Annals of Gastroenterological Surgery最新文献

{"title":"Clinical impact of low fornix perfusion on devascularized whole stomach as a risk factor for anastomotic leakage after esophagectomy","authors":"Keita Takahashi,&nbsp;Masami Yuda,&nbsp;Yoshitaka Ishikawa,&nbsp;Takahiro Masuda,&nbsp;Takanori Kurogochi,&nbsp;Naoko Fukushima,&nbsp;Akira Matsumoto,&nbsp;Kazuto Tsuboi,&nbsp;Katsunori Nishikawa,&nbsp;Fumiaki Yano,&nbsp;Ken Eto","doi":"10.1002/ags3.12905","DOIUrl":"https://doi.org/10.1002/ags3.12905","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Backgrounds</h3>\u0000 \u0000 <p>We previously reported poor vascularity of narrow gastric tube evaluated by thermography was associated with anastomotic leakage (AL) after esophagectomy. Meanwhile, the association between the fornix low perfusion on devascularized whole stomach (DWS) and the incidence of AL remains unclear. Therefore, this study aimed to clarify the impact of the fornix low perfusion on DWS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 238 patients who underwent Mckeown esophagectomy with gastric tube reconstruction between 2008 and 2021 were analyzed. Patients were divided into non-AL and AL groups and their clinical outcomes including vascular factors of DWS and gastric tube were compared. Additionally, the logistic regression analysis was conducted to detect the risk factors of AL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>AL occurred in 31 patients (13.0%). Regarding vascular factors, avascular area temperature retain rate (Av-TRr) on DWS, right gastroepiploic artery length rate and anastomotic viability index (AVI) on gastric tube were significantly smaller in the AL group than in the non-AL group. In logistic regression model for AL, multivariate analysis showed that diabetes (Odds ratio [OR], 3.90; 95% confidence interval [CI], 1.32–11.60), hand-sewn anastomosis (OR, 4.42;95% CI, 1.05–18.60), Av-TRr on DWS&lt;0.91 (OR, 4.67; 95% CI, 2.00–10.90), and AVI&lt;0.64 (OR, 2.68; 95% CI, 1.12–6.39) were significant risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Fornix low perfusion on DWS was a risk factor of AL as well as low AVI on gastric conduit. Additionally, fornix low perfusion on DWS was correlated with low AVI on gastric conduit.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 2","pages":"226-234"},"PeriodicalIF":2.9,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12905","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgments","authors":"","doi":"10.1002/ags3.12899","DOIUrl":"10.1002/ags3.12899","url":null,"abstract":"&lt;p&gt;The publication of invaluable papers in &lt;i&gt;Annals of Gastroenterological Surgery&lt;/i&gt; depends on the prompt, careful review of submitted manuscripts. We would like to thank the following experts for reviewing manuscripts submitted between December 1, 2023 and November 30, 2024.&lt;/p&gt;&lt;p&gt;Reviewer Full Name&lt;/p&gt;&lt;p&gt;Abe, Tatsuya&lt;/p&gt;&lt;p&gt;Abe, Yuta&lt;/p&gt;&lt;p&gt;Aizawa, Masaki&lt;/p&gt;&lt;p&gt;Ajiki, Tetsuo&lt;/p&gt;&lt;p&gt;Akahoshi, Keiichi&lt;/p&gt;&lt;p&gt;Akamatsu, Nobuhisa&lt;/p&gt;&lt;p&gt;Akita, Hirofumi&lt;/p&gt;&lt;p&gt;Akiyoshi, Takashi&lt;/p&gt;&lt;p&gt;Aoki, Takeshi&lt;/p&gt;&lt;p&gt;Aoki, Taku&lt;/p&gt;&lt;p&gt;Aoyama, Toru&lt;/p&gt;&lt;p&gt;Araki, Kenichiro&lt;/p&gt;&lt;p&gt;Arigami, Takaaki&lt;/p&gt;&lt;p&gt;Arita, Junichi&lt;/p&gt;&lt;p&gt;Baba, Kenji&lt;/p&gt;&lt;p&gt;Ban, Daisuke&lt;/p&gt;&lt;p&gt;Bekki, Yuki&lt;/p&gt;&lt;p&gt;Booka, Eisuke&lt;/p&gt;&lt;p&gt;Daiko, Hiroyuki&lt;/p&gt;&lt;p&gt;Ebata, Tomoki&lt;/p&gt;&lt;p&gt;Ebihara, Yuma&lt;/p&gt;&lt;p&gt;Eguchi, Hidetoshi&lt;/p&gt;&lt;p&gt;Etoh, Tsuyoshi&lt;/p&gt;&lt;p&gt;Fujimura, Takashi&lt;/p&gt;&lt;p&gt;Fujita, Fumihiko&lt;/p&gt;&lt;p&gt;Fujita, Takeo&lt;/p&gt;&lt;p&gt;Fukagawa, Takeo&lt;/p&gt;&lt;p&gt;Fukami, Yasuyuki&lt;/p&gt;&lt;p&gt;Fukushima, Ryoji&lt;/p&gt;&lt;p&gt;Ganeko, Riki&lt;/p&gt;&lt;p&gt;Hagi, Takaomi&lt;/p&gt;&lt;p&gt;Hamabe, Atsushi&lt;/p&gt;&lt;p&gt;Hanaoka, Marie&lt;/p&gt;&lt;p&gt;Harada, Kazuto&lt;/p&gt;&lt;p&gt;Harimoto, Norifumi&lt;/p&gt;&lt;p&gt;Haruki, Koichiro&lt;/p&gt;&lt;p&gt;Hasegawa, Kiyoshi&lt;/p&gt;&lt;p&gt;Hasegawa, Yasushi&lt;/p&gt;&lt;p&gt;Hashimoto, Daisuke&lt;/p&gt;&lt;p&gt;Hashimoto, Masashi&lt;/p&gt;&lt;p&gt;Hatano, Etsuro&lt;/p&gt;&lt;p&gt;Hayami, Shinya&lt;/p&gt;&lt;p&gt;Hayashi, Hiromitsu&lt;/p&gt;&lt;p&gt;Hibi, Taizo&lt;/p&gt;&lt;p&gt;Hida, Koya&lt;/p&gt;&lt;p&gt;Hidaka, Masaaki&lt;/p&gt;&lt;p&gt;Hijioka, Susumu&lt;/p&gt;&lt;p&gt;Hirano, Satoshi&lt;/p&gt;&lt;p&gt;Hirano, Yasumitsu&lt;/p&gt;&lt;p&gt;Hirashita, Teijiro&lt;/p&gt;&lt;p&gt;Hiyoshi, Yukiharu&lt;/p&gt;&lt;p&gt;Honda, Goro&lt;/p&gt;&lt;p&gt;Hosoda, Kei&lt;/p&gt;&lt;p&gt;Ichikawa, Nobuki&lt;/p&gt;&lt;p&gt;Iguchi, Tomohiro&lt;/p&gt;&lt;p&gt;Ikeda, Masataka&lt;/p&gt;&lt;p&gt;Ikeda, Satoshi&lt;/p&gt;&lt;p&gt;Ikeuchi, Hiroki&lt;/p&gt;&lt;p&gt;Ikoma, Hisashi&lt;/p&gt;&lt;p&gt;Imamura, Yu&lt;/p&gt;&lt;p&gt;Inaki, Noriyuki&lt;/p&gt;&lt;p&gt;Inoue, Mikihiro&lt;/p&gt;&lt;p&gt;Iseda, Norifumi&lt;/p&gt;&lt;p&gt;Ishido, Keinosuke&lt;/p&gt;&lt;p&gt;Ishihara, Soichiro&lt;/p&gt;&lt;p&gt;Ishizawa, Takeaki&lt;/p&gt;&lt;p&gt;Ishizuka, Mitsuru&lt;/p&gt;&lt;p&gt;Itatani, Yoshiro&lt;/p&gt;&lt;p&gt;Ito, Takashi&lt;/p&gt;&lt;p&gt;Itoh, Shinji&lt;/p&gt;&lt;p&gt;Iwatsuki, Masaaki&lt;/p&gt;&lt;p&gt;Jiang, Xingming&lt;/p&gt;&lt;p&gt;Kagawa, Hiroyasu&lt;/p&gt;&lt;p&gt;Kagawa, Yoshinori&lt;/p&gt;&lt;p&gt;Kaibori, Masaki&lt;/p&gt;&lt;p&gt;Kaido, Toshimi&lt;/p&gt;&lt;p&gt;Kajiwara, Yoshiki&lt;/p&gt;&lt;p&gt;Kanda, Mitsuro&lt;/p&gt;&lt;p&gt;Kanemitsu, Yukihide&lt;/p&gt;&lt;p&gt;Kasai, Shunsuke&lt;/p&gt;&lt;p&gt;Kato, Atsushi&lt;/p&gt;&lt;p&gt;Kato, Motohiko&lt;/p&gt;&lt;p&gt;Kato, Yutaro&lt;/p&gt;&lt;p&gt;Kawachi, Shigeyuki&lt;/p&gt;&lt;p&gt;Kawada, Kenji&lt;/p&gt;&lt;p&gt;Kawai, Kazushige&lt;/p&gt;&lt;p&gt;Kawai, Manabu&lt;/p&gt;&lt;p&gt;Kawamura, Junichiro&lt;/p&gt;&lt;p&gt;Kawazoe, Tetsuro&lt;/p&gt;&lt;p&gt;Kim, Dong-Sik&lt;/p&gt;&lt;p&gt;Kimura, Yasutoshi&lt;/p&gt;&lt;p&gt;Kimura, Yutaka&lt;/p&gt;&lt;p&gt;Kinami, Shinichi&lt;/p&gt;&lt;p&gt;Kinoshita, Takahiro&lt;/p&gt;&lt;p&gt;Kitagawa, Akihiro&lt;/p&gt;&lt;p&gt;Kitago, Minoru&lt;/p&gt;&lt;p&gt;Kitai, Toshiyuki&lt;/p&gt;&lt;p&gt;Kitayama, Joji&lt;/p&gt;&lt;p&gt;Kiyomatsu, Tomomichi&lt;/p&gt;&lt;p&gt;Kobayashi, Hirotoshi&lt;/p&gt;&lt;p&gt;Kobayashi, Minako&lt;/p&gt;&lt;p&gt;Kobayashi, Shogo&lt;/p&gt;&lt;p&gt;Kobayashi, Toshimichi&lt;/p&gt;&lt;p&gt;Koda, Keiji&lt;/p&gt;&lt;p&gt;Koike, Yuhki&lt;/p&gt;&lt;p&gt;Komatsu, Shuhei&lt;/p&gt;&lt;p&gt;Konishi, Hirotaka&lt;/p&gt;&lt;p&gt;Kosuga, Toshiyuki&lt;/p&gt;&lt;p&gt;Kosumi, Keisuke&lt;/p&gt;&lt;p&gt;Koyama, Fumikazu&lt;/p&gt;&lt;p&gt;Koyanagi, Kazuo&lt;/p&gt;&lt;p&gt;Kubo, Shoji&lt;/p&gt;&lt;p&gt;Kubota, Takeshi&lt;/p&gt;&lt;p&gt;Kumagai, Koshi&lt;/p&gt;&lt;p&gt;Kumagai, Youichi&lt;/p&gt;&lt;p&gt;Kunisaki, Chikara&lt;/p&gt;&lt;p&gt;Kuroda, Shinji&lt;/p&gt;&lt;p&gt;Lee, Sang-Woong&lt;/p&gt;&lt;p&gt;Makino, Isamu&lt;/p&gt;&lt;p&gt;Manabe, Tatsuya&lt;/p&gt;&lt;p&gt;Marubashi, Shigeru&lt;/p&gt;&lt;p&gt;Maruyama, Suguru&lt;/p&gt;&lt;p&gt;Mats","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 1","pages":"211-213"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative management for malignant biliary obstruction and gastric outlet obstruction from pancreatic cancer","authors":"Pengfei Wu,&nbsp;Kai Chen,&nbsp;Jin He","doi":"10.1002/ags3.12902","DOIUrl":"https://doi.org/10.1002/ags3.12902","url":null,"abstract":"<p>Pancreatic cancer is among the leading causes of gastrointestinal cancer-related death, with a dismal prognosis. Over 80% of pancreatic cancer patients present with advanced disease, making curative resection unfeasible. These patients are often presented with