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Chewing Gum to Treat Postoperative Nausea and Vomiting in Female Patients: A Multicenter Randomized Trial. 用口香糖治疗女性患者术后恶心和呕吐：一项多中心随机试验。
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2024-10-30 DOI: 10.1097/ALN.0000000000005283
Jai N Darvall, Anurika P De Silva, Britta von Ungern-Sternberg, David A Story, Andrew J Davidson, Megan L Allen, An Tran-Duy, Cindy Schultz-Ferguson, Vi Ha, Sabine Braat, Kate Leslie
{"title":"Chewing Gum to Treat Postoperative Nausea and Vomiting in Female Patients: A Multicenter Randomized Trial.","authors":"Jai N Darvall, Anurika P De Silva, Britta von Ungern-Sternberg, David A Story, Andrew J Davidson, Megan L Allen, An Tran-Duy, Cindy Schultz-Ferguson, Vi Ha, Sabine Braat, Kate Leslie","doi":"10.1097/ALN.0000000000005283","DOIUrl":"10.1097/ALN.0000000000005283","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nausea and vomiting is common after general anesthesia, with consequences for patient outcomes, satisfaction with care, and healthcare costs. The aim was to compare a new treatment, chewing gum, with a widely used intravenous agent, ondansetron, to treat postoperative nausea and vomiting in female patients in the postanesthesia care unit.</p><p><strong>Methods: </strong>This study was a multicenter, randomized, controlled noninferiority trial in 17 hospitals in Australia and New Zealand. Female patients aged 12 yr or older undergoing volatile anesthetic-based general anesthesia for laparoscopic or breast surgery were enrolled. Protocolized antiemetic prophylaxis was administered. Patients who developed postoperative nausea and vomiting in the postanesthesia care unit were randomized to either 15 min of chewing gum or 4 mg intravenous ondansetron. The primary outcome was cessation of nausea, retching, or vomiting with no recurrence nor rescue medication for 2 h after administration of the randomized intervention ( i.e. , complete response).</p><p><strong>Results: </strong>Of 865 enrolled patients, 218 were randomized. In a per-protocol analysis, 50 of 105 (47.6%) ondansetron-treated patients compared with 31 of 103 (30.1%) chewing gum-treated patients achieved the primary outcome (absolute risk difference [95% CI], -17.3 [-30.4 to -4.3]%), not reaching the prespecified noninferiority limit. The time to complete response was longer for patients randomized to chewing gum (hazard ratio [95% CI], 0.53 [0.34 to 0.83]), and they were more likely to receive antiemetics in the 24 h after surgery (absolute risk difference [95% CI], 14.1 [1.6 to 26.5]%).</p><p><strong>Conclusions: </strong>Chewing gum cannot be recommended as an alternative to ondansetron for treatment of postoperative nausea and vomiting in female patients administered antiemetic prophylaxis.</p>","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"454-464"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit.
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/ALN.0000000000005381
{"title":"Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit.","authors":"","doi":"10.1097/ALN.0000000000005381","DOIUrl":"10.1097/ALN.0000000000005381","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"142 3","pages":"A11"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the Darkness: The Visionary Scientists Who Unlocked the Mysteries of Sleep. 绘制黑暗：有远见的科学家们揭开了睡眠的奥秘。
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-01-13 DOI: 10.1097/ALN.0000000000005303
Kathryn E McGoldrick
{"title":"Mapping the Darkness: The Visionary Scientists Who Unlocked the Mysteries of Sleep.","authors":"Kathryn E McGoldrick","doi":"10.1097/ALN.0000000000005303","DOIUrl":"10.1097/ALN.0000000000005303","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"585-587"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
This Month in Anesthesiology.
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/ALN.0000000000005382
{"title":"This Month in Anesthesiology.","authors":"","doi":"10.1097/ALN.0000000000005382","DOIUrl":"10.1097/ALN.0000000000005382","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"142 3","pages":"A1-A2"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anesthesia Workforce Supply and Demand Imbalance: Comment.
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/ALN.0000000000005321
K Elliott Higgins, Jina Sinskey, Amy E Vinson
{"title":"Anesthesia Workforce Supply and Demand Imbalance: Comment.","authors":"K Elliott Higgins, Jina Sinskey, Amy E Vinson","doi":"10.1097/ALN.0000000000005321","DOIUrl":"10.1097/ALN.0000000000005321","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"142 3","pages":"579-581"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anesthesia Workforce Supply and Demand Imbalance: Reply.
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/ALN.0000000000005322
Amr Abouleish, Mary Dale Peterson, Maxime Cannesson, Oluwaseun Akeju, James P Rathmell, Daniel J Cole
{"title":"Anesthesia Workforce Supply and Demand Imbalance: Reply.","authors":"Amr Abouleish, Mary Dale Peterson, Maxime Cannesson, Oluwaseun Akeju, James P Rathmell, Daniel J Cole","doi":"10.1097/ALN.0000000000005322","DOIUrl":"10.1097/ALN.0000000000005322","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"142 3","pages":"581-582"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Not Miss the Critical Window during Esophagogastroduodenoscopy.
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/ALN.0000000000005266
Qingyu Shi, Chong Chen, Lina Yu, Min Yan
{"title":"Do Not Miss the Critical Window during Esophagogastroduodenoscopy.","authors":"Qingyu Shi, Chong Chen, Lina Yu, Min Yan","doi":"10.1097/ALN.0000000000005266","DOIUrl":"10.1097/ALN.0000000000005266","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"142 3","pages":"546-547"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liposomal Bupivacaine for Nerve Blockade: Comment.
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/ALN.0000000000005306
Shuyuan Gan, Fangping Bao, Diansan Su
{"title":"Liposomal Bupivacaine for Nerve Blockade: Comment.","authors":"Shuyuan Gan, Fangping Bao, Diansan Su","doi":"10.1097/ALN.0000000000005306","DOIUrl":"10.1097/ALN.0000000000005306","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"142 3","pages":"574"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anesthesiology.
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/ALN.0000000000005404
{"title":"Anesthesiology.","authors":"","doi":"10.1097/ALN.0000000000005404","DOIUrl":"10.1097/ALN.0000000000005404","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"142 3","pages":"431-588"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Covert Operation: On the Hunt for Periop Stroke.
IF 9.1 1区 医学
Anesthesiology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/ALN.0000000000005371
Sasa Rajsic, Holly B Ende, Jonathan P Wanderer
{"title":"Covert Operation: On the Hunt for Periop Stroke.","authors":"Sasa Rajsic, Holly B Ende, Jonathan P Wanderer","doi":"10.1097/ALN.0000000000005371","DOIUrl":"10.1097/ALN.0000000000005371","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"142 3","pages":"A16"},"PeriodicalIF":9.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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