{"title":"Is vortioxetine as preferable a molecule as duloxetine in depressed patients with fibromyalgia?","authors":"Derya Adali Aker , Deniz Öke","doi":"10.1016/j.amp.2025.09.004","DOIUrl":"10.1016/j.amp.2025.09.004","url":null,"abstract":"<div><h3>Aim</h3><div>Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, sleep disturbances, fatigue, and frequently comorbid psychiatric conditions such as depression and anxiety. Its multifactorial nature, involving neurobiological, psychological, and social dimensions, complicates treatment and underscores the importance of targeted interventions. Among pharmacological options, antidepressants play a central role. Duloxetine, a serotonin–norepinephrine reuptake inhibitor (SNRI), has been widely studied and is considered adequate in FM due to its dual modulation of serotonergic and noradrenergic pathways, which are critical in both mood regulation and pain perception. Vortioxetine, on the other hand, is a newer multimodal antidepressant that combines serotonin transporter inhibition with receptor-level modulation and has been associated with potential benefits in mood and cognitive symptoms. However, data on vortioxetine in FM remains scarce. This study aimed to prospectively examine the sociodemographic and psychiatric characteristics of FM patients with comorbid depressive disorders, and to evaluate whether vortioxetine can be considered as preferable to duloxetine in this population. By following patients for six months and applying a comprehensive battery of psychiatric and cognitive assessment tools, the study sought to clarify the comparative effectiveness of these two agents on depression, anxiety, somatic amplification, distress tolerance, and subjective cognitive complaints.</div></div><div><h3>Methods</h3><div>The study included 100 patients diagnosed with FM and comorbid depressive disorder who attended the psychiatric outpatient clinic between February and June 2024. Diagnosis of FM was confirmed in collaboration with the physical therapy and rehabilitation clinic. Eligible participants were adults between 18 and 65 years of age who were literate and capable of providing informed consent. Exclusion criteria included psychotic disorders, bipolar disorder, dementia, intellectual disability, or unwillingness to continue follow-up. Patients were assigned to one of two groups: Group D received duloxetine at a mean daily dose of 60<!--> <!-->mg, while Group V received vortioxetine at a mean daily dose of 15<!--> <!-->mg. Only monotherapy cases were included, and patients were followed for six months. Assessments were conducted at baseline and the end of the treatment period. The following validated instruments were administered: (1) Beck Depression Inventory (BDI) to assess depressive symptoms; (2) Beck Anxiety Inventory (BAI) to evaluate the severity of anxiety symptoms; (3) Toronto Alexithymia Scale (TAS) to measure difficulties in emotional awareness and expression; (4) British Columbia Cognitive Complaints Inventory (BC-CCI) to capture subjective cognitive difficulties; (5) Somatosensory Amplification Scale (SSAS) to assess tendency to exaggerate bodily sensations; (6) Discomfort Intolerance Scal","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 5","pages":"Pages 356-364"},"PeriodicalIF":0.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148193566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Marc Louis Bourgeois (1934–2025)","authors":"Hélène Verdoux","doi":"10.1016/j.amp.2026.04.001","DOIUrl":"10.1016/j.amp.2026.04.001","url":null,"abstract":"<div><div>Marc Louis Bourgeois (1934–2025), one of the most eminent founders of the academic psychiatry in Bordeaux University. He was a pioneer of medical psychiatry, open to international psychiatric models, with an integrative approach that respected other theoretical models. His reputation spread far beyond Bordeaux and France, and he was one of the first French university psychiatrists to train in the United States in the 1970s. He played a major role in the dissemination of the DSM-III in France, as well as psychometric tools and guidelines for use of psychopharmacological drugs. Marc Louis Bourgeois enthusiastically transmitted to generations of psychiatrists a rigorous and demanding model of psychiatry practice aimed at providing the best care to users, laying the foundations for the Bordeaux school on bipolar disorders. With the same enthusiasm, he promoted and encouraged clinical and epidemiological research in Bordeaux. His visionary spirit, his outstanding and iconoclastic intelligence, his creativity, his humor and his encyclopedic culture left a lasting impression on all those who met him.</div></div>","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 5","pages":"Pages 285-289"},"PeriodicalIF":0.