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Development of a CFC-free glucocorticoid metered-dose aerosol system to optimize drug delivery to the lung 无氟氯化碳糖皮质激素计量气溶胶系统的发展，以优化药物输送到肺部
Pharmaceutical science & technology today Pub Date : 2000-05-01 DOI: 10.1016/S1461-5347(00)00259-5
David Donnell
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引用次数: 1
Gene therapy leads to sporting success 基因疗法导致运动成功
Pharmaceutical science & technology today Pub Date : 2000-05-01 DOI: 10.1016/S1461-5347(00)00260-1
David Bradley
{"title":"Gene therapy leads to sporting success","authors":"David Bradley","doi":"10.1016/S1461-5347(00)00260-1","DOIUrl":"10.1016/S1461-5347(00)00260-1","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 5","pages":"Pages 153-154"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00260-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21633342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain drug delivery technologies: novel approaches for transporting therapeutics 脑药物输送技术:运送治疗药物的新方法
Pharmaceutical science & technology today Pub Date : 2000-05-01 DOI: 10.1016/S1461-5347(00)00258-3
Jamal Temsamani , Jean-Michel Scherrmann , Anthony R Rees , Michel Kaczorek
{"title":"Brain drug delivery technologies: novel approaches for transporting therapeutics","authors":"Jamal Temsamani ,&nbsp;Jean-Michel Scherrmann ,&nbsp;Anthony R Rees ,&nbsp;Michel Kaczorek","doi":"10.1016/S1461-5347(00)00258-3","DOIUrl":"10.1016/S1461-5347(00)00258-3","url":null,"abstract":"<div><p>The blood–brain barrier (BBB) denies many therapeutic agents access to brain tumours and other diseases of the central nervous system (CNS). Despite remarkable advances in our understanding of the mechanisms involved in the development of the brain diseases and the actions of neuroactive agents, drug delivery to the brain remains a challenge. For more than 20 years, extensive efforts have been made to enhance delivery of therapeutic molecules across vascular barriers of the CNS. The current challenge is to develop drug-delivery strategies that will allow the passage of drug molecules through the BBB in a safe and effective manner, and this review will provide an insight into some of the strategies developed to enhance drug delivery across the BBB.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 5","pages":"Pages 155-162"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00258-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21633343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
Optimal process design for the manufacture of transdermal drug delivery systems 经皮给药系统制造的最佳工艺设计
Pharmaceutical science & technology today Pub Date : 2000-05-01 DOI: 10.1016/S1461-5347(00)00251-0
Hans-Michael Wolff
{"title":"Optimal process design for the manufacture of transdermal drug delivery systems","authors":"Hans-Michael Wolff","doi":"10.1016/S1461-5347(00)00251-0","DOIUrl":"10.1016/S1461-5347(00)00251-0","url":null,"abstract":"<div><p>In a pharmaceutical market characterized by increasing competition, assessment criteria related to system design are assuming greater importance. This is true for both conventional dosage forms and drug delivery systems (DDS), as manufacturers strive to achieve adequate patient convenience and compliance. At the same time, the process design for the manufacture of DDS must comply with current good manufacturing practices, and give sufficient consideration to associated environmental issues. Related problems must be solved under social and safety pressures, which, in turn, become economic pressures, such as the consideration of control methods. In addition, both the system design and the process design have a major impact on the cost of goods, as well as on the levels of complexity or risk associated with development.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 5","pages":"Pages 173-181"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00251-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21633345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
New first-line monotherapy for epilepsy 新的一线单一疗法治疗癫痫
Pharmaceutical science & technology today Pub Date : 2000-05-01 DOI: 10.1016/S1461-5347(00)00263-7
Anya M Hillery
{"title":"New first-line monotherapy for epilepsy","authors":"Anya M Hillery","doi":"10.1016/S1461-5347(00)00263-7","DOIUrl":"10.1016/S1461-5347(00)00263-7","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 5","pages":"Pages 152-153"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00263-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21633341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The formulation of biopharmaceutical products 生物制药产品的配方
Pharmaceutical science & technology today Pub Date : 2000-04-01 DOI: 10.1016/S1461-5347(00)00248-0
Dave A. Parkins (Head of BioPharmaceutical Formulation Sciences) , Ulla T. Lashmar
