Y. Zerdani , H. Nguyen-Chi , J.-B. Monfort , P. Senet , E. Tella , E. Mahé , The Groupe Angiodermatologie (GAD) of the Société Française de Dermatologie
{"title":"Management of hypertensive leg ulcers: A French national survey","authors":"Y. Zerdani , H. Nguyen-Chi , J.-B. Monfort , P. Senet , E. Tella , E. Mahé , The Groupe Angiodermatologie (GAD) of the Société Française de Dermatologie","doi":"10.1016/j.annder.2025.103353","DOIUrl":"10.1016/j.annder.2025.103353","url":null,"abstract":"<div><h3>Background</h3><div>Hypertensive leg ulcers (HLUs) are superficial, rapidly spreading, necrotic ulcers that are frequently resistant to standard local wound care. The available literature on HLU management is relatively poor. This survey-based study aimed to evaluate the management of HLUs in France.</div></div><div><h3>Methods</h3><div>A questionnaire was sent in December 2019 to all members of the Angiodermatology Group of the French Society of Dermatology. The questionnaire collected information about physicians and their department, and about their management of HLUs, including examinations and specific and non-specific topical and systemic treatments.</div></div><div><h3>Results</h3><div>Forty-four physicians responded. The most frequently performed examinations were lower-limb arterial Doppler (88.6%), ankle-brachial pressure index tests (83.7%) and venous Doppler (60.5%). Blood sampling for autoimmunity testing was requested by 27.3% of physicians and skin biopsy by 20.5%. The most frequently used first-line therapy was skin grafting (97.7%). Other treatments included topical steroids (58.1%), negative-pressure therapy (15.9%), electrostimulation (15.9%), auto-haemotherapy (14.0%), and iloprost (11.4%). The mechanism of action of electrostimulation is not very clear. Its main benefit lies in controlling the pain of HLU. Iloprost appears to be an interesting vasodilator although it has not been validated to date. An additional antiplatelet agent was proposed by 19.0% of the physicians and modification of anticoagulant treatment (use of a vitamin K antagonist in addition to direct oral anticoagulants) was proposed by 19.5% of physicians.</div></div><div><h3>Discussion</h3><div>The survey results showed that HLU evaluation involved searching for associated peripheral arterial disease and that HLU management in France was disparate. Skin grafting was the sole consensual treatment and was generally used as a first-line option. Other treatments require further evaluation. Management disparities could be reduced by the drafting and publication of a consensus guideline to harmonise HLU management.</div></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103353"},"PeriodicalIF":3.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Duplaine , J. Tannous , J. Seneschal , K. Ezzedine , T. Passeron , N. Dupin , G. Quereux , M. Beylot-Barry , O. Chosidow , B. Guillot , for the Centre of Evidence of the French Society of Dermatology
{"title":"Value of tacrolimus 0.1% in the treatment of vitiligo in the era of targeted therapy","authors":"A. Duplaine , J. Tannous , J. Seneschal , K. Ezzedine , T. Passeron , N. Dupin , G. Quereux , M. Beylot-Barry , O. Chosidow , B. Guillot , for the Centre of Evidence of the French Society of Dermatology","doi":"10.1016/j.annder.2025.103352","DOIUrl":"10.1016/j.annder.2025.103352","url":null,"abstract":"<div><h3>Background</h3><div>Vitiligo, a prevalent depigmenting condition, affects both adults and children, significantly impacting their quality of life. The standard treatment approach involves the application of topical corticosteroids in conjunction with narrow-band ultraviolet B (UVB) phototherapy. A novel topical treatment, ruxolitinib (a Janus kinase inhibitor), has recently received approval. Notwithstanding the absence of marketing authorization for this particular indication in France, numerous practitioners have adopted the use of tacrolimus ointment 0.1% for the treatment of vitiligo, frequently in conjunction with phototherapy. The objective of this study is to present the benefit/risk ratio of tacrolimus in the treatment of vitiligo.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted by the Centre of Evidence (CDP) of the French Society of Dermatology (SFD) to ascertain the efficacy and safety of topical calcineurin inhibitors (TCIs) in vitiligo. The search strategy encompassed meta-analyses (MAs) and prospective multicentric cohort studies.</div></div><div><h3>Results</h3><div>Literature data – in particular three meta-analyses and one randomised controlled trial – confirm the superiority of tacrolimus versus placebo and its non-inferiority versus super-potent topical corticosteroids. In a subgroup analysis, tacrolimus suggests superior efficacy in children and in facial vitiligo. The combined use of tacrolimus and phototherapy exhibited synergistic efficacy.</div></div><div><h3>Conclusion</h3><div>Notwithstanding the market access of topical ruxolitinib, tacrolimus remains a viable treatment option for vitiligo, as substantiated by extant efficacy and safety in the literature. A recent decision of the French National Agency for the Safety of Medicines and Health Products (ANSM) authorized the compassionate prescription of tacrolimus and its reimbursement for patients.</div></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103352"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global interest in tattoos in decline while interest in tattoo removal is on the rise","authors":"N. Kluger","doi":"10.1016/j.annder.2025.103349","DOIUrl":"10.1016/j.annder.2025.103349","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103349"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hobnail hemangioma","authors":"A. Cuypers , S. Blaise","doi":"10.1016/j.annder.2025.103343","DOIUrl":"10.1016/j.annder.2025.103343","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103343"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