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148193555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Déprescription des psychotropes en pratique avancée infirmière : données de la littérature, enjeux et perspectives : revue de la portée de la littérature","authors":"Franz Bulmé , Fabrice Berna , Franck Schürhoff","doi":"10.1016/j.amp.2025.12.009","DOIUrl":"10.1016/j.amp.2025.12.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Deprescribing refers to a process of optimizing pharmacological treatment for a given patient, with the aim of identifying the minimum effective dose, which may extend to treatment discontinuation when appropriate. In psychiatry, and particularly with regard to psychotropic medications, this approach represents a major clinical and ethical issue. On the one hand, it is driven by the need to involve people receiving psychotropic treatment and to respond to their requests; on the other hand, it aims to personalize treatment by better integrating the temporal dimension of psychiatric disorders, distinguishing between acute and maintenance phases, which involve different clinical objectives and risks. In contrast to treatment initiation, deprescribing remains far less formalized by scientific societies, clinical guidelines and educational frameworks. This scoping review explores the nursing contributions identified in the literature in relation to psychotropic deprescribing.</div></div><div><h3>Methods</h3><div>A scoping review was conducted using the PubMed, CINAHL and Cochrane databases, covering publications from 2015 to 2025. The search strategy targeted deprescribing, psychotropic medications, mental health, nursing care and advanced practice nursing. Articles were screened based on title, abstract and full-text screening. Studies explicitly referring to nursing involvement in adult psychiatric populations were included. Articles focusing on major neurocognitive disorders, non-psychiatric sleep disorders, non-psychotropic medications, child and adolescent psychiatry, or not mentioning nursing care were excluded. Qualitative, quantitative and mixed-methods studies were eligible. Out of 44 records initially identified, eight articles met the inclusion criteria after full-text review.</div></div><div><h3>Results</h3><div>The included articles were predominantly qualitative or narrative in design, with only one mixed-methods study. The psychotropic drug classes addressed were antipsychotics, antidepressants and benzodiazepines. Study populations included adults with psychiatric disorders in general, as well as specific groups such as individuals with intellectual disabilities or older adults. Across the studies, nurses and Advanced Practice Nurses (APNs) were described as playing a contributory role in psychotropic deprescribing. Their involvement included clinical observation of adverse drug effects, monitoring of withdrawal or relapse symptoms, patient education, facilitation of shared decision-making, and coordination of care within interprofessional teams. When nurses practiced in advanced roles, they were directly involved in deprescribing strategies. Several obstacles were identified, including fear of relapse, difficulties in distinguishing withdrawal from relapse, limited time, lack of formalized protocols, insufficient training, and symbolic importance of psychotropic medications among patients, relatives and ","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 5","pages":"Pages 347-355"},"PeriodicalIF":0.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148193565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Moi et sous-moi : Freud contre Surbled","authors":"Marion Hendrickx , Emmanuel Drouin","doi":"10.1016/j.amp.2025.10.002","DOIUrl":"10.1016/j.amp.2025.10.002","url":null,"abstract":"<div><div>Georges Surbled (1855–1913), physician, remains largely forgotten today, despite developing the concept of the “sous-moi”, a concept that could have enriched Freudian theory in suggesting a more fluid and less conflictual relationship between conscious and unconscious processes. In this article, we define the surbled underego in the light of Freud's theories. In the 1920s, Freud (1856–1939) began by demonstrating that the first model of dividing the psyche into unconscious, preconscious, and conscious (first topic) was no longer sufficient to account for psychic functioning. As a result, he introduced the second topic: a new division of the psyche into three instances, the ego (le moi), the id (le ça) and the underego (sur-moi). At the same time, Georges Surbled (1855–1913), a French physician, was developing his own theory. According to Surbled, the clear-cut division between conscious and subconscious in this topic was not acceptable because, as he states, nature does not make a leap nor hiatus. Thus, between full consciousness and subconsciousness, there are many degrees, imperceptible transitions that must