Journal of lipid mediators and cell signalling最新文献_第10页

Platelet activating factor (PAF) in memory formation: role as a retrograde messenger in long-term potentiation 血小板活化因子(PAF)在记忆形成中的作用:作为逆行信使在长期增强中的作用

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)01517-9

Elizabeth Kornecki , Andrzej Wieraszko , Jane Chan , Yigal H. Ehrlich

{"title":"Platelet activating factor (PAF) in memory formation: role as a retrograde messenger in long-term potentiation","authors":"Elizabeth Kornecki , Andrzej Wieraszko , Jane Chan , Yigal H. Ehrlich","doi":"10.1016/0929-7855(96)01517-9","DOIUrl":"10.1016/0929-7855(96)01517-9","url":null,"abstract":"<div>Long-term potentiation (LTP) is a neurophysiological process that has been implicated in memory formation. The elevation of intracellular Ca2+ levels in postsynaptic neurons, an essential step in the induction of LTP in the hippocampus, can lead to activation of the enzyme acetyl-CoA:lyso-PAF acetyltransferase that is required for PAF synthesis in neurons. Thus, during the induction of LTP, stimulation of Ca2+ influx by glutamate receptors would lead to a postsynaptic increase in PAF biosynthesis. A main target for PAF action in neurons is the stimulation of neurotransmitter release via Ca2+-dependent vesicular exocytosis, a process that occurs presynaptically. In this article we describe the evidence obtained to-date for the pre- and postsynaptic events outlined above, and demonstrate for the first time that during the induction of LTP by high-frequency stimulation (HFS) a 9-fold increase in PAF release to the extracellular environment occurs within 60 min following HFS. This finding provides the evidence that PAF can diffuse from postsynaptic sites of synthesis to presynaptic sites of action, and thus function as a retrograde messenger in the induction of LTP. Based on these data, we present a scheme in which postsynaptic glutamate receptors cooperate with presynaptic PAF receptors in a reverberating cycle that can amplify the transmission in a Hebbian synapse.</div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 115-126"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)01517-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19870971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Effects of endothelin on phospholipases and generation of second messengers in cat iris sphincter and SV-CISM-2 cells 内皮素对猫虹膜括约肌和sv - csm -2细胞磷脂酶和第二信使生成的影响

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)00520-2

Ata A. Abdel-Latif, Ke-Hong Ding, Rashid A. Akhtar, Sardar Y.K. Yousufzai

{"title":"Effects of endothelin on phospholipases and generation of second messengers in cat iris sphincter and SV-CISM-2 cells","authors":"Ata A. Abdel-Latif, Ke-Hong Ding, Rashid A. Akhtar, Sardar Y.K. Yousufzai","doi":"10.1016/0929-7855(96)00520-2","DOIUrl":"10.1016/0929-7855(96)00520-2","url":null,"abstract":"<div>In both immortalized cat iris sphincter smooth muscle cells (SV-CISM-2 cells) and cat iris sphincter, endothelin-1 (ET-1) markedly increased the activities of phospholipase A2 (PLA2), as measured by the release of arachidonic acid (AA), phospholipase C (PLC), as measured by the production of inositol triphosphate (IP3), and phospholipase D (PLD), as measured by the formation of phosphatidylethanol (PEt). In SV-CISM-2 cells, ET-1 induced AA release, IP3 production and PEt formation in a dose- and time-dependent manner. The dose-response studies showed that the peptide is more potent in activating PLD (EC50 = 1.2 nM) than in activating PLC (EC50 = 1.5 nM) or PLA2 (EC50 = 1.7 nM). The time course studies revealed that ET-1 activated the phospholipases in a temporal sequence in which PLA2 was stimulated first (<math><mtext>t</mtext><msub><mi></mi><mn><mtext>1</mtext><mtext>2</mtext></mn></msub><mtext> = 12 </mtext><mtext>s</mtext></math>), followed by PLC (<math><mtext>t</mtext><msub><mi></mi><mn><mtext>1</mtext><mtext>2</mtext></mn></msub><mtext> = 48 </mtext><mtext>s</mtext></math>) and lastly PLD (<math><mtext>t</mtext><msub><mi></mi><mn><mtext>1</mtext><mtext>2</mtext></mn></msub><mtext> = 106 </mtext><mtext>s</mtext></math>). In SV-CISM-2 cells, in contrast to the intact iris sphincter, sarafotoxin-c, an ETB receptor agonist, had no effect on the phospholipases, and indomethacin, a cyclooxygenase inhibitor, had no effect on the stimulatory effect of ET-1 on the phospholipases. These results suggest that in this smooth muscle cell line, ET-1 interacts with the ETA receptor subtype to activate, via G proteins, phospholipases A2, C and D in a temporal sequence.</div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 147-155"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00520-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19870974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Retrograde messengers and long-term potentiation: A progress report 逆行信使和长期增强:进展报告

