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Progress in cell cycle research最新文献

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Roles and regulation of serine/threonine-specific protein phosphatases in the cell cycle. 丝氨酸/苏氨酸特异性蛋白磷酸酶在细胞周期中的作用和调控。
Progress in cell cycle research Pub Date : 2003-01-01
Norbert Berndt
{"title":"Roles and regulation of serine/threonine-specific protein phosphatases in the cell cycle.","authors":"Norbert Berndt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As cell cycle research enters its fourth decade, multiple protein kinases are firmly established as key regulators of the cell cycle, and some of them have emerged as promising drug targets. This review will discuss the serine/threonine-specific protein phosphatases that oppose the actions of protein kinases. Typically, a phosphatase may stimulate one cell cycle transition, and inhibit another; alternatively, two different phosphatase holoenzymes may have opposing effects on the same cell cycle transition. Thus, both activation and inhibition of these enzymes could result in cell cycle arrest and/or apoptosis. Specific findings, the challenges and approaches to exploit this potential will be discussed.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"497-510"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytometry of cell cycle regulatory proteins. 细胞周期调节蛋白的细胞计数。
Progress in cell cycle research Pub Date : 2003-01-01
Zbigniew Darzynkiewicz, Gloria Juan, Frank Traganos
{"title":"Cytometry of cell cycle regulatory proteins.","authors":"Zbigniew Darzynkiewicz,&nbsp;Gloria Juan,&nbsp;Frank Traganos","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunocytochemical detection of cyclins, inhibitors of cyclin-dependent kinases and other cell cycle regulatory proteins, combined with analysis of cell cycle position (DNA content) by multiparameter cytometry offers unique analytical possibilities. This review focuses on applications of the methodology that yield information on the abundance, modification or interactions of these proteins in relation to cell cycle progression that cannot be obtained by other methods. Particular attention is given to the use of multiparameter cytometry in analysis of the mechanism by which antitumor drugs affect cell cycle progression and induce cell cycle phase-specific apoptosis.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"533-42"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Condensin and biological role of chromosome condensation. 染色体凝聚蛋白及其生物学作用。
Progress in cell cycle research Pub Date : 2003-01-01
Alexander V Strunnikov
{"title":"Condensin and biological role of chromosome condensation.","authors":"Alexander V Strunnikov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mitotic chromosome condensation is an essential cellular function ensuring proper compaction and segregation of sister chromatids during cell division. Condensin, a five-subunit complex, conserved among eukaryotes, is the key molecular machine of chromosome condensation. Recent advances in the structural biology and functional analysis of condensin demonstrate the unique nature and indispensable biological role of this complex. Condensin functions span chromosome dynamics during mitotic cell division, cell-cycle feedback control mechanisms, as well as formation and maintenance of interphase chromosome structure. Being at the intersection of several cell-cycle regulatory networks condensin is a promising therapeutic target for control over cell proliferation.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"361-7"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins. 人乳头瘤病毒癌蛋白诱导的中心体异常和基因组不稳定性。
Progress in cell cycle research Pub Date : 2003-01-01
Stefan Duensing, Karl Münger
{"title":"Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins.","authors":"Stefan Duensing,&nbsp;Karl Münger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cervical cancer is tightly associated with infection by high-risk human papillomaviruses (HPVs). Many high-risk HPV-positive lesions are genomically unstable and show chromosomal gains and losses already at early stages of carcinogenic progression. These genomic aberrations are caused by the HPV-encoded oncoproteins E6 and E7, which subvert mitotic fidelity of the infected host cell. Whereas E7 drives genomic instability by inducing abnormal centrosome numbers, E6 cooperates with E7 presumably by relaxing critical checkpoint control mechanisms. The ability of E7 to induce centrosome duplication errors (CDEs) may be linked to the re-programming of the host cell cycle machinery, including dysregulation of cyclin/cyclin-dependent kinase (cdk) 2 activity. Given the role of cdk2 as a regulatory node not only for cell cycle progression but also for centrosome duplication, inhibition of cdk2 may not only retard cellular proliferation but also decrease CDEs and centrosome-related mitotic defects. Compared to some conventional cytotoxic agents, which exclusively target DNA replication, modulation of cdk2 activity may hold the promise of diminishing the development of genomically unstable, aneuploid tumor cells that are frequently the source of chemotherapy resistance in malignant tumors.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"383-91"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
p27kip1 contributions to cancer. P27kip1与癌症有关。
Progress in cell cycle research Pub Date : 2003-01-01
Richard Seonghun Nho, Robert J Sheaff
{"title":"p27kip1 contributions to cancer.","authors":"Richard Seonghun Nho,&nbsp;Robert J Sheaff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Deregulation of the tumor suppressor p27kip1 (p27) has been implicated in a variety of human cancers, suggesting it might be a viable therapeutic target. Developing p27-specific intervention strategies requires understanding its role and regulation in normal and pathologic states. Although p27 has been extensively characterized as an inhibitor of cyclin-dependent kinases, disruption of this function is inadequate to explain its role in tumorigenesis. A more comprehensive understanding of p27 biology would facilitate development of therapeutic responses to p27 disruption in human cancers.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"249-59"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24055038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cell cycle of pathogenic fungi: target for drugs. 病原真菌的细胞周期:药物的靶点。
