Zoonoses research最新文献_第8页

Variants of SARS Coronavirus-2 and Their Potential Impact on the Future of the COVID-19 Pandemic SARS冠状病毒2的变异及其对未来COVID-19大流行的潜在影响

Zoonoses research Pub Date : 2021-09-10 DOI: 10.15212/zoonoses-2021-1003

Xin Li, K. To, K. Yuen

{"title":"Variants of SARS Coronavirus-2 and Their Potential Impact on the Future of the COVID-19 Pandemic","authors":"Xin Li, K. To, K. Yuen","doi":"10.15212/zoonoses-2021-1003","DOIUrl":"https://doi.org/10.15212/zoonoses-2021-1003","url":null,"abstract":"The emergence of SARS-CoV-2 variants of concern (VOCs), especially the sweeping spread of the delta variant, and differing public health management strategies, have rendered global eradication of SARS-CoV-2 unlikely. The currently available COVID-19 vaccines, including the inactivated whole virus vaccines, mRNA vaccines, and adenovirus-vectored vaccines, are effective in protecting people from severe disease and death from COVID-19, but they may not confer good mucosal immunity to prevent the establishment of infection and subsequent viral shedding and transmission. Mucosal vaccines delivered via intranasal route may provide a promising direction, which, if given as a third dose after a two-dose series of intramuscular vaccination, likely promotes mucosal immunity in addition to boosting the systemic cell-mediated immunity and antibody response. However, immunity induced by vaccination, and natural infection as well, is likely to wane followed by re-infection as in the case of human coronaviruses OC43, 229E, NL63, and HKU1. It is a challenge to prevent and control COVID-19 worldwide with the increasing number of VOCs associated with increased transmissibility and changing antigenicity. Nevertheless, we may seek to end the current pandemic situation through mass vaccination and gradual relaxation of non-pharmaceutical measures, which would limit the incidence of severe COVID-19. Repeated doses of booster vaccine will likely be required, similar to influenza virus, especially for the elderly and the immunocompromised patients who are most vulnerable to infection.","PeriodicalId":79199,"journal":{"name":"Zoonoses research","volume":"242 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89124938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Analysis of Intermediate Hosts and Susceptible Animals of SARS-CoV-2 by Computational Methods 用计算方法分析SARS-CoV-2中间宿主和易感动物

Zoonoses research Pub Date : 2021-09-04 DOI: 10.15212/zoonoses-2021-0010

Yueying Yang, Meng-zhu Zheng, Yang Liu, Yali Wang, Yang Xu, Yirong Zhou, De-juan Sun, Lixia Chen, Hua Li

{"title":"Analysis of Intermediate Hosts and Susceptible Animals of SARS-CoV-2 by Computational Methods","authors":"Yueying Yang, Meng-zhu Zheng, Yang Liu, Yali Wang, Yang Xu, Yirong Zhou, De-juan Sun, Lixia Chen, Hua Li","doi":"10.15212/zoonoses-2021-0010","DOIUrl":"https://doi.org/10.15212/zoonoses-2021-0010","url":null,"abstract":"COVID-19, a disease caused by SARS-CoV-2 that produces major symptoms of pneumonia, has been a disaster worldwide. The traceability of SARS-CoV-2 and the discovery of susceptible animal species is crucial to halt viral transmission and explore the mechanism of cross-species transmission. We selected 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the hACE2 protein. All selected ACE2 proteins were subjected to homology modeling. Potential natural and intermediate hosts, as well as animal species susceptible to SARS-CoV-2, were analyzed systematically by calculation of the binding free energy of ACE2 protein to the RBD of SARS-CoV-2. Primates, some wild Felidae, civets, goats, spotted hyenas and golden hamsters are susceptible to SARS-CoV-2 and may be potential intermediate hosts, whereas pangolins, birds and reptiles are unlikely to be intermediate hosts. Mice, rats and guinea pig are not susceptible to SARS-CoV-2. Given their possible susceptibility, non-human primates, goats and golden hamsters could potentially be used as experimental models to examine SARS-CoV-2 infection without transgenesis. Herein, possible candidates for the natural and intermediate hosts of SARS-CoV-2 are suggested, to provide guidance for subsequent studies.","PeriodicalId":79199,"journal":{"name":"Zoonoses research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87098179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

SARS-CoV-2 Lambda Variant: Spatiotemporal Distribution and Potential Public Health Impact SARS-CoV-2 Lambda变异:时空分布和潜在的公共卫生影响