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)00542-1

J.H. Williams

引用次数: 23

Ceramide: Role in growth inhibitory cascades 神经酰胺:生长抑制级联反应中的作用

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)00538-X

Supriya Jayadev, Yusuf A. Hannun

引用次数: 19

Lysosphingomyelin-elicited Ca2+ mobilization from rat brain microsomes 溶鞘磷脂诱导大鼠脑微粒体Ca2+动员

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)00539-1

Shigeki Furuya , Sadamu Kurono , Yoshio Hirabayashi

引用次数: 12

Membrane-associated phospholipase D activity in neural cell line PC12 膜相关磷脂酶D在神经细胞系PC12中的活性

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)00531-7

Yoshiko Banno , Yuzuru Ito , Katsuhiro Ojio , Hiroyuki Kanoh , Shigeru Nakashima , Yoshinori Nozawa

引用次数: 7

Membrane localization of N-acylphosphatidylethanolamine in central neurons: Studies with exogenous phospholipases n -酰基磷脂酰乙醇胺在中枢神经元中的膜定位:外源性磷脂酶的研究

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)00510-X

Hugues Cadas, Sergio Schinelli , Daniele Piomelli

{"title":"Membrane localization of N-acylphosphatidylethanolamine in central neurons: Studies with exogenous phospholipases","authors":"Hugues Cadas, Sergio Schinelli , Daniele Piomelli","doi":"10.1016/0929-7855(96)00510-X","DOIUrl":"10.1016/0929-7855(96)00510-X","url":null,"abstract":"<div>We studied the localization of N-acyl phosphatidylethanolamine (NAPE), a putative cannabinoid precursor, in primary cultures of striatal and cortical neurons from the rat brain. We probed intact neurons with various exogenous phospholipases, including S. chromofuscus phospholipase D (PLD). S. chromofuscus PLD does not penetrate into neurons (as demonstrated by a lack of internalization of 125I-labeled PLD), and does not cause gross damage to the neuronal membrane (as demonstrated by a lack of effect of PLD on [3H]γ-aminobutyric acid release). When neurons, labeled to isotopic equilibrium with [3H]ethanolamine, were incubated for 10 min with S. chromofuscus PLD, approximately 50% of neuronal NAPE was hydrolysed. This hydrolysis was accompanied by the release of a family of N-acyl ethanolamines (NAE) (assessed by high performance liquid chromatography), which included the cannabinoid receptor agonist, anandamide. Exogenous phospholipase A2 (PLA2) (Apis mellifera) and PLC (B. cereus) mobilized [3H]arachidonate and [3H]diacylglycerol, respectively, but had no effect on NAE formation under these conditions. These experiments indicate that ∼ 50% of neuronal NAPE is localized in a compartment that is easily accessible to extracellular PLD, possibly the plasmalemma, where it would also be easily hydrolyzed upon stimulation to produce NAE.</div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 63-70"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00510-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19871614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Lipid messengers in the nervous system. Proceedings of a satellite symposium of the 15th meeting of the International Society for Neurochemistry. Tokyo, Japan, June 28-30, 1995. 神经系统中的脂质信使。第十五届国际神经化学学会卫星研讨会论文集。1995年6月28日至30日，日本东京。

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01

引用次数: 0

Heterogeneity of diacylglycerol kinase in terms of molecular structure, biochemical characteristics and gene expression localization in the brain 二酰基甘油激酶在脑内分子结构、生化特性和基因表达定位方面的异质性

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)00533-0

Kaoru Goto, Hisatake Kondo

{"title":"Heterogeneity of diacylglycerol kinase in terms of molecular structure, biochemical characteristics and gene expression localization in the brain","authors":"Kaoru Goto, Hisatake Kondo","doi":"10.1016/0929-7855(96)00533-0","DOIUrl":"10.1016/0929-7855(96)00533-0","url":null,"abstract":"<div>Three different cDNA clones for diacylglycerol (DG) kinase were isolated from a rat brain cDNA library and designated DGK-I, DGK-II and DGK-III. These three encode distinct polypeptides with 58% identity to each other and contain EF-hand motifs, cysteine-rich zinc finger-like sequences and putative ATP-binding sites. A high kinase activity is shown in COS cells transfected with either one of the three cDNAs without substrate specificity among DG species, and the kinase activity is Ca-dependent. The activity for DGK-I is recovered dominantly in the soluble fraction of the cell, that for DGK-II in the particulate fraction; and that for DGK-III equally in both of the fractions. The difference in their expression localization is most noticeable: DGK-I is expressed in oligodendrocytes of the brain as well as T-lymphocytes in the thymus and spleen; DGK-II is expressed in neurons of the caudate-putamem, accumbens nucleus and olfactory tubercle; and DGK-III in the cerebellar Purkinje cells and granule cells. The functional significance of the discovery of three DG kinase isozymes is briefly discussed.</div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 251-257"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00533-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19870758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Phosphatidylcholine hydrolysis and protein kinase C activation for intracellular signaling network 磷脂酰胆碱水解和蛋白激酶C在细胞内信号网络中的激活

Journal of lipid mediators and cell signalling Pub Date : 1996-09-01 Epub Date: 1999-03-22 DOI: 10.1016/0929-7855(96)00525-1

Shun-ichi Nakamura

引用次数: 14