Annals of Gastroenterological Surgery最新文献

{"title":"Response to \"Sequential Portal Vein-Hepatic Vein Embolization: Progress Yet Unaccounted Pitfalls\".","authors":"Thanh Tung Lai, Masaki Kaibori","doi":"10.1002/ags3.70175","DOIUrl":"10.1002/ags3.70175","url":null,"abstract":"","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 2","pages":"631-632"},"PeriodicalIF":3.3,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Message From the New Editor-In-Chief: Advancing AGSurg Into a Leading International Surgical Journal","authors":"Ken Shirabe","doi":"10.1002/ags3.70151","DOIUrl":"https://doi.org/10.1002/ags3.70151","url":null,"abstract":"<p>Trends in the Impact Factor of <i>Annals of Gastroenterological Surgery (Ag Surg)</i>. <i>AGSurg</i> achieved an impressive first impact factor of 5.164 in 2021. Although the impact factor temporarily declined to 2.7, it has since recovered, reaching 3.3 last year.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"4-5"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgments","authors":"","doi":"10.1002/ags3.70154","DOIUrl":"https://doi.org/10.1002/ags3.70154","url":null,"abstract":"&lt;p&gt;The publication of invaluable papers in &lt;i&gt;Annals of Gastroenterological Surgery&lt;/i&gt; depends on the prompt, careful review of submitted manuscripts. We would like to thank the following experts for reviewing manuscripts submitted between December 1, 2024 and November 30, 2025.&lt;/p&gt;&lt;p&gt;Abe, Yuta&lt;/p&gt;&lt;p&gt;Aizawa, Masaki&lt;/p&gt;&lt;p&gt;Ajiki, Tetsuo&lt;/p&gt;&lt;p&gt;Akagi, Tomonori&lt;/p&gt;&lt;p&gt;Akamatsu, Nobuhisa&lt;/p&gt;&lt;p&gt;Akita, Hirofumi&lt;/p&gt;&lt;p&gt;Akiyama, Shintaro&lt;/p&gt;&lt;p&gt;Akiyoshi, Takashi&lt;/p&gt;&lt;p&gt;Ando, Koji&lt;/p&gt;&lt;p&gt;Aoki, Takeshi&lt;/p&gt;&lt;p&gt;Aoki, Taku&lt;/p&gt;&lt;p&gt;Aoyagi, Yasuko&lt;/p&gt;&lt;p&gt;Aoyama, Toru&lt;/p&gt;&lt;p&gt;Araki, Kenichiro&lt;/p&gt;&lt;p&gt;Arigami, Takaaki&lt;/p&gt;&lt;p&gt;Arima, Kota&lt;/p&gt;&lt;p&gt;Asai, Koji&lt;/p&gt;&lt;p&gt;Asano, Toshimichi&lt;/p&gt;&lt;p&gt;Baba, Kenji&lt;/p&gt;&lt;p&gt;Bekki, Yuki&lt;/p&gt;&lt;p&gt;Booka, Eisuke&lt;/p&gt;&lt;p&gt;Daiko, Hiroyuki&lt;/p&gt;&lt;p&gt;Ebata, Tomoki&lt;/p&gt;&lt;p&gt;Eguchi, Hidetoshi&lt;/p&gt;&lt;p&gt;Endo, Shungo&lt;/p&gt;&lt;p&gt;Eo, Wankyu&lt;/p&gt;&lt;p&gt;Etoh, Tsuyoshi&lt;/p&gt;&lt;p&gt;Fujio, Atsushi&lt;/p&gt;&lt;p&gt;Fujita, Fumihiko&lt;/p&gt;&lt;p&gt;Fujita, Takeo&lt;/p&gt;&lt;p&gt;Fujiyoshi, Kenji&lt;/p&gt;&lt;p&gt;Fukami, Yasuyuki&lt;/p&gt;&lt;p&gt;Fukui, Yudai&lt;/p&gt;&lt;p&gt;Fukushima, Ryoji&lt;/p&gt;&lt;p&gt;Furuhata, Tomohisa&lt;/p&gt;&lt;p&gt;Furukawa, Kenei&lt;/p&gt;&lt;p&gt;Fuse, Masahiro&lt;/p&gt;&lt;p&gt;Ganeko, Riki&lt;/p&gt;&lt;p&gt;Gohda, Yoshimasa&lt;/p&gt;&lt;p&gt;Goto, Toru&lt;/p&gt;&lt;p&gt;Hagi, Takaomi&lt;/p&gt;&lt;p&gt;Hamabe, Atsushi&lt;/p&gt;&lt;p&gt;Hamada, Madoka&lt;/p&gt;&lt;p&gt;Hanaoka, Marie&lt;/p&gt;&lt;p&gt;Harada, Kazuto&lt;/p&gt;&lt;p&gt;Harimoto, Norifumi&lt;/p&gt;&lt;p&gt;Haruki, Koichiro&lt;/p&gt;&lt;p&gt;Hasegawa, Kiyoshi&lt;/p&gt;&lt;p&gt;Hasegawa, Suguru&lt;/p&gt;&lt;p&gt;Hasegawa, Yasushi&lt;/p&gt;&lt;p&gt;Hashimoto, Daisuke&lt;/p&gt;&lt;p&gt;Hashimoto, Masashi&lt;/p&gt;&lt;p&gt;Hatano, Etsuro&lt;/p&gt;&lt;p&gt;Hayama, Tamuro&lt;/p&gt;&lt;p&gt;Hayami, Shinya&lt;/p&gt;&lt;p&gt;Hayano, Koichi&lt;/p&gt;&lt;p&gt;Hayashi, Hiromitsu&lt;/p&gt;&lt;p&gt;Hayata, Keiji&lt;/p&gt;&lt;p&gt;Hibi, Taizo&lt;/p&gt;&lt;p&gt;Hida, Koya&lt;/p&gt;&lt;p&gt;Hidaka, Masaaki&lt;/p&gt;&lt;p&gt;Hirano, Satoshi&lt;/p&gt;&lt;p&gt;Hirano, Yasumitsu&lt;/p&gt;&lt;p&gt;Hirashita, Teijiro&lt;/p&gt;&lt;p&gt;Hisaka, Toru&lt;/p&gt;&lt;p&gt;Hiyoshi, Yukiharu&lt;/p&gt;&lt;p&gt;Honda, Goro&lt;/p&gt;&lt;p&gt;Honda, Michitaka&lt;/p&gt;&lt;p&gt;Hosoda, Kei&lt;/p&gt;&lt;p&gt;Hu, Qingjiang&lt;/p&gt;&lt;p&gt;Ichikawa, Nobuki&lt;/p&gt;&lt;p&gt;Igaki, Takahiro&lt;/p&gt;&lt;p&gt;Ikenaga, Naoki&lt;/p&gt;&lt;p&gt;Ikeuchi, Hiroki&lt;/p&gt;&lt;p&gt;Ikoma, Hisashi&lt;/p&gt;&lt;p&gt;Imai, Katsunori&lt;/p&gt;&lt;p&gt;Inaki, Noriyuki&lt;/p&gt;&lt;p&gt;Inoue, Mikihiro&lt;/p&gt;&lt;p&gt;Inoue, Yosuke&lt;/p&gt;&lt;p&gt;Irino, Tomoyuki&lt;/p&gt;&lt;p&gt;Ishido, Keinosuke&lt;/p&gt;&lt;p&gt;Ishiyama, Yasuhiro&lt;/p&gt;&lt;p&gt;Ishizawa, Takeaki&lt;/p&gt;&lt;p&gt;Ishizuka, Mitsuru&lt;/p&gt;&lt;p&gt;Ito, Sono&lt;/p&gt;&lt;p&gt;Ito, Takashi&lt;/p&gt;&lt;p&gt;Itoh, Shinji&lt;/p&gt;&lt;p&gt;Iwashita, Yoshiaki&lt;/p&gt;&lt;p&gt;Jiang, Weizhong&lt;/p&gt;&lt;p&gt;Kagawa, Hiroyasu&lt;/p&gt;&lt;p&gt;Kagawa, Yoshinori&lt;/p&gt;&lt;p&gt;Kaibori, Masaki&lt;/p&gt;&lt;p&gt;Kaido, Toshimi&lt;/p&gt;&lt;p&gt;Kajiwara, Yoshiki&lt;/p&gt;&lt;p&gt;Kakisaka, Tatsuhiko&lt;/p&gt;&lt;p&gt;Kakiuchi, Nobuyuki&lt;/p&gt;&lt;p&gt;Kaku, Keizo&lt;/p&gt;&lt;p&gt;Kanaji, Shingo&lt;/p&gt;&lt;p&gt;Kanemitsu, Yukihide&lt;/p&gt;&lt;p&gt;Kanetaka, Kengo&lt;/p&gt;&lt;p&gt;Kasai, Shunsuke&lt;/p&gt;&lt;p&gt;Kato, Yutaro&lt;/p&gt;&lt;p&gt;Kawaguchi, Yoshihiko&lt;/p&gt;&lt;p&gt;Kawai, Kazushige&lt;/p&gt;&lt;p&gt;Kawai, Manabu&lt;/p&gt;&lt;p&gt;Kawaida, Hiromichi&lt;/p&gt;&lt;p&gt;Kawamura, Junichiro&lt;/p&gt;&lt;p&gt;Kawamura, Mikio&lt;/p&gt;&lt;p&gt;Kawanaka, Hirofumi&lt;/p&gt;&lt;p&gt;Kawazoe, Tetsuro&lt;/p&gt;&lt;p&gt;Kikuchi, Hirotoshi&lt;/p&gt;&lt;p&gt;Kimura, Yasutoshi&lt;/p&gt;&lt;p&gt;Kimura, Yutaka&lt;/p&gt;&lt;p&gt;Kinoshita, Takahiro&lt;/p&gt;&lt;p&gt;Kishi, Yoji&lt;/p&gt;&lt;p&gt;Kishino, Takayoshi&lt;/p&gt;&lt;p&gt;Kitago, Minoru&lt;/p&gt;&lt;p&gt;Kitahata, Yuji&lt;/p&gt;&lt;p&gt;Kitami, Chie&lt;/p&gt;&lt;p&gt;Kitano, Shoichi&lt;/p&gt;&lt;p&gt;Kobayashi, Hirotoshi&lt;/p&gt;&lt;p&gt;Kobayashi, Shogo&lt;/p&gt;&lt;p&gt;Kobayashi, Tsuyoshi&lt;/p&gt;&lt;p&gt;Koike, Yuhki&lt;/p&gt;&lt;p&gt;Komatsu, Shoh","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"288-290"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential Portal Vein-Hepatic Vein Embolization: Progress Yet Unaccounted Pitfalls.","authors":"Syeda Rabiah Shahid, Ahmad Furqan Anjum","doi":"10.1002/ags3.70148","DOIUrl":"10.1002/ags3.70148","url":null,"abstract":"","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 2","pages":"633-634"},"PeriodicalIF":3.3,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Laparoscopic and Endoscopic Cooperative Surgery for Gastric Cancer as an Alternative Treatment in Elderly Patients: A Prospective Observational Study\".","authors":"Shyam Sundar Sah, Abhishek Kumbhalwar","doi":"10.1002/ags3.70143","DOIUrl":"10.1002/ags3.70143","url":null,"abstract":"","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 2","pages":"629-630"},"PeriodicalIF":3.3,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Evaluation of Bladder Perfusion Using Indocyanine Green Fluorescence Imaging During Total