Progress in cell cycle research Pub Date : 2003-01-01
Florence Bordon-Pallier, Nathalie Jullian, Jean-Luc Haesslein
{"title":"The cell cycle of pathogenic fungi: target for drugs.","authors":"Florence Bordon-Pallier,&nbsp;Nathalie Jullian,&nbsp;Jean-Luc Haesslein","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Life-threatening fungal infections are becoming more frequent and involve a greater variety of strains, many of which are drug-resistant. Both public research organisations and the pharmaceutical industry are committed to the development of new drugs to satisfy this increasing medical need. The approach described here exemplifies the efforts directed towards the discovery of drugs which are active against novel targets, exemplified by the cell-cycle regulator, Civ1.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"81-90"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24055159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy. 通过蛋白酶体抑制肿瘤细胞周期进程的中断:对癌症治疗的影响。
Progress in cell cycle research Pub Date : 2003-01-01
Q Ping Dou, David M Smith, Kenyon G Daniel, Aslamuzzaman Kazi
{"title":"Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy.","authors":"Q Ping Dou,&nbsp;David M Smith,&nbsp;Kenyon G Daniel,&nbsp;Aslamuzzaman Kazi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ubiquitin/proteasome-dependent protein degradation pathway plays an essential role in both up-regulation of cell proliferation and down-regulation of cell death in human cancer cells. The idea that proteasome function is required for tumor cell survival has prompted the design, synthesis and evaluation of various pharmacological proteasome inhibitors. Both in vitro and in vivo experimental and clinical results have demonstrated the potential use of proteasome inhibitors as novel anticancer drugs.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"441-6"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24055424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of cyclin-dependent kinases in apoptosis. 细胞周期蛋白依赖性激酶在细胞凋亡中的作用。
Progress in cell cycle research Pub Date : 2003-01-01
Annie Borgne, Roy M Golsteyn
{"title":"The role of cyclin-dependent kinases in apoptosis.","authors":"Annie Borgne,&nbsp;Roy M Golsteyn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cell division and apoptosis are key aspects of cancer biology. The combination of increased cell proliferation and reduced cell death lies very close to the reason why cancer is a deadly disease. The importance of apoptosis and cell division in tumor biology has made them targets of new anti-cancer therapies. Although the cell division cycle and apoptosis might appear to be quite different from a physiological perspective and thus provide independent targets for therapy, recent evidence suggests that they are intertwined, and that an enzyme in one system might also have an important role in the other system. Protein kinase complexes known as cyclin-dependent kinases (Cdks) are the first example of such enzymes. In this review, we focus on the role of the subunits of different Cdks in both apoptosis and the cell cycle.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"453-9"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24055426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yeast genomics and proteomics in drug discovery and target validation. 酵母基因组学和蛋白质组学在药物发现和靶标验证中的应用。
Progress in cell cycle research Pub Date : 2003-01-01
Ainslie B Parsons, Ron Geyer, Timothy R Hughes, Charles Boone
{"title":"Yeast genomics and proteomics in drug discovery and target validation.","authors":"Ainslie B Parsons,&nbsp;Ron Geyer,&nbsp;Timothy R Hughes,&nbsp;Charles Boone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Small, cell permeable, and target-specific chemical ligands are highly valuable, not only as therapeutics but also as research tools. The synthesis, identification and characterization of these compounds is often a difficult task. The straightforward genetics of the budding yeast Saccharomyces cerevisiae, and the high degree of conservation of basic cellular processes between yeast and higher organisms makes yeast an excellent tool for drug development studies, particularly in regards to anticancer and anti-fungal drug discovery. Recent advances in yeast functional genomics and proteomics studies are changing the field of yeast research. Many of these new technologies are readily applicable to drug target identification and other aspects of drug discovery. This review will focus on current genetic, genomic, and proteomic methodologies in S. cerevisiae that have the potential to be useful in drug discovery and target validation.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"159-66"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents. 蛋白法尼基转移酶抑制剂作为基于信号的抗癌药物的发展。
Progress in cell cycle research Pub Date : 2003-01-01
Junko Ohkanda, Michelle A Blaskovich, Saïd M Sebti, Andrew D Hamilton
{"title":"The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.","authors":"Junko Ohkanda,&nbsp;Michelle A Blaskovich,&nbsp;Saïd M Sebti,&nbsp;Andrew D Hamilton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The presence of mutated Ras in more that 30% of human cancers has spurred interest in the identification of molecules that can block its uncontrolled signaling function. A particular focus in recent years has been a key posttranslational modification of Ras that places a farnesyl group on a cysteine residue near the C-terminus of the protein. In this chapter we describe recent progress in the design of inhibitors for the enzyme that catalyzes this step, protein farnesyltransferase, and show their potential for blocking oncogenic cell growth.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"211-7"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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