Transition Metal Chemistry最新文献

{"title":"Effect of ore characteristics on the extraction recovery of gold in the Carbon in Leach (CIL): geometallurgical approach on gold processing","authors":"Ni’matul Azizah Raharjanti,&nbsp;Felix Arie Setiawan,&nbsp;Kris Tri Basuki,&nbsp;Moch Setyadji,&nbsp;Fika Rofiek,&nbsp;Gyan Prameswara,&nbsp;I. Wayan Warmada,&nbsp;Himawan Tri Bayu Murti Petrus","doi":"10.1007/s11243-026-00725-2","DOIUrl":"10.1007/s11243-026-00725-2","url":null,"abstract":"<div>\u0000 \u0000 <p>Gold mineralization in low-sulfidation epithermal systems is strongly controlled by vein-hosted quartz mineralization and associated hydrothermal alterations. This study evaluates the mineralogical and geometallurgical characteristics of ore samples using petrographic analysis, ore microscopy, X-ray diffraction (XRD), and analytical spectral device (ASD), with gold recovery assessed through carbon-in-leach (CIL) testing. The ores are characterized by low sulfide contents (&lt; 5%), dominated by pyrite with minor sphalerite, where visible gold was absent due to its submicroscopic nature. CIL testing on 49 samples (25 veins, 24 wallrocks) yielded average recoveries of 79.94% in quartz veins (range 56.53–95.44%) and a broad range of 27.42–94.64% in wallrock samples. Vein-hosted ores contained up to 6.11 ppm Au compared to ≤ 1.64 ppm in wallrock. Recovery efficiency varied systematically with alteration type: Type I (well-crystallized kaolinite) exhibited the lowest recoveries (&lt; 50%), Type II (poorly crystalline kaolinite–smectite) achieved higher values (60–90%), and Type III (chlorite–kaolinite assemblages) showed wide variability (30–80%). Geochemical analysis demonstrated that sulfur content, primarily from pyrite, negatively correlated with recovery (<i>r</i> = − 0.763; R² = 58.3%), whereas Au grade exerted a strong positive influence on CIL recovery in vein samples (<i>r</i> = 0.94; R² = 88.3%). These findings underscore the critical roles of clay mineralogy and sulfide abundance in governing CIL performance and highlight the necessity of detailed geometallurgical characterization to optimize processing strategies in epithermal gold systems.</p>\u0000 </div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pentacoordinate Co(II) complex based on bulky tridentate and bidentate ligands with field-supported slow magnetic relaxation","authors":"Marek Szabó Dózsa,&nbsp;Richard Smolko,&nbsp;Erika Samoľová,&nbsp;Erik Čižmár,&nbsp;Juraj Černák","doi":"10.1007/s11243-026-00723-4","DOIUrl":"10.1007/s11243-026-00723-4","url":null,"abstract":"<div><p>Reaction of cobalt(II) acetate with neocuproine (<i>neoc</i>, 2,9-dimethyl-1,10-phenantroline) and Schiff base H₂(<i>samphe</i>) (Schiff base formed by condensation of salicylaldehyde with 2-amino-4-methylphenol) afforded complex [Co(<i>neoc</i>)(<i>samphe</i>)] (<b>1</b>) which was chemically and spectroscopically characterized. Crystal structure of <b>1</b> is composed of neutral complex molecules in which the Co(II) atom is pentacoordinated and its coordination sphere is formed by one chelating <i>neoc</i> ligand and one tridentate dianionic chelating ligand <i>samphe</i>^2- (ONO-donor). Calculated <i>τ</i>_<i>5</i> value of 0.435 indicates that the coordination polyhedron can be viewed as an intermediate shape between a square pyramid and a trigonal bipyramid. The complex <b>1</b> displays enhanced thermal stability up to 330 °C. The magnetic study of <b>1</b> has shown that Co(II) is in a high-spin state <i>S</i> = 3/2 and exhibits easy-axis magnetic anisotropy with parameters <i>D</i> = -48.7 cm^-1 and <i>E/D</i> = 0.166. The AC magnetic study indicates the presence of field-supported slow magnetic relaxation with a maximum of the imaginary component above 10 kHz. The results of the magnetic study are supported by theoretical calculations.