Torbjörn K Nilsson, J David Spence, Peter M Nilsson, Mats Eliasson, Jan-Håkan Jansson, Kurt Boman
{"title":"Quantitative measurement of carotid atherosclerosis in relation to levels of von Willebrand factor and fibrinolytic variables in plasma--a 2-year follow-up study.","authors":"Torbjörn K Nilsson, J David Spence, Peter M Nilsson, Mats Eliasson, Jan-Håkan Jansson, Kurt Boman","doi":"10.1177/174182670200900406","DOIUrl":"https://doi.org/10.1177/174182670200900406","url":null,"abstract":"<p><strong>Background: </strong>It has been proposed that the mechanism of action of the new risk factors for myocardial infarction and stroke, von Willebrand factor (vWF), tissue plasminogen activator (tPA) and tissue plasminogen activator inhibitor-1 (PAI-1) could possibly be mediated via a primary effect on atherogenesis but there is little data to substantiate this.</p><p><strong>Design: </strong>A prospective single-centre cohort study of progression of atherosclerosis.</p><p><strong>Methods: </strong>Carotid plaque area was quantitated by two-dimensional (2D) ultrasound in 258 subjects at entry and after 1 and 2 years. Plasma and serum samples were drawn at baseline and serum lipids and plasma levels of haemostatic factors were measured.</p><p><strong>Results: </strong>The traditional risk factors, smoking, total cholesterol, hypertension and male gender explained 51% of the variance in plaque area at baseline and 48% at 1-year follow-up. There were small positive associations of plaque area with vWF, tPA and tPA/PAI-1 complex and a tendency to negative associations with PAI-1 levels, independent from the traditional risk factors. The additional explanatory power of the haemostatic factors did not exceed 3%.</p><p><strong>Conclusion: </strong>The data accord with a marginal role in atherogenesis of vWF and tPA, and underline the major impact of smoking, hypertension and cholesterol on carotid plaque area progression.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"9 4","pages":"215-21"},"PeriodicalIF":0.0,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/174182670200900406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22077601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. S. Jónsdóttir, N. Sigfússon, V. Gudnason, H. Sigvaldason, G. Thorgeirsson
{"title":"Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study.","authors":"L. S. Jónsdóttir, N. Sigfússon, V. Gudnason, H. Sigvaldason, G. Thorgeirsson","doi":"10.1016/S1567-5688(01)80169-0","DOIUrl":"https://doi.org/10.1016/S1567-5688(01)80169-0","url":null,"abstract":"","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"9 2 1","pages":"67-76"},"PeriodicalIF":0.0,"publicationDate":"2001-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1567-5688(01)80169-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56890198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Triglycerides and coronary heart disease: implications of recent clinical trials.","authors":"H B Rubins","doi":"10.1177/204748730000700507","DOIUrl":"https://doi.org/10.1177/204748730000700507","url":null,"abstract":"<p><p>This paper reviews the clinical trial data that offer insight into the question of whether, and in what groups of people, triglycerides might be an appropriate therapeutic target for the primary or secondary prevention of atherosclerotic cardiovascular disease. Two angiographic trials (the Lopid Coronary Angiography Trial and the Bezafibrate Coronary Atherosclerosis Intervention Trial) and three clinical endpoint trials (the Helsinki Heart Study, the Bezafibrate Infarction Prevention Study, and the VA HDL Intervention Trial) are reviewed. Hypertriglyceridemia per se is probably not an appropriate therapeutic target for the prevention of atherosclerotic cardiovascular disease because it is a poor marker of atherogenic risk and because there have been no clinical trials that have directly addressed the question of whether lowering the triglyceride level reduces the number of clinical events. The studies reviewed here, however, suggest that patients with established coronary heart disease and a high triglyceride level, in association with either a low high-density lipoprotein-cholesterol level or perhaps other features of the metabolic syndrome, such as obesity, diabetes, or hypertension, may benefit from fibrate therapy. For patients without established coronary heart disease, it is reasonable to consider hypertriglyceridemia as a risk marker prompting the aggressive treatment of other risk factors such as hypertension, diabetes, high low-density lipoprotein-cholesterol, and obesity.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"7 5","pages":"339-45"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/204748730000700507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21966066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Somatic risk factors for myocardial infarction among Swedish railway engine drivers.","authors":"S Piros, S Karlehagen, G Lappas, L Wilhelmsen","doi":"10.1177/204748730000700511","DOIUrl":"https://doi.org/10.1177/204748730000700511","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have indicated an increased incidence of myocardial infarction among railway engine drivers.</p><p><strong>Objective: </strong>To analyse whether somatic risk factors for myocardial infarction among male drivers in different geographical areas in Sweden differed from that in general population samples drawn from the same geographical areas.</p><p><strong>Design: </strong>A cross-sectional study comparing drivers and men from the general population.