Zoonoses research Pub Date : 2021-08-31 DOI: 10.15212/zoonoses-2021-0009

Cao Chen, Qiang Shi, Xiao-Ping Dong

{"title":"SARS-CoV-2 Lambda Variant: Spatiotemporal Distribution and Potential Public Health Impact","authors":"Cao Chen, Qiang Shi, Xiao-Ping Dong","doi":"10.15212/zoonoses-2021-0009","DOIUrl":"https://doi.org/10.15212/zoonoses-2021-0009","url":null,"abstract":"Various SARS-CoV-2 variants have continually emerged since the summer of 2020. Recently, the spread and potential effects of the Lambda variant on public health have caused great scientific and public concern. The Lambda variant (C.37), first identified in Peru in December 2020, contains a novel deletion (Δ246–252) and two novel mutations, L452Q and F490S, not present in the ancestral strain and other variants. The Lambda variant was designated a variant of interest in April of 2021. By the end of July, this variant sequence was detected in more than 30 countries worldwide, mostly in South America. This study analyzed the global spatiotemporal distribution of the Lambda variant from the beginning of January to the end of July from publicly available data. The Lambda variant spread rapidly in Peru and became predominant in March. Circulation of the Lambda variant has also been observed in some neighboring countries, i.e., Argentina, Chile and Ecuador, where it has remained at remarkably low levels. The circulation of the Lambda variant in other countries in South America (e.g., Brazil and Colombia) and other regions of the world has also occurred at very low levels, even though this variant has been known for a long time. Multivariate linear regression analyses of the proportion of case fatalities attributable to the Lambda variant, the new deaths and the new confirmed cases per million (7-day rolling average) in Peru did not show significant associations. A review of the most recent data on the Lambda variant has suggested this variant’s relatively high infectivity in cultured cells and low neutralizing titers of convalescent sera and vaccine-elicited antibodies in vitro. However, the exact effects of this variant on clinical severity and vaccine effectiveness remain poorly documented. The currently authorized COVID-19 vaccines are still believed to provide efficient protection against the Lambda variant.","PeriodicalId":79199,"journal":{"name":"Zoonoses research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89415599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Dynamic Changes in Chest CT Images Over 167 Days in 11 Patients with COVID-19: A Case Series and Literature Review 11例COVID-19患者167天内胸部CT图像的动态变化:病例系列和文献综述

Zoonoses research Pub Date : 2021-08-26 DOI: 10.15212/zoonoses-2021-1001

Jianqing Liang, Guizeng Liu, Shu-guan Yu, Yang Yang, Yanchun Li, Hong-mei Tian, Zhe Chen, W. Gong

{"title":"Dynamic Changes in Chest CT Images Over 167 Days in 11 Patients with COVID-19: A Case Series and Literature Review","authors":"Jianqing Liang, Guizeng Liu, Shu-guan Yu, Yang Yang, Yanchun Li, Hong-mei Tian, Zhe Chen, W. Gong","doi":"10.15212/zoonoses-2021-1001","DOIUrl":"https://doi.org/10.15212/zoonoses-2021-1001","url":null,"abstract":"\u0000\u0000Recently, CT findings have been widely reported to be associated with the clinical severity of COVID-19. However, few studies have reported the correlation between CT findings and long-term outcomes in patients with COVID-19.\u0000\u0000\u0000\u0000Herein, we conducted a 167 day long-term follow-up of CT examination on 11 patients with COVID-19 to evaluate their long-term prognosis, particularly in severe cases. We found that the course of COVID-19 can be divided into four stages according to the characteristics of CT images: 1) early stage (1–4 days), with chest CT showing quasi-circular ground-glass shadows and fine mesh shadows; 2) progressive stage (5–10 days), showing lesion spread through the axial interstitium along the bronchi and gradual diffusion to the whole lung; 3) recovery stage (11–74 days), showing gradual absorption of the fibre cord, ground-glass, and consolidation shadows; and 4) normal stage (74 days later), indicating no serious permanent lung injuries.\u0000\u0000\u0000\u0000Our data indicate that chest CT can enable early detection of COVID-19 and determination of the different stages of COVID-19. Furthermore, mild cases tended to have better prognosis, whereas severe cases still showed cord-like fibrosis in the lungs in follow-up at the 167th day after symptom onset.\u0000","PeriodicalId":79199,"journal":{"name":"Zoonoses research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76084240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Rapid Global Spread of the SARS-CoV-2 Delta (B.1.617.2) Variant: Spatiotemporal Variation and Public Health Impact SARS-CoV-2 δ (B.1.617.2)变体的全球快速传播:时空变化和公共卫生影响