malignant biliary obstruction (MBO) and gastric outlet obstruction (GOO). In these cases, palliative management is aimed to alleviate symptoms, enhance quality of life, and facilitate subsequent chemotherapy. Currently, neoadjuvant chemotherapy is frequently used in both borderline resectable and resectable pancreatic cancer, necessitating effective biliary and gastrointestinal drainage in a growing number of patients. Traditionally, surgical bypass was the gold standard, performed via either a minimally invasive or open approach. However, notable progress has emerged in developing endoscopic techniques, such as endoscopic retrograde cholangiopancreatography (ERCP) stenting for MBO and endoscopic enteral stenting for GOO. While these procedures provide rapid symptom relief, they are associated with higher stent dysfunction rates and more frequent re-intervention needs. When ERCP fails, percutaneous transhepatic biliary drainage is a widely accepted alternative for MBO. Endoscopic ultrasound (EUS)-guided techniques, including EUS-guided biliary drainage and EUS-guided gastroenterostomy, have recently gained prominence. Emerging clinical data suggest that these methods may be superior, potentially becoming the preferred first-line palliative treatment for unresectable pancreatic cancer. This review will summarize the current evidence on managing MBO and GOO in patients with pancreatic cancer.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 2","pages":"218-225"},"PeriodicalIF":2.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes of hepatectomy and systemic chemotherapy based on oncological resectability criteria for hepatocellular carcinoma","authors":"Shohei Komatsu,&nbsp;Yoshihiko Yano,&nbsp;Nobuaki Ishihara,&nbsp;Masahiro Kido,&nbsp;Hidetoshi Gon,&nbsp;Kenji Fukushima,&nbsp;Takeshi Urade,&nbsp;Hiroaki Yanagimoto,&nbsp;Hirochika Toyama,&nbsp;Takumi Fukumoto","doi":"10.1002/ags3.12893","DOIUrl":"https://doi.org/10.1002/ags3.12893","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The oncological resectability criteria for hepatocellular carcinoma (HCC) have recently been established (R/BR1/BR2), and validating the outcomes is an urgent issue. This study aimed to analyze the outcomes of hepatectomy and systemic chemotherapy based on the oncological resectability criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 931 patients in the hepatectomy group and 273 in the systemic chemotherapy group who received atezolizumab/bevacizumab, lenvatinib, or durvalumab plus tremelimumab were recruited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median survival times (MST) in the hepatectomy group were R, 107.2 mo; BR1, 44.4 mo; and BR2, 18.4 mo (<i>p</i> &lt; 0.0001). The MSTs in the systemic chemotherapy group were R, 16.3 mo; BR1, 24.5 mo; and BR2, 16.1 mo (<i>p</i> = 0.3598). A comparison of survival of patients in the BR2 category revealed no significant difference between the two groups for those with modified albumin-bilirubin grade 1 + 2a (<i>p</i> = 0.7343) and grade 2b + 3 (<i>p</i> = 0.6589). The BR2 definition comprised three tumor factors, and the MST of patients with only one BR2-defining factor tended to be better in the hepatectomy group than in the systemic chemotherapy group (22.9 vs 20.2 mo, <i>p</i> = 0.0977). Meanwhile, the MST tended to be better in the systemic chemotherapy group than in the hepatectomy group (16.5 vs 12.6 mo) for those with two to three BR2-defining factors, although the difference was insignificant (<i>p</i> = 0.4252).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The oncological resectability criteria for HCC effectively stratified the prognosis after hepatectomy. Treatment outcomes of hepatectomy in patients with two to three BR2-defining factors are limited, suggesting the need for multidisciplinary treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 2","pages":"235-243"},"PeriodicalIF":2.