Pelvic Exenteration After Interruption of Blood Flow From the Internal Iliac Vessels.","authors":"Mamoru Uemura, Chikako Kusunoki, Mao Osaki, Hiroshi Kusafuka, Satoshi Higuchi, Yuki Sekido, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Koji Munakata, Hirofumi Ota, Yuichiro Doki, Hidetoshi Eguchi","doi":"10.1002/ags3.70131","DOIUrl":"10.1002/ags3.70131","url":null,"abstract":"<p><strong>Background: </strong>In lateral lymph node dissection (LLND) for locally advanced or recurrent rectal cancer, concomitant resection of the internal iliac vessels is sometimes required. Because the bladder receives its primary blood supply from branches of the internal iliac artery, concerns arise regarding bladder perfusion when these vessels are resected. However, the extent to which bladder perfusion depends on the internal iliac system remains unclear.</p><p><strong>Methods: </strong>Between 2020 and 2023, 25 patients with locally advanced or recurrent rectal cancer who underwent total pelvic exenteration (TPE) with bilateral LLND were prospectively enrolled. After division of all ventral branches of the internal iliac vessels, including the umbilical, obturator, and vesical vessels, bladder perfusion was evaluated intraoperatively using indocyanine green (ICG) fluorescence imaging. Time to visualization of bladder perfusion was recorded.</p><p><strong>Results: </strong>Bladder perfusion was successfully visualized in all patients without complications. Median time to visualization was 30 s (interquartile range, 20-50). Perfusion originated exclusively from the pubic side, and fluorescence of the entire bladder wall was confirmed after mobilization. Patients were classified into early (≤ 30 s) and delayed (> 30 s) visualization groups. Older age was significantly associated with delayed visualization (<i>p</i> = 0.044), whereas no other clinical or surgical factors showed associations.</p><p><strong>Conclusions: </strong>Bladder perfusion was maintained even after complete interruption of both arterial supply and venous drainage from the internal iliac vessels, owing to blood supply from the pubic side. These findings support the safety of internal iliac vessel resection during extended LLND in rectal cancer surgery.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 2","pages":"543-547"},"PeriodicalIF":3.3,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Pancreas-Sparing Total Duodenectomy for Severe Duodenal Polyposis in Patients With Familial Adenomatous Polyposis.","authors":"Takehiro Shiraishi, Hideyuki Ishida, Takatoshi Matsuyama, Noriyasu Chika, Yoshiko Mori, Norimichi Chiyonobu, Youichi Kumagai, Ibuki Fujinuma, Toshiro Ogura","doi":"10.1002/ags3.70125","DOIUrl":"10.1002/ags3.70125","url":null,"abstract":"<p><strong>Aim: </strong>Spigelman stage IV duodenal polyposis (SP-stage IV DP) is associated with high duodenal cancer risk in patients with familial adenomatous polyposis (FAP). This study evaluated the surgical and oncological outcomes of pancreas-sparing total duodenectomy (PSTD) as a surgical prophylaxis for severe duodenal polyposis in FAP.</p><p><strong>Methods: </strong>Medical records were reviewed to evaluate factors concerning short- and long-term clinical and oncological outcomes in consecutive patients with FAP who underwent PSTD for SP-stage IV DP.