Zoonoses research Pub Date : 2021-08-17 DOI: 10.15212/zoonoses-2021-0005

Qiang Shi, Xiao-Ping Dong

{"title":"Rapid Global Spread of the SARS-CoV-2 Delta (B.1.617.2) Variant: Spatiotemporal Variation and Public Health Impact","authors":"Qiang Shi, Xiao-Ping Dong","doi":"10.15212/zoonoses-2021-0005","DOIUrl":"https://doi.org/10.15212/zoonoses-2021-0005","url":null,"abstract":"The COVID-19 pandemic has already affected human society for more than 1.5 years. As of August 8, 2021, this pandemic had caused more than 203 million infected and 4.3 million deaths worldwide. As an RNA virus, SARS-CoV-2 is prone to genetic evolution, thus resulting in development of mutations over time. Numerous variants of SARS-CoV-2 have been described globally, four of which are considered variants of concern (VOCs) by the WHO: Alpha (B.1.1.7), Beta (B.1.351), Gamma (P1) and Delta (B.1.617.2). The Delta VOC was first reported in India in December of 2020 and has since affected approximately 130 different countries and regions. Herein, the spatiotemporal spread of the Delta VOC during April to July 2021 in 20 selected countries with available data were analyzed. The prevalence of the Delta VOC sequences was maintained at low levels in the beginning of April, increased rapidly in the following 3 months and is now becoming the predominant viral strain in most regions of the world. We also discuss the effects of the Delta VOC on transmissibility, clinical severity and vaccine effectiveness according to the latest data. The Delta VOC has greater transmissibility and risk of hospitalization than the ancestral SARS-CoV-2 strains and the other three VOCs. The Delta VOC places partially or unvaccinated sub-populations at high risk. Currently authorized vaccines, regardless of vaccine type, still have reliable effectiveness against symptomatic infections and hospitalizations due to the Delta VOC.","PeriodicalId":79199,"journal":{"name":"Zoonoses research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79435537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Malaria-free Certification in China: Achievements and Lessons Learned from the National Malaria Elimination Programme 中国无疟疾认证:国家消除疟疾规划的成就和经验教训

Zoonoses research Pub Date : 2021-07-23 DOI: 10.15212/ZOONOSES-2021-1002

Jun Feng, Li Zhang, Z. Xia, Shui-sen Zhou, N. Xiao

引用次数: 10

Emerging and Re-emerging Zoonoses are Major and Global Challenges for Public Health 新出现和再出现的人畜共患病是公共卫生的重大和全球性挑战

Zoonoses research Pub Date : 2021-06-28 DOI: 10.15212/zoonoses-2021-0001

Xiao-Ping Dong, L. Soong

引用次数: 30

Publisher’s Note: Zoonoses—A New Open Access Journal 出版商注:人畜共患病——一种新的开放获取期刊

Zoonoses research Pub Date : 2021-06-21 DOI: 10.3390/zoonoses1010001

Shu-Kun Lin

引用次数: 1

Zoonotic Transmissions and Host Switches of Malaria Parasites. 疟疾寄生虫的人畜共患传播和宿主转换。

Zoonoses research Pub Date : 2021-01-01 Epub Date: 2021-11-02 DOI: 10.15212/zoonoses-2021-0015

Xin-Zhuan Su, Jian Wu

{"title":"Zoonotic Transmissions and Host Switches of Malaria Parasites.","authors":"Xin-Zhuan Su, Jian Wu","doi":"10.15212/zoonoses-2021-0015","DOIUrl":"10.15212/zoonoses-2021-0015","url":null,"abstract":"Malaria is a deadly disease that affects the health of hundreds of millions of people annually. There are five Plasmodium parasite species that can naturally infect humans, including Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi. Some of the parasites can also infect various non-human primates. Parasites mainly infecting monkeys such as Plasmodium cynomolgi (in fact P. knowlesi was considered as a parasite of monkeys for years) can also be transmitted to human hosts. Recently, many new Plasmodium species were discovered in African apes, and it is possible that some of the parasites can be transmitted to humans in the future. Here, we searched PubMed and the internet via Google and selected articles concerning zoonotic transmission and evolution of selected malaria parasite species. We reviewed the current advances in the relevant topics emphasizing on transmissions of malaria parasites between humans and non-human primates. We also briefly discuss the transmissions of some avian malaria parasites between wild birds and domestic fowls. Zoonotic malaria transmissions are widespread, which poses a threat to public health. More studies on parasite species identification in non-human primates, transmission, and evolution are needed to reduce or prevent transmission of malaria parasites from non-human primates to humans.","PeriodicalId":79199,"journal":{"name":"Zoonoses research","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75386589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on viruses in East African bats (Chiroptera). 1. Haemagglutination inhibition and circulation of arboviruses. 东非蝙蝠(翼翅目)病毒的研究。1. 血凝抑制和虫媒病毒的循环。

Zoonoses research Pub Date : 1964-08-01

R C Shepherd, M C Williams

引用次数: 0