Anesthesiology最新文献

{"title":"Assisted Fluid Management for Major Liver Surgery: Comment.","authors":"Enrico Giustiniano, Maxim Neganov, Fulvio Nisi","doi":"10.1097/ALN.0000000000005472","DOIUrl":"10.1097/ALN.0000000000005472","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"143 1","pages":"224-225"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elective Anesthesia Is Really, Really Safe.","authors":"Richard P Dutton","doi":"10.1097/ALN.0000000000005501","DOIUrl":"10.1097/ALN.0000000000005501","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"143 1","pages":"9-11"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paravertebral versus Pectoralis-II Blocks: Reply.","authors":"Brian M Ilfeld, Rodney A Gabriel","doi":"10.1097/ALN.0000000000005497","DOIUrl":"10.1097/ALN.0000000000005497","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"143 1","pages":"239-240"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Acute Kidney Injury: Reply.","authors":"Nicholas J Douville, Allison M Janda, Milo C Engoren, Michael R Mathis","doi":"10.1097/ALN.0000000000005493","DOIUrl":"10.1097/ALN.0000000000005493","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"143 1","pages":"236-237"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Pain during Cesarean Delivery under Neuraxial Anesthesia: A Systematic Review and Meta-analysis.","authors":"Elinor A Charles, Hester Carter, Susanna Stanford, Lindsay Blake, Victoria Eley, Brendan Carvalho, Pervez Sultan, Justin Kua, James E O'Carroll","doi":"10.1097/ALN.0000000000005486","DOIUrl":"10.1097/ALN.0000000000005486","url":null,"abstract":"<p><strong>Background: </strong>Neuraxial anesthesia is the definitive standard technique for cesarean delivery; however, pain during cesarean delivery may be underreported. The primary aim of this systematic review and meta-analysis was to determine the incidence of patient-reported intraoperative pain during cesarean delivery under neuraxial anesthesia.</p><p><strong>Methods: </strong>A literature search of databases (PubMed, MEDLINE, Embase, Web of Science, Scopus, Cochrane Database of Systematic Reviews, and Central Register of Controlled Trials) was conducted. Search topics included terminology concerning cesarean delivery, neuraxial anesthesia, pain, and incidence. Meta-analyses were performed to calculate pooled incidences of patient-reported pain and how mode of anesthesia influenced the incidence of patient-reported pain, with included articles assessed for risk of bias.</p><p><strong>Results: </strong>A total of 2,061 abstracts were screened; 34 articles were included (21 randomized studies and 13 nonrandomized studies). The crude incidence of intraoperative pain under neuraxial anesthesia was 10.8% (1,229 of 11,351 patients), and the pooled incidence was 17% (95% CI, 13 to 22%; 1,229 of 11,351 patients). Patients who received spinal anesthesia had the lowest pooled incidence of pain of 14% (95% CI, 10.0 to 20.0%; 662 of 8,002 patients), and those who received epidural top-up had the highest pooled incidence of pain of 33% (95% CI, 17.0 to 54.0%; 253 of 1,395 patients). Risk of bias assessments showed high risk of bias in half of the included studies.</p><p><strong>Conclusions: </strong>Patient-reported pain during cesarean delivery under neuraxial anesthesia is common, with spinal and combined spinal-epidural anesthesia reporting a lower incidence of pain than epidural anesthesia. Intraoperative pain can have significant psychologic impact for patients and medicolegal implications for providers. Further prospective studies are required to characterize and understand the impact of patient experiences of pain and develop techniques to reduce this complication.</p>","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"156-167"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice.","authors":"Aislinn D Maguire, Shawn M Lamothe, Muhammad Saad Yousuf, Kree Goss, Jayadeep Rao, Gustavo Tenorio, Sridhar R Kaulagari, Lori Hazlehurst, Jason R Plemel, Anna M W Taylor, Harley T Kurata, Thomas Simmen, Bradley J Kerr","doi":"10.1097/ALN.0000000000005453","DOIUrl":"10.1097/ALN.0000000000005453","url":null,"abstract":"<p><strong>Background: </strong>In the peripheral nervous system, nociceptors become hyperexcitable in both acute and chronic pain conditions. This phenotype can be mediated by dysregulated calcium, which occurs if the endoplasmic reticulum and mitochondria fail to buffer it appropriately. The redox enzyme endoplasmic reticulum oxidoreductin 1 (ERO1) regulates calcium transfer at endoplasmic reticulum-mitochondria contact sites (ERMCSs). This study hypothesized that inhibiting ERO1 and thereby dampening ERMCS calcium transfer might lower nociceptor hyperexcitability in sensory neurons and pain-like behaviors in mice.</p><p><strong>Methods: </strong>C57BL/6 mice were used for histology, behavior, and cell culture experiments. Behavior included thermal tail flick, the formalin hind paw injection model of acute inflammatory pain, and hind paw incision postsurgical pain. Postmortem human dorsal root ganglia (DRGs) were used for immunohistochemistry and in vitro calcium imaging.</p><p><strong>Results: </strong>This study demonstrates that the α isoform of ERO1 is expressed in mouse DRGs across multiple subtypes of mouse sensory neurons. This led us to peripherally administer an ERO1 inhibitor in mice, which acutely reversed nociception in acute inflammatory and postsurgical pain models. The hypothesis was that this may be due to reduced excitability of DRG neurons and tested ERO1 inhibition in vitro. In cultured DRGs, ERO1 inhibition dampened nociceptor excitability and mitochondrial function, suggesting that reduced calcium transfer through ERMCS could be responsible for the behavior observed in vivo . ERO1α expression was also found in human DRGs using immunohistochemistry and previously published single-cell RNA-sequencing data. Finally, the study showed that ERO1 inhibition modulates human sensory neuronal excitability in cultured post-mortem DRGs.</p><p><strong>Conclusions: </strong>This study found that ERO1 inhibition dampens mitochondrial function, sensory neuron excitability, and acute pain-like behavior in mice. Additionally, ERO1 inhibition decreases sensory neuron excitability in post-mortem human sensory neurons in vitro. The results indicate that targeting ERO1 may be a viable strategy for non-narcotic acute pain relief.</p>","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":"168-190"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assisted Fluid Management for Major Liver Surgery: Comment.","authors":"Qingyong Luo, Shiyao Gu, Si Zeng","doi":"10.1097/ALN.0000000000005473","DOIUrl":"10.1097/ALN.0000000000005473","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"143 1","pages":"225-226"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Connectivity at Loss of Consciousness: Comment.","authors":"Claudia Niño, Juan Mejía, Gabriela Montoya, Jesús Guerra","doi":"10.1097/ALN.0000000000005495","DOIUrl":"10.1097/ALN.0000000000005495","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"143 1","pages":"237-238"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty: Facts, Fables, and Future.","authors":"Nikolaos J Skubas, Sascha Ott","doi":"10.1097/ALN.0000000000005506","DOIUrl":"10.1097/ALN.0000000000005506","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"143 1","pages":"6-8"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paravertebral versus Pectoralis-II Blocks: Comment.","authors":"Gianluca Cappelleri, Andrea Fanelli, Daniela Ghisi","doi":"10.1097/ALN.0000000000005496","DOIUrl":"10.1097/ALN.0000000000005496","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"143 1","pages":"238-239"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}