Anesthesiology最新文献

{"title":"Impact of the REGAIN and RAGA Trials on Use of Neuraxial Anesthesia among Surgically Managed Hip Fracture Patients: An Interrupted Time Series Analysis.","authors":"Periklis Giannakis, Junying Wang, Alex Illescas, Juliet E Rowe, Crispiana Cozowicz, Alexander B Stone, Philipp Gerner, Jiabin Liu, Stavros G Memtsoudis, Jashvant Poeran","doi":"10.1097/ALN.0000000000006254","DOIUrl":"10.1097/ALN.0000000000006254","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"1051-1054"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway Management Risks in Pediatric Anesthesia: Comment: Erratum.","authors":"Yasin Tire, Bedia Mine Hanedan, Bülent Hanedan, Abdullah Celep","doi":"10.1097/ALN.0000000000006295","DOIUrl":"10.1097/ALN.0000000000006295","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"1086"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordant Estimated Glomerular Filtration Rates: Comment.","authors":"Chenchen Jiang, Yi Lu","doi":"10.1097/ALN.0000000000006244","DOIUrl":"10.1097/ALN.0000000000006244","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"1070-1071"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let the Children Speak.","authors":"Wallis T Muhly, Paul A Stricker","doi":"10.1097/ALN.0000000000006270","DOIUrl":"10.1097/ALN.0000000000006270","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"145 4","pages":"828-830"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric Oxide and Kidney Injury after Heart Surgery: Reply.","authors":"Bijan Safaee Fakhr, Andrea Bolchini, Pankaj Arora, Lorenzo Berra","doi":"10.1097/ALN.0000000000006229","DOIUrl":"10.1097/ALN.0000000000006229","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"1065-1067"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Endothelial Signature: A Biomarker of Delirium Risk and Severity in Postoperative Patients.","authors":"Rosa Dolores Prieto-Utrera, Adrián García-Concejo, Esther Gómez-Sánchez, Miguel Bardají-Carrillo, Rosa Cobo-Zubia, Irina Rebollo-Mato, Marina Pérez-Mazzali, Jessica Matesanz-Isabel, Álvaro Tamayo-Velasco, María Sherezade Tovar-Doncel, Peter Adamove, María Fernández-Arranz, Rosario Calaveras, José Ignacio Alonso-Fernández, Iciar Martínez-Almeida, Eva López-Santín, Hugo Gonzalo-Benito, Rocío López-Herrero, Rafael Badenes, Federico Bilotta, Roberto Hornero, David Bernardo, Mario Lorenzo-López, Eduardo Tamayo, Rodrigo Poves-Álvarez","doi":"10.1097/ALN.0000000000006137","DOIUrl":"10.1097/ALN.0000000000006137","url":null,"abstract":"<p><strong>Background: </strong>Delirium is a frequent complication in critically ill and septic patients and has been linked to endothelial dysfunction, microvascular injury, and blood-brain barrier disruption. Circulating endothelial cells may reflect endothelial phenotypic alterations beyond soluble markers. The authors investigated the association between endothelial subsets and postoperative sepsis-related delirium in intensive care unit (ICU) patients. This study aimed to investigate the role of circulating endothelial subsets in the development of delirium in postsurgical sepsis patients and their relationship with hypoperfusion and clinical outcomes, to identify potential prognostic biomarkers and mechanistic insights.</p><p><strong>Methods: </strong>In this prospective cohort study, 214 postoperative ICU patients were enrolled at the time of surgery or sepsis diagnosis and classified as nonseptic ICU (n = 77), sepsis (n = 61), or septic shock (n = 76) according to Sepsis-3 criteria. Blood samples were obtained within 24 h of critical illness onset. Circulating endothelial subsets were characterized using high-dimensional flow cytometry with unsupervised clustering. Delirium was assessed daily using the Confusion Assessment Method for the ICU. Cox regression, receiver operating characteristic analysis, and causal mediation models were applied to evaluate associations with 28-day delirium and organ dysfunction-related clinical events occurring after sampling.