</p><p><strong>Methods: </strong>Engine railway drivers aged 25-59 years (n = 2318) were compared with randomly selected men (n = 3016) with respect to their serum cholesterol, systolic and diastolic blood pressures and smoking habits.</p><p><strong>Results: </strong>The levels of the risk factors did not differ between engine drivers and the reference groups except for the Stockholm area which showed a higher percentage of tobacco smokers as well as higher means for systolic and diastolic blood pressures. The risk ratio compared with the reference samples was significantly elevated in Stockholm but not in any of the other areas.</p><p><strong>Conclusions: </strong>These somatic risk factors for myocardial infarction do not explain the approximately 40% reported increase in myocardial infarction incidence among railway engine drivers. In the following study, psychosocial factors will also be examined.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"7 5","pages":"377-87"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/204748730000700511","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21966008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bibliography. Current world literature.","authors":"","doi":"10.1177/204748730000700514","DOIUrl":"https://doi.org/10.1177/204748730000700514","url":null,"abstract":"Acta Cardiologica (Acta Cardiol) American Heart Journal (Am Heart J) American Journal of Cardiology (Am J Cardiol) American Journal of Hypertension (Am J Hypertens) American Journal of Preventive Medicine (Am J Prev Med) Annals of Internal Medicine (Ann Intern Med) Annals of Medicine (Ann Med) Annals of Thoracic Surgery (Ann Thorac Surg) Annual Review of Medicine (Annu Rev Med) Annual Review of Public Health (Annu Rev Public Health) Arteriosclerosis Thrombosis and Vascular Biology (Arterioscler Thromb Vasc BioI) Atherosclerosis (Atherosclerosis) British Joumal of Hospital Medicine (Br J Hosp Mad) British Medical Journal (BMJ) Cardiology (Cardiology) Cardiovascular Research (Cardiovasc Res) Cerebrovascular Diseases (Cerebrovasc Dis) Circulation (Circulation) Circulation Research (Circ Res) Clinical Cardiology (Clin Cardiol) Clinical and Experimental Hypertension (Clin Exp Hypertens) Coronary Artery Disease (Coron Artery Dis) . Current Problems in Cerdiology (Curr Probl Oardiol) Diabetes Research and Clinical Practice (Diabetes Res Clin Pract) Diabetic Medicine (Diabet Med) European Heart Journal (Eur Heart J) Heart (Heart) Heart and Lung (Heart Lung) Hypertension (Hypertension) .' Intemational Journal of Epidemiology (lnt J Epldemlol) International Journal of Obesity and Related Metabolic Disorders (lnt JObes Relat Metab Disord) JAMA Journal of the American Medical Association (JAMA) Japanese Heart Journal (Jpn Heart J) Journal of Clinical Epidemiology (J Clin Epidemiol) Journal of Clinical Pharmacy and Therapeutics (J Clin Pharm Ther) Journal of Human Hypertension (J Hum Hypertena) Journal of Hypertension (J Hypertens) Journal of Internal Medicine (J Intern Med) Journal of Thoracic and Cardiovascular Surgery (J Thoracic Cardiovasc Surg) Journal of the American College of Cardiology (J Am Coli Cardiol) Lancet (Lancet) New England Journal of Medicine (N Engl J Med) PACE Pacing and Clinical Electrophysiology (PACE Pacing Clin Electrophyslol) Pediatric Cardiology (Padiatr Cardiol) Pediatric Clinics of North America (Pediatr Clin North Am) Postgraduate Medical Journal (Postgrad Med J) Postgraduate Medicine (Postgrad Med) Preventive Medicine (Prev Med) Progress in Cardiovascular Diseases (Prog Cardiovasc Dis) Public Health (Public Health) Scandinavian Cardiovascular Journal (Scand Cardiovasc J) Seminars in Thrombosis and Hemostasis (Semin Thromb Hemost) Stroke (Stroke) Thoracic and Cardiovascular Surgeon (Thorac Cardiovasc Surg)","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"7 5","pages":"401 - 402"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/204748730000700514","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21966011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relationship between mortality caused by cardiovascular diseases and two climatic factors in densely populated areas in Norway and Ireland.","authors":"H Eng, J B Mercer","doi":"10.1177/204748730000700510","DOIUrl":"https://doi.org/10.1177/204748730000700510","url":null,"abstract":"<p><strong>Background: </strong>Seasonal variations in mortality due to cardiovascular disease have been demonstrated in many countries, with the highest levels occurring during the coldest months of the year. It has been suggested that this can be explained by cold climate. In this study, we examined the relationship between mortality and two different climatic factors in two densely populated areas (Dublin, Ireland and Oslo/Akershus, Norway).</p><p><strong>Methods: </strong>Meteorological data (mean daily air temperatures and wind speed) and registered daily mortality data for three groups of cardiovascular disease for the period 1985-1994 were obtained for the two respective areas. The daily mortality ratio for both men and women of 60 years and older was calculated from the mortality data. The wind chill temperature equivalent was calculated from the Siple and Passels formula.</p><p><strong>Results: </strong>The seasonal variations in mortality were greater in Dublin than in Oslo/Akershus, with mortality being highest in winter. This pattern was similar to that previously shown for the two respective countries as a whole. There was a negative correlation between mortality and both air temperature and wind chill temperature equivalent for all three groups of diseases. The slopes of the linear regression lines describing the relationship between mortality and air temperature were a lot steeper for the Irish data than for the Norwegian data. However, the difference between the steepness of the linear regression lines for the relationship between mortality and wind chill temperature equivalent was considerably less between the two areas. This can be explained by the fact that Dublin is a much windier area than Oslo/Akershus.