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Safeguarding Mail-Order DNA Synthesis in the Age of Artificial Intelligence. 在人工智能时代保护邮购 DNA 合成。
IF 0.5
Applied Biosafety Pub Date : 2024-06-20 eCollection Date: 2024-06-01 DOI: 10.1089/apb.2023.0020
Stephanie Batalis, Caroline Schuerger, Gigi Kwik Gronvall, Matthew E Walsh
{"title":"Safeguarding Mail-Order DNA Synthesis in the Age of Artificial Intelligence.","authors":"Stephanie Batalis, Caroline Schuerger, Gigi Kwik Gronvall, Matthew E Walsh","doi":"10.1089/apb.2023.0020","DOIUrl":"10.1089/apb.2023.0020","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence (AI) tools continue to be developed and used within the life sciences. The impact of these tools on the biosecurity landscape surrounding mail-order DNA synthesis and how to address the impacts have not been critically examined in the literature.</p><p><strong>Methods: </strong>The impacts of AI-driven chatbots and biological design tools on the biosecurity landscape surrounding mail-order DNA synthesis were analyzed and described. The findings are informed by the authors' experience in the field.</p><p><strong>Results: </strong>Generally, chatbots lower barriers to access of information that could be misused while biological design tools may provide new abilities to users with the intent of misuse. Six recommendations to the United States Government that attempt to maximize the benefits of these new technologies while mitigating risks are provided.</p><p><strong>Conclusion: </strong>Mandating mail-order DNA synthesis providers to screen DNA synthesis orders is a critical safeguarding step that should be taken as soon as possible. Over time, biological design tools will reduce the effectiveness of such a regulation and actions should be taken now to limit the negative impacts in the future.</p>","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141915971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Call for Volume 30 (2025) Special Issue Papers: Biosafety and Biosecurity for Potential Pandemic Pathogens and Dual-Use Research of Concern: Deadline for Manuscript Submission: October 31, 2024. 征集第 30 卷（2025 年）特刊论文：潜在流行病病原体和两用研究的生物安全和生物安保：投稿截止日期：2024 年 10 月 31 日：投稿截止日期：2024 年 10 月 31 日。
IF 0.5
Applied Biosafety Pub Date : 2024-06-20 eCollection Date: 2024-06-01 DOI: 10.1089/apb.2024.48276.cfp
George Poste, Filippa Lentzos, Barbara Johnson, David R Gillum
{"title":"<i>Call for Volume 30 (2025) Special Issue Papers:</i> Biosafety and Biosecurity for Potential Pandemic Pathogens and Dual-Use Research of Concern: Deadline for Manuscript Submission: October 31, 2024.","authors":"George Poste, Filippa Lentzos, Barbara Johnson, David R Gillum","doi":"10.1089/apb.2024.48276.cfp","DOIUrl":"https://doi.org/10.1089/apb.2024.48276.cfp","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141915970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Method to Sterilize Isolators for the Housing of Germ-Free Birds and Production of Germ-Free Eggs 用于饲养无菌鸟类和生产无菌鸡蛋的隔离器消毒新方法
IF 1.5
Applied Biosafety Pub Date : 2024-05-13 DOI: 10.1089/apb.2024.0007
Martin Murphy, Rhys Jones, Ariane dos Santos, Modupeore Adeyemi, Catherine Caulfield
{"title":"A Novel Method to Sterilize Isolators for the Housing of Germ-Free Birds and Production of Germ-Free Eggs","authors":"Martin Murphy, Rhys Jones, Ariane dos Santos, Modupeore Adeyemi, Catherine Caulfield","doi":"10.1089/apb.2024.0007","DOIUrl":"https://doi.org/10.1089/apb.2024.0007","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140982485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Clinical Trials Involving Genetically Modified Bacteria, Bacteriophages and Their Associated Risk Assessments 涉及转基因细菌、噬菌体的临床试验及其相关风险评估综述
IF 1.5
Applied Biosafety Pub Date : 2024-05-08 DOI: 10.1089/apb.2024.0002
Paul Gulig, Scott Swindle, Mark Fields, Daniel Eisenman
