Biological signals and receptors最新文献_第6页

Suppression of UV-induced erythema by topical treatment with melatonin. Influence of the application time point. 褪黑素局部治疗对紫外线致红斑的抑制作用。应用时间点的影响。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014581

T Fischer, E Bangha, P Elsner, G S Kistler

{"title":"Suppression of UV-induced erythema by topical treatment with melatonin. Influence of the application time point.","authors":"T Fischer, E Bangha, P Elsner, G S Kistler","doi":"10.1159/000014581","DOIUrl":"https://doi.org/10.1159/000014581","url":null,"abstract":"The UV-suppressive effect of topical melatonin was assessed at different application time points in a double-blind randomized clinical trial. The lower back of 20 healthy volunteers was treated with 0.6 mg/cm2 melatonin or vehicle either 15 min before or 1, 30 or 240 min after UV irradiation. The erythema was evaluated visually and measured by chromametry 24 h after irradiation. UV-absorbing effects of melatonin were measured at a concentration of 8 microg/ml with a spectrophotometer. Melatonin absorbs UV light at a wavelength of 225-275 nm which is clearly below the wavelength of UVA and UVB (290-390 nm). The visual score showed that application of melatonin 15 min before irradiation significantly suppressed erythema compared to treatment with vehicle alone (p < 0.001). Similar results were found by chromametry (p < 0.001). Treatment after irradiation showed no UV suppression. The erythema suppressive effect of melatonin might be explained by the radical-scavenging mechanism of quenching meanly hydroxyl radicals (.OH) which are known to be most present in sunburn reaction of the skin. The protective effect of the pre-irradiation treatment might be explained by penetration into the skin within 15 min and the presence in a local concentration at the irradiation time point.","PeriodicalId":79565,"journal":{"name":"Biological signals and receptors","volume":"8 1-2","pages":"132-5"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000014581","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20957649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

A melatonin preparation with a pulsatile liberation pattern: a new form of melatonin in replacement therapy. 一种具有搏动释放模式的褪黑素制剂:一种替代疗法中的新形式褪黑素。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014576

A Hoffmann, K Farker, M Dittgen, H Hoffmann

引用次数: 12

Structure-affinity relationships of indole-based melatonin analogs. 吲哚类褪黑激素类似物的结构亲和关系。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014564

G Spadoni, M Mor, G Tarzia

引用次数: 14

Melatonin influences human balance. 褪黑素影响人体平衡。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014578

F Fraschini, A Cesarani, D Alpini, D Esposti, B M Stankov

{"title":"Melatonin influences human balance.","authors":"F Fraschini, A Cesarani, D Alpini, D Esposti, B M Stankov","doi":"10.1159/000014578","DOIUrl":"https://doi.org/10.1159/000014578","url":null,"abstract":"In order to evaluate a possible correlation between melatonin, the cerebellum and, consequently, human balance, a double-blind pilot study was performed in 5 subjects with random administration of different doses of melatonin. Before and 1 h after a single administration, a complete otoneurological examination was performed. This first pilot study revealed that melatonin had effects on human equilibrium although these effects were not dosage related and were different in individual subjects. On the basis of these results, a second study was performed. Fourteen healthy volunteers were investigated before and 1 h after administration of a single dose of 10 mg melatonin. The otoneurological examination was restricted to the evaluation of: horizontal saccades, horizontal sinusoidal smooth pursuit, eyes open, eyes closed and head retroflexed static posturography. All subjects showed a decrease in posturographic performances, especially in the simplest test (eyes open) and half of them (6 out of 13) showed also impairment of eye movements. These results confirm the role of melatonin in the control of sensorimotor performances, and the cerebellar receptors might be correlated with the control of human balance.","PeriodicalId":79565,"journal":{"name":"Biological signals and receptors","volume":"8 1-2","pages":"111-9"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000014578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20958380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

New actions of melatonin on tumor metabolism and growth. 褪黑素对肿瘤代谢和生长的新作用。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014568

D E Blask, L A Sauer, R Dauchy, E W Holowachuk, M S Ruhoff

引用次数: 38

Melatonin in epilepsy: first results of replacement therapy and first clinical results. 褪黑素在癫痫中的作用:替代疗法的初步结果和初步临床结果。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014577

J Fauteck, H Schmidt, A Lerchl, G Kurlemann, W Wittkowski

引用次数: 136

The use of melatonin for the treatment of insomnia. 褪黑素用于治疗失眠。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014574

N Zisapel

引用次数: 49

Melatonin in psychiatric disorders - subtyping affective disorder. 褪黑素在精神疾病中的作用——情感障碍亚型。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014579

B Wahlund

引用次数: 11

Methods for the evaluation of drug action at the human melatonin receptor subtypes. 药物对人褪黑激素受体亚型作用的评价方法。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014566

R Nonno, F Fraschini, B M Stankov

{"title":"Methods for the evaluation of drug action at the human melatonin receptor subtypes.","authors":"R Nonno, F Fraschini, B M Stankov","doi":"10.1159/000014566","DOIUrl":"https://doi.org/10.1159/000014566","url":null,"abstract":"NIH3T3 fibroblast cells transfected with the full-length coding regions of the mt1 and MT2 human melatonin receptors stably expressed the receptor, coupled to a pertussis-toxin-sensitive G protein and exhibiting high affinity for melatonin. Both mt1 and MT2 melatonin receptors mediated the incorporation of [35S]GTPgammaS into isolated membranes via receptor-catalyzed exchange of [35S]GTPgammaS for GDP. The relative intrinsic activity and potency of the compounds were subsequently studied by using [35S]GTPgammaS incorporation. The order of potency was equal to the order of apparent affinity. Melatonin and full agonists increased [35S]GTPgammaS binding. Luzindole did not increase basal [35S]GTPgammaS binding but competitively inhibited melatonin-stimulated [35S]GTPgammaS binding, thus exhibiting antagonist action. Two other mt1 antagonists, 4P-PDOT and N-[(2-phenyl-1H-indol-3-yl)ethyl]cyclobutanecarboxamide, behaved as partial agonists at the MT2 subtype, with relative intrinsic activities of 0.37 and 0.39, respectively. For the first time, these findings show important differences in analogue intrinsic activity between the human mt1 and MT2 melatonin receptor subtypes.","PeriodicalId":79565,"journal":{"name":"Biological signals and receptors","volume":"8 1-2","pages":"32-40"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000014566","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20957925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The oxidant/antioxidant network: role of melatonin. 氧化/抗氧化网络:褪黑素的作用。

Biological signals and receptors Pub Date : 1999-01-01 DOI: 10.1159/000014569

R J Reiter, D X Tan, J Cabrera, D D'Arpa, R M Sainz, J C Mayo, S Ramos

引用次数: 280