Journal of lipid mediators and cell signalling最新文献_第8页

Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine ml-m4 receptors in neuroblastoma-derived hybrid cells 肌醇三磷酸/Ca2+作为缓激肽B2和毒蕈碱乙酰胆碱ml-m4受体在神经母细胞瘤来源的杂交细胞中的信使

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00523-8

Mami Noda , Nobuto Ishizaka , Shigeru Yokoyama , Naoto Hoshi , Yasuhiro Kimura , Minako Hashii , Megumi Taketo , Alla Egorova , Rimma Knijnik , Kazuhiko Fukuda , Hitoshi Morikawa , David A. Brown , Haruhiro Higashida

{"title":"Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine ml-m4 receptors in neuroblastoma-derived hybrid cells","authors":"Mami Noda , Nobuto Ishizaka , Shigeru Yokoyama , Naoto Hoshi , Yasuhiro Kimura , Minako Hashii , Megumi Taketo , Alla Egorova , Rimma Knijnik , Kazuhiko Fukuda , Hitoshi Morikawa , David A. Brown , Haruhiro Higashida","doi":"10.1016/0929-7855(96)00523-8","DOIUrl":"10.1016/0929-7855(96)00523-8","url":null,"abstract":"<div><p>Neuroblastoma × glioma hybrid NG108-15 and neuroblastoma × fibroblast hybrid NL308 cells possess endogenous bradykinin B<sub>2</sub> receptors and m4 muscarinic acetylcholine receptors (mAChRs), which couple to phospholipase C and adenylate cyclase, respectively. Four genetic subtypes of mAChRs differed in their effects when stimulated in NG108-15 and NL308 cells overexpressing mAChRs. Broadly speaking, the principal effects fell into two categories: the odd-numbered receptors (ml and m3) activated phospholipase C and increased inositol trisphosphate/Ca<sup>2+</sup>, as bradykinin did, whereas the even-numbered receptors (m2 and m4) inhibited adenylate cyclase via a pertussis toxin (PTx)-sensitive G-protein in NG108-15 cells. But all four types of NL308 cells overexpressing each m1, m2, m3 and m4 receptor activated phospholipase C, while keeping the PTx-sensitivity in m2/m4, but not in m1/m3 receptors. Coupling to ion channel effectors showed a comparable dichotomy in NG108-15 cells, while cross-activation occurred in NL308 cells.</p></div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 175-185"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00523-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19870868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Acute regulation of the receptor-mediated phosphoinositide signal transduction pathway 受体介导的磷酸肌肽信号转导途径的急性调控

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00521-4

G.B. Willars, R.A.J. Challiss, S.R. Nahorski

引用次数: 10

Enzymes for anandamide biosynthesis and metabolism 用于大麻酰胺生物合成和代谢的酶

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00509-3

Natsuo Ueda , Yuko Kurahashi , Kei Yamamoto , Shozo Yamamoto , Takashi Tokunaga

引用次数: 12

Relative contribution of the de novo and remodelling pathways to the synthesis of platelet-activating factor in brain areas and during ischemia 脑缺血时新生和重构通路对血小板活化因子合成的相对贡献

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)01513-1

Ermelinda Francescangeli , Krystina Domanska-Janik , Gianfrancesco Goracci

{"title":"Relative contribution of the de novo and remodelling pathways to the synthesis of platelet-activating factor in brain areas and during ischemia","authors":"Ermelinda Francescangeli , Krystina Domanska-Janik , Gianfrancesco Goracci","doi":"10.1016/0929-7855(96)01513-1","DOIUrl":"10.1016/0929-7855(96)01513-1","url":null,"abstract":"<div><p>Two distinct pathways for the synthesis of platelet-activating factor (PAF) have been demonstrated in the nervous tissue. This potent lipid mediator is involved in physiological and pathological processes. The relative contribution of the two pathways to its synthesis during various conditions needs to be defined, thus the activities of the enzymes directly responsible for PAF synthesis, PAF-synthesizing phosphocholinetransferase (PAF-PCT) and lyso-PAF acetlytransferase (lyso-PAF AcT), have been assayed in rat brain areas. The former catalyses the last reaction of the de novo pathway and the latter that of the remodelling one. PAF-PCT activity was always more elevated thant hat of lyso PAF AcT. No differences were observed among different brain areas when enzyme activities were assayed in their homogenates. In microsomes, the highest PAF-PCT activity was found in cerebellum whereas lyso-PAF AcT activity was greater in cerebellum and in hippocampus than in the other brain areas. The activity of PAF-synthesizing enzymes was also studied in the gerbil during ischemia and reperfusion. After 6 min from bilateral occlusion of the carotid arteries, a significant increase of lyso-PAF AcT activity was observed in the hippocampus. This enzyme activity remained relatively high up to 3 days after reperfusion whereas, in other brain areas it reached basal levels much earlier. Since it has been shown that the PAF levels increase in the brain of animals during ischemia, these results suggest that the remodelling pathway may provide an important contribution to its synthesis particularly in the hippocampus, where a selective neuronal death is observed. In this area during reperfusion, a further contribution to PAF synthesis might be also provided by the de novo pathway.</p></div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 89-98"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)01513-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19871617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release 血小板活化因子和生长抑素激活丝裂原活化蛋白激酶(MAP激酶)和花生四烯酸酯释放