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11243-026-00723-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platinum(II) complexes with a dipyridyl-benzimidazolylidene ligand: synthesis and structure of a diplatinamacrocycle featuring intramolecular Pt(II)···Pt(II) and π–π interactions","authors":"Jamal Moussa,&nbsp;Lise-Marie Chamoreau","doi":"10.1007/s11243-026-00716-3","DOIUrl":"10.1007/s11243-026-00716-3","url":null,"abstract":"<div><p>A novel NHC-mercury(II) transmetallating reagent [Hg(<b>L</b>)₂][BF₄]₂ (<b>3</b>), obtained from the proligand <b>L·HBF</b>_<b>4</b> (<b>1</b>), lead upon reaction with [Pt(Cl)₂(cod)] to a novel platinum(II) diplatinamacrocycle of molecular formulae {[Pt(Cl)(<b>L</b>)][BF₄]}₂ (<b>4</b>) which structure was ascertained by single-crystal X-ray diffraction analysis. Oxidative addition of the C-H bond of the benzimidazolium moiety of the proligand <b>L·HBF</b>_<b>4</b> (<b>1</b>) to [Pt(PPh₃)₄] occurs upon heating. As a result, a mononuclear platinum(II) hydride complex formulated as <i>trans</i>-[Pt(H)<b>(L</b>)(PPh₃)₂]BF₄ <b>(5</b>) could be characterized but the hydride ligand proved easy to hydrolyse.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt(II) and zinc(II) anthrahydrazone complexes: synthesis, crystal structure, divergent anticancer and antibacterial activities","authors":"Chao Liu,&nbsp;Xue-bin Bi,&nbsp;Jia-yu Xu,&nbsp;Rui-xue Liu,&nbsp;Shu-feng Zhang","doi":"10.1007/s11243-026-00724-3","DOIUrl":"10.1007/s11243-026-00724-3","url":null,"abstract":"<div>\u0000 \u0000 <p>Two new metal complexes 9-AIH-Co and 9-AIH-Zn, were synthesized using (<i>Z</i>)-2-(2-(anthracen-9-ylmethylene)hydrazineyl)-4,5-dihydro-1<i>H</i>-imidazole (9-AIH) as the ligand and evaluated as anticancer agents. Their structures were determined by single-crystal X-ray diffraction, elemental analysis and mass spectroscopy. The 9-AIH ligand crystallized in acetate form within the <i>orthorhombic</i> crystal system with space group <i>P</i>na2₁. The cobalt complex, 9-AIH-Co, is a mononuclear complex with chloride counterions, adopting a tetrahedral coordination geometry and crystallizing in the monoclinic system with space group P2₁/n. Similarly, the zinc complex, 9-AIH-Zn, with acetate counterions, also exhibits a tetrahedral configuration but crystallizes in the monoclinic system with space group C2/c. Anticancer activity assays revealed that 9-AIH-Co demonstrated significant inhibitory effects against three representative tumor cell lines, MGC-803 (gastric cancer), SK-OV-3 (ovarian cancer), and HepG-2 (liver cancer), which were selected for their clinical relevance as models for prevalent and challenging solid tumors. The IC₅₀ values were 6.45 ± 0.78, 8.28 ± 0.80 and 8.87 ± 2.26 µM, respectively, showing superior activity compared to both the free ligand 9-AIH and the 9-AIH-Zn. In vitro antibacterial tests indicated that 9-AIH-Co possessed antimicrobial properties similar to those of 9-AIH against four common pathogenic bacteria, including <i>Bacillus subtilis</i>, with MIC values ranging from 3.9 to 7.8 µg/mL. Conversely, 9-AIH-Zn showed markedly diminished antibacterial effects, with the MIC value of 125 µg/mL. These findings collectively suggest that metal ions play a pivotal role in modulating the comprehensive biological activities of metal complexes. The coordination of imidazole with Co(II) synergistically enhances both anticancer and antibacterial activities, whereas Zn(II) appears more appropriate for developing complexes with lower cytotoxicity. This research provides fundamental insights into the metal-ion-specific behavior of anthrahydrazone complexes, highlighting cobalt coordination as a promising strategy for developing dual-functional metallodrugs.