Proliferative potential and malignant transformation of ganglioglioma: immunohistochemical studies by MIB-1 and p53 staining.

Noshuyo byori = Brain tumor pathology Pub Date : 1995-01-01

M Nagai, T Tejima, T Arai, J Narita, K Watanabe, C Ochiai, Y Yoshimoto, M Endoh

引用次数: 0

Abstract

We studied two cases of ganglioglioma immunohistochemically by MIB-1 and p53 staining. The positive rate of MIB-1 in the ganglionic cells was 5.5% in Case 1 and 7.8% in Case 2, and that of MIB-1 in the gliomatous cells was 1.4 and 6.6% respectively. The labeling index of p53 in the ganglionic cells was 7.3% in Case 1 and 7.7% in Case 2, and that of the gliomatous cells was 1.9 and 3.4% respectively. MIB-1 and p53 did not stain ganglionic precursor cells. These results indicate that the ganglionic cells also take part in proliferation and have potential of malignant transformation.

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神经节胶质瘤的增殖潜能和恶性转化:免疫组织化学研究的mb -1和p53染色。

我们用免疫组织化学方法对2例神经节胶质瘤进行了研究。病例1和病例2中mb -1在神经节细胞中的阳性率分别为5.5%和7.8%，在胶质瘤细胞中的阳性率分别为1.4%和6.6%。在病例1和病例2中，神经节细胞的p53标记指数分别为7.3%和7.7%，胶质瘤细胞的p53标记指数分别为1.9和3.4%。MIB-1和p53对神经节前体细胞无染色作用。这些结果提示神经节细胞也参与增殖，具有恶性转化的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Noshuyo byori = Brain tumor pathology

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