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00515-9

Takao Shimizu, Mikiro Mori, Haruhiko Bito, Chie Sakanaka, Sadaharu Tabuchi, Makoto Aihara, Kazuhiko Kume

引用次数: 15

Roles of phospholipases A2 in brain cell and tissue injury associated with ischemia and excitotoxicity 磷脂酶A2在缺血和兴奋性毒性相关的脑细胞和组织损伤中的作用

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00503-2

Joseph V. Bonventre

{"title":"Roles of phospholipases A2 in brain cell and tissue injury associated with ischemia and excitotoxicity","authors":"Joseph V. Bonventre","doi":"10.1016/0929-7855(96)00503-2","DOIUrl":"10.1016/0929-7855(96)00503-2","url":null,"abstract":"<div><p>Phospholipase A<sub>2</sub> (PLA<sub>2</sub>) activity is an important contributor to destructive cellular processes in the central nervous system. Two cytosolic forms of calcium independent PLA<sub>2</sub> have been characterized in the gerbil brain and the neuronal cultures from rat brain. PLA<sub>2</sub> enzymatic activity in cell free extracts from cortical neuronal cultures is upregulated after cells are exposed to glutamate. Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA<sub>2</sub> activity. Stable activation of the two cytosolic forms of PLA<sub>2</sub> occur prior to evidence of cell death and this activation is reversible. The larger molecular mass form was characterized as cPLA<sub>2</sub>. The smaller form (∼ 14 kDa) was distinct from Group I and II PLA<sub>2</sub>. Exposure to glutamate shifted the calcium activation curve of the smaller form to the left suggesting a novel mechanism of regulation of PLA<sub>2</sub>. Glutamate-induced stable enhancement of PLA<sub>2</sub> activity, by processes involving calcium and protein kinase C activation, is a potential molecular switch likely mediating changes in synaptic function and contribution to excitotoxicity.</p></div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 15-23"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00503-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19872465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 68

Sphingoid bioregulators in the differentiation of cells of neural origin 神经源性细胞分化中的鞘生物调节剂

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00535-4

Guido Tettamanti, Alessandro Prinetti, Rosaria Bassi, Paola Viani, Paola Giussani, Laura Riboni

{"title":"Sphingoid bioregulators in the differentiation of cells of neural origin","authors":"Guido Tettamanti, Alessandro Prinetti, Rosaria Bassi, Paola Viani, Paola Giussani, Laura Riboni","doi":"10.1016/0929-7855(96)00535-4","DOIUrl":"10.1016/0929-7855(96)00535-4","url":null,"abstract":"<div><p>The involvement of ceramide in the differentiation of two neuroblastoma cell lines, Neuro2a and SH-SY5Y, and cerebellar granule cells in primary culture was investigated. The following results were obtained: (a) the cellular content of ceramide markedly increased with induced differentiation of Neuro2a cells (inducers: RA, FCS deprivation), SH-SY5Y cells (inducers: RA, PMA), and spontaneous differentiation of cerebellar granule cells; (b) all the investigated cells in the differentiated form displayed a higher ability to produce ceramide from exogenously administered [<sup>3</sup>H]Sph-SM and expressed a higher content of neutral sphingomyelinase and, in the case of cerebellar granule cells, also of acidic sphingomyelinase; (c) inhibition of ceramide biosynthesis by Fumonisin B1 blocked the process of differentiation in Neuro2a and cerebellar granule cells; and (d) treatments capable of enhancing ceramide level (administration of sphingosine or C<sub>2</sub>-Ceramide) induced differentiation in both Neuro2a and SH-SY5Y cells. The data obtained support the notion that ceramide plays a general biomodulatory role in neural cell differentiation.</p></div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 263-275"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00535-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19870760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Phospholipid metabolism in Alzheimer's disease and in a human cholinergic cell 阿尔茨海默病和人类胆碱能细胞的磷脂代谢

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00545-7

Julian N. Kanfer , Indrapal N. Singh , Jay W. Pettegrew , Douglas G. McCartney , Giuseppe Sorrentino

引用次数: 39

Arachidonic acid synthesis and lipid metabolism in retinoic acid-differentiated neuroblastoma cells 视黄酸分化神经母细胞瘤细胞中花生四烯酸的合成和脂质代谢

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00506-8

Anna Petroni, Milena Blasevich, Patrizia La Spada, Nadia Papini, Claudio Galli

引用次数: 2

Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events wortmanning对磷脂酰肌醇3-激酶介导的细胞事件的抑制作用

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 DOI: 10.1016/0929-7855(96)00534-2

Osamu Hazeki , Kaoru Hazeki , Toshiaki Katada , Michio Ui

引用次数: 26