CELL POPULATIONS IN THE BONE MARROW OF GUINEA PIG FETUSES WITH INTRAUTERINE GROWTH RETARDATION

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association Pub Date : 1997-07-01 DOI:10.1080/107710497174525

L. Ernst, M. Sanders, C. Salafia, A. Carter

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Abstract

Bone marrow smears and blood samples were examined in guinea pig fetuses in which intrauterine growth retardation (IUGR) had been induced by uterine artery ligation and compared with those of control (well-grown) fetuses from uterine horns with intact circulation. Differential bone marrow cell counts were obtained from a count of 300 cells per smear and blood samples were assayed for hemoglobin concentration and 2,3-diphosphoglycerate (DPG). Results of blood assays showed no difference in hemoglobin concentration. DPG levels were reduced in the IUGR guinea pigs (P < .05), which could be a consequence of decreased glucose availability or represent an adaptation to reduced oxygen availability. Comparisons of bone marrow counts revealed an increase in total erythrocyte precursors (P < .05) and a decrease in total granulocytic precursors (P < .05) in IUGRfetuses. Within the erythroid lineage there was a significant increase in late (orthochromatic) erythroblasts (P < .005) in the IUGR animals compared with co...

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宫内发育迟缓豚鼠胎儿骨髓细胞群的研究

对子宫动脉结扎致宫内生长迟缓(IUGR)的豚鼠胎儿进行骨髓涂片和血液检查，并与循环完整的子宫角发育良好的对照胎儿进行比较。通过每张涂片300个细胞的计数获得骨髓细胞的差异计数，并检测血液样本的血红蛋白浓度和2,3-二磷酸甘油酸(DPG)。血液分析结果显示血红蛋白浓度无差异。IUGR豚鼠的DPG水平降低(P < 0.05)，这可能是葡萄糖可用性降低的结果，也可能是对氧可用性降低的适应。骨髓计数比较显示，iugr胎儿总红细胞前体细胞增加(P < 0.05)，总粒细胞前体细胞减少(P < 0.05)。在红系谱系中，IUGR动物的晚期(正色)红母细胞数量显著高于对照组(P < 0.005)。

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Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association

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