Annales De Dermatologie Et De Venereologie最新文献

{"title":"Immune checkpoint inhibitors induced subcutaneous panniculitis-like T-cell lymphoma","authors":"S. Idoudi, A. De Masson, C. Gandon, M. Battistella, S. Caillat-Zucman, S. Pinel, L. Vercellino, F. Jouenne, S. Mourah, B. Baroudjian, C. Lebbe","doi":"10.1016/j.annder.2025.103366","DOIUrl":"10.1016/j.annder.2025.103366","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 3","pages":"Article 103366"},"PeriodicalIF":3.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apremilast: Real-life efficacy and safety in psoriasis limited to the nails","authors":"M. Iorizzo ,&nbsp;G. Damiani ,&nbsp;S.R. Lipner ,&nbsp;A. Pacifico ,&nbsp;D. Rigopoulos ,&nbsp;A. Sechi ,&nbsp;A. Villani ,&nbsp;I. Zaraa ,&nbsp;B. Richert","doi":"10.1016/j.annder.2025.103377","DOIUrl":"10.1016/j.annder.2025.103377","url":null,"abstract":"<div><h3>Background</h3><div>Apremilast, an oral phosphodiesterase inhibitor, offers advantages in psoriasis patients in whom biologics are not approved or accepted and where topical treatments have failed. Psoriasis involving the nails, scalp, and genitals is difficult to treat and is associated with a significant decrease in quality of life, requiring an effective treatment.</div></div><div><h3>Objectives</h3><div>This study aimed to retrospectively assess the efficacy and safety of apremilast 30 mg twice daily in treating psoriasis limited to the nails.</div></div><div><h3>Methods</h3><div>The charts of 55 adult patients with nail psoriasis treated with apremilast were retrospectively evaluated. Baseline characteristics, including the nail psoriasis severity index (NAPSI) and dermatology life quality index (DLQI), were recorded.</div></div><div><h3>Results</h3><div>At 6 months of treatment, a statistically significant decrease in both the NAPSI score (44.7 ± 26.9 vs. 19.03 ± 14.2) and the DLQI score (14.5 ± 5 vs. 7.2 ± 4.1) was observed (<em>p</em> &lt; 0.01). None of the patients discontinued the treatment due to side effects.</div></div><div><h3>Conclusions</h3><div>This study shows improvements in nail psoriasis severity and quality of life with apremilast treatment. Despite potential confounders like psoriatic arthritis, smoking, and manual work, consistent improvements were observed. Apremilast appears to be a valuable treatment option for nail psoriasis. However, further prospective studies are necessary to address the limitations of this retrospective analysis and explore additional endpoints.</div></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103377"},"PeriodicalIF":3.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the French version of the hidradenitis suppurativa quality of life (HiSQOL) questionnaire","authors":"S. Berros ,&nbsp;A.-S. Ficheux ,&nbsp;L. Misery ,&nbsp;N. Jouan ,&nbsp;E. Brenaut","doi":"10.1016/j.annder.2025.103379","DOIUrl":"10.1016/j.annder.2025.103379","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103379"},"PeriodicalIF":3.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse molluscum contagiosum associated with GATA2 deficiency","authors":"C. Bourseau-Quetier,&nbsp;M.-S. Doutre","doi":"10.1016/j.annder.2025.103378","DOIUrl":"10.1016/j.annder.2025.103378","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103378"},"PeriodicalIF":3.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of excess weight on clinical features of psoriasis and efficacy of biologic therapies in children with severe psoriasis: Analysis of data from the BiPe cohorts","authors":"E. Mahé ,&nbsp;V. di Lernia ,&nbsp;A.-C. Bursztejn ,&nbsp;S. Hadj-Rabia ,&nbsp;N. Quiles-Tsimaratos ,&nbsp;A. Belloni Fortina ,&nbsp;I. Neri ,&nbsp;A. Lasek ,&nbsp;A. Maruani ,&nbsp;G. Chaby ,&nbsp;J. Gottlieb ,&nbsp;S. Barbarot ,&nbsp;H. Aubert ,&nbsp;C. Droitcourt ,&nbsp;S. Mallet ,&nbsp;A. Phan ,&nbsp;M. Severino-Freire ,&nbsp;F. Boralévi ,&nbsp;H. Barthélémy ,&nbsp;C. Girard ,&nbsp;A. Beauchet","doi":"10.1016/j.annder.2025.103376","DOIUrl":"10.1016/j.annder.2025.103376","url":null,"abstract":"<div><h3>Background</h3><div>Being overweight or obese is associated with both the occurrence of childhood psoriasis and increased severity thereof. We evaluated the impact of being overweight or obese on the clinical features of severe psoriasis in children treated with etanercept, adalimumab, or ustekinumab, and on the therapeutic effectiveness of these treatments using data from the BiPe cohorts.</div></div><div><h3>Patients and methods</h3><div>Children from the BiPe cohorts with available baseline body mass index data were included. Data from two groups, “normal weight” and “overweight-to-obese” (OTO), and from two OTO subgroups, overweight and obese, were analyzed.