation Chinese medicine, to target and enter M1 macrophages through the folate receptor on the cytomembrane for simultaneous repolarization of the M2 macrophage and elimination of the M1 macrophage. As expected, FA-TP@NPs exhibited an oxidation-responsive TP release via disulfide-bond oxidation and ester-bond hydrolysis in the presence of intracellular ROS, which accumulated preferentially in inflamed joints. FA-TP@NPs exerted a potent anti-arthritic effect with high biosafety in CIA mice, as evidenced by repolarizing M2 macrophages, inducing M1 macrophage apoptosis, and reducing TNF-α, IL-6, and IL-1β expression. This work shows that FA-TP@NPs give a deep insight into disulfide bond-based oxidation-responsive drug delivery systems, and provide a potential platform for RA treatment.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"4 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of 3D printing technology in tumor radiotherapy in the era of precision medicine","authors":"Chao Jiang, Zhiwei Jiang, Shuxin Dai, Dengxiong Li, Ruicheng Wu, Jie Wang, Qingxin Yu, Luxia Ye, Fanglin Shao, Zhipeng Wang, Koo Han Yoo, Yubo Yang, Mang Ke, William C. Cho, Wuran Wei, Zhouting Tuo, Dechao Feng","doi":"10.1016/j.apmt.2024.102368","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102368","url":null,"abstract":"Three-dimensional (3D) printing technology is a new technology based on computer 3D digital imaging and multi-level continuous printing. From the initial field of construction manufacturing, it has gradually developed into the field of biology and medicine. Currently, 3D printing is widely utilized in orthopedics, dentistry, and other medical disciplines, and is gaining increasing attention in tumor radiotherapy. As a key cancer treatment, the trend towards precision and personalization in radiotherapy aligns perfectly with the capabilities of 3D printing. This innovative technology enables the creation of highly personalized treatment plans through the production of patient-specific anatomical models, radiation boluses, and implantable devices. It facilitates accurate visualization of complex tumor geometries, allowing for precise targeting and dose distribution. Additionally, 3D printing enhances the customization of radiotherapy accessories, improving radiation delivery conformity and minimizing exposure to surrounding healthy tissues. This review highlights the current advancements, applications, and future prospects of 3D printing in tumor radiotherapy, emphasizing its potential to enhance treatment efficacy and patient outcomes.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"35 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed multicolor Prussian blue-viologen hybrid electrochromic devices: Toward high contrast ratio and fast switching electrochromic devices","authors":"Le Huy Thai, Le Thi Thanh Nhi, Truong Chau Giang, Nguyen Minh Hiep, Truong Quang Trung, Tran Quang Hung, Le Hoang Sinh","doi":"10.1016/j.apmt.2024.102369","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102369","url":null,"abstract":"A new 3D printed multicolor Prussian blue-viologen inorganic-organic hybrid electrochromic device was successfully developed using digital light processing. Photocurable 1-(2 cyanophenyl)-1′-(2-hydroxyethyl)-[4,4′-bipyridine]-1,1′-diium (CPHEV)-based ionogel was printed on ITO glass as an electrochromic layer. The thin film of Prussian blue (PB) was electrodeposited on another ITO glass as an ion storage layer. With PB thin film, the ECDs exhibited a bleaching time 330 times faster than that of ECDs without PB. The ECD showed excellent electrochromic performance with a high color contrast ratio of 93.4 % at -2.5 V with a pulse width of 5 s. Moreover, the ECDs also exhibited multi-coloration in L*a*b* color space with the highest different color points (ΔE*) value of 75.2 between the bleaching state and coloring state. A high coloration efficiency of the ECD was obtained at 296 cm C corresponding to 60 % of a full optical switch at -2.5 V. The 3D printed ECD was successfully demonstrated using digital light processing (DLP) with high dimensional accuracy and resolution.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"128 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}