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Progress in cell cycle research最新文献

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Cell cycle regulation by the Cdc25 phosphatase family. Cdc25磷酸酶家族调控细胞周期。
Progress in cell cycle research Pub Date : 2000-01-01 DOI: 10.1007/978-1-4615-4253-7_10
I Nilsson, I Hoffmann
{"title":"Cell cycle regulation by the Cdc25 phosphatase family.","authors":"I Nilsson,&nbsp;I Hoffmann","doi":"10.1007/978-1-4615-4253-7_10","DOIUrl":"https://doi.org/10.1007/978-1-4615-4253-7_10","url":null,"abstract":"<p><p>Activation of cyclin-dependent kinases in higher eukaryotic cells can be achieved through dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and Cdc25C. Cdc25A plays an important role at the G1/S-phase transition. Cdc25B undergoes activation during S-phase and plays a role in activating the mitotic kinase Cdk1/cyclin B in the cytoplasm. Active Cdk1/cyclin B then phosphorylates and activates Cdc25C leading to a positive feedback mechanism and to entry into mitosis. Cdc25A and B are potential human oncogenes. In addition, Cdc25 is a main player of the G2 arrest caused by DNA damage or in the presence of unreplicated DNA.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"4 ","pages":"107-14"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4615-4253-7_10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21591956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 453
Circadian variation of cell proliferation and cell cycle protein expression in man: clinical implications. 人类细胞增殖和细胞周期蛋白表达的昼夜变化:临床意义。
Progress in cell cycle research Pub Date : 2000-01-01 DOI: 10.1007/978-1-4615-4253-7_17
G A Bjarnason, R Jordan
{"title":"Circadian variation of cell proliferation and cell cycle protein expression in man: clinical implications.","authors":"G A Bjarnason,&nbsp;R Jordan","doi":"10.1007/978-1-4615-4253-7_17","DOIUrl":"https://doi.org/10.1007/978-1-4615-4253-7_17","url":null,"abstract":"<p><p>Most physiological, biochemical and behavioural processes have been shown to vary in a regular and predictable periodic manner with respect to time. This review focuses on the circadian rhythm in cell proliferation in bone marrow and gut and how this is associated with a circadian expression of cell cycle proteins in human oral mucosa. The control of circadian rhythms by the suprachiasmatic nuclei and the evolving understanding of the genetic and molecular biology of the circadian clock is outlined. Finally, the potential clinical impact of chronobiology in cancer medicine is discussed.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"4 ","pages":"193-206"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4615-4253-7_17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21591963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 102
Molecular switches that govern the balance between proliferation and apoptosis. 控制增殖和凋亡平衡的分子开关。
Progress in cell cycle research Pub Date : 2000-01-01 DOI: 10.1007/978-1-4615-4253-7_18
B Schutte, F C Ramaekers
{"title":"Molecular switches that govern the balance between proliferation and apoptosis.","authors":"B Schutte,&nbsp;F C Ramaekers","doi":"10.1007/978-1-4615-4253-7_18","DOIUrl":"https://doi.org/10.1007/978-1-4615-4253-7_18","url":null,"abstract":"<p><p>Tissue modelling during embryogenesis and tissue homeostasis during adult life is governed by a dynamic equilibrium between growth and programmed cell death (apoptosis). Growth control and apoptosis are intimately associated, and a disturbance of the balance between these two processes often leads to pathological situations, such as for example cell accumulations in cancer. To date many of the molecular mechanisms controlling growth control on the one hand, and apoptosis on the other hand are known, whereas the switch that controls the decision between both pathways remains elusive. A cell is continuously exposed to multiple opposing \"death\" and \"survival\" triggers. A challenging question is how a cell senses these signals and decides to live or die. A decision in favour of survival should automatically result in a shut down of the death pathways. Alternatively, a decision for death should result in inhibition of futile attempts to survive. The molecular events controlling this balance of signals will be discussed with special emphasis on the role of cyclin-dependent kinases and the ubiquitin-dependent and proteasome-mediated protein degradation pathway.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"4 ","pages":"207-17"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4615-4253-7_18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21591964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