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for postoperative complications in laparoscopic and robot-assisted surgery for octogenarians with colorectal cancer: A multicenter retrospective study","authors":"Takehito Yamamoto,&nbsp;Koya Hida,&nbsp;Kentaro Goto,&nbsp;Meiki Fukuda,&nbsp;Susumu Inamoto,&nbsp;Hiroki Hashida,&nbsp;Ryo Matsusue,&nbsp;Ryo Takahashi,&nbsp;Rei Mizuno,&nbsp;Hiroaki Terajima,&nbsp;Kazutaka Obama","doi":"10.1002/ags3.12874","DOIUrl":"https://doi.org/10.1002/ags3.12874","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Minimally invasive surgery for colorectal cancer is increasing globally. However, the safety in older patients have not been thoroughly examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with colorectal cancer who underwent laparoscopic or robot-assisted surgery at Kyoto University Hospital and 18 affiliated institutions in Japan that participated in the Kyoto Colorectal Surgery Group between 2018 and 2023 were enrolled. Focusing on patients ≥80 y, we investigated the risk factors for postoperative complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 7303 patients were enrolled in this study. The mean age was 71 ± 11 y, with 1665 patients (22.8%) ≥80 y old. Older patients (≥80 y) had significantly higher ASA and ECOG-PS scores and more comorbidities including diabetes, chronic obstructive pulmonary disease (COPD), hypertension, heart disease, and cerebrovascular disease than patients ≤79 y old (all <i>p</i> &lt; 0.05). In the older group, postoperative complications (Clavien–Dindo grade ≥II) occurred in 210 patients (12.6%). After adjusting for covariates using the multivariable logistic regression model, rectal cancer (odds ratio [OR]: 1.84, 95% confidence interval [CI]: 1.30–2.60, <i>p</i> = 0.001), operation time ≥300 min (OR: 1.52, 95% CI: 1.07–2.16, <i>p</i> = 0.020), and blood loss ≥100 mL (OR: 2.19, 95% CI: 1.80–3.24, <i>p</i> &lt; 0.001) were associated with the occurrence of complications, whereas their comorbidities showed no association.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In minimally invasive colorectal cancer surgery for older patients (≥80 y old), prioritizing shorter operation time and blood loss control is crucial, especially for patients with rectal cancer because of their high risk of complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 2","pages":"319-328"},"PeriodicalIF":2.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12874","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interview with Prof. Dr. Jeffrey Drebin, President of the 2024 President Elect of the American Surgical Association","authors":"Koshi Mimori,&nbsp;Tsutomu Fujii,&nbsp;Masayuki Sho,&nbsp;Itaru Endo,&nbsp;Ken Shirabe,&nbsp;Yuko Kitagawa","doi":"10.1002/ags3.12882","DOIUrl":"10.1002/ags3.12882","url":null,"abstract":"<p><b>Dr. Jeffrey A. Drebin</b> is Chair of the Department of Surgery at the Memorial Sloan Kettering Cancer Center and holds the Murray F. Brennan Endowed Chair. He is also Professor of Surgery at Weill Cornell Medical College. He was previously the John Rhea Barton Professor and Chair of the Department of Surgery at the Perelman School of Medicine of the University of Pennsylvania. He received his M.D. and Ph.D. degrees from Harvard, where his Ph.D. work involved the development of the first monoclonal antibodies targeting the HER2/neu oncogene. He subsequently performed his surgical training in General Surgery and a Fellowship in Surgical Oncology at the Johns Hopkins Hospital. Upon completing his clinical training, Dr. Drebin was recruited to Washington University School of Medicine in 1995, rising to Professor of Surgery and of Molecular Biology &amp; Pharmacology in 2002.