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Optimal timing of research after anterior cruciate ligament resection in rabbits. 兔前交叉韧带切除术后最佳时机的研究。

Contemporary topics in laboratory animal science Pub Date : 2004-11-01

Nikolaos Papaioannou, Nikolaos Krallis, Ioannis Triantafillopoulos, Lubna Khaldi, Ismene Dontas, George Lyritis

{"title":"Optimal timing of research after anterior cruciate ligament resection in rabbits.","authors":"Nikolaos Papaioannou, Nikolaos Krallis, Ioannis Triantafillopoulos, Lubna Khaldi, Ismene Dontas, George Lyritis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We sought to determine whether the post-traumatic pathology in the rabbit knee induced by anterior cruciate ligament (ACL) transection is a model of cartilage injury and repair (i.e., irreversible osteoarthritis) or one in which phases of degeneration and regeneration occur. After knee instability was induced in 15 New Zealand White rabbits by ACL transection, the animals were separated into two groups according to the time of euthanasia (i.e., 8 weeks [n = 9] or 16 weeks [n = 6] after ACL transection). The macroscopic parameters evaluated were location, type, and extent of articular changes. The microscopic parameters evaluated were morphology of the articular cartilage and subchondral bone (degeneration indices) and articular cartilage thickness, chondrocyte arrangement, and chondrocyte metabolic activity (regeneration indices). A total score of all histological sections from each animal was based on a modified Mankin's grading system characterizing the progression of osteoarthritic damage. The only statistically significant differences (P < 0.05) between groups were those regarding chondral thickness, chondrocyte arrangement, and metabolic activity, indicating repairing of the articular cartilage. ACL transection led to rapid osteoarthritic changes during the first 8 weeks. However, during the later post-traumatic period, these changes progressed slowly because of a concurrent repair effort. Therefore, this experimental animal model offers investigators the choice of which phase-degenerative (early) or regenerative (late)-is most appropriate for their research purposes.</p>","PeriodicalId":80269,"journal":{"name":"Contemporary topics in laboratory animal science","volume":"43 6","pages":"22-7; quiz 58"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25062249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to balance humane endpoints, scientific data collection and appropriate veterinary interventions in animal studies. 在动物研究中如何平衡人道终点、科学数据收集和适当的兽医干预。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Leticia V medina

引用次数: 0

Multi-phase approach to eradicate enzootic mouse coronavirus infection. 多阶段方法根除鼠流行性冠状病毒感染。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Debra L Hickman, Kami J Thompson

{"title":"Multi-phase approach to eradicate enzootic mouse coronavirus infection.","authors":"Debra L Hickman, Kami J Thompson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Infections with mouse coronavirus (also known as mouse hepatitis virus, MHV) are common and prompt concern because the adverse research effects of infection have been well documented. The animal facility we describe had contained an enzootic infection of mouse coronavirus for more than a decade. Eradication of the virus had been tried with limited success in the past. With an increase in the populations of immune-compromised and transgenic animals elsewhere in the facility, eradication of the virus became a high priority. The affected animals were in multiple breeding colonies comprising more than 4000 mice representing more than 50 site-specific strains, lines, and sublines. A task force designed to ensure representation of all interested parties developed a multi-phase approach which included (a) culling of nonessential animals, (b) cessation of breeding, (c) testing and culling of individual animals, and (d) cross-fostering to clean dams. To date, all of the strains, lines, and sublines manipulated through this multi-phase eradication approach continue to test negative for mouse coronavirus. This multi-phase approach may be useful for other institutions attempting to eradicate mouse coronavirus.</p>","PeriodicalId":80269,"journal":{"name":"Contemporary topics in laboratory animal science","volume":" ","pages":"22-8"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40900081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Euthanasia of mouse fetuses and neonates. 小鼠胎儿和新生儿的安乐死。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Brenda A Klaunberg, James O'malley, Terri Clark, Judith A Davis

