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Goodbye 再见
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00324-2
Debbie Tranter
{"title":"Goodbye","authors":"Debbie Tranter","doi":"10.1016/S1461-5347(00)00324-2","DOIUrl":"10.1016/S1461-5347(00)00324-2","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Page 431"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00324-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transdermal testing: practical aspects and methods 透皮试验:实用方面和方法
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00316-3
Ayman El-Kattan, Charles S Asbill, Sam Haidar
{"title":"Transdermal testing: practical aspects and methods","authors":"Ayman El-Kattan,&nbsp;Charles S Asbill,&nbsp;Sam Haidar","doi":"10.1016/S1461-5347(00)00316-3","DOIUrl":"10.1016/S1461-5347(00)00316-3","url":null,"abstract":"<div><p>Interest in transdermal drug delivery has increased in recent years owing to its many advantages over other routes of administration. In order to evaluate a transdermal product effectively, three main issues need to be addressed: (1) the kind of skin model that will be used to evaluate the drug permeation; (2) the mathematical model that will be used to characterize the permeation of the drug across the skin; and (3) the diffusion apparatus that will be used to conduct the permeation study.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Pages 426-430"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00316-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Bacteriophage on the menu 菜单上有噬菌体
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00313-8
Richard Weld
{"title":"Bacteriophage on the menu","authors":"Richard Weld","doi":"10.1016/S1461-5347(00)00313-8","DOIUrl":"10.1016/S1461-5347(00)00313-8","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Pages 404-405"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00313-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56492748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Applications of immobilized stationary-phase liquid chromatography: a potential in vitro technique 固定化固定相液相色谱的应用:一种有潜力的体外技术
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00315-1
Thiraviyam Geetha, Saranjit Singh
{"title":"Applications of immobilized stationary-phase liquid chromatography: a potential in vitro technique","authors":"Thiraviyam Geetha,&nbsp;Saranjit Singh","doi":"10.1016/S1461-5347(00)00315-1","DOIUrl":"10.1016/S1461-5347(00)00315-1","url":null,"abstract":"<div><p>Immobilized artificial-membrane chromatography is a potential <em>in vitro</em><span> technique for determining lipophilicity<span> and studying drug transport and membrane interactions. It is reproducible, efficient and simple. Several other and newer applications of immobilized stationary-phase liquid chromatography have been reported, including the purification of membrane proteins, the synthesis of biomolecules and the simultaneous determination of enzyme activity and enantioselectivity. This article describes the immobilized artificial-membrane concept and provides an overview of the applications, advantages and limitations, in general, of immobilized stationary-phase chromatography.</span></span></p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Pages 406-416"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00315-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Monitor editorship 监控编辑
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00325-4
Debbie Tranter
{"title":"Monitor editorship","authors":"Debbie Tranter","doi":"10.1016/S1461-5347(00)00325-4","DOIUrl":"10.1016/S1461-5347(00)00325-4","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Page 431"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00325-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress 进步
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00322-9
Andrew Lloyd
{"title":"Progress","authors":"Andrew Lloyd","doi":"10.1016/S1461-5347(00)00322-9","DOIUrl":"10.1016/S1461-5347(00)00322-9","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Pages 431-434"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00322-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pharmaceutical science and technology today: evolving to reflect the modern industrial life-science environment 今天的制药科学技术:不断发展以反映现代工业生命科学环境
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00320-5
Debbie Tranter
{"title":"Pharmaceutical science and technology today: evolving to reflect the modern industrial life-science environment","authors":"Debbie Tranter","doi":"10.1016/S1461-5347(00)00320-5","DOIUrl":"10.1016/S1461-5347(00)00320-5","url":null,"abstract":"<div><p>“The barriers between ‘silos’ in pharmaceutical R&amp;D workflows are slowly eroding and this is driving a wider exchange of information across the various R&amp;D disciplines.”</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Pages 399-400"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00320-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Non-invasive administration of drugs through the skin: challenges in delivery system design 通过皮肤的非侵入性给药:给药系统设计的挑战
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00317-5
Marianna Foldvari
{"title":"Non-invasive administration of drugs through the skin: challenges in delivery system design","authors":"Marianna Foldvari","doi":"10.1016/S1461-5347(00)00317-5","DOIUrl":"10.1016/S1461-5347(00)00317-5","url":null,"abstract":"<div><p><span>Vehicles designed to enhance drug delivery through the skin must incorporate specific elements that improve the ability of the delivery system to overcome the barrier posed by the stratum corneum. This review discusses several chemical penetration enhancers that have been investigated as potential tools to increase </span>drug flux<span>. In addition, lipid-based delivery systems offer an attractive alternative to traditional drug vehicles. The relationship between liposome composition and drug permeation is discussed, in addition to the possible mechanism of action of lipid vesicle-mediated drug delivery.</span></p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Pages 417-425"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00317-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 157
Angiogenesis inhibitor enters clinical trials 血管生成抑制剂进入临床试验
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00319-9
David Bradley
{"title":"Angiogenesis inhibitor enters clinical trials","authors":"David Bradley","doi":"10.1016/S1461-5347(00)00319-9","DOIUrl":"10.1016/S1461-5347(00)00319-9","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Page 403"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00319-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Therapeutic needs revive arsenic compound 治疗需要恢复砷化合物
Pharmaceutical science & technology today Pub Date : 2000-12-01 DOI: 10.1016/S1461-5347(00)00318-7
David Bradley
{"title":"Therapeutic needs revive arsenic compound","authors":"David Bradley","doi":"10.1016/S1461-5347(00)00318-7","DOIUrl":"10.1016/S1461-5347(00)00318-7","url":null,"abstract":"<div><p>An arsenic compound<span>, previously used as an insecticide<span>, is set to become the latest addition to the armoury for treating a rare form of leukaemia. On 26 September 2000, the FDA announced the approval of Trisenox (arsenic trioxide) for the treatment of acute promyelocytic leukaemia (APL), which affects approximately 2000 people each year in the USA.</span></span></p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":"3 12","pages":"Page 401"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00318-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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