</p><p><strong>Conclusion: </strong>The results of this study demonstrate that the inclusion of two climatic factors rather than just one changes the impression of the relationship between climate and cardiovascular disease mortality.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"7 5","pages":"369-75"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/204748730000700510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21966007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The insulin resistance syndrome: impact on lipoprotein metabolism and atherothrombosis.","authors":"H N Ginsberg, L S Huang","doi":"10.1177/204748730000700505","DOIUrl":"https://doi.org/10.1177/204748730000700505","url":null,"abstract":"<p><p>Insulin resistance is a common metabolic abnormality that is associated with an increased risk of both atherosclerosis and type 2 diabetes. The phenotype of insulin resistance includes a dyslipidemia characterized by an elevation of very low-density lipoprotein triglyceride, a reduction in high-density lipoprotein cholesterol, and the presence of small, triglyceride-enriched low-density lipoproteins. The underlying metabolic abnormality driving this dylipidemia is an increased assembly and secretion of very low-density lipoprotein particles, leading to an increased plasma level of triglyceride. Hypertriglyceridemia, in turn, results in a reduction in the high-density lipoprotein level and the generation of small, dense low-density lipoproteins; these events are mediated by cholesteryl ester transfer protein. In addition, hypertension, obesity, and a prothrombotic state are also integral components of the insulin resistance syndrome. In this review, we will provide a pathophysiologic basis, based on studies on humans and in tissue culture, for the dyslipidemia of insulin resistance. We will also review the effects of insulin resistance on the coagulation and fibrinolytic pathways. It is hoped that this review will allow health professionals better to evaluate and treat their patients with insulin resistance, thereby reducing the very much increased risk of atherosclerotic cardiovascular disease carried by these individuals.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"7 5","pages":"325-31"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/204748730000700505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21966064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S De Henauw, D De Bacquer, P de Smet, M Kornitzer, G De Backer
{"title":"Trends and regional differences in coronary risk factors in two areas in Belgium: final results from the MONICA Ghent-Charleroi Study.","authors":"S De Henauw, D De Bacquer, P de Smet, M Kornitzer, G De Backer","doi":"10.1177/204748730000700508","DOIUrl":"https://doi.org/10.1177/204748730000700508","url":null,"abstract":"<p><strong>Objective: </strong>To study regional differences and trends in coronary risk factors and in predicted coronary risk calculated on the basis of multiple logistic function equations for the general population aged 25-64 years in two areas in Belgium during the period 1985-1992.</p><p><strong>Design: </strong>A comparison of cross-sectional data on coronary risk factors between two cities and different survey periods.</p><p><strong>Method: </strong>In the cities of Ghent (in Flanders) and Charleroi (in Walloonia) in Belgium, three consecutive cross-sectional age-stratified and sex-stratified random samples of 2000 subjects each were selected from the general population. We studied their coronary risk factors between 1985 and 1992. The field work was carried out according to the protocol of the international WHO-MONICA project.</p><p><strong>Results: </strong>We observed a significant decrease in the prevalence of smoking among men in the two cities over the three surveys, while a gradual increase in diastolic blood pressure for all subgroups in Ghent was seen (this was statistically significant for men aged 45-64 years and women aged 25-44 years). The overall coronary risk predicted on the basis of multiple-logistic-function equations did not however, exhibit significant trends over time in either city. Comparisons between the two centres revealed significantly higher mean serum levels of total cholesterol in Charleroi than in Ghent (for all subgroups except women aged 45-64 years) and significantly higher mean systolic blood pressures in Charleroi for all subgroups defined in terms of age and sex. Prevalences of hypertension in Ghent were significantly lower than those in Charleroi for individuals aged 25-44 years, while the prevalence of obesity in all subgroups in Ghent was also significantly lower. The overall predicted coronary risk in Charleroi was also significantly higher, except for men aged 45-64 years. The differences in mean predicted risk ranged from 5.0% for men aged 45-64 years to 21.2% for women aged 45-64 years.</p><p><strong>Conclusions: </strong>From the data in this article it seems that the trends in overall coronary risk profiles in Ghent and Charleroi are not in accordance with the observed trends in incidence of coronary heart disease (CHD) in these two cities. On the other hand, the differences in predicted coronary risk between the two cities are in the same direction as the observed differences in incidence of CHD between the two cities, but are however too small to explain fully the observed difference in incidence of CHD between the two centres.