Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association最新文献_第10页

Hepatic heterotopias in the jejunum: a case study over time showing progressive degenerative changes. 空肠肝脏异位:一个随时间推移显示进行性退行性改变的病例研究。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01 DOI: 10.1080/15513819709168745

M. Magid, T. Godwin, Wenxin Zheng

引用次数: 4

Reduced inferior olivary neuron number in early Down syndrome. 早期唐氏综合征患者下橄榄神经元数量减少。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01 DOI: 10.1080/15513819709168730

S. S. Pine, B. Landing, W. Shankle

{"title":"Reduced inferior olivary neuron number in early Down syndrome.","authors":"S. S. Pine, B. Landing, W. Shankle","doi":"10.1080/15513819709168730","DOIUrl":"https://doi.org/10.1080/15513819709168730","url":null,"abstract":"Counts of total neuron number per section and of neurons per microscopic field of inferior olivary principal nuclei were made on sections from 10 patients with Down syndrome (DS) aged 0.36 to 28 months and seven control (C) patients aged 1 to 29 months. After stereologic and appropriate shrinkage corrections of the count data, the ratios of values for DS/C were calculated. For mean principal olivary nucleus neuron number, DS/C = 0.64; for mean number of neurons per field, DS/C = 0.84; for mean volume of olivary neuronal band per section, DS/C = 0.79; and for mean volume of neuronal band per neuron, DS/C = 1.27. The data are in accord with other data suggesting that (1) numbers of cells in various cell populations, including various areas of the cerebrum, in DS approximate two-thirds normal (DS/C approximately 0.67); (2) for the volumes of such cell populations, DS/C = 0.82 normal; and (3) for volumes of individual cells, DS/C = 1.22 normal. The data of the present study suggest that the inferior olivary nuclei in DS are affected in the same way and to a similar degree as other brain areas, with the age distribution and histologic features of the specimens studied suggesting that the reduced olivary principal nucleus number in early Down syndrome results from reduced initial neuron production rather than postnatal neuron loss.","PeriodicalId":79453,"journal":{"name":"Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association","volume":"11 1","pages":"537-45"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89462071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hepatocellular carcinoma following neonatal hepatitis. 新生儿肝炎后肝细胞癌。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01 DOI: 10.1080/15513819709168737

L. Moore, A. J. Bourne, BS David Moore, BS Henry Preston, BS Roger Byard

{"title":"Hepatocellular carcinoma following neonatal hepatitis.","authors":"L. Moore, A. J. Bourne, BS David Moore, BS Henry Preston, BS Roger Byard","doi":"10.1080/15513819709168737","DOIUrl":"https://doi.org/10.1080/15513819709168737","url":null,"abstract":"Hepatocellular carcinoma is an uncommon malignancy in young children associated with a variety of congenital and acquired conditions. It has been generally held that idiopathic neonatal hepatitis is not an antecedent of hepatocellular neoplasia in childhood. We report a 28-month-old girl in whom a diagnosis of neonatal giant cell hepatitis was confirmed by liver biopsy at 4 months of age who was followed up with serial liver biopsies. Hepatitis B and C virus infection and metabolic abnormalities had been excluded by appropriate testing. There was no history of parenteral nutrition. The morphologic criteria for a diagnosis of cirrhosis were satisfied in a liver biopsy undertaken at 23 months of age. At 28 months a laparotomy was performed because of continuing jaundice and the development of an abdominal mass. Biopsy of the mass revealed a hepatocellular carcinoma. Ploidy studies showed an aneuploid tumor and a hyperdiploid karyotype was confirmed by chromosomal analysis. This case demonstrates by sequential biopsy the progression from neonatal hepatitis to cirrhosis and hepatocellular carcinoma in a young child.","PeriodicalId":79453,"journal":{"name":"Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association","volume":"62 1","pages":"601-10"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84737801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Opportunistic infections in pediatric HIV infection: a study of 74 autopsy cases from Latin America. The Latin American AIDS Pathology Study Group. 小儿HIV感染中的机会性感染:对拉丁美洲74例尸检病例的研究。拉丁美洲艾滋病病理研究小组。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01 DOI: 10.1080/15513819709168733

R. Drut, V. Anderson, M. Greco, C. Gutiérrez, B. León-Bojorge, D. Menezes, A. Peruga, G. Quijano, C. Ridaura, M. Siminovich, P. Mayoral, M. Weissenbacher

{"title":"Opportunistic infections in pediatric HIV infection: a study of 74 autopsy cases from Latin America. The Latin American AIDS Pathology Study Group.","authors":"R. Drut, V. Anderson, M. Greco, C. Gutiérrez, B. León-Bojorge, D. Menezes, A. Peruga, G. Quijano, C. Ridaura, M. Siminovich, P. Mayoral, M. Weissenbacher","doi":"10.1080/15513819709168733","DOIUrl":"https://doi.org/10.1080/15513819709168733","url":null,"abstract":"The present report describes opportunistic infections found at 74 autopsies of pediatric HIV/AIDS patients performed at several hospitals in Latin American countries. Fungal infections were the most common (53 cases), Candida sp. (39.18%) and Pneumocystis carinii (20.27%) being the most frequently recognized. Other fungal diseases included histoplasmosis, aspergillosis, and cryptococcosis. Viral infections were present in 31 cases, 38.7% being due to cytomegalovirus. Other viruses recognized included herpes simplex and adenovirus. Additional opportunistic infections were due to Mycobacterium avium-intracellulare, toxoplasmosis, and tuberculosis. Nonspecific bacterial bronchopneumonia was present in 11 cases. Cytomegalovirus and P. carinii coinfection was the most common association found. In this series patients died at a younger age (72% at or younger than 1 year old) and there was a slightly higher number of cases of histoplasmosis and brain toxoplasmosis than in other previously published series of infants and children.","PeriodicalId":79453,"journal":{"name":"Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association","volume":"175 1","pages":"569-76"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80992116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Skeletal abnormalities in Meckel syndrome. Meckel综合征的骨骼异常。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01