be quantified. Surbled remains largely forgotten today, despite developing the concept of the “sous-moi”, a concept that could have enriched Freudian theory in suggesting a more fluid and less conflictual relationship between conscious and unconscious processes. The objective of this article is to explore the theories of Freud and Surbled, in order to compare them, and analyse their development. It appears to us that the concept of the “underego” offers valuable insights for the contemporary psychoanalyst, in particular casting light on relational model theories that emphasize the fluid boundaries of the life of the psyche. Freud sometimes cites Surbled's works, but it is likely that he only became aware of this underego (described by Surbled) at the end of his life. It lays the groundwork for a future exploration of the concept of the “sous-moi” (underego) from a Freudian perspective, using Surbled's work and modern developments.</div></div>","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 5","pages":"Pages 336-339"},"PeriodicalIF":0.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148193563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Un corps guéri, une âme en sursis : le travail de la guérison chez l’adulte guéri d’un cancer","authors":"Valentine Cochou , Anne-Laure Poujol","doi":"10.1016/j.amp.2025.06.001","DOIUrl":"10.1016/j.amp.2025.06.001","url":null,"abstract":"<div><h3>Context</h3><div>Over the past several years, psychological research has explored the mental life of illness, particularly during the experience of cancer. This approach rejects the duality between a damaged body and an intact psyche in the face of illness (Le Blanc, 2006). Cancer, with its traumatic potential, affects both the body and psychological balance (Reich, 2009). Pedinielli's (1994) hypothesis on the “work of illness” illustrates the inherent psychological processes of the illness experience. This mental work is not limited to the treatment period, as cancer recovery also involves a psychological reorganization, akin to a “work of recovery.” Research shows the persistence of psychological difficulties and a sense of vulnerability years after cancer onset (Esplen et al., 2018). While medicine declares a physical cure, it may clash with patients who struggle to perceive themselves as “cured” (Dhomont, 2004). For some individuals, this medical recovery may not be integrated psychologically, hindering their sense of healing.</div></div><div><h3>Objectives</h3><div>This study aims to describe the transitional process from the “work of illness” to the “work of recovery” in adults who have been cured of cancer. This description will illustrate the psychological dynamics that facilitate or hinder access to a sense of healing.</div></div><div><h3>Methodology</h3><div>Fourteen participants, who were medically declared cancer-free, were divided into two groups based on their sense of healing. The subjects presented with different types of cancer, but all had advanced-stage cancers (Stage 3 or 4) and had undergone at least chemotherapy. Individual interviews were conducted, recorded, and transcribed. The corpus was analyzed using an inductive thematic analysis, identifying themes and subthemes to develop a thematic analysis grid, validated by inter-rater reliability analysis (Paillé and Muchelli, 2012).</div></div><div><h3>Main results</h3><div>The work of illness acts as a protective factor against the traumatic potential of cancer. We have observed that when patients engage in this psychological work during treatment, it promotes the development of a psychic life around the disease. This process makes it possible to attribute meaning to the cancer experience and helps restore a sense of control over the treatment trajectory. These psychological processes facilitate the integration of the cancer experience, helping individuals to overcome its traumatic impact. “Healing work” can then unfold as the losses associated with the disease are gradually integrated, allowing the cancer to be situated in the past and making the experience of healing possible. In people who feel healed, a narrative process becomes accessible, in which cancer is no longer experienced as a radical rupture but as a sequence integrated into the continuity of their life history. Conversely, detachment from the patient's identity may be hampered by unresolved trauma. In t","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 4","pages":"Pages 248-254"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthias Brunn , Elisa Chelle , Alain Blanchet , Xavier Briffault , Philippe Carrière , Julie Cartailler , Renaud Colson , Bruno Falissard , Coralie Gandré , Raphaël Gourevitch , Jean-Baptiste Hazo , Céline Loubières , Jasmina Mallet , Salma Mesmoudi , Maeva Musso , Zeynep Or , François Petitjean , Pierre Robicquet , Yann Auxéméry