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"7 5","pages":"347-57"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/204748730000700508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21966067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Social gradients in cardiovascular risk factors and symptoms of Swedish men and women: the Göteborg MONICA Study 1995.","authors":"K Manhem, A Dotevall, L Wilhelmsen, A Rosengren","doi":"10.1177/204748730000700509","DOIUrl":"https://doi.org/10.1177/204748730000700509","url":null,"abstract":"<p><strong>Background: </strong>Even though coronary mortality in middle and old age is decreasing, social gradients may be increasing; but they need not necessarily be the same for men and women. In order to develop efficient preventive strategies more knowledge of the current distributions of risk factors both for men and for women is needed.</p><p><strong>Objective: </strong>To investigate and to compare the socio-economic gradients for coronary risk factors of men and women.</p><p><strong>Design: </strong>A cross-sectional study.</p><p><strong>Methods: </strong>We studied 686 men and 825 women aged 25-64 years from a random population sample. Socio-economic status (SES) was classified according to the occupation-based Swedish Socio-economic Index.</p><p><strong>Results: </strong>For women, high SES was associated with lower levels of total and low-density lipoprotein cholesterol, lower serum levels of triglycerides, higher levels of high-density lipoprotein cholesterol and lower blood pressure. For men, no relation between occupational status and levels of lipids and blood pressure was found. Obesity was associated with low SES both for men and for women. Socioeconomic differences in smoking habits were more pronounced for women than they were for men. The proportion of post-menopausal women was higher among the unskilled workers, despite there being no differences in age. Optimal risk factor status (non-smoker, total cholesterol level < 5 mmol/l, blood pressure < 140/90 mmHg without treatment and body mass index < 25 kg/m2) was unusual both among men and among women, but 34% of the higher officials among the women had optimal risk factor status, compared with 10% of the unskilled workers. Corresponding values for the men were 16 and 9% (P for interaction 0.09). The relation between low SES and level of low-density lipoprotein cholesterol was independent of smoking, post-menopausal state, use of oestrogen and waist:hip ratio (P = 0.04) and so was the relation between systolic blood pressure and low SES (P = 0.0003).</p><p><strong>Conclusions: </strong>In Sweden, low SES exerts a stronger adverse influence on cardiovascular risk factors of women than it does on those of men.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"7 5","pages":"359-68"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/204748730000700509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21966006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychosocial risk factors for myocardial infarction among Swedish railway engine drivers [corrected].","authors":"S Piros, S Karlehagen, G Lappas, L Wilhelmsen","doi":"10.1177/204748730000700512","DOIUrl":"https://doi.org/10.1177/204748730000700512","url":null,"abstract":"<p><strong>Background: </strong>Several earlier investigations have found an increased incidence of myocardial infarction among male drivers and, not least, among railway engine drivers. In a previous study we found that increased serum cholesterol, blood pressure or tobacco smoking did not explain this increased risk.</p><p><strong>Objective: </strong>To investigate psychosocial factors and primarily work-related factors among male engine drivers.</p><p><strong>Design: </strong>Engine drivers were compared with random population samples in a cross-sectional study.</p><p><strong>Method: </strong>Two thousand three hundred and eighteen engine drivers aged 25-59 years were compared with 331 randomly selected men who were mainly from the Göteborg MONICA population study. Job demands and job decision latitude as well as social support were the main factors compared.</p><p><strong>Results: </strong>Job demands were reported as being significantly lower by both younger and older engine drivers compared to their referents (P = 0.002 and P = 0.0001, respectively). Decision latitude was reported as being lower by both younger and older engine drivers than among controls (P = 0.0001 for both groups). Engine drivers experienced deficient support from their superiors compared to the referents (P = 0.0001 for younger as well as older engine drivers). Low decision latitude was associated with significantly higher diastolic blood pressure (r = -0.11 and P = 0.0001), but otherwise there were no significant relationships between psychosocial work characteristics and somatic risk factors.</p><p><strong>Conclusions: </strong>The combination of low decision latitude and low social support seems to be a key factor in the increased risk of myocardial infarction among railway engine drivers. They generally undertake shift work which may be an additional risk factor for myocardial infarction.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"7 5","pages":"389-94"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/204748730000700512","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21966009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}