{"title":"Euthanasia of mouse fetuses and neonates.","authors":"Brenda A Klaunberg, James O'malley, Terri Clark, Judith A Davis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We sought to determine whether any of the common methods of euthanasia for adult rodents would lead to an acceptable death for fetuses or neonates. We wanted to identify a method that was rapid, free of signs of pain or distress, reliable, and minimally distressful to the person performing the procedure and that minimized the amount of handling required to perform the procedure. We evaluated six methods of euthanasia, with and without anesthesia, in three age groups of mice: gravid mice (E14-20) and neonatal pups (P1-P7 and P8-P14). Euthanasia methods included: halothane inhalation, carbon dioxide inhalation, intraperitoneal sodium pentobarbital, intravenous potassium chloride, and cervical dislocation with and without anesthesia. Noninvasive echocardiography was used to assess heartbeat during euthanasia. With cardiac arrest as the definition of death, no method of euthanasia killed fetal mice. Halothane inhalation (5% by vaporizer) was not an acceptable method of euthanasia for mice of the age groups tested. Intraperitoneal administration of sodium pentobarbital for euthanasia required a higher dose than the previously established dose, and there is a risk of reduced efficacy in pregnant animals due to potential intrauterine injection. Carbon dioxide asphyxiation was the most efficient method of euthanasia for neonatal mouse pups P1-14. For pregnant adult mice, intravenous potassium chloride under anesthesia, carbon dioxide asphyxiation, and cervical dislocation alone or under anesthesia were excellent methods of euthanasia.</p>","PeriodicalId":80269,"journal":{"name":"Contemporary topics in laboratory animal science","volume":" ","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40900082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of pH measurement devices for determining vaginal pH in cynomolgus macaques. 食蟹猴阴道pH值测定装置的比较。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

George E De Los Santos, Satch Zuniga

引用次数: 0

Hebb-Williams mazes. Hebb-Williams迷宫。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Kathleen Pritchett, Guy Mulder

引用次数: 0

Designing your new animal facility part II: integration of engineering controls in animal facility design. 设计您的新动物设施第二部分:在动物设施设计中集成工程控制。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Germain F Rivard

引用次数: 0

The use of the hairless guinea pig in tattoo research. 无毛豚鼠在纹身研究中的应用。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Matthew A Fox, Roger J McNichols, Ashok Gowda, Massoud Motamedi

引用次数: 0

Comparison of body surface temperature measurement and conventional methods for measuring temperature in the mouse. 小鼠体表温度测量与常规测温方法的比较。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

Denise M Newsom, Gerry L Bolgos, Lesley Colby, Jean A Nemzek

{"title":"Comparison of body surface temperature measurement and conventional methods for measuring temperature in the mouse.","authors":"Denise M Newsom, Gerry L Bolgos, Lesley Colby, Jean A Nemzek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Temperature is a valuable parameter used to judge wellness of animals in a research setting; therefore, reliable, noninvasive, and inexpensive methods for monitoring temperature are becoming a necessity in research laboratories. A new method for obtaining temperature in mice, the measurement of body surface temperature via an external probe, was compared to two more common methods, the rectal probe and telemetry. The comparisons of the temperature measuring devices were performed in mice made hypothermic via prolonged anesthesia and in mice made hyperthermic by injection of endotoxin. The results demonstrated good correlation between the surface temperature measurements and the temperatures obtained by both telemetry and the rectal probe. The correlations were particularly significant when core body temperatures were below normal. In addition, the surface probe compared favorably with the other methods with regard to animal stress, observed complications, and initial cost. These results suggest that the surface probe could provide an efficient means for obtaining valuable physiological data and determining humane endpoints.</p>","PeriodicalId":80269,"journal":{"name":"Contemporary topics in laboratory animal science","volume":" ","pages":"13-8"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40900079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fostering procedures for orphaned infants in a breeding colony of African green monkeys. 非洲绿猴繁殖地孤儿的抚养程序。

Contemporary topics in laboratory animal science Pub Date : 2004-09-01

M Babette Fontenot, Destiny M Galentine, Lindsay J Cummings

{"title":"Fostering procedures for orphaned infants in a breeding colony of African green monkeys.","authors":"M Babette Fontenot, Destiny M Galentine, Lindsay J Cummings","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We developed procedures to foster orphaned African green monkey infants to females with natural infants of a similar age to the foster infant (< 1 month). Our purpose was to assess the feasibility of fostering additional infants to females with natural infants. The subjects were 4 infants (age 1 to 5 days) that were removed from the natural mother because of neglect or trauma. The recipient females varied in parity (0 to 7 previous infants). Within 24 h of removal from the natural mother, the foster infants were presented to a group of potential recipient females by placing the foster infant directly into the cage of the female that demonstrated positive behavior toward the foster infant (reaching toward the infant and lip-smacking). Analysis of the behavioral data collected when the infants were 3 to 6 months of age indicated that foster mothers spent significantly more time nursing the natural infant alone, but the percentage time spent nursing both infants simultaneously was not significantly different than the time spent nursing either infant individually. No significant differences between weaning weight of the natural and foster infants or single infants were observed at 6 months of age. Overall our success rate at weaning (75%) suggests that fostering additional infants on females with a natural infant may be a viable strategy for raising orphaned African green monkeys and may prevent the development of abnormal behaviors that typically are manifested by nursery-reared infants.</p>","PeriodicalId":80269,"journal":{"name":"Contemporary topics in laboratory animal science","volume":" ","pages":"41-3"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40900085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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