</div></div><div><h3>Results</h3><div>Of the 134 children included, 98 (73.1%) were of normal weight, and 36 (26.9%) were OTO, including 21 (15.7%) overweight and 15 (11.2%) obese children. There were no between-group differences in age at psoriasis onset, family history, clinical features, or severity. Compared to the normal weight group, psoriatic arthritis was more frequent in the OTO group (5.1% versus 16.7% respectively; <em>P</em> = 0.03) and in the overweight and obese subgroups (5.1% versus 14.3% and 20.0%, respectively; <em>P</em> = 0.08). Analysis of PASI scores after 3 months of treatment suggested that biologic therapy efficacy was higher for the OTO group than the normal weight group. Drug continuation rates tended to be lower for the OTO group, particularly for adalimumab (<em>P</em> = 0.0002).</div></div><div><h3>Discussion</h3><div>OTO status was associated with a higher frequency of psoriatic arthritis in children with psoriasis. Except for lower rates of adalimumab continuation, overall biologic therapy efficacy was similar in the normal and OTO groups. Studies involving larger cohorts are needed to confirm these findings.</div></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103376"},"PeriodicalIF":3.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous pemphigoid following radiotherapy combined with ipilimumab-nivolumab therapy","authors":"A. Pankakoski,&nbsp;J. Panelius,&nbsp;N. Kluger","doi":"10.1016/j.annder.2025.103367","DOIUrl":"10.1016/j.annder.2025.103367","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103367"},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asynchronous radiation recall dermatitis on two different irradiated areas","authors":"I. Berkaoui,&nbsp;N. Litrowski,&nbsp;C. Boulard","doi":"10.1016/j.annder.2025.103372","DOIUrl":"10.1016/j.annder.2025.103372","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103372"},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-interleukin-23-associated alopecia areata in patients with psoriasis: two cases and a literature review","authors":"Y. Hameg,&nbsp;S. Vildy,&nbsp;E. Mahé,&nbsp;the Groupe de Recherche sur le Psoriasis GRPso of the Société Française de Dermatologie","doi":"10.1016/j.annder.2025.103374","DOIUrl":"10.1016/j.annder.2025.103374","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103374"},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the time-of-day in the administration of immunotherapy and its efficacy in patients with advanced melanoma: A retrospective observational study","authors":"M. Amici ,&nbsp;E. Neveu ,&nbsp;F. Poizeau ,&nbsp;J. Edeline ,&nbsp;T. Lesimple ,&nbsp;E. Oger ,&nbsp;G. Danton ,&nbsp;A. Dupuy ,&nbsp;M. Fouchard","doi":"10.1016/j.annder.2025.103371","DOIUrl":"10.1016/j.annder.2025.103371","url":null,"abstract":"<div><h3>Background</h3><div>Certain publications suggest that immunotherapy would be more effective if it were synchronised with the circadian oscillations of the immune system. We hypothesised that late treatment delivery in melanoma patients would correlate with worse survival outcomes.</div></div><div><h3>Patients and methods</h3><div>We conducted a monocentric retrospective study in patients with advanced cutaneous melanoma receiving immune checkpoint inhibitors as first-line therapy. We used the median clock time of all infusions (11:00) as the cut-off point to differentiate morning from afternoon. Patients were allocated to the morning or afternoon group depending on whether they had received &gt;50% of their infusions before or after 11:00. A propensity score was calculated. Timing groups were assessed for association with overall and progression-free survival using a Cox proportional hazards model, survival curves were compared, and treatment-related adverse events (AEs) were analysed.</div></div><div><h3>Results</h3><div>We included 154 patients treated with frontline immunotherapy in a metastatic setting from 1 January 2013 to 1 January 2022, with a median age of 67 years (interquartile range: 56–75). Late treatment delivery was associated neither with worse overall survival (median not reached [34.9-not estimable] vs. 70.8 months; hazard ratio (HR) = 0.94 [0.63–1.39]) nor worse progression-free survival (22.3 vs. 26.5; HR = 0.99 [0.71–1.38]), and there were no differences in survival outcomes between the groups. Severe treatment-related AEs were significantly more frequent in the afternoon group than in the morning group (33 [34%] vs. 6 [11%] respectively, weighted <em>p</em>-value = 0.004).</div></div><div><h3>Conclusion</h3><div>Timing was not associated with worse efficacy outcomes, but morning administration appears to improve safety.</div></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103371"},"PeriodicalIF":3.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leser-Trélat sign on BRAF inhibitors","authors":"C. Decaestecker ,&nbsp;R. Levard ,&nbsp;J.-M. L’Orphelin","doi":"10.1016/j.annder.2025.103368","DOIUrl":"10.1016/j.annder.2025.103368","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103368"},"PeriodicalIF":3.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}