X. Humbert, J. Dupouy, V. Renard, D. Pouchain, B. Tudrej, H. Partouche, N. Rousselot, Y.-M. Vincent, G. Ibanez, A. Malmartel, M. Jego, S. Gilberg, M. Francois, E. Ferrat, O. Saint-Lary, R. Boussageon, Scientific Council of the French College of Academic General Practitioners (Collège national des généralistes enseignants, Conseil scientifique)
{"title":"Systematic screening for skin cancers: Is it a good idea?","authors":"X. Humbert, J. Dupouy, V. Renard, D. Pouchain, B. Tudrej, H. Partouche, N. Rousselot, Y.-M. Vincent, G. Ibanez, A. Malmartel, M. Jego, S. Gilberg, M. Francois, E. Ferrat, O. Saint-Lary, R. Boussageon, Scientific Council of the French College of Academic General Practitioners (Collège national des généralistes enseignants, Conseil scientifique)","doi":"10.1016/j.annder.2025.103350","DOIUrl":"10.1016/j.annder.2025.103350","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103350"},"PeriodicalIF":3.1,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A giant patch of dermatoporosis secondary to inappropriate topical corticosteroid use","authors":"N. Kluger","doi":"10.1016/j.annder.2025.103348","DOIUrl":"10.1016/j.annder.2025.103348","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103348"},"PeriodicalIF":3.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Descos, C. Girard, M. Girod, G. Boursier, D. Bessis
{"title":"Acrodermatitis continua of Hallopeau successfully treated with spesolimab","authors":"M. Descos, C. Girard, M. Girod, G. Boursier, D. Bessis","doi":"10.1016/j.annder.2025.103347","DOIUrl":"10.1016/j.annder.2025.103347","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103347"},"PeriodicalIF":3.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Fera , A. Pausé , C. Louacheni , C. Kwan , C. Scalbert , E. Chirpaz , A. Bertolotti
{"title":"Estimation of the proportion of skin cancers attributable to occupational sun exposure in Reunion Island","authors":"C. Fera , A. Pausé , C. Louacheni , C. Kwan , C. Scalbert , E. Chirpaz , A. Bertolotti","doi":"10.1016/j.annder.2025.103351","DOIUrl":"10.1016/j.annder.2025.103351","url":null,"abstract":"<div><h3>Background</h3><div>The increasing prevalence of cutaneous malignancies has led to their categorization as a public health concern. The main risk factor is ultraviolet (UV) radiation, which can be particularly high in certain overseas territories. As a result, outdoor workers constitute a high-risk population.</div></div><div><h3>Objectives</h3><div>The aim of this study was to determine the proportion of skin cancers potentially attributable to occupational sun exposure in Reunion Island.</div><div>The increasing prevalence of skin cancer in recent years has led to its recognition as a significant public health concern. The primary risk factor is ultraviolet (UV) radiation, which has been observed to reach elevated levels in certain overseas territories. Consequently, individuals engaged in outdoor work are considered a high-risk population. The objectives of this study were to determine the proportion of skin cancers potentially attributable to occupational sun exposure in Reunion Island and to identify factors associated with such exposure.</div></div><div><h3>Methods</h3><div>This study covers all melanomas, cutaneous squamous cell carcinomas and a representative sample of basal cell carcinomas, diagnosed over one year in subjects who had worked for at least 3 years on the island. Telephone interviews were conducted with each subject to gather data on their exposure to sunlight during childhood, leisure activities and work. Cancers were classified as potentially attributable to work if the time spent in the sun at work was greater than the time spent in the sun during leisure time, taking into account sun protection data and the site of the skin cancer (areas exposed during work).</div></div><div><h3>Results</h3><div>Of the 329 people included, 37.7% had skin cancer(s) attributable to occupational UV exposure. Several high-risk professions were identified, including farmers. Among people surveyed, 93% reported that their employers had taken any steps to prevent sun exposure and 73% had never used sunscreen at work.</div></div><div><h3>Conclusion</h3><div>The percentage of people with skin cancer potentially attributable to occupational sun exposure in Reunion Island is considerable. Prevention and education on photoprotection in the workplace are essential. Recognition of skin cancer in exposed workers as an occupational disease should be considered in Reunion Island.</div></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103351"},"PeriodicalIF":3.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Tzoumpa , B. Papouin , C. Guillaud , S. Ingen-Housz-Oro
{"title":"Primary localized cutaneous AL lambda amyloidosis with an anetodermic presentation in a patient with Sjögren’s syndrome","authors":"S. Tzoumpa , B. Papouin , C. Guillaud , S. Ingen-Housz-Oro","doi":"10.1016/j.annder.2025.103345","DOIUrl":"10.1016/j.annder.2025.103345","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 2","pages":"Article 103345"},"PeriodicalIF":3.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}