{"title":"The formulation of biopharmaceutical products","authors":"Dave A. Parkins (Head of BioPharmaceutical Formulation Sciences) ,&nbsp;Ulla T. Lashmar","doi":"10.1016/S1461-5347(00)00248-0","DOIUrl":"10.1016/S1461-5347(00)00248-0","url":null,"abstract":"<div><p>Biopharmaceutical products represent a diverse group of products that includes proteins, peptides, nucleic acids, whole cells, viral particles and vaccines. The conformation of the macromolecule or cell must be maintained to retain biological activity, and animal models for biological activity and characterization assays are often developed in tandem with initial formulation studies. This presents the formulation scientist with a unique set of challenges when compared to those for small molecules. This review focuses on approaches to the formulation of macromolecules into biopharmaceutical products, and provides examples of studies that have been undertaken within the authors’ laboratories.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 4","pages":"Pages 129-137"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00248-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21604922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 75
AAPS triggers quest for magic bullet AAPS触发了对魔弹的探索
Pharmaceutical science & technology today Pub Date : 2000-04-01 DOI: 10.1016/S1461-5347(00)00253-4
Andrew W. Lloyd , A.Christy Hunter , Adrian Smith
{"title":"AAPS triggers quest for magic bullet","authors":"Andrew W. Lloyd ,&nbsp;A.Christy Hunter ,&nbsp;Adrian Smith","doi":"10.1016/S1461-5347(00)00253-4","DOIUrl":"10.1016/S1461-5347(00)00253-4","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 4","pages":"Pages 118-120"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00253-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56492685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Monitor: progress and profiles 监控:进度和概要文件
Pharmaceutical science & technology today Pub Date : 2000-04-01 DOI: 10.1016/S1461-5347(00)00254-6
Andrew W Lloyd, A.Christy Hunter
{"title":"Monitor: progress and profiles","authors":"Andrew W Lloyd,&nbsp;A.Christy Hunter","doi":"10.1016/S1461-5347(00)00254-6","DOIUrl":"10.1016/S1461-5347(00)00254-6","url":null,"abstract":"<div><p>provides an insight into the latest developments in pharmaceutical science and technology through brief synopses of recent presentations, publications and patents, and expert commentaries on the latest technologies. There are two sections: <em>Progress</em> summarizes the latest developments in pharmaceutical process technology, formulation, analytical technology, sterilization, controlled drug delivery systems and regulatory issues; <em>Profiles</em> offers expert commentary on emerging technologies, novel processes and strategic, organizational and logistic issues underlying pharmaceutical R&amp;D.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 4","pages":"Pages 146-150"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00254-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21604925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccinology: the challenges for non-injected approaches 疫苗学:非注射方法的挑战
Pharmaceutical science & technology today Pub Date : 2000-04-01 DOI: 10.1016/S1461-5347(00)00252-2
David J Brayden
{"title":"Vaccinology: the challenges for non-injected approaches","authors":"David J Brayden","doi":"10.1016/S1461-5347(00)00252-2","DOIUrl":"10.1016/S1461-5347(00)00252-2","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 4","pages":"Pages 115-117"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00252-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56492673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent technological advances in oral drug delivery – a review 口服给药技术的最新进展
Pharmaceutical science & technology today Pub Date : 2000-04-01 DOI: 10.1016/S1461-5347(00)00247-9
Srikonda Venkateswara Sastry, Janaki Ram Nyshadham, Joseph A. Fix
{"title":"Recent technological advances in oral drug delivery – a review","authors":"Srikonda Venkateswara Sastry,&nbsp;Janaki Ram Nyshadham,&nbsp;Joseph A. Fix","doi":"10.1016/S1461-5347(00)00247-9","DOIUrl":"10.1016/S1461-5347(00)00247-9","url":null,"abstract":"<div><p><span>Despite disadvantages, oral drug delivery remains the preferred route of drug delivery. Novel technologies with improved performance, patient compliance, and enhanced quality have emerged in the recent past. Oral fast-dispersing dosage forms, three-dimensional Printing (3DP) and electrostatic coating are a few examples of a few existing technologies with the potential to accommodate various physico-chemical, </span>pharmacokinetic<span> and pharmacodynamic characteristics of drugs. This article provides a comprehensive review of these three technologies.</span></p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 4","pages":"Pages 138-145"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00247-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21604924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 636
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