</p>\u0000 </div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of a V-substituted Lindqvist polyoxotungstate: physicochemical properties, spectroscopic analysis, Hirshfeld surface study, and DFT-computational modeling","authors":"Islem Meskini,&nbsp;Gassoumi Bouzid,&nbsp;Frédéric Capet,&nbsp;Brahim Ayed","doi":"10.1007/s11243-026-00718-1","DOIUrl":"10.1007/s11243-026-00718-1","url":null,"abstract":"<div><p>In this work, a V-substituted Lindqvist polyoxotungstate, (C₇H₁₁N₂)₄[V₂.₁₂W₃.₈₈O₁₉]•4 H₂O (1), was synthesized via a solution-based synthetic methodology and comprehensively characterized. The identification of the characteristic functional groups was achieved through infrared spectroscopy, revealing distinct vibrational absorption bands representative of the hybrid polyoxometalate structure. UV-visible absorption spectroscopy was employed to investigate the optical properties of the material. Furthermore, computational studies were conducted to assess the stability of the compound. The binding stability is enhanced by strong hydrogen bonding, van der Waals forces, and electrostatic interactions occurring within the three-dimensional (3D) supramolecular network formed between the vanadotungstate polyanion and the organic moieties, as demonstrated by single-crystal X-ray diffraction and Hirshfeld surface analysis. In addition, density functional theory (DFT) calculations were performed to gain further insights into the electronic structure and stability of the compound.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147341714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, and characterization of square planar nickel dithiolates","authors":"Mohammad El-khateeb,&nbsp;Phil Köhler,&nbsp;Wolfgang Weigand","doi":"10.1007/s11243-026-00717-2","DOIUrl":"10.1007/s11243-026-00717-2","url":null,"abstract":"<div>\u0000 \u0000 <p>This study aims to explore the synthesis and structural characterization of nickel dithiolato complexes derived from thiolato ligands and phosphine co-ligands, with a focus on understanding their formation pathways and geometrical features. Treatment of nickel(II) chloride with thiolato anions afforded the known hexakis[di(alkylthiolato)nickel [Ni(SR)₂]₆, where R = CH₂Ph (<b>1</b>) or CH₂CH₂Ph (<b>2</b>). Cluster <b>1</b> reacts with bis(diphenylphosphino)alkane ligands {dppa = bis(diphenylphosphino)ethane (dppe) and bis(diphenylphosphino)propane (dppp)} to yield the corresponding mononuclear nickel dithiolato complexes, (dppe)Ni(SCH₂Ph)₂ (<b>3</b>a) and (dppp)Ni(SCH₂Ph)₂ (<b>3b</b>). Alternatively, complexes <b>3a</b> and <b>3b</b> can also be synthesized directly by the reaction of (dppe/dppp)NiCl₂ with lithium thiolates (RSLi). Complexes <b>3</b> were characterized by a combination of spectroscopic techniques, including UV–Vis, IR, and multinuclear NMR (¹H, ³¹P{¹H}), in addition to elemental analysis. Single-crystal X-ray diffraction studies of complexes <b>2</b> and <b>3a</b> are presented.