Contemporary topics in laboratory animal science最新文献_第10页

Persistent shedding of mouse hepatitis virus in mouse lines selected for genetic differences in alcohol sensitivity. 小鼠肝炎病毒在酒精敏感性遗传差异的小鼠系中持续脱落。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Debra L Hickman

引用次数: 0

X-ray safety in veterinary practice. 兽医工作中的x射线安全。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

John KurKomelis

引用次数: 0

Effects of anesthesia and vehicle injection on circulating blood elements in C3H/HeN male mice. 麻醉和载药注射对C3H/HeN雄性小鼠循环血液元素的影响。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Kenneth O Jacobsen, Vilmar Villa, Venita L Miner, Mark H Whitnall

{"title":"Effects of anesthesia and vehicle injection on circulating blood elements in C3H/HeN male mice.","authors":"Kenneth O Jacobsen, Vilmar Villa, Venita L Miner, Mark H Whitnall","doi":"","DOIUrl":"","url":null,"abstract":"The induction and maintenance of general anesthesia can lead to profound alterations of many organ systems, especially the cardiovascular, pulmonary, and nervous systems. Moreover, distinct from their cardiopulmonary effects, certain anesthetics can induce physiologic and behavioral changes, which may persist after recovery from anesthesia. Knowledge of the effects of anesthesia and anesthetic agents on hematologic measurements is important. Although the effects of anesthesia were clinically unapparent, the effect on levels of circulating blood elements was an important determinant for the results of our study. We sought to evaluate the effect of anesthesia and vehicle injection on the levels of circulating blood elements in C3H/HeN male mice. We used an automated hematology system to obtain complete blood counts with differentials in anesthetized and unanesthetized mice receiving subcutaneous injections of polyethylene glycol (PEG-400). Two days after a 30-min exposure to isoflurane anesthesia, mean white blood cell counts had deceased by 15.4%, mean neutrophil counts had decreased by 26.9%, and mean platelet counts by 11.2% compared with levels in unanesthetized mice. Our results indicate that the effect of anesthesia is an important consideration when circulating blood elements in mice must be measured.","PeriodicalId":80269,"journal":{"name":"Contemporary topics in laboratory animal science","volume":" ","pages":"8-12"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40900809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endotracheal tubes versus laryngeal mask airways in rabbit inhalation anesthesia: ease of use and waste gas emissions. 兔吸入性麻醉中气管内管与喉罩气道:使用方便及废气排放。

Contemporary topics in laboratory animal science Pub Date : 2004-07-01

Jennifer C Smith, Linda D Robertson, Ann Auhll, Tim J March, Cheryl Derring, Brad Bolon

{"title":"Endotracheal tubes versus laryngeal mask airways in rabbit inhalation anesthesia: ease of use and waste gas emissions.","authors":"Jennifer C Smith, Linda D Robertson, Ann Auhll, Tim J March, Cheryl Derring, Brad Bolon","doi":"","DOIUrl":"","url":null,"abstract":"In this study, we compared two endotracheal tubes (cuffed [Murphy Eye type] and uncuffed [Cole type]) and a pediatric laryngeal mask airway (LMA) with respect to their ease of use in rabbits and their capacities to limit waste isoflurane emissions. Animals (New Zealand White, 3.3 to 5.0 kg, n = 8) were sedated with intramuscular ketamine (50 mg/kg) and xylazine (10 mg/kg). After 5 min, the larynx was numbed with cetocaine, an intubation device was positioned, and anesthesia was maintained with isoflurane (2%) in oxygen (1 liter/min). Real-time atmospheric isoflurane emissions were assessed at the rabbit's oral commissure and in the operator's breathing zone (45 cm from the rabbit's nose) by using a portable infrared spectrophotometer. The LMA was placed more easily than was either endotracheal tube, especially by novices. The cuffed tube was positioned more readily than was the uncuffed variant. All three devices emitted isoflurane. The concentrations measured at the oral commissure for the LMA (mean +/- standard error, 8.4 +/- 0.6 ppm) were modestly higher than those acquired for the cuffed (6.7 +/- 0.5 ppm) and uncuffed (6.3 +/- 0.4 ppm) endotracheal tubes; the difference between the LMA and uncuffed tube was significant (P = 0.012). Isoflurane was not detected in the operator's breathing zone. These data show that the uncuffed endotracheal tube (usually used to anesthetize birds and reptiles) and the pediatric LMA can be used in rabbits as readily as a cuffed tube. In addition, our findings indicate that tradeoffs will be required in selecting a delivery system for this species, as the easiest apparatus (the LMA) also emits the most isoflurane waste.","PeriodicalId":80269,"journal":{"name":"Contemporary topics in laboratory animal science","volume":"43 4","pages":"22-5"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24625091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of cage micro-environment of mice housed on various types of bedding materials. 不同床上材料饲养小鼠笼微环境评价。

Contemporary topics in laboratory animal science Pub Date : 2004-07-01

Ellen Smith, Jason D Stockwell, Isabelle Schweitzer, Stephen H Langley, Abigail L Smith

{"title":"Evaluation of cage micro-environment of mice housed on various types of bedding materials.","authors":"Ellen Smith, Jason D Stockwell, Isabelle Schweitzer, Stephen H Langley, Abigail L Smith","doi":"","DOIUrl":"","url":null,"abstract":"A variety of environmental factors can affect the outcomes of studies using laboratory rodents. One such factor is bedding. Several new bedding materials and processing methods have been introduced to the market in recent years, but there are few reports of their performance. In the studies reported here, we have assessed the cage micro-environment (in-cage ammonia levels, temperature, and humidity) of mice housed on various kinds of bedding and their combinations. We also compared results for bedding supplied as Nestpaks versus loose bedding. We studied C57BL/6J mice (commonly used) and NOD/LtJ mice (heavy soilers) that were maintained, except in one study, in static duplex cages. In general, we observed little effect of bedding type on in-cage temperature or humidity; however, there was considerable variation in ammonia concentrations. The lowest ammonia concentrations occurred in cages housing mice on hardwood bedding or a mixture of corncob and alpha cellulose. In one experiment comparing the micro-environments of NOD/LtJ male mice housed on woodpulp fiber bedding in static versus ventilated caging, we showed a statistically significant decrease in ammonia concentrations in ventilated cages. Therefore, our data show that bedding type affects the micro-environment in static cages and that effects may differ for ventilated cages, which are being used in vivaria with increasing frequency.","PeriodicalId":80269,"journal":{"name":"Contemporary topics in laboratory animal science","volume":"43 4","pages":"12-7"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24625754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin A toxicity and vitamin E deficiency in a rabbit colony. 兔群维生素A毒性和维生素E缺乏症。

Contemporary topics in laboratory animal science Pub Date : 2004-07-01

Mark B St Claire, Mary J Kennett, Cynthia L Besch-Williford

引用次数: 0

Introduction to lasers and laser safety. 介绍激光和激光安全。

Contemporary topics in laboratory animal science Pub Date : 2004-07-01

J Kurkomelis

引用次数: 0

Vaginal and cervical atresia in a cynomolgus macaque. 食蟹猕猴阴道和宫颈闭锁。

Contemporary topics in laboratory animal science Pub Date : 2004-07-01

Michael M Laffins, Lydia Andrews-Jones