J Shanks, B Kerr, S A Russell, H Kingston, L Moore

引用次数: 0

Mucosal calcified nodule of the hard palate in an infant: case report and review of the literature. 1例婴儿硬腭粘膜钙化结节:病例报告及文献复习。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01

M N Afzal, S Dancea, J de Nanassy

引用次数: 0

Malignancy metastatic to the products of conception: a case report with literature review. 恶性肿瘤转移到受孕产物:1例报告并文献复习。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01

J Ackerman, E Gilbert-Barness

引用次数: 0

CELL POPULATIONS IN THE BONE MARROW OF GUINEA PIG FETUSES WITH INTRAUTERINE GROWTH RETARDATION 宫内发育迟缓豚鼠胎儿骨髓细胞群的研究

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01 DOI: 10.1080/107710497174525

L. Ernst, M. Sanders, C. Salafia, A. Carter

{"title":"CELL POPULATIONS IN THE BONE MARROW OF GUINEA PIG FETUSES WITH INTRAUTERINE GROWTH RETARDATION","authors":"L. Ernst, M. Sanders, C. Salafia, A. Carter","doi":"10.1080/107710497174525","DOIUrl":"https://doi.org/10.1080/107710497174525","url":null,"abstract":"Bone marrow smears and blood samples were examined in guinea pig fetuses in which intrauterine growth retardation (IUGR) had been induced by uterine artery ligation and compared with those of control (well-grown) fetuses from uterine horns with intact circulation. Differential bone marrow cell counts were obtained from a count of 300 cells per smear and blood samples were assayed for hemoglobin concentration and 2,3-diphosphoglycerate (DPG). Results of blood assays showed no difference in hemoglobin concentration. DPG levels were reduced in the IUGR guinea pigs (P < .05), which could be a consequence of decreased glucose availability or represent an adaptation to reduced oxygen availability. Comparisons of bone marrow counts revealed an increase in total erythrocyte precursors (P < .05) and a decrease in total granulocytic precursors (P < .05) in IUGRfetuses. Within the erythroid lineage there was a significant increase in late (orthochromatic) erythroblasts (P < .005) in the IUGR animals compared with co...","PeriodicalId":79453,"journal":{"name":"Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association","volume":"65 1","pages":"561-568"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88954646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory cytokine mRNAs in surgical specimens of necrotizing enterocolitis and normal newborn intestine. 坏死性小肠结肠炎和正常新生儿肠道手术标本中的炎性细胞因子mrna。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01 DOI: 10.1080/15513819709168731

R. Viscardi, Nancy H. Lyon, Chen-Chih J. Sun, J. Richard Hebel, J. D. Hasday

{"title":"Inflammatory cytokine mRNAs in surgical specimens of necrotizing enterocolitis and normal newborn intestine.","authors":"R. Viscardi, Nancy H. Lyon, Chen-Chih J. Sun, J. Richard Hebel, J. D. Hasday","doi":"10.1080/15513819709168731","DOIUrl":"https://doi.org/10.1080/15513819709168731","url":null,"abstract":"Coagulation necrosis, inflammation, and hemorrhage are pathologic hallmarks of necrotizing enterocolitis (NEC). Because cytokines are peptides that mediate inflammatory cell recruitment and amplify the immune response, several of the inflammatory cytokines have been implicated in NEC. We hypothesized that mRNA levels for the interrelated cytokines interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), IL-6, and the neutrophil chemotactic factor IL-8 would be increased in NEC and would be associated with the presence of inflammation. In this study, we determined the relative levels and localization of mRNA for these cytokines in surgical pathology archival intestinal tissue from 29 premature infants with acute NEC and 15 control infants with congenital intestinal malformations using a novel quantitative in situ hybridization technique. Compared with controls, there were higher IL-1 beta mRNA levels in full-thickness sections and higher TNF-alpha mRNA levels in full-thickness and mucosa sections of acute NEC samples, suggesting a potential role for these cytokines in the pathogenesis of local inflammation in NEC. IL-6 and IL-8 mRNA levels were similar in samples of control and acute NEC cases. Analysis of covariance including all subjects showed that the presence of acute inflammation was associated with increased IL-1 beta mRNA levels in mucosa (P = .035) and increased IL-8 in full-thickness sections (P = .005) and mucosa (P = .01). In four of five NEC cases in which intestinal specimens were available from reanastomosis surgery, cytokine mRNA levels decreased to low or undetectable levels. These data suggest that the inflammatory cytokines are involved in neutrophil recruitment and augmentation of the inflammatory response in neonatal intestine.","PeriodicalId":79453,"journal":{"name":"Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association","volume":"232 1","pages":"547-59"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88965140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 105

Right-sided high origin of diaphragm associated with accessory lobe of liver, lobulated right atrial appendage, and ipsilateral phrenic nerve hamartoma: a case report. 右侧膈高起点伴肝副叶，分叶状右心房附件，同侧膈神经错构瘤1例。

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01 DOI: 10.1080/15513819709168744

John Kasznica, R. Praagh, Abraham T. Philip

引用次数: 6