The cell cycle in protozoan parasites. 原生寄生虫的细胞周期。
Progress in cell cycle research Pub Date : 2000-01-01 DOI: 10.1007/978-1-4615-4253-7_15
C Doerig, D Chakrabarti, B Kappes, K Matthews
{"title":"The cell cycle in protozoan parasites.","authors":"C Doerig,&nbsp;D Chakrabarti,&nbsp;B Kappes,&nbsp;K Matthews","doi":"10.1007/978-1-4615-4253-7_15","DOIUrl":"https://doi.org/10.1007/978-1-4615-4253-7_15","url":null,"abstract":"<p><p>Research into cell cycle control in protozoan parasites, which are responsible for major public health problems in the developing world, has been hampered by the difficulties in performing classical genetic analysis with these organisms. Nevertheless, in a large part thanks to the data gathered in other eukaryotic systems and to the acquisition of the sequences of parasite genes homologous to cell cycle regulators, many molecular tools required for an in-depth study of the cell cycle in protozoan parasites have been collected over the past few years. Despite the considerable phylogenetic divergence between these organisms and other eukaryotes, and notwithstanding important specificities such as the apparent lack of checkpoints during cell cycle progression, available data indicate that the major families of cell cycle regulators appear to operate in protozoan parasites. Functional studies are now needed to define the precise role of these regulators in the life cycle of the parasites, and to possibly validate cell cycle control elements as potential targets for chemotherapy.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"4 ","pages":"163-83"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4615-4253-7_15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21591961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control. 增殖细胞核抗原的多重作用:DNA复制、修复和细胞周期控制。
Progress in cell cycle research Pub Date : 1997-01-01 DOI: 10.1007/978-1-4615-5371-7_15
E Prosperi
{"title":"Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control.","authors":"E Prosperi","doi":"10.1007/978-1-4615-5371-7_15","DOIUrl":"https://doi.org/10.1007/978-1-4615-5371-7_15","url":null,"abstract":"<p><p>The proliferating cell nuclear antigen (PCNA), the auxiliary protein of DNA polymerase delta and epsilon, is involved in DNA replication and repair. This protein forms a homotrimeric structure which, encircling DNA, loads the polymerase on the DNA template. A role for PCNA in the cell cycle control is recognised on the basis of the interaction with cyclins, cyclin-dependent kinases (cdks) and the cdk-inhibitor p21 waf1/cip1/sdi1 protein. Association with the growth-arrest and DNA-damage inducible proteins gadd45 and MyD118, further demonstrates the role of PCNA as a component of the cell cycle control apparatus.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"3 ","pages":"193-210"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20473756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 126
The cdc18 protein initiates DNA replication in fission yeast. cdc18蛋白在裂变酵母中启动DNA复制。
Progress in cell cycle research Pub Date : 1997-01-01 DOI: 10.1007/978-1-4615-5371-7_11
H Nishitani, P Nurse
{"title":"The cdc18 protein initiates DNA replication in fission yeast.","authors":"H Nishitani,&nbsp;P Nurse","doi":"10.1007/978-1-4615-5371-7_11","DOIUrl":"https://doi.org/10.1007/978-1-4615-5371-7_11","url":null,"abstract":"<p><p>Recent work has demonstrated that cdc18p plays a crucial role in regulating the onset of S phase in fission yeast. cdc18p is a major product of START specific transcription and associates with ORC and MCM proteins which are required for the initiation of DNA replication. High expression of cdc18p induces continuing DNA synthesis and is thought to drive the assembly of initiation complexes. In addition to its role in bringing about DNA replication, cdc18p participates in the cell cycle checkpoint control linking S phase to START and mitosis. We propose that cdc18p is central to the molecular mechanism co-ordinating S phase and M phase in concert with changes in activity of the master cell cycle regulator, the cdc2 protein kinase.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"3 ","pages":"135-42"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20473805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Cell cycle regulation of organelle transport. 细胞器运输的细胞周期调控。
Progress in cell cycle research Pub Date : 1997-01-01 DOI: 10.1007/978-1-4615-5371-7_6
A M Robertson, V J Allan
