Noshuyo byori = Brain tumor pathology最新文献_第5页

Radioimaging of human glioma by indium-111 labeled G-22 anti-glioma monoclonal antibody. 用铟-111标记的G-22抗胶质瘤单克隆抗体放射显像人胶质瘤。

Noshuyo byori = Brain tumor pathology Pub Date : 1995-01-01

T Wakabayashi, J Yoshida, H Okada, K Sugita, K Itoh, M Tadokoro, M Ohshima

{"title":"Radioimaging of human glioma by indium-111 labeled G-22 anti-glioma monoclonal antibody.","authors":"T Wakabayashi, J Yoshida, H Okada, K Sugita, K Itoh, M Tadokoro, M Ohshima","doi":"","DOIUrl":"","url":null,"abstract":"We previously have reported that indium-111 labeled anti-glioma monoclonal antibody G-22 (111In-G-22) exhibits diagnostic potential against human glioma xenografts in athymic mice. Herein, we report the selective tumor localization of 111In-G-22 in patients with glioma. Five patients were administered an average of 2.2 mCi of 111In-G-22 whole IgG intravenously. No immediate or delayed side effects were attributable to 111In-G-22 injection. Serial gamma scintigraphy and single photon emission computed tomography (SPECT) were performed, and the distribution in the brain and intratumoral accumulation of 111In-G-22 were evaluated. CT and/or magnetic resonance (MR) images were performed simultaneously and these images were compared. In the case of malignant glioma, tumor-imaging was successfully obtained beginning at 6 h following injection with a maximum uptake tumor/brain ratio at 48 h. The distribution of 111In was selective. It predominantly accumulated in the biologically active areas of the tumor. Furthermore, the tracer uptake appeared to correlate with the histologic tumor grade. This confirms the G-22 monoclonal antibody specifically binds to biologically active and malignant glioma tissue, and tumor-imaging using 111In-G-22 may give support to the diagnosis of malignant glioma.","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19834361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clear cell variants of intracranial tumors: meningioma and ependymoma. 颅内肿瘤的透明细胞变异:脑膜瘤和室管膜瘤。

Noshuyo byori = Brain tumor pathology Pub Date : 1995-01-01

A Kakita, H Takahashi, T Fusejima, K Konno, T Nakazawa, K Aoki, R Tanaka, F Ikuta

{"title":"Clear cell variants of intracranial tumors: meningioma and ependymoma.","authors":"A Kakita, H Takahashi, T Fusejima, K Konno, T Nakazawa, K Aoki, R Tanaka, F Ikuta","doi":"","DOIUrl":"","url":null,"abstract":"We report two cases of rare histological types of intracranial clear cell tumor. Case 1: The tumor, on the left frontal convexity in a 64-year-old woman, consisted largely of polygonal cells with clear cytoplasm which were divided into lobules of uneven size by abundant fibrous connective tissue. Most of the tumor cells were immunopositive for epithelial membrane antigen and vimentin. Ultrastructurally, the tumor cells showed conspicuous interdigitations of their plasma membranes with frequent junctional complexes, and contained numerous glycogen granules in the cytoplasm and its processes. Occasionally, amianthoid collagen fibers were found in the fibrous stroma. Our diagnosis of this tumor was clear cell meningioma. Case 2: The tumor, in the right cerebellar hemisphere in a 64-year-old woman, consisted of round, clear cells with a honeycomb-like pattern. The tumor cells were positive for glial fibrillary acidic protein, vimentin and S-100 protein. Ultrastructurally, the tumor was composed of round cells arranged in a cell-to-cell pattern, and the adjacent cells often formed microrosettes containing microvilli in their lumina. There were scattered cells with accumulatios of glycogen granules in their cytoplasm. Our diagnosis of this tumor was clear cell ependymoma. From the light microscopic features of these tumors, it does not necessarily seem easy to discriminate them from other intracranial tumors composed of similar clear cells, such as oligodendroglioma, central neurocytoma, hemangioblastoma and metastic renal cell carcinoma. Ultrastructural examination is crucial in the identification of the clear cell variants of meningioma and ependymoma.","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19834362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of medullomyoblastoma from classical medulloblastoma following a long term latency. 经典髓母细胞瘤经长期潜伏期发展为髓母细胞瘤。

Noshuyo byori = Brain tumor pathology Pub Date : 1995-01-01

H Yokoo, A Maeshima, A Sasaki, J Hirato, Y Nakazato, M Tamura

引用次数: 0

Immunohistochemical and electron microscopic study of subependymal giant cell astrocytoma. 室管膜下巨细胞星形细胞瘤的免疫组化及电镜研究。

Noshuyo byori = Brain tumor pathology Pub Date : 1995-01-01

M C Huang, O Kubo, Y Tajika, K Takakura

引用次数: 0

Proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs) in benign, atypical and malignant meningiomas. 良性、非典型和恶性脑膜瘤的增殖细胞核抗原(PCNA)和核仁组织区(NORs)。

Noshuyo byori = Brain tumor pathology Pub Date : 1995-01-01

M C Lee, M W Kang, B S Yang, C S Park, S W Juhng, S Jung, J H Kim, S H Kim, S S Kang, J H Lee