</p><p><strong>Results: </strong>There were twenty-seven patients (median age: 48 years) from 26 families, of whom 12 were female. Clavien-Dindo grade IIIa/IIIb complications included delayed gastric emptying (<i>n</i> = 14) and pancreatic fistula (<i>n</i> = 10); no mortalities were observed. Histopathological examinations revealed no malignant neoplasms deeper than T1a in the duodenum and ampulla. Follow-up (median 6.4 years) revealed anastomotic stricture of the reconstructed neo-common channel (<i>n</i> = 5), anastomotic ulcer of the gastrojejunostomy site (<i>n</i> = 5), acute pancreatitis (<i>n</i> = 4), and acute cholangitis (<i>n</i> = 2), all of which were successfully treated endoscopically or conservatively. Malignant neoplasms after PSTD included gastric cancer (<i>n</i> = 3), remnant ano-rectal cancer (<i>n</i> = 3), ileal cancer (<i>n</i> = 1), ileal pouch cancer (<i>n</i> = 1), and endometrial cancer (<i>n</i> = 1). The cumulative 10-year survival rate following PSTD was 87.4%.</p><p><strong>Conclusions: </strong>PSTD for the prophylactic management of SP-stage IV DP was associated with notable but manageable postoperative morbidity. Long-term surveillance remains essential for the development of extraduodenal malignancies to confirm the oncological efficacy of this type of surgery.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 2","pages":"534-542"},"PeriodicalIF":3.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in Pancreatoduodenectomy Volume at Mid-Volume Facilities in the United States: A National Cancer Database Analysis.","authors":"Koichi Tomita, Naruhiko Ikoma","doi":"10.1002/ags3.70129","DOIUrl":"10.1002/ags3.70129","url":null,"abstract":"<p><strong>Background: </strong>The annual number of pancreatoduodenectomies (PDs) in the United States has increased over the past decade, but the facility types driving this growth and whether outcomes have improved remain unclear. We aimed to identify characteristics of facilities with increasing PD volumes and assess national trends in centralization.</p><p><strong>Materials and methods: </strong>We queried the National Cancer Database to identify PD cases from 2011 to 2020. We categorized facilities by average annual PD volume (low [< 5 cases/year], medium [5-19], and high [≥ 20]) and compared changes in surgical outcomes and other factors over time across facility categories. We used logistic regression to identify factors associated with increasing annual PD volume.</p><p><strong>Results: </strong>We identified 41 147 PD cases from 810 facilities (589 low-, 171 medium-, 50 high-volume). Overall, the annual PD volume rose from 3217 in 2011 to 4355 in 2020. The increase was primarily due to medium-volume facilities, which performed 903 more cases in 2020 than in 2011 (a 71% increase). Surgical outcomes improved over time across all facility categories, but outcomes at low- and medium-volume facilities remained inferior to those at high-volume facilities. Among medium-volume facilities, the adoption of minimally invasive PD and a higher proportion of PDs for advanced-stage disease were associated with increasing volume.</p><p><strong>Conclusion: </strong>Medium-volume facilities accounted for most of the recent growth in PD volume in the United States but continued to demonstrate less favorable outcomes than high-volume centers. These findings underscore the importance of continued efforts to promote the outcome-driven centralization of PD to improve surgical outcomes.