Y Kaneko, K Yanagihara, M Kuroki, H Ohi, H Kakeya, Y Miyazaki, Y Higashiyama, Y Hirakata, K Tomono, J I Kadota, S Kohno
{"title":"Effects of parenterally administered ciprofloxacin in a murine model of pulmonary Pseudomonas aeruginosa infection mimicking ventilator-associated pneumonia.","authors":"Y Kaneko, K Yanagihara, M Kuroki, H Ohi, H Kakeya, Y Miyazaki, Y Higashiyama, Y Hirakata, K Tomono, J I Kadota, S Kohno","doi":"10.1159/000048553","DOIUrl":"10.1159/000048553","url":null,"abstract":"<p><strong>Background and methods: </strong>We compared the bacteriological, pharmacological and histopathological effects of parenterally administered ciprofloxacin (CPFX) to those of imipenem/cilastatin (IMP/CS) and cefozopran (CZOP) in a murine model of mucoid Pseudomonas aeruginosa pneumonia mimicking ventilator-associated pneumonia.</p><p><strong>Results: </strong>The minimum inhibitory concentrations (MICs) of CPFX, IMP and CZOP were 1.0, 1.0 and 4.0 mg/l, respectively. Treatment with CPFX resulted in a significant decrease in the number of viable bacteria [control, IMP/CS, CZOP and CPFX (mean +/- SEM): 5.02 +/- 0.20, 4.96 +/- 0.38, 5.44 +/- 0.13 and 3.27 +/- 0.02 log(10) colony-forming units lung, respectively]. Histopathological examination revealed that inflammatory changes in the CPFX-treated group were less marked than in other groups. Of the drugs analyzed, the pharmacokinetic parameters of area under the time-concentration curve (AUC)/MIC, AUC exceeding MIC and the time that lung concentrations of drug remained above the MIC were highest for CPFX.</p><p><strong>Conclusion: </strong>Our results suggest that parenterally administered ciprofloxacin is effective in ventilator-associated P. aeruginosa pneumonia.</p>","PeriodicalId":78882,"journal":{"name":"Biometrische Zeitschrift","volume":"2 1","pages":"421-9"},"PeriodicalIF":3.3,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000048553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73211698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systematische Untersuchungen zur eigentlich nichtlinearen Regressionsrechnung mit Sigmoidfunktionen. (Fortsetzung)","authors":"J. Scharf, J. Peil, H. Helwin","doi":"10.1002/BIMJ.19730150104","DOIUrl":"https://doi.org/10.1002/BIMJ.19730150104","url":null,"abstract":"","PeriodicalId":78882,"journal":{"name":"Biometrische Zeitschrift","volume":"15 1","pages":"21-46"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/BIMJ.19730150104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50668959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Zur Beobachtung stochastischer Einschwingprozesse mit stationärem Fehleranteil","authors":"H. Bandemer, Le Anh Son","doi":"10.1002/BIMJ.19730150108","DOIUrl":"https://doi.org/10.1002/BIMJ.19730150108","url":null,"abstract":"","PeriodicalId":78882,"journal":{"name":"Biometrische Zeitschrift","volume":"15 1","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/BIMJ.19730150108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50668878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nichtparametrischer Nachweis von Syndromen durch simultane Binomialtests","authors":"J. Krauth, G. Lienert","doi":"10.1002/BIMJ.19730150103","DOIUrl":"https://doi.org/10.1002/BIMJ.19730150103","url":null,"abstract":"","PeriodicalId":78882,"journal":{"name":"Biometrische Zeitschrift","volume":"15 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/BIMJ.19730150103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50668907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Betrachtungen über einige Methoden zur Optimierung von Fermentationsmedien","authors":"H. Grimm, G. Wesser, H. Bocker","doi":"10.1002/BIMJ.19730150109","DOIUrl":"https://doi.org/10.1002/BIMJ.19730150109","url":null,"abstract":"","PeriodicalId":78882,"journal":{"name":"Biometrische Zeitschrift","volume":"15 1","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/BIMJ.19730150109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50668925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RIGGS, D. S.: The mathematical approach to physiological problems. M. I. T. Press, Cambridge, Massachusetts, London 1970. XIV, 445 S., 93 Abb., 10 Tab., 134 Lit., $5.85.","authors":"K. Bellmann","doi":"10.1002/BIMJ.19730150111","DOIUrl":"https://doi.org/10.1002/BIMJ.19730150111","url":null,"abstract":"","PeriodicalId":78882,"journal":{"name":"Biometrische Zeitschrift","volume":"15 1","pages":"93-94"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/BIMJ.19730150111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50669048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the planning of the experiment on estimation of intraclass correlation","authors":"E. Ginsburg","doi":"10.1002/BIMJ.19730150105","DOIUrl":"https://doi.org/10.1002/BIMJ.19730150105","url":null,"abstract":"","PeriodicalId":78882,"journal":{"name":"Biometrische Zeitschrift","volume":"15 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/BIMJ.19730150105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50669078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}