</p><p><strong>Results: </strong>Among 13 endothelial subpopulations identified, the CD32b + subset was independently associated with 28-day delirium (hazard ratio [HR], 2.41; 95% CI, 1.32 to 4.40; P = 0.004). The CD32b + subset demonstrated discriminative performance for delirium (area under the receiver operating characteristics curve [AUC], 0.79; 95% CI, 0.60 to 0.98), which improved after adjustment for age and sex (AUC, 0.89; 95% CI, 0.82 to 0.98). Models based solely on organ dysfunction-related clinical events showed lower performance (AUC, 0.69; 95% CI, 0.52 to 0.86). Mediation analysis indicated that approximately 20% of the total effect was mediated through organ dysfunction-related events, suggesting partial mediation, while the remaining 80% may involve alternative endothelial and microvascular mechanisms not captured by conventional measures.</p><p><strong>Conclusions: </strong>The elevated CD32b + subset is associated with postoperative delirium and organ dysfunction-related clinical events in critically ill patients, supporting an association between endothelial phenotypic alterations and vulnerability to brain dysfunction.</p>","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"976-990"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive Arterial Pressure Monitoring during Anesthesia.","authors":"Agnes S Meidert, Bernd Saugel","doi":"10.1097/ALN.0000000000006070","DOIUrl":"10.1097/ALN.0000000000006070","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"1022-1030"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Contributors to Postoperative Delirium and Their Implications for Dementia Outcomes.","authors":"Kewen Ding, Xiaojin Wei, Yifei Tao, Sihan Chen, Changteng Zhang, Runfu Chen, Hai Chen, Xikun Han, Jiangning Song, Jin Liu, Shu Zhang, Chan Chen","doi":"10.1097/ALN.0000000000006191","DOIUrl":"10.1097/ALN.0000000000006191","url":null,"abstract":"<p><strong>Background: </strong>Postoperative delirium (POD) is a perioperative neurocognitive disorder that substantially impairs patient recovery. Unfortunately, its genetic risk profile and relationship with subsequent dementia remain unclear. This study aimed to elucidate genetic contributors to POD identified via Hospital Episode Statistics codes and to examine its association with subsequent dementia.</p><p><strong>Methods: </strong>The study included 230,179 noncardiac and 21,254 cardiac surgery subjects from the UK Biobank, defining POD using delirium codes from the International Classification of Diseases (10th revision) recorded within the first 7 postoperative days. Genome-wide association studies were performed in the noncardiac and cardiac cohorts and their prespecified subgroups, followed by functional annotation, gene prioritization and drug-target analyses. Associations between POD and subsequent dementia were estimated using Cox models.</p><p><strong>Results: </strong>In the noncardiac cohort, one genome-wide significant locus was identified at the APOE region, with rs429358 as the lead variant ( P = 5.00 × 10 -28 ). Integrative gene prioritization analyses highlighted multiple genes within this locus. Exploratory drug-target analyses suggested potential subgroup-specific drug-target enrichment. In the cardiac cohort, no genome-wide significant signals were detected. POD was associated with all-cause dementia after both noncardiac (hazard ratio, 6.45; 95% CI, 5.45 to 7.63) and cardiac (hazard ratio, 2.95; 95% CI, 1.71 to 5.08) surgeries.</p><p><strong>Conclusions: </strong>This study demonstrates APOE as a genetic risk locus for International Classification of Diseases-coded POD in the noncardiac surgery setting and confirms an association between POD and subsequent dementia.</p>","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"857-871"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow- versus Pressure-controlled Ventilation: Reply.","authors":"Simon Becker, Christian T Kurz, Johannes Geppert, Lisa-Marie Wichelhaus, Robin Denz, Jonas Poepping, Martin Rembecki, Declan G Bates, Peter K Zahn","doi":"10.1097/ALN.0000000000006221","DOIUrl":"10.1097/ALN.0000000000006221","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"1062-1064"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripartum Cardiac Arrest during Anesthetic Care: Reply.","authors":"Michael J Furdyna, Sharon C Reale","doi":"10.1097/ALN.0000000000006253","DOIUrl":"10.1097/ALN.0000000000006253","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"1080-1081"},"PeriodicalIF":9.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}