{"title":"A Review of Clinical Trials Involving Genetically Modified Bacteria, Bacteriophages and Their Associated Risk Assessments","authors":"Paul Gulig, Scott Swindle, Mark Fields, Daniel Eisenman","doi":"10.1089/apb.2024.0002","DOIUrl":"https://doi.org/10.1089/apb.2024.0002","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress and Prospects for a Nucleic Acid Screening Test Set 核酸筛选测试装置的进展与前景
IF 1.5
Applied Biosafety Pub Date : 2024-05-03 DOI: 10.1089/apb.2023.0033
Nicole E. Wheeler, Craig Bartling, Sarah R. Carter, Adam Clore, James Diggans, Kevin Flyangolts, Bryan T. Gemler, Brittany Rife Magalis, Jacob Beal
{"title":"Progress and Prospects for a Nucleic Acid Screening Test Set","authors":"Nicole E. Wheeler, Craig Bartling, Sarah R. Carter, Adam Clore, James Diggans, Kevin Flyangolts, Bryan T. Gemler, Brittany Rife Magalis, Jacob Beal","doi":"10.1089/apb.2023.0033","DOIUrl":"https://doi.org/10.1089/apb.2023.0033","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141016615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to Applied Biosafety’s Second Special Issue on Synthetic Genomics 应用生物安全》第二期 "合成基因组学 "特刊简介
IF 1.5
Applied Biosafety Pub Date : 2024-05-03 DOI: 10.1089/apb.2024.0015
Sarah R. Carter, Rocco Casagrande, S. Patlovich, David R. Gillum
{"title":"Introduction to Applied Biosafety’s Second Special Issue on Synthetic Genomics","authors":"Sarah R. Carter, Rocco Casagrande, S. Patlovich, David R. Gillum","doi":"10.1089/apb.2024.0015","DOIUrl":"https://doi.org/10.1089/apb.2024.0015","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141015053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substitution Attacks: A Catalyst to Reframe the DNA Manufacturing Cyberbiosecurity Landscape in the Age of Benchtop Synthesizers 替代攻击：在台式合成器时代重塑 DNA 制造网络生物安全格局的催化剂
IF 1.5
Applied Biosafety Pub Date : 2024-05-02 DOI: 10.1089/apb.2023.0035
Laura Adam, George H. McArthur
{"title":"Substitution Attacks: A Catalyst to Reframe the DNA Manufacturing Cyberbiosecurity Landscape in the Age of Benchtop Synthesizers","authors":"Laura Adam, George H. McArthur","doi":"10.1089/apb.2023.0035","DOIUrl":"https://doi.org/10.1089/apb.2023.0035","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141019943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches for the Inactivation of Yersinia pestis 灭活鼠疫耶尔森菌的方法
IF 1.5
Applied Biosafety Pub Date : 2024-04-09 DOI: 10.1089/apb.2023.0022
A. Brady, Maggie Tomaszewski, Taylor M Garrison, M. Lawrenz
{"title":"Approaches for the Inactivation of Yersinia pestis","authors":"A. Brady, Maggie Tomaszewski, Taylor M Garrison, M. Lawrenz","doi":"10.1089/apb.2023.0022","DOIUrl":"https://doi.org/10.1089/apb.2023.0022","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140724838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Sensitivity Study for Interpreting Nucleic Acid Sequence Screening Regulatory and Guidance Documentation: Toward a Foundational Synthetic Nucleic Acid Sequence Screening Framework 解读核酸序列筛选监管和指导文件的敏感性研究：建立基础合成核酸序列筛选框架
IF 1.5
Applied Biosafety Pub Date : 2024-04-08 DOI: 10.1089/apb.2023.0026
Bryan T. Gemler, Chiranjit Mukherjee, Patrick A. Fullerton, James Diggans, Craig Bartling
{"title":"A Sensitivity Study for Interpreting Nucleic Acid Sequence Screening Regulatory and Guidance Documentation: Toward a Foundational Synthetic Nucleic Acid Sequence Screening Framework","authors":"Bryan T. Gemler, Chiranjit Mukherjee, Patrick A. Fullerton, James Diggans, Craig Bartling","doi":"10.1089/apb.2023.0026","DOIUrl":"https://doi.org/10.1089/apb.2023.0026","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five Things Not to Do When Discovering a Biosecurity Vulnerability 发现生物安全漏洞时不能做的五件事
IF 1.5
Applied Biosafety Pub Date : 2024-04-08 DOI: 10.1089/apb.2023.0038
Piers Millett
{"title":"Five Things Not to Do When Discovering a Biosecurity Vulnerability","authors":"Piers Millett","doi":"10.1089/apb.2023.0038","DOIUrl":"https://doi.org/10.1089/apb.2023.0038","url":null,"abstract":"","PeriodicalId":7962,"journal":{"name":"Applied Biosafety","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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