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 2","pages":"578-590"},"PeriodicalIF":3.3,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Letter to the Editor Regarding Prognostic Impact of Hepatectomy Versus Radiofrequency Ablation for Non-Small Hepatocellular Carcinoma (2-3 cm): A Case-Matched Study\".","authors":"Yuki Kitano, Hiromitsu Hayashi, Takumi Tanizaki, Yoshiyuki Tagayasu, Takashi Matsumoto, Rumi Itoyama, Shigeki Nakagawa, Hirohisa Okabe, Masaaki Iwatsuki","doi":"10.1002/ags3.70126","DOIUrl":"10.1002/ags3.70126","url":null,"abstract":"","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 2","pages":"625-626"},"PeriodicalIF":3.3,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumoral <i>Fusobacterium nucleatum</i> Drives Cancer-Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma.","authors":"Takashi Ofuchi, Qingjiang Hu, Kazuki Omachi, Kosuke Kanemitsu, Hajime Otsu, Yusuke Yonemura, Taro Tobo, Yoshifumi Baba, Masaaki Iwatsuki, Koshi Mimori","doi":"10.1002/ags3.70116","DOIUrl":"10.1002/ags3.70116","url":null,"abstract":"<p><strong>Background: </strong><i>Fusobacterium nucleatum</i>, an oral commensal bacterium, has been increasingly recognized for its oncogenic role in gastrointestinal malignancies. In esophageal squamous cell carcinoma (ESCC), <i>F. nucleatum</i> has been implicated in promoting tumor progression and facilitating immune evasion. However, its relationship with stromal remodeling and the tumor microenvironment (TME) remains unclear.</p><p><strong>Methods: </strong>We performed integrative analyses using metagenomic profiling and transcriptomic deconvolution, and histopathological assessment of 93 The Cancer Genome Atlas (TCGA)-ESCC cases and an independent cohort of 126 resected tumors. <i>F. nucleatum</i> status was determined by microbial abundance and quantitative Polymerase Chain Reaction (q-PCR).</p><p><strong>Results: </strong><i>F. nucleatum</i>-positive tumors showed significant enrichment of TNFα/NF-κB signaling and reduced CD8⁺ T cell infiltration. Stromal analysis revealed a marked increase in cancer-associated fibroblasts (CAFs) in <i>F. nucleatum</i>-positive tumors, confirmed by transcriptomic deconvolution and α-SMA immunohistochemistry. Notably, immunohistochemical analysis demonstrated increased nuclear localization of NF-κB p65, indicating <i>F. nucleatum</i>-induced NF-κB activation in tumor cells. Clinically, among elderly patients with poor performance status, the prevalence of <i>F. nucleatum</i> positivity was significantly higher.</p><p><strong>Conclusion: </strong><i>F. nucleatum</i> may contribute to the progression of ESCC by inducing NF-κB-mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, <i>F. nucleatum</i> positivity may reflect broader host vulnerability, particularly in frail elderly individuals. These findings highlight <i>F. nucleatum</i> as a potential biomarker of tumor immune dynamics and suggest the importance of maintaining good oral hygiene to reduce <i>F. nucleatum</i> colonization.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 2","pages":"611-620"},"PeriodicalIF":3.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}