{"title":"Santé mentale en tension : enjeux épistémologiques, politiques et cliniques d’un espace fragmenté","authors":"Matthias Brunn , Elisa Chelle , Alain Blanchet , Xavier Briffault , Philippe Carrière , Julie Cartailler , Renaud Colson , Bruno Falissard , Coralie Gandré , Raphaël Gourevitch , Jean-Baptiste Hazo , Céline Loubières , Jasmina Mallet , Salma Mesmoudi , Maeva Musso , Zeynep Or , François Petitjean , Pierre Robicquet , Yann Auxéméry","doi":"10.1016/j.amp.2025.12.006","DOIUrl":"10.1016/j.amp.2025.12.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Mental health has emerged as a major policy issue at the crossroads of health, political, and ethical concerns. Declared a “national cause” in 2025 and 2026, it is receiving renewed attention while the associated theoretical paradigms and public programs are the subject of intense debate. In this context, an interdisciplinary workshop entitled “Mental Health Policies: Pluralistic Concepts and Perspectives” was held in June of 2025. The event aimed to foster dialogue between researchers, clinicians, and institutional actors regarding the tensions that structure the mental health landscape.</div></div><div><h3>Materials and methods</h3><div>We report the discussions that took place during this workshop based on an inductive analysis of the exchanges using Braun and Clarke's (2006) method. The corpus, consisting of all interactions, was coded into more than 1700 segments grouped into thematic axes, then manually refined.</div></div><div><h3>Results</h3><div>First, the lack of collective representation of care providers appears to be a persistent consequence of a fragmented health care organization. Care delivery modes and patient populations vary greatly, and the different paths (private practice, community-based care, academic–hospital settings, etc.) often operate in silos. While this diversity reflects initiative and innovation, it does not uphold an unified voice. Second, paradigmatic reframing is considered necessary, integrating prevention, diagnosis, and care. New tools make it possible to articulate biological, clinical, social, or linguistic data without imposing a single overarching model. The objective is to create transparent, interoperable and inclusive methodologies between biomedical, psychodynamic, and social approaches to strengthen user involvement. . Third, in a context of budgetary constraint, it is also crucial to re-allocate funding toward what is most useful for care. This requires identifying financing mechanisms that promote good practices through appropriate incentives and support the many teams engaged in experimentation and evaluation.</div></div><div><h3>Discussion</h3><div>This workshop shed light on the major forces at play: an acknowledged plurality of approaches, constructive disagreements over evidence-based models, and a shared commitment to tying together the complexity of clinical situations and organizational structures. Its main contribution lies in bringing into dialogue worlds that rarely meet : clinical practice, social sciences, and institutions. The exchanges showed how these perspectives can enrich one another when they are articulated together.</div></div><div><h3>Conclusion</h3><div>Our team effort is expected to grow through further meetings , particularly on: (i) research policy issues in mental health (data and commons); (ii) the role of care providers, users, and caregivers in decision-making processes; and (iii) the financing of psychiatry (allocated budgets and psychot","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 4","pages":"Pages 237-243"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ingrid Pujet , Axelle Vizet , Mareva Calteau , Elodie Py-Leroy , Anaïs David
{"title":"Quand les psychiatres ne concluent pas à un diagnostic psychiatrique : à propos d’un cas d’encéphalite auto-immune","authors":"Ingrid Pujet , Axelle Vizet , Mareva Calteau , Elodie Py-Leroy , Anaïs David","doi":"10.1016/j.amp.2025.11.011","DOIUrl":"10.1016/j.amp.2025.11.011","url":null,"abstract":"<div><div>Anti-NMDA receptor encephalitis (also called anti-NMDAr encephalitis) has been described since 2007 and most often manifests itself through psychiatric and cognitive disorders and dysautonomia. This diagnosis is still little known among practitioners. In rare cases, this pathology has a solely psychiatric presentation. We propose here to address the situation of a 26-year-old young woman who presented with a psychotic-like decompensation, with some atypical points, leading to a form of diagnostic wandering for almost a year before the hypothesis of ANTI-NMDAr encephalitis was validated and appropriate therapy was initiated. In this article, we describe the care pathway of this patient, the clinical hypotheses and the multidisciplinary consultations that led to this diagnosis.