</p><p>In 2004 he was recruited to the University of Pennsylvania as Chief of the GI Surgery Division and in 2009 he became department Chair. At Washington University and at the University of Pennsylvania he established himself as a busy clinical surgeon, focusing on pancreaticobiliary, upper gastrointestinal, and liver surgery. He also established a successful translational research lab, receiving research support from the NIH, the Department of Defense, and the Burroughs Welcome fund for this work. Multiple surgery residents who worked in Dr. Drebin's laboratory have themselves gone on to successful academic surgical careers. He has published over 150 peer-reviewed articles, chapters, editorials, and reviews, and has served on the editorial boards of multiple journals.</p><p>Today, we are honored to have Professor Jeff Drebin, M.D., Ph.D., from Memorial Sloan Kettering Cancer Center, and the 2024 President Elect of the American Surgical Association, as our guest. We extend our sincere gratitude to Professor Drebin for taking time out of his busy schedule to join us at the 79th Annual Meeting of The Japanese Society of Gastroenterological Surgery. In addition, we deeply appreciate your participation and your contribution to the journal, <i>Annals of Gastroenterological Surgery</i>, an official journal of JSGS. Thank you very much, Professor Jeff.</p><p>We're going to wrap up this conversation. Thank you very much for your insightful elaboration and explanation about pancreatic cancer. We face significant challenges in curing pancreatic cancer, but today's discussion with Professor Drebin provides a glimmer of hope. In the future, we may be able to eradicate pancreatic cancer. Thank you very much for your active discussion.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 1","pages":"24-31"},"PeriodicalIF":2.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver resection in patients with a history of local ablation for hepatocellular carcinoma has the risk of poor survival and serosal invasion","authors":"Yusuke Nishi,&nbsp;Katsunori Sakamoto,&nbsp;Mio Uraoka,&nbsp;Tomoyuki Nagaoka,&nbsp;Masahiko Honjo,&nbsp;Kei Tamura,&nbsp;Naotake Funamizu,&nbsp;Kohei Ogawa,&nbsp;Yasutsugu Takada,&nbsp;Yuzo Umeda","doi":"10.1002/ags3.12872","DOIUrl":"https://doi.org/10.1002/ags3.12872","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim was to evaluate the impact of previous local ablation (LA) on long-term prognoses and tumor histopathological findings following hepatectomy for hepatocellular carcinoma (HCC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study used data from patients who underwent initial hepatectomy for HCC at Ehime University Hospital between October 2003 and July 2021. Using data from a total of 234 patients, after excluding patients with distant metastasis or macroscopic residual tumors and patients with mixed HCC, a group of 39 patients who underwent post-ablation liver resection (PALR) was compared with a group of 195 non-PALR patients with respect to patient characteristics, perioperative data, pathological findings, and outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Number of tumors was significantly greater and diameter of tumor was smaller in PALR group than those of non-PALR group. Both overall survival (OS) and recurrence-free survival (RFS) were significantly poor in PALR group than those of non-PALR (5-year OS 54.1% vs. 66.9%, <i>p</i> = 0.024; 5-year RFS 24.7% vs. 37.0%, <i>p</i> = 0.019). However, PALR was not selected as independent prognosticator in multivariate analyses. In PALR group, tumor size ≥3 cm was sole independent prognosticator in multivariate analyses. Multivariate analysis showed that PALR [odds ratio (OR), 8.989; 95% confidence interval (CI), 2.807–28.787], alpha-fetoprotein level &gt;40 ng/mL (OR, 2.923; 95% CI, 1.063–8.035), and des-γ-carboxyprothrombin level &gt;170 mAU/mL (OR, 5.164; 95% CI, 1.622–16.438) were independent predictors of pathological serosal invasion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Hepatectomy for patients with history of LA for HCC had a risk of serosal invasion and poor survival.