</p>\u0000 </div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147341092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and anticancer evaluation of platinum(II)-robustine complexes","authors":"Ju-Mei Zhang,&nbsp;Xiao-Zhen Qin,&nbsp;Fu-Liu Luo,&nbsp;Zhen Zhou,&nbsp;Ming-Xiong Tan,&nbsp;Chun-Jie Liang,&nbsp;Hong Liang,&nbsp;Qi-Pin Qin","doi":"10.1007/s11243-026-00720-7","DOIUrl":"10.1007/s11243-026-00720-7","url":null,"abstract":"<div><p>In this study, two Pt(II)–8-hydroxyquinoline derivatives, [Pt(Rob)(DMSO)Cl] (<b>RoPt</b>), and [Pt(Ah)(DMSO)Cl] (<b>AhPt</b>), incorporating robustine (H-Rob) and 5-amino-8-hydroxyquinoline (H-Ah), respectively, were synthesized and characterized. <b>RoPt</b> and <b>AhPt</b> exhibited antiproliferative effects in human cisplatin-resistant ovarian SK-OV-3/DDP (3SKD) and ovarian SK-OV-3 (3SK) cancer cells, with <b>RoPt</b> showing the strongest activity (IC₅₀ = 6.42 ± 0.21 μM) compared with cisplatin, cis-Pt(DMSO)₂Cl₂, <b>AhPt</b>, H-Rob, and H-Ah. Notably, <b>RoPt</b> and <b>AhPt</b> induced apoptosis in 3SKD cells by triggering mitophagy pathways and inhibiting ATP and mitochondrial respiratory chain complex I/IV (MiRCC-I/MiRCC-IV) production. In vivo, <b>RoPt</b> displayed marked tumor suppression (ca. 37.1%) without causing notable body weight loss or mortality in 3SK tumor-bearing mice. These findings highlight the Pt(II)-robustine derivatives <b>RoPt</b> and <b>AhPt</b> as promising antiproliferative agents warranting further investigation.</p><h3>Graphical abstract</h3><p>Complexes <b>RoPt</b> and <b>AhPt</b> exerted cell apoptosis via induction of mitophagy pathways, inhibition of ATP and mitochondrial respiratory chain production.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147341142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Action innovation: schiff base for trace Cu2+ ions detection and powerful antibacterial potential","authors":"Alaa Shafie,&nbsp;Mohammed Fareed Felemban,&nbsp;Faris J. Tayeb,&nbsp;Amal Adnan Ashour","doi":"10.1007/s11243-025-00698-8","DOIUrl":"10.1007/s11243-025-00698-8","url":null,"abstract":"<div><p>A novel Schiff base <b>SBA1</b>, was successfully synthesized and structurally characterized using UV-Vis, FTIR, and ¹H NMR spectroscopy. Its sensing capabilities were systematically investigated against a broad range of metal ions, including Cu²⁺, Co²⁺, Zn²⁺, Pb²⁺, Ag⁺, Cd²⁺, Mg²⁺, Ni²⁺, Ca²⁺, Fe³⁺, Mn²⁺, Hg²⁺, K⁺, and Na⁺. Among these, <b>SBA1</b> exhibited a highly selective and distinct colorimetric response toward Cu²⁺ ions, marked by a visible color change from yellow to colorless. Fluorescence studies further revealed a substantial enhancement in emission intensity upon Cu²⁺ binding, indicating strong interaction and excellent sensing performance. The sensor demonstrated impressive sensitivity, achieving a limit of detection (LOD) of 0.0031 ppm (0.049 µM) and a limit of quantification (LOQ) of 0.0096 ppm, enabling trace-level detection of Cu²⁺ ions in aqueous media. To evaluate its practical utility, the <b>SBA1</b> was tested in real environmental samples, including soil-extracted water, drinking water, lake water, river water, and pond water. Fluorescence titration with Cu²⁺-spiked samples showed outstanding recovery rates ranging from 91.0% to 102.0%, confirming the sensor reliability and accuracy in complex matrices. In addition to its sensing capabilities, the antibacterial potential of <b>SBA1</b> was also assessed against selected bacterial strains. The compound exhibited notable antibacterial activity, indicating its dual functionality as both a highly sensitive Cu²⁺ sensor and an effective antimicrobial agent. These findings position <b>SBA1</b> as a promising multifunctional material for environmental monitoring and biomedical applications.