</div></div>","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 4","pages":"Pages 271-274"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypothermie iatrogène en psychiatrie","authors":"Antoine Casel, Dounia Amroune, Khalid Benechebli","doi":"10.1016/j.amp.2025.05.004","DOIUrl":"10.1016/j.amp.2025.05.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Hyperthermia, in the context of Neuroleptic Malignant Syndrome, is a well-known adverse effect. However, iatrogenic hypothermia (temperature below 35<!--> <!-->°C) due to antipsychotic drugs is less recognized. Common psychiatric treatments that can cause hypothermia include atypical neuroleptics, benzodiazepines, and certain antidepressants. Hypothermia leads to cardiovascular, respiratory, and neurological disturbances. The risk of sudden death increases with the severity of the condition.</div></div><div><h3>Results and discussion</h3><div>We report two cases of iatrogenic hypothermia occurring in a psychiatric hospital setting. The first patient, a 57-year-old woman, followed for schizophrenia, developed acute respiratory distress with hypothermia at 34.8<!--> <!-->°C, 10<!--> <!-->days after her admission. She had been treated with Clopixol and Clozapine. A pneumonia was treated with empirical antibiotic therapy. The evolution showed respiratory improvement, but hypothermia persisted (33.8<!--> <!-->°C to 35<!--> <!-->°C). Iatrogenic hypothermia was considered, and discontinuing Clopixol led to normalization of her temperature within 5 days. The second patient, a 60-year-old woman with a history of hypothyroidism, was hospitalized for psychotic decompensation following the discontinuation of her medications. Three days after admission, she developed hypothermia at 30<!--> <!-->°C, along with neurological symptoms (Glasgow score 12) and sinus bradycardia with a prolonged QT interval of 470<!--> <!-->ms, while being treated with Quetiapine and Carbamazepine (her baseline treatment prior to admission). The TSH level at 25<!--> <!-->mU/L did not seem to explain the symptoms. She was transferred to the intensive care unit, and the hypothermia improved 24<!--> <!-->hours after stopping the psychotropic medications. No recurrence of hypothermia was noted after Quetiapine was resumed. The cause of her hypothermia appeared to be multifactorial: the effect of psychotropics on thermoregulation, deep nocturnal sedation causing a fall and prolonged grounding, and hypothyroidism.</div></div><div><h3>Conclusion</h3><div>Hypothermia is a serious side effect that can compromise the patient's vital prognosis. Monitoring of body temperature after the introduction or modification of psychotropic treatments must be rigorous, especially in frail, malnourished, or elderly individuals who may have impaired thermoregulation.</div></div>","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 4","pages":"Pages 255-257"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Greffe d’identité : l’étude des changements de personnalité chez les transplantés","authors":"Renaud Évrard","doi":"10.1016/j.amp.2025.10.009","DOIUrl":"10.1016/j.amp.2025.10.009","url":null,"abstract":"<div><h3>Context</h3><div>Advances in organ transplantation medicine have coincided with the emergence of a new form of exceptional experience at the frontiers of life: personality changes attributed by transplant recipients to the donor or the organ received. Studies with small sample sizes began to build a database in the 1990s, alongside popular interest in the subject, which was reflected in several works of fiction. A fraction of transplant recipients identify changes in one or more areas of their lives: emotions, diet, sexual orientation, religious or spiritual beliefs, memories, physical activities, etc.</div></div><div><h3>Methods</h3><div>After a summary presentation of a few cases from this literature, we propose a review of the literature on the various changes observed, the factors possibly involved (immunosuppressive drugs, vascular and metabolic factors, psychological and emotional stress factors), and the main explanatory models (cellular memory, psychosocial adaptation phenomenon, and non-ordinary phenomenon).</div></div><div><h3>Discussion</h3><div>We then discuss the associated risks for transplant recipients, donor families, the public, and in the context of medical practice. Next, we analyze the clinical recommendations recently promoted by some researchers: prioritizing the scientific perspective, reframing identity changes within a multifactorial context, and developing a clinical approach to accommodate these narratives without directly invalidating them. Finally, we propose research perspectives to improve our knowledge of this phenomenon.</div></div>","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"184 4","pages":"Pages 258-263"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}