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 2","pages":"347-358"},"PeriodicalIF":2.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12872","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of short-term outcomes and perioperative costs in laparoscopic versus robotic surgery for rectal cancers: A real-world cohort study using Japanese nationwide inpatient database","authors":"Hiroki Hamamoto,&nbsp;Masato Ota,&nbsp;Takafumi Shima,&nbsp;Toru Kuramoto,&nbsp;Kazuya Kitada,&nbsp;Kohei Taniguchi,&nbsp;Mitsuhiro Asakuma,&nbsp;Yasuhiro Oura,&nbsp;Yuri Ito,&nbsp;Sang-Woong Lee","doi":"10.1002/ags3.12884","DOIUrl":"10.1002/ags3.12884","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Many studies have revealed the benefits of robotic surgery for rectal cancer; however, real-world data are insufficient. This study aimed to compare the short-term outcomes and perioperative costs of laparoscopic and robotic surgery for rectal cancer using a real-world database.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The data of patients who underwent laparoscopic or robotic surgery for rectal cancer between January 2018 and January 2021 from a nationwide Japanese inpatient database provided by Medical Data Vision Co., Ltd. were analyzed. We performed propensity score matching (PSM) analysis to compare the in-hospital mortality, morbidity, readmission rate, reoperation rate, length of postoperative stay, and medical costs between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We performed PSM analysis on 18 952 eligible patients. After PSM, 1396 patients in the laparoscopic group and 1396 in the robotic group were compared. The robotic group had a lower surgical site infection rate (2.9% vs. 1.5%, <i>p</i> = 0.010), lower respiratory failure rate (1.3% vs. 0.6%, <i>p</i> = 0.049), and higher operative medical costs (1 291 371 vs. 1 312 462 JPY, <i>p</i> = 0.013). The total medical costs of the two groups were comparable (1 862 439 vs. 1 895 822 JPY, <i>p</i> = 0.051).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PSM analysis revealed that robotic surgery was associated with better outcomes than laparoscopic surgery in terms of surgical site infection and respiratory failure rates. The operative medical costs of robotic surgery were significantly higher than those of laparoscopic surgery. However, there was no significant difference in the total medical costs between robotic and laparoscopic surgery for rectal cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 1","pages":"4-11"},"PeriodicalIF":2.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of risk factors for postoperative complications after right colectomy and low anterior resection in patients ≥85 years old with colorectal cancer using the National Clinical Database","authors":"Tomonori Akagi,&nbsp;Shiori Nishimura,&nbsp;Yoshitake Ueda,&nbsp;Masafumi Inomata,&nbsp;Hidefumi Shiroshita,&nbsp;Shuji Takiguchi,&nbsp;Yoshiharu Sakai,&nbsp;Hiraku Kumamaru,&nbsp;Hideki Ueno,&nbsp;Yuko Kitagawa","doi":"10.1002/ags3.12876","DOIUrl":"https://doi.org/10.1002/ags3.12876","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The purpose of this study was to evaluate factors associated with surgical outcomes and postoperative complications (Grade ≥3 by Clavien–Dindo classification) of right hemicolectomy (RH) and low anterior resection (LAR) for colorectal cancer in patients ≥85 years old.