引用次数: 0

Proliferative potential and malignant transformation of ganglioglioma: immunohistochemical studies by MIB-1 and p53 staining. 神经节胶质瘤的增殖潜能和恶性转化:免疫组织化学研究的mb -1和p53染色。

Noshuyo byori = Brain tumor pathology Pub Date : 1995-01-01

M Nagai, T Tejima, T Arai, J Narita, K Watanabe, C Ochiai, Y Yoshimoto, M Endoh

引用次数: 0

Brain tumor: immunohistochemical studies on the stress-response proteins, p53 protein and proliferating cell nuclear antigen. 脑肿瘤:应激反应蛋白、p53蛋白和增殖细胞核抗原的免疫组化研究。

Noshuyo byori = Brain tumor pathology Pub Date : 1995-01-01

S Kato, T Morita, T Hori, M Kato, A Hirano, F Herz, E Ohama

{"title":"Brain tumor: immunohistochemical studies on the stress-response proteins, p53 protein and proliferating cell nuclear antigen.","authors":"S Kato, T Morita, T Hori, M Kato, A Hirano, F Herz, E Ohama","doi":"","DOIUrl":"","url":null,"abstract":"This retrospective immunohistochemical study compares the expression of five stress-response (heat-shock) proteins (srp's) [srp 90, srp 72, srp 27, alpha B-crystallin and ubiquitin], p53 protein and proliferating cell nuclear antigen (PCNA) in 118 primary brain tumors and 21 carcinoma metastases to the central nervous system. Serial sections of formalin-fixed, paraffin-embedded tissues were used. Most astrocytomas (9/13), ependymomas (5/5), glioblastoma multiforme (GBM) (11/12), schwannomas (19/21), meningiomas (22/23) and breast carcinoma metastases (Br-Mt) (9/10), and some medulloblastomas (5/15), primitive neuroectodermal tumors (PNETs) (5/11), pituitary adenomas (4/7) and lung carcinoma metastases (6/11), but none of 10 oligodendrogliomas had tumor cells that expressed one or more (up to five) srp's. The percentage of tumors with p53-positive cells was variable; the proportion was highest among srp-expressing GBMs (mean: 16.1%) and Br-Mts (mean: 15.3%). The mean PCNA-labeling index (LI) also varied, ranging from 1.2% in the group of pituitary adenomas to 24.5% in Br-Mts, with GBMs (20.4%) and medulloblastomas (18.4%) approaching the latter value. PCNA-LI was higher in the astrocytomas, GBMs, medulloblastomas and PNETs that expressed srp's than in those did not. A high proportion of p53-positive cells (31.3 to 59.0%) and the highest PCNA-LIs (41.0 to 49.0%) were seen in two GBMs and one Br-Mt that expressed all five srp's. We conclude that primary and metastatic tumors of the brain produce one or more stress-related proteins, and that a variable proportion of the tumor cells have immunohistochemically-detectable p53, the expression of which may depend, at least in part, on the growth potential of a given tumor.","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19834364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image analysis of nuclear DNA content and morphometric characteristics of the tumor cells in human astrocytomas. 人星形细胞瘤细胞核DNA含量及形态特征的图像分析。

Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01

A Saito, Y Yoshii, T Nose

引用次数: 0

[Symptomatic Rathke's cleft cyst: a clinicopathologic study of 9 cases]. 症状性Rathke裂隙囊肿9例临床病理分析

Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01

T Fukushima, S Sakamoto, H Kimura, T Matsuda, H Tsugu, M Tomonaga

{"title":"[Symptomatic Rathke's cleft cyst: a clinicopathologic study of 9 cases].","authors":"T Fukushima, S Sakamoto, H Kimura, T Matsuda, H Tsugu, M Tomonaga","doi":"","DOIUrl":"","url":null,"abstract":"Nine cases of symptomatic Rathke's cleft cyst are reported. Their most frequent signs and symptoms included headache, chiasmal syndrome and hypopituitarism, while one of the cases developed a sudden onset of headache and vomiting following diabetes insipidus. Endocrinological findings showed a decreased ACTH, gonadotropin and growth hormone more frequently while there were 2 cases of hyperprolactinemia and 1 case of diabetes insipidus. In a neuroradiological examination, a plain skull X-ray showed 5 cases of ballooning of the sella turcica, and a CT scan demonstrated a low to high density of the cyst and 2 cases of marginal enhancement of the cyst. MRI mostly demonstrated a well delineated mass at the sella extending mostly into the suprasellar region and a low to high intensity of the cyst in the T1-weighted image. Two cases were marginally enhanced after gadolinium DTPA administration. The pathological examination, done on 6 cases, showed either single or multiple layers of the epithelium which were mostly ciliated. The epithelium was positive in PAS and Alcian blue in all cases and a histochemical examination showed 3 cases to be positive in EMA and 2 cases positive in CEA. A resection of the cyst wall and an opening of the cyst is thus recommended in symptomatic cases. Therefore, the transsphenoidal approach should be the choice of treatment in an intra- and suprasellar extension of the cysts with sellar enlargement.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19152670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes of the bromodeoxyuridine labeling index of astrocytic tumors between primary and recurrent lesions. 星形细胞肿瘤原发与复发病变间溴脱氧尿苷标记指数的变化。

Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01

M Tamura, N Ono, A Zama, H Kurihara

引用次数: 0