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147339933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two novel benzotriazole Cu(II) complexes: synthesis, structure and antidiabetic activity","authors":"Xia Wang,&nbsp;Han-Bing Li,&nbsp;Di Cheng,&nbsp;Meng-Meng Cao,&nbsp;Wen-Ke Yang,&nbsp;Tan-Peng Zhou","doi":"10.1007/s11243-025-00708-9","DOIUrl":"10.1007/s11243-025-00708-9","url":null,"abstract":"<div><p>Two novel benzotriazole Cu(II) complexes, [Cu(bmem)(CH₃O)Cl]_n (<b>1</b>) and [Cu(btmt)(H₂O)(SO₄)]₂ (<b>2</b>), were synthesized and characterized using 1-(benzotriazole-1-methyl)-1-(2-ethylimidazole) (bmem) and 1-(benzotriazole-1-methyl)-1-triazole (btmt) as ligands. X-ray single crystal diffraction analysis indicates that complex <b>1</b> forms a one-dimensional chain structure of a double-nuclear copper unit, while complex <b>2</b> forms a discrete binuclear copper unit. Their antidiabetic activities were thoroughly investigated. The antidiabetic activity assays demonstrated that both complexes exhibited inhibitory effects against α-amylase and α-glycosidase enzymes. Specifically, complex <b>1</b> showed IC₅₀ values of 2.92 × 10^− 3 M for α-amylase and 2.39 × 10^− 6 M for α-glycosidase, while complex <b>2</b> exhibited IC₅₀ values of 1.89 × 10^− 3 M and 1.63 × 10^− 6 M, respectively, with complex <b>2</b> displaying a stronger inhibitory effect overall. Furthermore, to evaluate the effects of complexes <b>1</b> and <b>2</b> on glucose metabolism, we treated insulin-resistant (IR) HepG2 cells with each complex. The results demonstrated that complexes <b>1</b> and <b>2</b> enhanced glucose uptake by 1.20-fold and 1.32-fold, respectively, compared to the untreated control.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147339945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel silver complexes bearing trans-cinnamaldehyde-derived thiosemicarbazones: synthesis, characterization, and effects against tumour cell lines","authors":"Ana Beatriz Lazzarini,&nbsp;Andresa Alves de Lima,&nbsp;Ana Maria Romão Polez,&nbsp;Pedro Henrique Sêneda Silveira,&nbsp;Renan Diego Zanetti,&nbsp;Angelica Ellen Graminha,&nbsp;José Clayston Melo Pereira,&nbsp;Mauro Almeida Lima,&nbsp;Fillipe Vieira Rocha,&nbsp;Renan Lira de Farias,&nbsp;Mariete Barbosa Moreira,&nbsp;Adelino Vieira de Godoy Netto,&nbsp;A. V. G. Netto","doi":"10.1007/s11243-025-00711-0","DOIUrl":"10.1007/s11243-025-00711-0","url":null,"abstract":"<div><p>Cancer represents a public health problem as well as an economic burden. Considering that cell resistance and side effects have limited the clinical use of anticancer platinum(II)-based chemotherapeutics, silver(I) compounds have appeared as potential candidates due to their multi-target mode of action and low toxicity in healthy cell lines. In this work, we report the synthesis, characterization and biological evaluation of new silver complexes [Ag(<i>R</i>-cTSC)(phen)]NO₃·H₂O, <b><i>R</i></b><b>-cTSC</b> = <i>trans</i>-cinnamaldehyde-<i>N</i>(4)-<i>R</i>-thiosemicarbazone (<i>R</i> = H (<b>C1</b>), methyl (<b>C2</b>), ethyl (<b>C3</b>), phenyl (<b>C4</b>)) and phen = 1,10-phenanthroline. Silver complexes <b>C1</b>-<b>C4</b> were tested against some tumour cell lines, with IC₅₀ values varying in the range of 1.6–4.4 µM (A2780cis), 5.4–23.3 µM (A549), and 6.5–15.9 µM (MCF-7). Results from cytotoxic evaluation and colony formation assay data indicated that <b>C3</b> exerted a good effect towards A2780cis (3.8 ± 0.3 µM), A549 (5.5 ± 0.1 µM) and MCF-7 (8.1 ± 0.7 µM) and displayed both cytotoxic and cytostatic effects against A2780cis cells at 1.1 µM. DNA binding studies showed that <b>C3</b> was able to release part of bound Hoechst 33258 from the minor groove and inhibited topoisomerase-IIα catalytic activity at low concentration (&gt; 1 µM). Additionally, in silico studies suggested interaction between the 1,10-phen moiety and topoisomerase-IIα Lys157 and Arg98 amino acid residues.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147339802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}