{"title":"Cell cycle regulation of organelle transport.","authors":"A M Robertson,&nbsp;V J Allan","doi":"10.1007/978-1-4615-5371-7_6","DOIUrl":"https://doi.org/10.1007/978-1-4615-5371-7_6","url":null,"abstract":"<p><p>Microtubule- and actin-based motors play a wide range of vital roles in the organisation and function of cells during both interphase and mitosis, all of which are likely to be under strict control. Here, we describe how one of these roles--the movement of membranes--is regulated through the cell cycle. Organelle movement in many species is greatly reduced in mitosis as compared to interphase, and this change occurs concomitantly with an inhibition of most membrane traffic functions. Data from in vitro studies is shedding light on how microtubule motor regulation may be achieved.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"3 ","pages":"59-75"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20473800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Mitosis and checkpoints that control progression through mitosis in vertebrate somatic cells. 脊椎动物体细胞中有丝分裂和控制有丝分裂进程的检查点。
Progress in cell cycle research Pub Date : 1997-01-01 DOI: 10.1007/978-1-4615-5371-7_24
C L Rieder, A Khodjakov
{"title":"Mitosis and checkpoints that control progression through mitosis in vertebrate somatic cells.","authors":"C L Rieder, A Khodjakov","doi":"10.1007/978-1-4615-5371-7_24","DOIUrl":"10.1007/978-1-4615-5371-7_24","url":null,"abstract":"<p><p>During mitosis in vertebrates the sister kinetochores on each replicated chromosome interact with two separating arrays of astral microtubules to form a bipolar spindle that produces and/or directs the forces for chromosome motion. In order to ensure faithful chromosome segregation cells have evolved mechanisms that delay progress into and out of mitosis until certain events are completed. At least two of these mitotic \"checkpoint controls\" can be identified in vertebrates. The first prevents nuclear envelope breakdown, and thus spindle formation, when the integrity of some nuclear component(s) is compromised. The second prevents chromosome disjunction and exit from mitosis until all of the kinetochores are attached to the spindle.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"3 ","pages":"301-12"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20474297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2. 进入m期的体内调控:细胞周期蛋白B/Cdc2的初始激活和核易位。
Progress in cell cycle research Pub Date : 1997-01-01 DOI: 10.1007/978-1-4615-5371-7_19
T Kishimoto, E Okumura
{"title":"In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2.","authors":"T Kishimoto,&nbsp;E Okumura","doi":"10.1007/978-1-4615-5371-7_19","DOIUrl":"https://doi.org/10.1007/978-1-4615-5371-7_19","url":null,"abstract":"<p><p>The cyclin B/Cdc2 complex, Cdc2 kinase governs M-phase. Although the intracomplex modification for its activation in vitro has been described extensively, its regulation in vivo is not so well explained so far. In this article, we will focus on the intracellular regulation of the cyclin B/Cdc2 activity, in particular, how it is initially activated in vivo, how its nuclear translocation is executed specifically at the onset of M-phase, and how the activation and the nuclear translocation are coordinated in the cell. These concerted regulations may determine the appropriate timing for the initiation of M-phase.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"3 ","pages":"241-9"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20474377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Intestinal cell cycle regulation. 肠细胞周期调节。
Progress in cell cycle research Pub Date : 1997-01-01 DOI: 10.1007/978-1-4615-5371-7_4
T C Ko, W A Bresnahan, E A Thompson
{"title":"Intestinal cell cycle regulation.","authors":"T C Ko,&nbsp;W A Bresnahan,&nbsp;E A Thompson","doi":"10.1007/978-1-4615-5371-7_4","DOIUrl":"https://doi.org/10.1007/978-1-4615-5371-7_4","url":null,"abstract":"<p><p>The intestinal epithelium is maintained by a balance between proliferation, differentiation and death that occurs as cells migrate up the crypt-villus axis. Cell cycle regulators such as cyclins, cyclin-dependent kinases (Cdks) and Cdk inhibitory proteins are expressed in a distinct pattern along the crypt-villus structure, suggesting their role in controlling intestinal cells. This is supported by observations that these cell cycle proteins are regulated by growth factors, nutrients and cell-cell contact in cultured intestinal epithelial cells. One of the key regulators of intestinal cell proliferation and differentiation is transforming growth factor-beta, which is expressed in the gut epithelium.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"3 ","pages":"43-52"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20473798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
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