Julian N. Kanfer , Indrapal N. Singh , Jay W. Pettegrew , Douglas G. McCartney , Giuseppe Sorrentino
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Phospholipid metabolism in Alzheimer's disease and in a human cholinergic cell
There is evidence available suggesting that membrane alterations occur in Alzheimer's disease including the metabolism of membrane phospholipids. We have quantitated in vitro the phospholipase D activity of homogenates from Alzheimer's disease brain tissue. There was a significant increase of this enzyme activity as compared to controls. Amyloid β protein is the predominant protein of the characteristics senile plaques found in Alzheimer's disease. Treatment of LA-N-2 cells, a human cholinergic neuroblastoma clone, with amyloid β protein results in an activation of phospholipases A, C and D.
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