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed National Clinical Database (NCD) data on patients aged ≥85 years who underwent RH and LAR for colorectal cancer between 2017 and 2020. All possible preoperative factors were used to explore the risk factors for serious postoperative complication in these very elderly patients with colorectal cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For RH, the operative mortality rate was 1.1% (98 cases), and the rate of serious postoperative complications was 5.2% (480 cases). Similarly, the mortality rate was 1.1% (27 cases), and the rate of serious complications (Clavien–Dindo Grade ≥3) was 8.7% (206 cases) for LAR. Based on multivariate analysis, independent risk factors for serious postoperative complications were male sex, ADL (partially dependent), hypertension, platelets (&lt;150 000/μL), serum Na (&lt;138 mEq/L), and PT-INR (&gt;1.1) for RH, and ASA-PS (Grade ≥3), history of pneumonia, creatinine (&gt;1.2 mg/day), and serum Na (&lt;138 mEq/L) for LAR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The present results for RH and LAR suggest that surgical treatment for patients aged ≥85 years old is safe and feasible. Surgeons need to pay special attention more to physical status and past medical history than to tumor factors to prevent serious postoperative complications in these older patients with colorectal cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 2","pages":"329-338"},"PeriodicalIF":2.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12876","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk stratification of residual abscess after surgical treatment for gastroduodenal perforation","authors":"Kana Ishikawa,&nbsp;Siyuan Yao,&nbsp;Takashi Kumode,&nbsp;Keisuke Tanino,&nbsp;Yugo Matsui,&nbsp;Shusaku Honma,&nbsp;Shinichi Hosokawa,&nbsp;Teppei Murakami,&nbsp;Takatsugu Kan,&nbsp;Sanae Nakajima","doi":"10.1002/ags3.12877","DOIUrl":"https://doi.org/10.1002/ags3.12877","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Residual abscess is a major complication after emergency surgery for gastroduodenal (GD) perforation. However, there is little evidence regarding potential risk factors contributing to its development. Establishing a risk stratification strategy would be valuable for the entire management process.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center, retrospective study analyzed 115 consecutive patients who underwent surgery for GD perforation between 2010 and 2023 at a secondary emergency care hospital. Patients were divided into two groups based on the presence or absence of residual abscesses. Potential risk factors for abscess formation were evaluated from various aspects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The incidence of residual abscesses was 19.1% (22 of 115). Multivariable analysis revealed that current use of nonsteroidal antiinflammatory drugs (odds ratio [OR] 3.76, <i>p</i> = 0.037), cancer chemotherapy (OR 13.56, <i>p</i> = 0.005), and preoperative renal dysfunction (OR 4.72, <i>p</i> = 0.018) were independent predictors. A potential scoring model could be created using these three parameters, and the number of risk factors correlated with the likelihood of developing a residual abscess (0 vs. 1 vs. ≥2; 6.2% vs. 29.4% vs. 50.0%, <i>p</i> &lt; 0.001). From a bacteriological point of view, the presence of <i>Enterococcus</i> in the ascites culture was closely related to its occurrence with 100% probability. Moreover, regarding early detection of this complication, C-reactive protein on postoperative d 5 had the highest predictive ability with an area under the curve of 0.818.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The risk of residual abscess formation after surgical treatment of GD perforation can be assessed utilizing both preoperative and postoperative information.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 2","pages":"263-270"},"PeriodicalIF":2.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12877","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}